Mbl2 (mannose binding lectin 2) - Rat Genome Database

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Gene: Mbl2 (mannose binding lectin 2) Rattus norvegicus
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Symbol: Mbl2 (Ensembl: LOC100911854)
Name: mannose binding lectin 2 (Ensembl:mannose-binding protein C-like)
RGD ID: 67380
Description: Enables several functions, including identical protein binding activity; monosaccharide binding activity; and phosphatidylinositol-4-phosphate binding activity. Involved in positive regulation of complement activation and positive regulation of protein processing. Located in extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bacterial infectious disease (multiple); fungal infectious disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MBL2 (mannose binding lectin 2); PARTICIPATES IN lectin complement pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH (+)-schisandrin B; (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ab2-001; Ab2-011; LOC100911854; mannan-binding protein; mannose binding lectin 2 (protein C); mannose-binding lectin (protein C) 2; mannose-binding protein C; mannose-binding protein C (liver); mannose-binding protein C-like; MBP-C; RA-reactive factor P28A subunit; ra-reactive factor polysaccharide-binding component p28A; raRF p28A; RARF/P28A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21228,016,439 - 228,024,736 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1236,419,619 - 236,424,489 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01243,349,309 - 243,354,179 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01236,171,876 - 236,176,773 (+)NCBIRnor_WKY
Rnor_6.01248,435,069 - 248,442,669 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,723,397 - 248,729,962 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01255,681,084 - 255,688,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,978,931 - 233,983,824 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,140,682 - 234,147,846 (+)NCBI
Celera1225,160,772 - 225,165,665 (+)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
Alzheimer's disease  (ISO)
Aneurysm  (ISO)
aortic valve insufficiency  (ISO)
Arterial Thrombosis  (ISO)
aspergillosis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autoimmune thyroiditis  (ISO)
Bacteremia  (ISO)
bacterial infectious disease  (ISO)
bacterial pneumonia  (ISO)
bacterial vaginosis  (ISO)
Behcet's disease  (ISO)
bipolar disorder  (ISO)
Birth Weight  (ISO)
Brain Injuries  (ISO)
bronchiectasis  (ISO)
bronchiolitis obliterans  (ISO)
bronchopneumonia  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Chagas Cardiomyopathy  (ISO)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
chorioamnionitis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Rhinosinusitis  (ISO)
coccidioidomycosis  (ISO)
common variable immunodeficiency  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Crohn's disease  (ISO)
cryptococcal meningitis  (ISO)
cryptosporidiosis  (ISO)
cystic fibrosis  (ISO)
Cytomegalovirus Infections  (ISO)
dermatomyositis  (ISO)
Diabetic Foot  (ISO)
Diffuse Panbronchiolitis  (ISO)
disease by infectious agent  (ISO)
end stage renal disease  (ISO)
Familial Thoracic Aortic Aneurysm 8  (ISO)
fungal infectious disease  (ISO)
gestational diabetes  (ISO)
Hashimoto Disease  (ISO)
hemolytic-uremic syndrome  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Intestinal Reperfusion Injury  (ISO)
invasive aspergillosis  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kartagener syndrome  (ISO)
Kawasaki disease  (ISO)
Legionnaires' disease  (ISO)
lepromatous leprosy  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
lung cancer  (ISO)
lupus nephritis  (ISO)
Mannose-Binding Protein Deficiency  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
newborn respiratory distress syndrome  (ISO)
obesity  (ISO)
otitis media  (ISO)
ovarian cancer  (ISO)
panic disorder  (ISO)
pemphigus  (ISO)
peripheral nervous system disease  (ISO)
peripheral vascular disease  (ISO)
Plasmodium falciparum malaria  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyalgia rheumatica  (ISO)
Premature Birth  (ISO)
primary open angle glaucoma  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
respiratory failure  (ISO)
Respiratory Tract Infections  (ISO)
rhinitis  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
Smoke Inhalation Injury  (ISO)
Spontaneous Abortions  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
thrombocytopenia  (ISO)
toxic shock syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
Varicose Ulcer  (ISO)
Vaso-occlusive Crisis  (ISO)
visceral leishmaniasis  (ISO)
vitiligo  (ISO)
vulvovaginal candidiasis  (ISO)
Yin Deficiency  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-amphetamine  (EXP)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-acetamidofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
aflatoxin B1  (ISO)
all-trans-retinol  (ISO)
ammonium chloride  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
endosulfan  (ISO)
flutamide  (EXP)
furan  (EXP)
glafenine  (EXP)
Lasiocarpine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
metam  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ozone  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MBL2 gene polymorphisms protect against development of thrombocytopenia associated with severe dengue phenotype. Acioli-Santos B, etal., Hum Immunol. 2008 Feb;69(2):122-8. doi: 10.1016/j.humimm.2008.01.005. Epub 2008 Feb 12.
2. Relation among mannose-binding lectin 2 genotype, beta-cell autoantibodies, and risk for type 1 diabetes in Finnish children. Aittoniemi J, etal., Hum Immunol. 2008 Feb;69(2):108-11. doi: 10.1016/j.humimm.2008.01.007. Epub 2008 Feb 20.
