RGD Reference Report - L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children. - Rat Genome Database

RGD Reference Report - L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children. - Rat Genome Database

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L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children.
Authors:	Cedzynski, M Atkinson, AP St Swierzko, A MacDonald, SL Szala, A Zeman, K Buczylko, K Bak-Romaniszyn, L Wiszniewska, M Matsushita, M Szemraj, J Banasik, M Turner, ML Kilpatrick, DC
Citation:	Cedzynski M, etal., Mol Immunol. 2009 Dec;47(2-3):415-9. Epub 2009 Sep 19.
RGD ID:	4889439
Pubmed:	PMID:19767106 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.molimm.2009.08.028 (Journal Full-text)
We previously reported an association between relative L-ficolin deficiency and recurrent respiratory infections co-existing with allergic disorders in children. To confirm and extend this preliminary finding, we performed a prospective study on children of a similar age (mean 8.9 years) designed to establish whether the principal relationship was with infection or allergy. Serum L-ficolin values in healthy children were normally distributed with a mean value of 3838 ng/ml. L-ficolin concentrations were generally lower in patients with asthma and/or allergic rhinitis with (mean 3413 ng/ml; p=0.02) or without (3512 ng/ml; p<0.07) respiratory infections, but not in patients with respiratory infections without allergic disease (3623 ng/ml; p=0.2). The lower average values in the group comprised of children with respiratory allergy and infections were largely due to a high proportion of very low values: 18.3% had values below 2150 ng/ml compared to only 5.5% of healthy controls (OR=3.9; p=0.01). This relationship was not apparent in the groups characterized by allergy without infection or infections without allergy. An association between mannan-binding lectin (MBL) insufficiency and recurrent respiratory infections was also confirmed. One of the patients was MASP-2 deficient, evidenced both by MASP2 genotyping and by lectin pathway activity measurement. In conclusion, L-ficolin may confer some protection from microorganisms that exacerbate allergic inflammation in the lung and its relative deficiency may contribute to enhanced susceptibility to respiratory infections. MBL insufficiency and MASP-2 deficiency are risk factors for recurrence of infections independently of allergic disease.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
MBL2	Human	Respiratory Tract Infections		IAGP		DNA:polymorphisms:5' utr and exon:multiple (human)	RGD
Mbl2	Rat	Respiratory Tract Infections		ISO	MBL2 (Homo sapiens)	DNA:polymorphisms:5' utr and exon:multiple (human)	RGD
Mbl2	Mouse	Respiratory Tract Infections		ISO	MBL2 (Homo sapiens)	DNA:polymorphisms:5' utr and exon:multiple (human)	RGD

Genes (Rattus norvegicus)


Mbl2 (mannose binding lectin 2)

Genes (Mus musculus)


Mbl2 (mannose-binding lectin (protein C) 2)

Genes (Homo sapiens)


MBL2 (mannose binding lectin 2)