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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70490
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nat1
Name: N-acetyltransferase 1
Acc ID: CHEBI:15351
Term: acetyl-CoA
Definition: An acyl-CoA having acetyl as its S-acetyl component.
Chemical ID: MESH:D000105
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nat1affects bindingISONAT1 (Homo sapiens)6480464CTDAcetyl Coenzyme A binds to NAT1 proteinPMID:22835378
Nat1multiple interactionsISONAT1 (Homo sapiens)6480464CTD[NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]; Acetyl Coenzyme A inhibits the reaction [Iodoacetamide results in decreased activity of NAT1 protein]PMID:20545351 PMID:22835378
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