3. Genotypes of the mannan-binding lectin gene and susceptibility to visceral leishmaniasis and clinical complications. Alonso DP, etal., J Infect Dis. 2007 Apr 15;195(8):1212-7. Epub 2007 Mar 5.
4. Mannan-binding lectin MBL2 gene polymorphism in chronic hepatitis C: association with the severity of liver fibrosis and response to interferon therapy. Alves Pedroso ML, etal., Clin Exp Immunol. 2008 May;152(2):258-64. doi: 10.1111/j.1365-2249.2008.03614.x. Epub 2008 Mar 10.
5. Mannose-binding lectin serum levels are low in persons with clinically active coccidioidomycosis. Ampel NM, etal., Mycopathologia. 2009 Apr;167(4):173-80. Epub 2008 Dec 14.
6. Polymorphisms in immunoregulatory genes and the risk of histologic chorioamnionitis in Caucasoid women: a case control study. Annells MF, etal., BMC Pregnancy Childbirth. 2005 Feb 21;5(1):4.
7. Mannan-binding lectin deficiency in pediatric patients with inflammatory bowel disease. Bak-Romaniszyn L, etal., Scand J Gastroenterol. 2011 Oct;46(10):1275-8. doi: 10.3109/00365521.2011.594087. Epub 2011 Jun 27.
8. The polymorphisms of the MBL2 and MIF genes associated with Pediatric Cochlear Implant Patients. Baysal E, etal., Int J Pediatr Otorhinolaryngol. 2013 Mar;77(3):338-40. doi: 10.1016/j.ijporl.2012.11.020. Epub 2012 Dec 14.
9. Polymorphisms in the mannose-binding lectin gene as determinants of age-defined risk of coronary artery lesions in Kawasaki disease. Biezeveld MH, etal., Arthritis Rheum. 2006 Jan;54(1):369-76.
10. Association of the wild-type A/A genotype of MBL2 codon 54 with asthma in a North Indian population. Birbian N, etal., Dis Markers. 2012;32(5):301-8. doi: 10.3233/DMA-2012-0892.
11. Epidemiology of chronic wound patients and relation to serum levels of mannan-binding lectin. Bitsch M, etal., Acta Derm Venereol. 2009 Nov;89(6):607-11. doi: 10.2340/00015555-0730.
12. Association between bronchopulmonary dysplasia and MBL2 and IL1-RN polymorphisms. Cakmak BC, etal., Pediatr Int. 2012 Dec;54(6):863-8. doi: 10.1111/j.1442-200X.2012.03714.x. Epub 2012 Nov 21.
13. Role played by human mannose-binding lectin polymorphisms in pulmonary tuberculosis. Capparelli R, etal., J Infect Dis. 2009 Mar 1;199(5):666-72.
14. Prevalence of atopic symptoms among blood donor carriers of mannose-binding lectin variant alleles. Cardinale F, etal., Int J Immunopathol Pharmacol. 2008 Jul-Sep;21(3):735-8.
15. Deficient serum mannose-binding lectin levels and MBL2 polymorphisms increase the risk of single and recurrent Cryptosporidium infections in young children. Carmolli M, etal., J Infect Dis. 2009 Nov 15;200(10):1540-7. doi: 10.1086/606013.
16. High polymorphism of the MBL2 gene in patients with atopic dermatitis. Carrera MC, etal., Ann Allergy Asthma Immunol. 2010 Jul;105(1):39-42. doi: 10.1016/j.anai.2010.03.017.
17. L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children. Cedzynski M, etal., Mol Immunol. 2009 Dec;47(2-3):415-9. Epub 2009 Sep 19.
18. Influence of mannose-binding lectin gene polymorphisms on the invasiveness of cytomegalovirus disease after solid organ transplantation. Cervera C, etal., Transplant Proc. 2009 Jul-Aug;41(6):2259-61.
19. Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation. Chen CB and Wallis R, J Biol Chem. 2001 Jul 13;276(28):25894-902. Epub 2001 May 3.
20. Mannose-binding lectin polymorphisms and recurrent respiratory tract infection in Chinese children. Chen J, etal., Eur J Pediatr. 2009 Nov;168(11):1305-13. Epub 2009 Jan 24.
21. Modulating effects of mannose binding lectin genotype on arterial stiffness in children after Kawasaki disease. Cheung YF, etal., Pediatr Res. 2004 Oct;56(4):591-6. Epub 2004 Aug 4.
22. Mannose-binding lectin in chronic hepatitis B virus infection. Chong WP, etal., Hepatology. 2005 Nov;42(5):1037-45. doi: 10.1002/hep.20891.
23. Mannose-binding lectin-2 genotypes and recurrent late pregnancy losses. Christiansen OB, etal., Hum Reprod. 2009 Feb;24(2):291-9. doi: 10.1093/humrep/den377. Epub 2008 Oct 16.
24. Resistance of MBL gene-knockout mice to experimental systemic aspergillosis. Clemons KV, etal., Immunol Lett. 2010 Feb 16;128(2):105-7. doi: 10.1016/j.imlet.2009.12.021. Epub 2010 Jan 12.
