Mbl2 (mannose-binding lectin (protein C) 2) - Rat Genome Database

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Gene: Mbl2 (mannose-binding lectin (protein C) 2) Mus musculus
Analyze
Symbol: Mbl2
Name: mannose-binding lectin (protein C) 2
RGD ID: 731472
MGI Page MGI
Description: Predicted to enable several functions, including calcium-dependent protein binding activity; monosaccharide binding activity; and phosphatidylinositol-4-phosphate binding activity. Acts upstream of or within defense response to other organism and positive regulation of phagocytosis. Located in extracellular space. Is expressed in early conceptus and embryo. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bacterial infectious disease (multiple); fungal infectious disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MBL2 (mannose binding lectin 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: L-MBP; mannan-binding protein; mannose binding lectin (C); mannose binding lectin, liver (C); mannose-binding protein C; MB; MBL; MBL-; MBL-C; MBP-; MBP-C; RA-reactive factor P28A subunit; RARF/P28A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,210,306 - 30,217,087 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,210,342 - 30,217,087 (+)EnsemblGRCm39 Ensembl
GRCm381930,232,906 - 30,239,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,232,942 - 30,239,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv371930,307,447 - 30,314,172 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,298,954 - 30,305,679 (+)NCBIMGSCv36mm8
Celera1931,010,980 - 31,017,684 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Mbl2Mouseadult respiratory distress syndrome susceptibilityISOMBL2 (Homo sapiens)4889476DNA:missense mutation:exon:p.G54N (human)RGD 
Mbl2Mouseallergic bronchopulmonary aspergillosis  ISOMBL2 (Homo sapiens)4889577Chronic Necrotizing Pulmonary Aspergillosis and DNA:missense mutation:exon:p.R52C (human)RGD 
Mbl2Mouseallergic bronchopulmonary aspergillosis susceptibilityISOMBL2 (Homo sapiens)8693711DNA:SNP:intron:1011G>A(human)RGD 
Mbl2MouseAlzheimer's disease  ISOMBL2 (Homo sapiens)4889155protein:decreased expression:cerebrospinal fluid (human)RGD 
Mbl2MouseAlzheimer's disease susceptibilityISOMBL2 (Homo sapiens)12910848DNA:haplotype:promoter:RGD 
Mbl2MouseAneurysm  ISOMBL2 (Homo sapiens)1582153associated with Mucocutaneous Lymph Node Syndrome more ...RGD 
Mbl2Mouseaortic valve insufficiency susceptibilityISOMBL2 (Homo sapiens)12910860associated with Rheumatic Fever and DNA:polymorphism:exon:RGD 
Mbl2MouseArterial Thrombosis treatmentISOMBL2 (Homo sapiens)11530049 RGD 
Mbl2Mouseaspergillosis susceptibilityIMP 8694071 RGD 
Mbl2Mouseasthma  ISOMBL2 (Homo sapiens)8693709associated with Bronchiolitis and DNA:polymorphism:exon:RGD 
Mbl2Mouseasthma susceptibilityISOMBL2 (Homo sapiens)12910828DNA:SNP:cds:p.G54D(human)RGD 
Mbl2Mouseatopic dermatitis susceptibilityISOMBL2 (Homo sapiens)8693720DNA:polymorphisms:promoter and exon:RGD 
Mbl2Mouseautoimmune thyroiditis susceptibilityISOMBL2 (Homo sapiens)8693703DNA:polymorphism:exon:RGD 
Mbl2Mouseautoimmune thyroiditis susceptibilityISOMBL2 (Homo sapiens)14696815associated with hepatitis C and DNA:SNP:exon:RGD 
Mbl2MouseBacteremia treatmentISOMBL2 (Homo sapiens)11530047associated with Multiple Myeloma:DNA:polymorphism:exon:RGD 
Mbl2Mousebacterial infectious disease susceptibilityISOMBL2 (Homo sapiens)11530056associated with Precursor B-Cell Lymphoblastic Leukemia-Lymphoma and DNA:polymorphism:exon:RGD 
Mbl2Mousebacterial pneumonia  ISOMBL2 (Homo sapiens)4889477Legionella Pneumonia more ...RGD 
Mbl2Mousebacterial vaginosis  ISOMBL2 (Homo sapiens)8693700DNA:SNP:cds:RGD 
Mbl2MouseBehcet's disease susceptibilityISOMBL2 (Homo sapiens)1582154DNA:polymorphisms:5' utr and exon:multiple (human)RGD 
Mbl2MouseBehcet's disease severityISOMBL2 (Homo sapiens)1582155protein:decreased secretion:serum (human)RGD 
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Mbl2Mousecystic fibrosis  ISOMBL2 (Homo sapiens)8554872ClinVar Annotator: match by term: Cystic fibrosisClinVarPMID:10071515 more ...
