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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70492
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nat2
Name: N-acetyltransferase 2
Acc ID: CHEBI:82284
Term: 2-Amino-9H-pyrido[2,3-b]indole
Definition: A pyridoindole that has formula C11H9N3.
Chemical ID: MESH:C017822
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nat2affects response to substanceISONAT2 (Homo sapiens)6480464CTDNAT2 gene polymorphism affects the susceptibility to 2-amino-9H-pyrido(2,3-b)indolePMID:19243127
Nat2multiple interactionsISONAT2 (Homo sapiens)6480464CTD[CYP1A2 protein co-treated with NAT2 gene polymorphism] promotes the reaction [2-amino-9H-pyrido(2,3-b)indole binds to and results in increased mutagenesis of HPRT1 gene]; NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-9H-pyrido(2,3-b)indolePMID:19243127 PMID:28160022
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