25. Mannose-binding lectin gene polymorphisms as a susceptibility factor for chronic necrotizing pulmonary aspergillosis. Crosdale DJ, etal., J Infect Dis. 2001 Sep 1;184(5):653-6. Epub 2001 Jul 24.
26. Increased serum complement component 3 and mannose-binding lectin levels in adult Chinese patients with chronic rhinosinusitis. Cui YH, etal., Rhinology. 2009 Jun;47(2):187-91.
27. Mannan-binding lectin and ficolin deposition in skin lesions of pemphigus. de Messias-Reason IJ, etal., Arch Dermatol Res. 2011 Sep;303(7):521-5. doi: 10.1007/s00403-011-1132-1. Epub 2011 Feb 16.
28. The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injury. de Vries B, etal., Am J Pathol. 2004 Nov;165(5):1677-88.
29. Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study. Dolman KM, etal., Arthritis Res Ther. 2008;10(2):R32. doi: 10.1186/ar2386. Epub 2008 Mar 11.
30. Mannose-binding proteins isolated from rat liver contain carbohydrate-recognition domains linked to collagenous tails. Complete primary structures and homology with pulmonary surfactant apoprotein. Drickamer K, etal., J Biol Chem 1986 May 25;261(15):6878-87.
31. Serum levels and H/L gene polymorphism of mannose-binding lectin in primary open angle glaucoma. Dursun O, etal., Curr Eye Res. 2012 Mar;37(3):212-7. doi: 10.3109/02713683.2011.639124.
32. Lack of genetic association of promoter and structural variants of mannan-binding lectin (MBL2) gene with susceptibility to generalized vitiligo. Dwivedi M, etal., Br J Dermatol. 2009 Jul;161(1):63-9. doi: 10.1111/j.1365-2133.2009.09140.x. Epub 2009 Apr 16.
33. Mannose-binding lectin in chronic hepatitis C in children. Dzwonek AB, etal., Scand J Gastroenterol. 2015;50(10):1276-84. doi: 10.3109/00365521.2015.1006673. Epub 2015 May 8.
34. Mannose-binding lectin genotypes in susceptibility to community-acquired pneumonia. Endeman H, etal., Chest. 2008 Dec;134(6):1135-40. Epub 2008 Jul 18.
35. Association of mannose-binding lectin-2 gene polymorphism with the development of hepatitis C-induced hepatocellular carcinoma. Eurich D, etal., Liver Int. 2011 Aug;31(7):1006-12. doi: 10.1111/j.1478-3231.2011.02522.x. Epub 2011 Apr 15.
36. Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin. Fernandez-Real JM, etal., Diabetologia. 2006 Oct;49(10):2402-11. Epub 2006 Aug 29.
37. Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanism. Fidler KJ, etal., Thorax. 2009 Feb;64(2):150-5. Epub 2008 Nov 6.
38. Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients. Filho CB, etal., Int J Immunogenet. 2012 Aug;39(4):357-61. doi: 10.1111/j.1744-313X.2012.01102.x. Epub 2012 Feb 23.
39. Bipolar and panic disorders may be associated with hereditary defects in the innate immune system. Foldager L, etal., J Affect Disord. 2014 Aug;164:148-54. doi: 10.1016/j.jad.2014.04.017. Epub 2014 Apr 19.
40. Association of mannose-binding lectin gene polymorphisms with antiphospholipid syndrome, cardiovascular disease and chronic damage in patients with systemic lupus erythematosus. Font J, etal., Rheumatology (Oxford). 2007 Jan;46(1):76-80. Epub 2006 Jun 26.
41. Mannan-binding lectin modulates the response to HSV-2 infection. Gadjeva M, etal., Clin Exp Immunol. 2004 Nov;138(2):304-11.
42. Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults. Garcia-Laorden MI, etal., J Allergy Clin Immunol. 2008 Aug;122(2):368-74, 374.e1-2. Epub 2008 Jun 25.
43. Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis. Garred P, etal., J Clin Invest. 1999 Aug;104(4):431-7.
44. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
45. Complement defects in patients with chronic rhinosinusitis. Gaunsbaek MQ, etal., PLoS One. 2012;7(11):e47383. doi: 10.1371/journal.pone.0047383. Epub 2012 Nov 7.
46. Mannose-binding lectin gene polymorphism, vulvovaginal candidiasis, and bacterial vaginosis. Giraldo PC, etal., Obstet Gynecol. 2007 May;109(5):1123-8.
47. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
48. Mannose-binding lectin gene polymorphism is a modulating factor in repeated respiratory infections. Gomi K, etal., Chest. 2004 Jul;126(1):95-9.
49. Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome. Gong MN, etal., Crit Care Med. 2007 Jan;35(1):48-56.
50. Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factors. Gregersen S, etal., Ann Allergy Asthma Immunol. 2010 Jun;104(6):503-10.
51. Genetic variants of mannose-binding lectin 2 gene influence progression and prognosis of patients with hepatitis B virus infection in China. Gu X, etal., Clin Res Hepatol Gastroenterol. 2016 Nov;40(5):614-621. doi: 10.1016/j.clinre.2015.12.015. Epub 2016 Feb 5.
52. Association of hepatitis C virus infection and liver fibrosis severity with the variants alleles of MBL2 gene in a Brazilian population. Halla MC, etal., Hum Immunol. 2010 Sep;71(9):883-7. doi: 10.1016/j.humimm.2010.05.021. Epub 2010 Jun 1.