Mbl2MouseFamilial Thoracic Aortic Aneurysm 8  ISOMBL2 (Homo sapiens)8554872ClinVar Annotator: match by term: Aortic aneurysm and familial thoracic 8ClinVarPMID:28492532
Mbl2MouseMannose-Binding Protein Deficiency  ISOMBL2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10071515 more ...
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Mbl2MouseBirth Weight  ISOMBL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20923744
Mbl2Mousedisease by infectious agent  ISOMBL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7707811
Mbl2Mousegestational diabetes  ISOMBL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15472209
Mbl2Mousehuman immunodeficiency virus infectious disease  ISOMBL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16960176
Mbl2MouseMannose-Binding Protein Deficiency  ISOMBL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Mbl2Mouseperipheral nervous system disease  ISOMBL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20864405
Mbl2MousePremature Birth  ISOMBL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16912583
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Mbl2MouseMannose-Binding Protein Deficiency  ISOMBL2 (Homo sapiens)7240710 OMIM 

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Mbl2Mouse(+)-schisandrin B multiple interactionsISOMbl2 (Rattus norvegicus)6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of MBL2 mRNA]CTDPMID:31150632
Mbl2Mouse(1->4)-beta-D-glucan multiple interactionsEXP 6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of MBL2 mRNACTDPMID:36331819
Mbl2Mouse(S)-amphetamine decreases expressionISOMbl2 (Rattus norvegicus)6480464Dextroamphetamine results in decreased expression of MBL2 mRNACTDPMID:16715494
Mbl2Mouse1,1-dichloroethene decreases expressionEXP 6480464vinylidene chloride results in decreased expression of MBL2 mRNACTDPMID:26682919
Mbl2Mouse1-naphthyl isothiocyanate multiple interactionsISOMBL2 (Homo sapiens)6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of MBL2 mRNACTDPMID:27344345
Mbl2Mouse17beta-estradiol decreases expressionISOMBL2 (Homo sapiens)6480464Estradiol results in decreased expression of MBL2 mRNACTDPMID:20106945
Mbl2Mouse17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of MBL2 mRNACTDPMID:39298647
Mbl2Mouse2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOMBL2 (Homo sapiens)64804642 more ...CTDPMID:31675489
Mbl2Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of MBL2 mRNACTDPMID:16120747 and PMID:23864506
Mbl2Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMbl2 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of MBL2 mRNACTDPMID:21215274 and PMID:21724226
Mbl2Mouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMBL2 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of MBL2 mRNACTDPMID:11489354 more ...
