MBL2 (mannose binding lectin 2) - Rat Genome Database

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Gene: MBL2 (mannose binding lectin 2) Pan paniscus
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Symbol: MBL2
Name: mannose binding lectin 2
RGD ID: 11735818
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); galactose binding (ortholog); INVOLVED IN complement activation, lectin pathway (ortholog); defense response to Gram-positive bacterium (ortholog); innate immune response (ortholog); PARTICIPATES IN lectin complement pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); allergic bronchopulmonary aspergillosis (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular space (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: mannose-binding protein C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11051,537,129 - 51,543,041 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1051,527,758 - 51,543,432 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01049,401,364 - 49,409,328 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
Alzheimer's disease  (ISO)
Aneurysm  (ISO)
aortic valve insufficiency  (ISO)
Arterial Thrombosis  (ISO)
aspergillosis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autoimmune thyroiditis  (ISO)
Bacteremia  (ISO)
bacterial infectious disease  (ISO)
bacterial pneumonia  (ISO)
bacterial vaginosis  (ISO)
Behcet's disease  (ISO)
bipolar disorder  (ISO)
Birth Weight  (ISO)
Brain Injuries  (ISO)
bronchiectasis  (ISO)
bronchiolitis obliterans  (ISO)
bronchopneumonia  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Chagas Cardiomyopathy  (ISO)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
chorioamnionitis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Rhinosinusitis  (ISO)
coccidioidomycosis  (ISO)
common variable immunodeficiency  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Crohn's disease  (ISO)
cryptococcal meningitis  (ISO)
cryptosporidiosis  (ISO)
cystic fibrosis  (ISO)
Cytomegalovirus Infections  (ISO)
dermatomyositis  (ISO)
Diabetic Foot  (ISO)
Diffuse Panbronchiolitis  (ISO)
disease by infectious agent  (ISO)
end stage renal disease  (ISO)
Familial Thoracic Aortic Aneurysm 8  (ISO)
fungal infectious disease  (ISO)
gestational diabetes  (ISO)
Hashimoto Disease  (ISO)
hemolytic-uremic syndrome  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Intestinal Reperfusion Injury  (ISO)
invasive aspergillosis  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kartagener syndrome  (ISO)
Kawasaki disease  (ISO)
Legionnaires' disease  (ISO)
lepromatous leprosy  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
lung cancer  (ISO)
lupus nephritis  (ISO)
Mannose-Binding Protein Deficiency  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
newborn respiratory distress syndrome  (ISO)
obesity  (ISO)
otitis media  (ISO)
ovarian cancer  (ISO)
panic disorder  (ISO)
pemphigus  (ISO)
peripheral nervous system disease  (ISO)
peripheral vascular disease  (ISO)
Plasmodium falciparum malaria  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyalgia rheumatica  (ISO)
Premature Birth  (ISO)
primary open angle glaucoma  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
respiratory failure  (ISO)
Respiratory Tract Infections  (ISO)
rhinitis  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
Smoke Inhalation Injury  (ISO)
Spontaneous Abortions  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
thrombocytopenia  (ISO)
toxic shock syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
Varicose Ulcer  (ISO)
Vaso-occlusive Crisis  (ISO)
visceral leishmaniasis  (ISO)
vitiligo  (ISO)
vulvovaginal candidiasis  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
MBL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11051,537,129 - 51,543,041 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1051,527,758 - 51,543,432 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01049,401,364 - 49,409,328 (-)NCBIMhudiblu_PPA_v0panPan3
MBL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1052,765,380 - 52,772,784 (-)EnsemblGRCh38hg38GRCh38
GRCh381052,765,380 - 52,772,784 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371054,525,140 - 54,532,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361054,195,146 - 54,201,466 (-)NCBINCBI36hg18NCBI36
Build 341054,195,146 - 54,201,466NCBI
Celera1047,788,072 - 47,794,392 (-)NCBI
Cytogenetic Map10q21.1NCBI
HuRef1048,503,748 - 48,510,068 (-)NCBIHuRef
CHM1_11054,806,939 - 54,813,257 (-)NCBICHM1_1
Mbl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,210,306 - 30,217,087 (+)NCBIGRCm39mm39
GRCm39 Ensembl1930,210,342 - 30,217,087 (+)Ensembl
GRCm381930,232,906 - 30,239,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,232,942 - 30,239,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv371930,307,447 - 30,314,172 (+)NCBIGRCm37mm9NCBIm37
MGSCv361930,298,954 - 30,305,679 (+)NCBImm8
Celera1931,010,980 - 31,017,684 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.14NCBI
Mbl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21228,016,439 - 228,024,736 (+)NCBI
Rnor_6.0 Ensembl1248,723,397 - 248,729,962 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01248,435,069 - 248,442,669 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01255,681,084 - 255,688,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,978,931 - 233,983,824 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11234,140,682 - 234,147,846 (+)NCBI
Celera1225,160,772 - 225,165,665 (+)NCBICelera
Cytogenetic Map1q52NCBI
Mbl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554257,702,137 - 7,709,006 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554257,704,371 - 7,708,951 (-)NCBIChiLan1.0ChiLan1.0
LOC479260
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1429,419,886 - 29,424,377 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha429,544,300 - 29,548,802 (-)NCBI
ROS_Cfam_1.0429,721,980 - 29,726,589 (-)NCBI
UMICH_Zoey_3.1429,591,559 - 29,596,084 (-)NCBI
UNSW_CanFamBas_1.0429,794,211 - 29,798,774 (-)NCBI
UU_Cfam_GSD_1.0430,148,194 - 30,152,765 (-)NCBI
MBL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,102,894 - 97,108,936 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,103,926 - 97,107,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214105,632,322 - 105,636,031 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MBL2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1978,389,534 - 78,394,753 (+)NCBI
ChlSab1.1 Ensembl978,389,947 - 78,396,079 (+)Ensembl
Vero_WHO_p1.0NW_02366604839,340,958 - 39,345,030 (+)NCBI
Mbl2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479110,881,319 - 10,886,294 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000059713   ⟹   ENSPPAP00000036819
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1051,527,758 - 51,543,432 (-)Ensembl
RefSeq Acc Id: XM_003806335   ⟹   XP_003806383
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11051,537,129 - 51,543,041 (-)NCBI
Mhudiblu_PPA_v01049,401,913 - 49,409,328 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008952646   ⟹   XP_008950894
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11051,537,129 - 51,543,038 (-)NCBI
Mhudiblu_PPA_v01049,401,364 - 49,409,325 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003806383 (Get FASTA)   NCBI Sequence Viewer  
  XP_008950894 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003806383   ⟸   XM_003806335
- Sequence:
RefSeq Acc Id: XP_008950894   ⟸   XM_008952646
- Sequence:
RefSeq Acc Id: ENSPPAP00000036819   ⟸   ENSPPAT00000059713
Protein Domains
C-type lectin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041167 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000036819 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000059713 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/TrEMBL
  Collagen UniProtKB/TrEMBL
  Collectin_CTLD UniProtKB/TrEMBL
  CTDL_fold UniProtKB/TrEMBL
  Mannose-binding_protein_C UniProtKB/TrEMBL
NCBI Gene MBL2 ENTREZGENE
PANTHER PTHR24024:SF34 UniProtKB/TrEMBL
Pfam Collagen UniProtKB/TrEMBL
  Lectin_C UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_2 UniProtKB/TrEMBL
SMART CLECT UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/TrEMBL
UniProt A0A2R9C4T9_PANPA UniProtKB/TrEMBL