53. A variant in the promoter of MBL2 is associated with protection against visceral leishmaniasis in Morocco. Hamdi S, etal., Infect Genet Evol. 2013 Jan;13:162-7. doi: 10.1016/j.meegid.2012.09.002. Epub 2012 Sep 18.
54. Deficient mannose-binding lectin-mediated complement activation despite mannose-binding lectin-sufficient genotypes in an outbreak of Legionella pneumophila pneumonia. Herpers BL, etal., Hum Immunol. 2009 Feb;70(2):125-9. doi: 10.1016/j.humimm.2008.11.002. Epub 2008 Dec 13.
55. Therapeutic role for mannose-binding lectin in cigarette smoke-induced lung inflammation? Evidence from a murine model. Hodge S, etal., Am J Respir Cell Mol Biol. 2010 Feb;42(2):235-42. Epub 2009 May 1.
56. Mannose-binding lectin variant associated with severe malaria in young African children. Holmberg V, etal., Microbes Infect. 2008 Apr;10(4):342-8. doi: 10.1016/j.micinf.2007.12.008. Epub 2007 Dec 28.
57. Association between mannose-binding lectin gene polymorphism and pediatric cytomegalovirus infection. Hu Y, etal., Viral Immunol. 2010 Aug;23(4):443-7.
58. Serum mannose-binding lectin levels are decreased in behcet's disease and associated with disease severity. Inanc N, etal., J Rheumatol. 2005 Feb;32(2):287-91.
59. Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection. Ip WK, etal., J Infect Dis. 2005 May 15;191(10):1697-704. Epub 2005 Apr 11.
60. Mannose-binding lectin variant alleles and HLA-DR4 alleles are associated with giant cell arteritis. Jacobsen S, etal., J Rheumatol. 2002 Oct;29(10):2148-53.
61. Elevated levels of mannan-binding lectin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL. Kaur S, etal., Clin Exp Immunol. 2006 Mar;143(3):414-9.
62. Protective role of mannan-binding lectin in a murine model of invasive pulmonary aspergillosis. Kaur S, etal., Clin Exp Immunol. 2007 May;148(2):382-9. Epub 2007 Mar 5.
63. Association of MBL2 polymorphism with asthma after bronchiolitis in infancy. Koponen P, etal., Pediatr Int. 2012 Oct;54(5):619-22. doi: 10.1111/j.1442-200X.2012.03651.x. Epub 2012 Jul 19.
64. A novel type of binding specificity to phospholipids for rat mannose-binding proteins isolated from serum and liver. Kuroki Y, etal., FEBS Lett. 1997 Sep 8;414(2):387-92.
65. Mannan-binding lectin in human serum, cerebrospinal fluid and brain tissue and its role in Alzheimer's disease. Lanzrein AS, etal., Neuroreport. 1998 May 11;9(7):1491-5.
66. Infections during induction therapy of childhood acute lymphoblastic leukemia--no association to mannose-binding lectin deficiency. Lausen B, etal., Eur J Haematol. 2006 Jun;76(6):481-7. Epub 2006 Feb 23.
67. Lectin-carbohydrate interactions: fine specificity difference between two mannose-binding proteins. Lee RT, etal., Biosci Rep. 1999 Aug;19(4):283-92.
68. Mannose-Binding Lectin Gene Polymorphism Contributes to Recurrence of Infective Exacerbation in COPD Patients. Lin CL, etal., Chest. 2010 Aug 5.
69. Impact of mannose-binding lectin 2 polymorphism on the risk of hepatocellular carcinoma: a case-control study in Chinese Han population. Lin Y, etal., J Epidemiol. 2015;25(5):387-91. doi: 10.2188/jea.JE20140194. Epub 2015 Mar 14.
70. Mannose-binding lectin gene polymorphic variants predispose to the development of bronchopulmonary complications but have no influence on other clinical and laboratory symptoms or signs of common variable immunodeficiency. Litzman J, etal., Clin Exp Immunol. 2008 Sep;153(3):324-30. Epub 2008 Jul 11.
71. The Chinese herbal formula Zhibai Dihuang Granule treat Yin-deficiency-heat syndrome rats by regulating the immune responses. Liu CM, etal., J Ethnopharmacol. 2018 Oct 28;225:271-278. doi: 10.1016/j.jep.2018.05.001. Epub 2018 May 2.
72. Genetically Determined MBL Deficiency Is Associated with Protection against Chronic Cardiomyopathy in Chagas Disease. Luz PR, etal., PLoS Negl Trop Dis. 2016 Jan 8;10(1):e0004257. doi: 10.1371/journal.pntd.0004257. eCollection 2016 Jan.
73. Mannose-binding lectin null alleles are associated with preserved epithelial cell integrity following intestinal ischemia reperfusion in man. Matthijsen RA, etal., Mol Immunol. 2009 Jul;46(11-12):2244-8. doi: 10.1016/j.molimm.2009.04.010. Epub 2009 May 23.