Mbl2Mouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOMBL2 (Homo sapiens)6480464[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of MBL2 mRNACTDPMID:26159488
Mbl2Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMBL2 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of MBL2 mRNACTDPMID:22298810
Mbl2Mouse2,4,6-tribromophenol decreases expressionISOMBL2 (Homo sapiens)64804642 more ...CTDPMID:31675489
Mbl2Mouse2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionEXP 64804642 more ...CTDPMID:38648751
Mbl2Mouse2-acetamidofluorene increases expressionEXP 64804642-Acetylaminofluorene results in increased expression of MBL2 mRNACTDPMID:21607683
Mbl2Mouse3,3',4,4',5-pentachlorobiphenyl increases expressionISOMBL2 (Homo sapiens)64804643 more ...CTDPMID:19692669
Mbl2Mouse3,3',4,4'-tetrachlorobiphenyl multiple interactionsEXP 64804643 more ...CTDPMID:19467301
Mbl2Mouse3,3',5,5'-tetrabromobisphenol A increases expressionISOMBL2 (Homo sapiens)6480464tetrabromobisphenol A results in increased expression of MBL2 proteinCTDPMID:31675489
Mbl2Mouse3H-1,2-dithiole-3-thione decreases expressionISOMbl2 (Rattus norvegicus)64804641 and 2-dithiol-3-thione results in decreased expression of MBL2 mRNACTDPMID:19162173

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Biological Process
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Mbl2Mouseantiviral innate immune response involved_inIEAUniProtKB:P11226 and ensembl:ENSP000005027892290270 EnsemblGO_REF:0000107
Mbl2Mouseantiviral innate immune response involved_inISOUniProtKB:P112262290270 GO_CentralGO_REF:0000119
Mbl2Mousecell surface pattern recognition receptor signaling pathway involved_inIEAUniProtKB:P11226 and ensembl:ENSP000005027892290270 EnsemblGO_REF:0000107
Mbl2Mousecell surface pattern recognition receptor signaling pathway involved_inISOUniProtKB:P112262290270 GO_CentralGO_REF:0000119
Mbl2Mousecomplement activation, classical pathway involved_inIEAUniProtKB-KW:KW-01802290270 UniProtGO_REF:0000043
Mbl2Mousecomplement activation, lectin pathway acts_upstream_of_or_withinIMPMGI:35773392290270 PMID:15148336MGIPMID:15148336
Mbl2Mousecomplement activation, lectin pathway acts_upstream_of_or_withinISOUniProtKB:P112262290270 MGIGO_REF:0000008
Mbl2Mousecomplement activation, lectin pathway acts_upstream_of_or_withinIDA 2290270 PMID:15148336MGIPMID:15148336
Mbl2Mousecomplement activation, lectin pathway acts_upstream_of_or_withinIGIMGI:969232290270 PMID:15148336MGIPMID:15148336
Mbl2Mousecomplement activation, lectin pathway involved_inISOUniProtKB:P112262290270 GO_CentralGO_REF:0000119
Mbl2Mousedefense response to Gram-positive bacterium acts_upstream_of_or_withinIGIMGI:969232290270 PMID:15148336MGIPMID:15148336
Mbl2Mousedefense response to Gram-positive bacterium acts_upstream_of_or_withinISOUniProtKB:P112262290270 MGIGO_REF:0000008
Mbl2Mouseinnate immune response involved_inISOUniProtKB:P112262290270 GO_CentralGO_REF:0000119
Mbl2Mousekilling by host of symbiont cells acts_upstream_of_or_withinIGIMGI:969232290270 PMID:15148336MGIPMID:15148336
Mbl2Mousenegative regulation of viral process involved_inISOUniProtKB:P112262290270 GO_CentralGO_REF:0000119
Mbl2Mousenegative regulation of viral process involved_inIEAUniProtKB:P11226 and ensembl:ENSP000005027892290270 EnsemblGO_REF:0000107
Mbl2Mousepositive regulation of complement activation  ISOMbl2 (Rattus norvegicus)9068941 RGDPMID:9920905 and REF_RGD_ID:4889148
Mbl2Mousepositive regulation of complement activation involved_inISOMbl2 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Mbl2Mousepositive regulation of opsonization involved_inIEAUniProtKB:P11226 and ensembl:ENSP000005027892290270 EnsemblGO_REF:0000107
Mbl2Mousepositive regulation of opsonization involved_inISOUniProtKB:P112262290270 GO_CentralGO_REF:0000119
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Cellular Component
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Mbl2Mousecollagen trimer part_ofIEAUniProtKB-KW:KW-01762290270 UniProtGO_REF:0000043
Mbl2Mouseextracellular space  ISOMbl2 (Rattus norvegicus)9068941 RGDPMID:3124748 and REF_RGD_ID:4889498
