RGD Reference Report - Serum mannose-binding lectin levels are decreased in behcet's disease and associated with disease severity. - Rat Genome Database

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Serum mannose-binding lectin levels are decreased in behcet's disease and associated with disease severity.

Authors: Inanc, N  Mumcu, G  Birtas, E  Elbir, Y  Yavuz, S  Ergun, T  Fresko, I  Direskeneli, H 
Citation: Inanc N, etal., J Rheumatol. 2005 Feb;32(2):287-91.
RGD ID: 1582155
Pubmed: (View Article at PubMed) PMID:15693089

OBJECTIVE: To investigate serum levels of mannose-binding lectin (MBL), a complement-like protein of collectin family, in patients with Behcet's disease (BD). METHODS: MBL levels were measured in sera of 130 patients with BD, 64 patients with recurrent oral ulcerations (ROU), and 105 healthy controls (HC) with ELISA. RESULTS: Patients with BD had significantly lower median serum MBL levels compared to HC (1857 vs 3136 ng/ml, p = 0.001). No significant difference was observed in median serum MBL levels between BD and ROU (2309 ng/ml, p = 0.252). Low MBL levels (/= 4) was more frequently observed in BD patients with very low serum MBL levels (

Annotation

Disease Annotations    
Behcet's disease  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Mbl2  (mannose binding lectin 2)

Genes (Mus musculus)
Mbl2  (mannose-binding lectin (protein C) 2)

Genes (Homo sapiens)
MBL2  (mannose binding lectin 2)


Additional Information