74. Use of a modeling framework to evaluate the effect of a modifier gene (MBL2) on variation in cystic fibrosis. McDougal KE, etal., Eur J Hum Genet. 2010 Jun;18(6):680-4. Epub 2010 Jan 13.
75. Structural polymorphism of the mannose-binding lectin 2 (MBL2 ) gene in HCV-infected patients with a serological marker for thyroid autoimmunity. Melo FM, etal., Int J Immunogenet. 2009 Dec;36(6):377-81. doi: 10.1111/j.1744-313X.2009.00871.x. Epub 2009 Aug 24.
76. Association of variant alleles of MBL2 gene with vasoocclusive crisis in children with sickle cell anemia. Mendonca TF, etal., Blood Cells Mol Dis. 2010 Apr 15;44(4):224-8. doi: 10.1016/j.bcmd.2010.02.004. Epub 2010 Feb 20.
77. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
78. High levels of serum mannose-binding lectin are associated with the severity of clinical signs of leptospirosis. Miranda KA, etal., Braz J Med Biol Res. 2009 Apr;42(4):353-7.
79. Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis. Mishra A, etal., Parasitol Int. 2015 Dec;64(6):591-6. doi: 10.1016/j.parint.2015.08.003. Epub 2015 Aug 19.
80. MBL2 polymorphism and risk of severe infections in multiple myeloma patients receiving high-dose melphalan and autologous stem cell transplantation. Molle I, etal., Bone Marrow Transplant. 2006 Oct;38(8):555-60. Epub 2006 Sep 4.
81. Mannan-binding lectin recognizes structures on ischaemic reperfused mouse kidneys and is implicated in tissue injury. Moller-Kristensen M, etal., Scand J Immunol. 2005 May;61(5):426-34.
82. Mannose-binding lectin gene variants and infections in patients receiving autologous stem cell transplantation. Moreto A, etal., BMC Immunol. 2014 May 3;15:17. doi: 10.1186/1471-2172-15-17.
83. Association between mannan-binding lectin and impaired lung function in cystic fibrosis may be age-dependent. Muhlebach MS, etal., Clin Exp Immunol. 2006 Aug;145(2):302-7.
84. Mannose binding lectin polymorphisms are associated with early age of disease onset and autoimmunity in common variable immunodeficiency. Mullighan CG, etal., Scand J Immunol. 2000 Feb;51(2):111-22.
85. Association between donor MBL promoter haplotype and graft survival and the development of BOS after lung transplantation. Munster JM, etal., Transplantation. 2008 Dec 27;86(12):1857-63.
86. Involvement of mannose-binding lectin in the pathogenesis of Kawasaki disease-like murine vasculitis. Nakamura A, etal., Clin Immunol. 2014 Jul;153(1):64-72. doi: 10.1016/j.clim.2014.03.019. Epub 2014 Apr 8.
87. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
88. Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994. Ned RM, etal., BMC Med Genet. 2010 Nov 5;11:155.
89. Coupling of prolyl peptide bond isomerization and Ca2+ binding in a C-type mannose-binding protein. Ng KK and Weis WI, Biochemistry. 1998 Dec 22;37(51):17977-89.
90. Structural analysis of monosaccharide recognition by rat liver mannose-binding protein. Ng KK, etal., J Biol Chem. 1996 Jan 12;271(2):663-74.
91. Mannan-binding lectin deficiency increases the risk of recurrent infections in children with Down's syndrome. Nisihara RM, etal., Hum Immunol. 2010 Jan;71(1):63-6. Epub .
92. Isolation and characterization of two distinct mannan-binding proteins from rat serum. Oka S, etal., Arch Biochem Biophys. 1988 Jan;260(1):257-66.
93. Primary structure of rat liver mannan-binding protein deduced from its cDNA sequence. Oka S, etal., J Biochem (Tokyo) 1987 Jan;101(1):135-44.
94. Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk. Olivo-Marston SE, etal., Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3375-83.
95. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
96. Might there be a link between mannose binding lectin and vitiligo? Onay H, etal., Eur J Dermatol. 2007 Mar-Apr;17(2):146-8. Epub 2007 Mar 2.
97. Genotypes coding for mannose-binding lectin deficiency correlated with cryptococcal meningitis in HIV-uninfected Chinese patients. Ou XT, etal., J Infect Dis. 2011 Jun 1;203(11):1686-91. doi: 10.1093/infdis/jir152.
98. Human mannose-binding lectin inhibitor prevents Shiga toxin-induced renal injury. Ozaki M, etal., Kidney Int. 2016 Jul 1. pii: S0085-2538(16)30202-2. doi: 10.1016/j.kint.2016.05.011.
99. Mannose binding lectin and ficolin-2 polymorphisms are associated with increased risk for bacterial infections in children with B acute lymphoblastic leukemia. Pana ZD, etal., Pediatr Blood Cancer. 2014 Jun;61(6):1017-22. doi: 10.1002/pbc.24951. Epub 2014 Jan 22.
100. Association of HYPA haplotype in the mannose-binding lectin gene-2 with Behcet's disease. Park KS, etal., Tissue Antigens. 2005 Mar;65(3):260-5.
101. Human mannose-binding lectin inhibitor prevents myocardial injury and arterial thrombogenesis in a novel animal model. Pavlov VI, etal., Am J Pathol. 2015 Feb;185(2):347-55. doi: 10.1016/j.ajpath.2014.10.015. Epub 2014 Dec 4.