Mbl2Mouseextracellular space located_inISOUniProtKB:P112262290270 GO_CentralGO_REF:0000119
Mbl2Mouseextracellular space located_inISOMbl2 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Mbl2Mouseextracellular space is_active_inIBAPANTHER:PTN002369884 more ...2290270 GO_CentralGO_REF:0000033
Mbl2Mouseextracellular space located_inIDA 2290270 PMID:15148336MGIPMID:15148336
Mbl2Mousemultivesicular body is_active_inIBAPANTHER:PTN002771384 more ...2290270 GO_CentralGO_REF:0000033
Mbl2Mouseprotein-containing complex  ISOMbl2 (Rattus norvegicus)9068941 RGDPMID:9920905 and REF_RGD_ID:4889148
Mbl2Mouseprotein-containing complex part_ofISOMbl2 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Mbl2Mouseserine-type endopeptidase complex part_ofISOUniProtKB:P112262290270 GO_CentralGO_REF:0000119
Mbl2Mouseserine-type endopeptidase complex part_ofIEAUniProtKB:P11226 and ensembl:ENSP000005027892290270 EnsemblGO_REF:0000107
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Molecular Function
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Mbl2Mousecalcium ion binding  ISOMbl2 (Rattus norvegicus)9068941 RGDPMID:9922166 and REF_RGD_ID:6903270
Mbl2Mousecalcium ion binding enablesISOMbl2 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Mbl2Mousecalcium-dependent protein binding enablesISOUniProtKB:P112262290270 GO_CentralGO_REF:0000119
Mbl2Mousecalcium-dependent protein binding enablesIEAUniProtKB:P11226 and ensembl:ENSP000005027892290270 EnsemblGO_REF:0000107
Mbl2MouseD-mannose binding  ISOMbl2 (Rattus norvegicus)9068941 RGDPMID:10589993 and REF_RGD_ID:1582160
Mbl2MouseD-mannose binding enablesISOUniProtKB:P112262290270 GO_CentralGO_REF:0000119
Mbl2MouseD-mannose binding enablesIEAUniProtKB:P11226 and ensembl:ENSP000005027892290270 EnsemblGO_REF:0000107
Mbl2MouseD-mannose binding enablesISOMbl2 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Mbl2Mousegalactose binding enablesISOMbl2 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Mbl2Mousegalactose binding  ISOMbl2 (Rattus norvegicus)9068941 RGDPMID:8557671 and REF_RGD_ID:6903273
Mbl2Mouseidentical protein binding  ISOMbl2 (Rattus norvegicus)9068941homooligomerizationRGDPMID:20118239 and REF_RGD_ID:7242176
Mbl2Mouseidentical protein binding enablesISOMbl2 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Mbl2Mouseidentical protein binding enablesIEAUniProtKB:P11226 and ensembl:ENSP000005027892290270 EnsemblGO_REF:0000107
Mbl2Mouseidentical protein binding enablesISOUniProtKB:P112262290270 GO_CentralGO_REF:0000119
Mbl2Mouseidentical protein binding  ISOMbl2 (Rattus norvegicus)9068941 RGDPMID:8557671 and REF_RGD_ID:6903273
Mbl2Mouseidentical protein binding  ISOMbl2 (Rattus norvegicus)9068941homotrimerizationRGDPMID:9230118 and REF_RGD_ID:1582157
Mbl2Mousephosphatidylinositol-4-phosphate binding enablesISOMbl2 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Mbl2Mousephosphatidylinositol-4-phosphate binding  ISOMbl2 (Rattus norvegicus)9068941 RGDPMID:9315725 and REF_RGD_ID:6903277
Mbl2Mouseprotease binding  ISOMasp1 (Rattus norvegicus) and Masp2 (Rattus norvegicus)9068941 RGDPMID:11337510 and REF_RGD_ID:4889149
Mbl2Mouseprotease binding enablesISOMbl2 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
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RGD Manual Annotations


  
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Mbl2Mouselectin complement pathway  ISOMbl2 (Rattus norvegicus)9068941 RGDPMID:9920905 and REF_RGD_ID:4889148

Imported Annotations - KEGG (archival)

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Mbl2Mousecoagulation cascade pathway   IEA 6907045 KEGGmmu:04610
Mbl2Mousecomplement system pathway  IEA 6907045 KEGGmmu:04610
Mbl2MouseStaphylococcus aureus infection pathway  IEA 6907045 KEGGmmu:05150

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Reference Title
Reference Citation
1. MBL2 gene polymorphisms protect against development of thrombocytopenia associated with severe dengue phenotype. Acioli-Santos B, etal., Hum Immunol. 2008 Feb;69(2):122-8. doi: 10.1016/j.humimm.2008.01.005. Epub 2008 Feb 12.
