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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70490
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nat1
Name: N-acetyltransferase 1
Acc ID: CHEBI:1784
Term: biphenyl-4-amine
Definition: An aminobiphenyl that is biphenyl substituted by an amino group at position 4.
Chemical ID: MESH:C006757
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nat1affects response to substanceISONAT1 (Homo sapiens)6480464CTDNAT1 mRNA alternative form affects the susceptibility to 4-biphenylaminePMID:21837760
Nat1increases acetylationISONAT1 (Homo sapiens)6480464CTDNAT1 protein polymorphism results in increased acetylation of 4-biphenylamine; NAT1 protein results in increased acetylation of 4-biphenylaminePMID:12088197 PMID:22010219
Nat1increases activityISONAT1 (Homo sapiens)6480464CTDNAT1 protein results in increased activity of 4-biphenylaminePMID:15450435
Nat1increases metabolic processingISONat1 (Mus musculus)6480464CTDNAT1 protein results in increased metabolism of 4-biphenylaminePMID:16815960
Nat1increases response to substanceISONAT1 (Homo sapiens)6480464CTDNAT1 polymorphism results in increased susceptibility to 4-biphenylamine; NAT1 protein polymorphism results in increased susceptibility to 4-biphenylaminePMID:22010219 PMID:22114069
Nat1multiple interactionsISONAT1 (Homo sapiens)6480464CTD[NAT1 polymorphism results in increased susceptibility to 4-biphenylamine] which results in increased mutagenesis of HPRT1 genePMID:22114069
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