102. Gene polymorphisms and febrile neutropenia in acute leukemia--no association with IL-4, CCR-5, IL-1RA, but the MBL-2, ACE, and TLR-4 are associated with the disease in Turkish patients: a preliminary study. Pehlivan M, etal., Genet Test Mol Biomarkers. 2014 Jul;18(7):474-81. doi: 10.1089/gtmb.2014.0004. Epub 2014 May 12.
103. Mannose-binding lectin 2 gene polymorphism and lung damage in primary ciliary dyskinesia. Pifferi M, etal., Pediatr Pulmonol. 2015 Feb;50(2):179-86. doi: 10.1002/ppul.23026. Epub 2014 Apr 19.
104. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
105. Association of mannose-binding lectin gene polymorphism but not of mannose-binding serine protease 2 with chronic severe aortic regurgitation of rheumatic etiology. Ramasawmy R, etal., Clin Vaccine Immunol. 2008 Jun;15(6):932-6. doi: 10.1128/CVI.00324-07. Epub 2008 Apr 9.
106. GOA pipeline RGD automated data pipeline
107. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
108. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
109. MBL genotype and risk of invasive pneumococcal disease: a case-control study. Roy S, etal., Lancet. 2002 May 4;359(9317):1569-73.
110. High rate of early restenosis after carotid eversion endarterectomy in homozygous carriers of the normal mannose-binding lectin genotype. Rugonfalvi-Kiss S, etal., Stroke. 2005 May;36(5):944-8. Epub 2005 Mar 24.
111. Mannose binding lectin gene (MBL2) functional polymorphisms are associated with systemic lupus erythematosus in southern Brazilians. Sandrin-Garcia P, etal., Hum Immunol. 2011 Jun;72(6):516-21. Epub 2011 Apr 8.
112. Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes. Sapkota BR, etal., Hum Immunol. 2010 Oct;71(10):992-8. doi: 10.1016/j.humimm.2010.07.001. Epub 2010 Aug 1.
113. MBL2 and MASP2 gene polymorphisms in patients with hepatocellular carcinoma. Segat L, etal., J Viral Hepat. 2008 May;15(5):387-91. doi: 10.1111/j.1365-2893.2007.00965.x.
114. Mannose-binding lectin 2 gene polymorphism in recurrent herpes simplex virus 2 infection. Seppanen M, etal., Hum Immunol. 2009 Apr;70(4):218-21. doi: 10.1016/j.humimm.2009.01.022. Epub 2009 Feb 4.
115. Functional mannose-binding lectin haplotype variants are associated with Alzheimer's disease. Sjölander A, etal., J Alzheimers Dis. 2013;35(1):121-7. doi: 10.3233/JAD-122044.
116. Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli. Smithson A, etal., Clin Vaccine Immunol. 2007 Mar;14(3):256-61. Epub 2007 Jan 3.
117. MBL2 genotypes and their associations with MBL levels and NICU morbidity in a cohort of Greek neonates. Speletas M, etal., J Immunol Res. 2015;2015:478412. doi: 10.1155/2015/478412. Epub 2015 Mar 24.
118. Association study between mannose-binding lectin haplotypes and X gene mutation of hepatitis B virus from treatment naïve patients. Su C, etal., Aging (Albany NY). 2016 Nov 7;8(11):2862-2870. doi: 10.18632/aging.101097.
119. Association between mannose-binding lectin variants, haplotypes and risk of hepatocellular carcinoma: A case-control study. Su C, etal., Sci Rep. 2016 Aug 25;6:32147. doi: 10.1038/srep32147.
120. Mannose-Binding Lectin (MBL) and MBL-associated serine protease-2 (MASP-2) in women with malignant and benign ovarian tumours. Swierzko AS, etal., Cancer Immunol Immunother. 2014 Nov;63(11):1129-40. doi: 10.1007/s00262-014-1579-y. Epub 2014 Jul 20.
121. Association between mannose-binding lectin and HIV infection and progression in a Chinese population. Tan Y, etal., Mol Immunol. 2009 Dec;47(2-3):632-8. doi: 10.1016/j.molimm.2009.08.020. Epub 2009 Sep 30.
122. MBL2 gene variants coding for mannose-binding lectin deficiency are associated with increased risk of nephritis in Danish patients with systemic lupus erythematosus. Tanha N, etal., Lupus. 2014 Oct;23(11):1105-11. doi: 10.1177/0961203314536478. Epub 2014 May 21.
123. Genetic polymorphisms and serum levels of mannose-binding lectin in Chinese pediatric patients with common infectious diseases. Tao R, etal., Int J Infect Dis. 2012 May;16(5):e403-7. doi: 10.1016/j.ijid.2012.01.014. Epub 2012 Mar 22.
124. An MBL2 haplotype and ABCB4 variants modulate the risk of liver disease in cystic fibrosis patients: a multicentre study. Tomaiuolo R, etal., Dig Liver Dis. 2009 Nov;41(11):817-22. Epub 2009 May 20.