2. Relation among mannose-binding lectin 2 genotype, beta-cell autoantibodies, and risk for type 1 diabetes in Finnish children. Aittoniemi J, etal., Hum Immunol. 2008 Feb;69(2):108-11. doi: 10.1016/j.humimm.2008.01.007. Epub 2008 Feb 20.
3. Genotypes of the mannan-binding lectin gene and susceptibility to visceral leishmaniasis and clinical complications. Alonso DP, etal., J Infect Dis. 2007 Apr 15;195(8):1212-7. Epub 2007 Mar 5.
4. Mannan-binding lectin MBL2 gene polymorphism in chronic hepatitis C: association with the severity of liver fibrosis and response to interferon therapy. Alves Pedroso ML, etal., Clin Exp Immunol. 2008 May;152(2):258-64. doi: 10.1111/j.1365-2249.2008.03614.x. Epub 2008 Mar 10.
5. Mannose-binding lectin serum levels are low in persons with clinically active coccidioidomycosis. Ampel NM, etal., Mycopathologia. 2009 Apr;167(4):173-80. Epub 2008 Dec 14.
6. Polymorphisms in immunoregulatory genes and the risk of histologic chorioamnionitis in Caucasoid women: a case control study. Annells MF, etal., BMC Pregnancy Childbirth. 2005 Feb 21;5(1):4.
7. Mannan-binding lectin deficiency in pediatric patients with inflammatory bowel disease. Bak-Romaniszyn L, etal., Scand J Gastroenterol. 2011 Oct;46(10):1275-8. doi: 10.3109/00365521.2011.594087. Epub 2011 Jun 27.
8. The polymorphisms of the MBL2 and MIF genes associated with Pediatric Cochlear Implant Patients. Baysal E, etal., Int J Pediatr Otorhinolaryngol. 2013 Mar;77(3):338-40. doi: 10.1016/j.ijporl.2012.11.020. Epub 2012 Dec 14.
9. Polymorphisms in the mannose-binding lectin gene as determinants of age-defined risk of coronary artery lesions in Kawasaki disease. Biezeveld MH, etal., Arthritis Rheum. 2006 Jan;54(1):369-76.
10. Association of the wild-type A/A genotype of MBL2 codon 54 with asthma in a North Indian population. Birbian N, etal., Dis Markers. 2012;32(5):301-8. doi: 10.3233/DMA-2012-0892.
11. Epidemiology of chronic wound patients and relation to serum levels of mannan-binding lectin. Bitsch M, etal., Acta Derm Venereol. 2009 Nov;89(6):607-11. doi: 10.2340/00015555-0730.
12. Association between bronchopulmonary dysplasia and MBL2 and IL1-RN polymorphisms. Cakmak BC, etal., Pediatr Int. 2012 Dec;54(6):863-8. doi: 10.1111/j.1442-200X.2012.03714.x. Epub 2012 Nov 21.
13. Role played by human mannose-binding lectin polymorphisms in pulmonary tuberculosis. Capparelli R, etal., J Infect Dis. 2009 Mar 1;199(5):666-72.
14. Prevalence of atopic symptoms among blood donor carriers of mannose-binding lectin variant alleles. Cardinale F, etal., Int J Immunopathol Pharmacol. 2008 Jul-Sep;21(3):735-8.
15. Deficient serum mannose-binding lectin levels and MBL2 polymorphisms increase the risk of single and recurrent Cryptosporidium infections in young children. Carmolli M, etal., J Infect Dis. 2009 Nov 15;200(10):1540-7. doi: 10.1086/606013.
