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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70490
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nat1
Name: N-acetyltransferase 1
Acc ID: CHEBI:80495
Term: benzidine
Definition: A member of the class of biphenyls that is 1,1'-biphenyl in which the hydrogen at the para-position of each phenyl group has been replaced by an amino group.
Chemical ID: MESH:C029876
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nat1affects acetylationISONAT1 (Homo sapiens)6480464CTDNAT1 polymorphism affects the acetylation of benzidinePMID:37097310
Nat1affects response to substanceISONAT1 (Homo sapiens)6480464CTDNAT1 polymorphism affects the susceptibility to benzidinePMID:37097310
Nat1increases activityISONAT1 (Homo sapiens)6480464CTDNAT1 protein results in increased activity of benzidinePMID:15450435
Nat1increases metabolic processingISONAT1 (Homo sapiens)6480464CTDNAT1 protein results in increased metabolism of benzidinePMID:33136180
Nat1multiple interactionsISONAT1 (Homo sapiens)6480464CTD[NAT1 polymorphism affects the susceptibility to benzidine] which affects the expression of H2AX; [NAT1 polymorphism affects the susceptibility to benzidine] which affects the mutagenesis of HPRT1PMID:37097310
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