125. Does MBL2 codon 54 polymorphism play a role in the pathogenesis of psoriasis? Turan H, etal., Int J Dermatol. 2014 Jan;53(1):34-8. doi: 10.1111/j.1365-4632.2012.5657.x. Epub 2012 Nov 1.
126. Distinct alleles of mannose-binding lectin (MBL) and surfactant proteins A (SP-A) in patients with chronic cavitary pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. Vaid M, etal., Clin Chem Lab Med. 2007;45(2):183-6.
127. Effects of mannose-binding lectin polymorphisms on irinotecan-induced febrile neutropenia. van der Bol JM, etal., Oncologist. 2010;15(10):1063-72. doi: 10.1634/theoncologist.2010-0033. Epub 2010 Oct 7.
128. Engineering novel complement activity into a pulmonary surfactant protein. Venkatraman Girija U, etal., J Biol Chem. 2010 Apr 2;285(14):10546-52. doi: 10.1074/jbc.M109.097493. Epub 2010 Jan 29.
129. Mannose binding lectin and FcgammaRIIa (CD32) polymorphism in Spanish systemic lupus erythematosus patients. Villarreal J, etal., Rheumatology (Oxford). 2001 Sep;40(9):1009-12.
130. Asymmetry adjacent to the collagen-like domain in rat liver mannose-binding protein. Wallis R and Drickamer K, Biochem J. 1997 Jul 15;325 ( Pt 2):391-400.
131. Molecular determinants of oligomer formation and complement fixation in mannose-binding proteins. Wallis R and Drickamer K, J Biol Chem. 1999 Feb 5;274(6):3580-9.
132. Mannose-binding lectin 2 rs11003123 polymorphism is associated with the development of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis in the Chinese population. Wang PS, etal., Hepatobiliary Pancreat Dis Int. 2016 Jun;15(3):282-8.
133. Mannose binding lectin (MBL) polymorphisms associated with low MBL production in patients with dermatomyositis. Werth VP, etal., J Invest Dermatol. 2002 Dec;119(6):1394-9.
134. Functional polymorphisms in the mannan-binding lectin 2 gene: effect on MBL levels and otitis media. Wiertsema SP, etal., J Allergy Clin Immunol. 2006 Jun;117(6):1344-50. Epub 2006 Apr 27.
135. Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in mice. Yager PH, etal., J Cereb Blood Flow Metab. 2008 May;28(5):1030-9. doi: 10.1038/sj.jcbfm.9600605. Epub 2008 Jan 9.
136. [Correlation between mannose-binding lectin gene codon 54 polymorphism and susceptibility of Kawasaki disease]. Yang J, etal., Zhonghua Er Ke Za Zhi. 2004 Mar;42(3):176-9.
137. HIV-1 Disease Progression and Survival in an Adult Population in Zimbabwe: Is There an Effect of the Mannose Binding Lectin Deficiency? Zinyama-Gutsire RB, etal., OMICS. 2015 Sep;19(9):542-52. doi: 10.1089/omi.2015.0047.
Additional References at PubMed
PMID:1607365   PMID:11549596   PMID:12421953   PMID:15148336   PMID:18596036   PMID:23544079  


Genomics

Comparative Map Data
Mbl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21228,016,439 - 228,024,736 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1236,419,619 - 236,424,489 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01243,349,309 - 243,354,179 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01236,171,876 - 236,176,773 (+)NCBIRnor_WKY
Rnor_6.01248,435,069 - 248,442,669 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,723,397 - 248,729,962 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01255,681,084 - 255,688,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,978,931 - 233,983,824 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,140,682 - 234,147,846 (+)NCBI
Celera1225,160,772 - 225,165,665 (+)NCBICelera
Cytogenetic Map1q52NCBI
MBL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381052,765,380 - 52,772,784 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1052,765,380 - 52,772,784 (-)EnsemblGRCh38hg38GRCh38
GRCh371054,525,140 - 54,532,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361054,195,146 - 54,201,466 (-)NCBINCBI36Build 36hg18NCBI36
Build 341054,195,146 - 54,201,466NCBI
Celera1047,788,072 - 47,794,392 (-)NCBICelera
Cytogenetic Map10q21.1NCBI
HuRef1048,503,748 - 48,510,068 (-)NCBIHuRef
CHM1_11054,806,939 - 54,813,257 (-)NCBICHM1_1
T2T-CHM13v2.01053,612,365 - 53,619,761 (-)NCBIT2T-CHM13v2.0
Mbl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,210,306 - 30,217,087 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,210,342 - 30,217,087 (+)EnsemblGRCm39 Ensembl
GRCm381930,232,906 - 30,239,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,232,942 - 30,239,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv371930,307,447 - 30,314,172 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,298,954 - 30,305,679 (+)NCBIMGSCv36mm8
Celera1931,010,980 - 31,017,684 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.14NCBI
Mbl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554257,702,137 - 7,709,006 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554257,704,371 - 7,708,951 (-)NCBIChiLan1.0ChiLan1.0
MBL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11051,537,129 - 51,543,041 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1051,527,758 - 51,543,432 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01049,401,364 - 49,409,328 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MBL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1429,419,886 - 29,424,377 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha429,544,300 - 29,548,802 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0429,721,980 - 29,726,589 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl429,721,981 - 29,726,540 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1429,591,559 - 29,596,084 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0429,794,211 - 29,798,774 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0430,148,194 - 30,152,765 (-)NCBIUU_Cfam_GSD_1.0
