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Genetic variability in N-acetyltransferase 2 gene determines susceptibility to childhood lymphoid or myeloid leukemia in Brazil.

Authors: Zanrosso, CW  Emerenciano, M  Faro, A  Goncalves, BA  Mansur, MB  Pombo-de-Oliveira, MS 
Citation: Zanrosso CW, etal., Leuk Lymphoma. 2012 Feb;53(2):323-7. doi: 10.3109/10428194.2011.619605. Epub 2011 Nov 25.
Pubmed: (View Article at PubMed) PMID:21888617
DOI: Full-text: DOI:10.3109/10428194.2011.619605

Seven single nucleotide polymorphisms (SNPs) were genotyped in 535 Brazilian children (158 with acute lymphoblastic leukemia [ALL], 74 with acute myeloid leukemia [AML] and 303 controls). The subjects were classified as fast or slow acetylators based on their genotypic variants. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals. N-acetyltransferase 2 (NAT2) SNP 341T > C frequency was higher among both leukemia subtypes compared to controls. There was also a significant difference in the frequency of SNP 590G > A in AML (OR, 1.57, 1.07-2.30). The haplotypes *14A, *5A and *5C conferred an increased risk in cases of ALL, while *14E, *6B and *6F conferred an increased risk for AML. An age-dependent analysis demonstrated that the NAT2 slow-acetylators conferred an increased risk association with leukemia in children /= 10 years old) (OR, 1.53, 1.01-2.31). However, in this latter group the magnitude was reduced. The results demonstrate that the different NAT2 haplotypes contribute to the risk of either ALL or AML.


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RGD Object Information
RGD ID: 11532769
Created: 2016-09-07
Species: All species
Last Modified: 2016-09-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.