MBL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,102,823 - 97,108,083 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,103,926 - 97,107,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214105,632,322 - 105,636,031 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MBL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1978,389,534 - 78,394,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl978,389,947 - 78,396,079 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604839,340,958 - 39,345,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mbl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479110,881,268 - 10,886,297 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479110,881,319 - 10,886,294 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mbl2
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:614
Count of miRNA genes:270
Interacting mature miRNAs:326
Transcripts:ENSRNOT00000072188
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1207702246228581766Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat

Markers in Region
AA893453  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,023,892 - 228,023,998 (+)MAPPERmRatBN7.2
Rnor_6.01248,730,774 - 248,730,879NCBIRnor6.0
Rnor_6.01248,442,474 - 248,442,579NCBIRnor6.0
Rnor_5.01255,979,555 - 255,979,660UniSTSRnor5.0
Rnor_5.01255,688,488 - 255,688,593UniSTSRnor5.0
RGSC_v3.41233,985,245 - 233,985,350UniSTSRGSC3.4
Celera1225,167,086 - 225,167,191UniSTS
RH 3.4 Map11616.9UniSTS
Cytogenetic Map1q51-q55UniSTS
D11440  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,022,336 - 228,022,416 (+)MAPPERmRatBN7.2
Rnor_6.01248,729,219 - 248,729,298NCBIRnor6.0
Rnor_6.01248,440,919 - 248,440,998NCBIRnor6.0
Rnor_5.01255,686,933 - 255,687,012UniSTSRnor5.0
Rnor_5.01255,978,000 - 255,978,079UniSTSRnor5.0
RGSC_v3.41233,983,690 - 233,983,769UniSTSRGSC3.4
Celera1225,165,531 - 225,165,610UniSTS
Cytogenetic Map1q51-q55UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 37 37
Low 7 4 4 2 2 1 5 2 2
Below cutoff 6 13 15 4 4 38 14 23 6 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072188   ⟹   ENSRNOP00000064876
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1248,723,397 - 248,729,962 (+)Ensembl
RefSeq Acc Id: NM_022704   ⟹   NP_073195
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21228,017,578 - 228,022,471 (+)NCBI
Rnor_6.01248,436,160 - 248,441,053 (+)NCBI
Rnor_5.01255,681,084 - 255,688,683 (+)NCBI
RGSC_v3.41233,978,931 - 233,983,824 (+)RGD
Celera1225,160,772 - 225,165,665 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231249   ⟹   XP_006231311
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21228,016,439 - 228,024,736 (+)NCBI
Rnor_6.01248,435,069 - 248,442,669 (+)NCBI
Rnor_5.01255,681,084 - 255,688,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231250   ⟹   XP_006231312
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21228,016,473 - 228,024,734 (+)NCBI
Rnor_6.01248,435,069 - 248,442,669 (+)NCBI
Rnor_5.01255,681,084 - 255,688,683 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_073195   ⟸   NM_022704
- Peptide Label: precursor
- UniProtKB: P08661 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006231311   ⟸   XM_006231249
- Peptide Label: isoform X1
- UniProtKB: P08661 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006231312   ⟸   XM_006231250
- Peptide Label: isoform X1
- UniProtKB: P08661 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064876   ⟸   ENSRNOT00000072188
Protein Domains
C-type lectin   Collagen-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08661-F1-model_v2 AlphaFold P08661 1-244 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67380 AgrOrtholog
BioCyc Gene G2FUF-55940 BioCyc
Ensembl Genes ENSRNOG00000050305 Ensembl
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  C-type_lectin_CS UniProtKB/Swiss-Prot
  Collagen UniProtKB/Swiss-Prot
  Collectin_CTLD UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  Mannose-binding_protein_C UniProtKB/Swiss-Prot
KEGG Report rno:64668 UniProtKB/Swiss-Prot
NCBI Gene 64668 ENTREZGENE
PANTHER PTHR24024:SF34 UniProtKB/Swiss-Prot
Pfam Collagen UniProtKB/Swiss-Prot
  Lectin_C UniProtKB/Swiss-Prot
PhenoGen Mbl2 PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
SMART CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
UniProt MBL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mbl2  mannose binding lectin 2  LOC100911854  mannose-binding protein C-like  Data Merged 737654 PROVISIONAL
2016-05-12 Mbl2  mannose binding lectin 2  Mbl2  mannose-binding lectin (protein C) 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911854  mannose-binding protein C-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-02-26 Mbl2  mannose-binding lectin (protein C) 2  Mbl2  mannose binding lectin 2 (protein C)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Mbl2  mannose binding lectin 2 (protein C)    mannose binding lectin 2, protein C  Name updated 1299863 APPROVED
2005-09-12 Mbl1  mannose binding lectin 2, protein C  Mbl2  mannose-binding protein C (liver)  Name updated 1299863 APPROVED
2002-06-10 Mbl2        Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a NH2-terminal cysteine rich region, a collagen-like domain and a COOH-terminal carbohydrate-binding domain 633272