16. High polymorphism of the MBL2 gene in patients with atopic dermatitis. Carrera MC, etal., Ann Allergy Asthma Immunol. 2010 Jul;105(1):39-42. doi: 10.1016/j.anai.2010.03.017.
17. L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children. Cedzynski M, etal., Mol Immunol. 2009 Dec;47(2-3):415-9. Epub 2009 Sep 19.
18. Influence of mannose-binding lectin gene polymorphisms on the invasiveness of cytomegalovirus disease after solid organ transplantation. Cervera C, etal., Transplant Proc. 2009 Jul-Aug;41(6):2259-61.
19. Mannose-binding lectin polymorphisms and recurrent respiratory tract infection in Chinese children. Chen J, etal., Eur J Pediatr. 2009 Nov;168(11):1305-13. Epub 2009 Jan 24.
20. Modulating effects of mannose binding lectin genotype on arterial stiffness in children after Kawasaki disease. Cheung YF, etal., Pediatr Res. 2004 Oct;56(4):591-6. Epub 2004 Aug 4.
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PMID:1637828   PMID:1712818   PMID:7592984   PMID:7766991   PMID:7894166   PMID:8702911   PMID:8961631   PMID:9107690   PMID:9525630   PMID:10047541   PMID:10349636   PMID:10922068  
PMID:11042159   PMID:11076861   PMID:11217851   PMID:11309157   PMID:12471128   PMID:12477932   PMID:14761934   PMID:15115753   PMID:15148336   PMID:15489334   PMID:15749852   PMID:15879138  
PMID:15972690   PMID:16141072   PMID:16141073   PMID:16299314   PMID:16424207   PMID:17015433   PMID:17015738   PMID:17114482   PMID:17363917   PMID:17475881   PMID:17646356   PMID:17785849  
PMID:18180310   PMID:18493734   PMID:18501966   PMID:18672286   PMID:18996748   PMID:19021581   PMID:19112490   PMID:19380618   PMID:19476514   PMID:19684159   PMID:19749170   PMID:19843088  
PMID:19854517   PMID:20140243   PMID:20305659   PMID:20375621   PMID:20585009   PMID:20810984   PMID:20870940   PMID:21182784   PMID:21257205   PMID:21305474   PMID:21677750   PMID:21873635  
PMID:21943708   PMID:22079428   PMID:22156595   PMID:22457620   PMID:22792067   PMID:23032324   PMID:23139754   PMID:23350727   PMID:23350935   PMID:23427256   PMID:23478320   PMID:23526211  
PMID:23936347   PMID:24167262   PMID:24743949   PMID:25008177   PMID:26367533   PMID:26442658   PMID:26603976   PMID:26631482   PMID:27106289   PMID:27689697   PMID:28378742   PMID:28700732  
PMID:28819174   PMID:29497373   PMID:30351498   PMID:30354247   PMID:30573546   PMID:30706943   PMID:30723261   PMID:30967639   PMID:30973865   PMID:31175160   PMID:31260126   PMID:31578522  
PMID:31869396   PMID:32325033   PMID:33927296   PMID:34031614   PMID:34547288   PMID:35021101   PMID:35671705   PMID:38034794   PMID:38062244   PMID:38280374   PMID:38355793   PMID:39226900  



Mbl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,210,306 - 30,217,087 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,210,342 - 30,217,087 (+)EnsemblGRCm39 Ensembl
GRCm381930,232,906 - 30,239,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,232,942 - 30,239,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv371930,307,447 - 30,314,172 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,298,954 - 30,305,679 (+)NCBIMGSCv36mm8
Celera1931,010,980 - 31,017,684 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.14NCBI
MBL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381052,765,380 - 52,772,784 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1052,765,380 - 52,772,784 (-)EnsemblGRCh38hg38GRCh38
GRCh371054,525,140 - 54,532,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361054,195,146 - 54,201,466 (-)NCBINCBI36Build 36hg18NCBI36
Build 341054,195,146 - 54,201,466NCBI
Celera1047,788,072 - 47,794,392 (-)NCBICelera
Cytogenetic Map10q21.1NCBI
HuRef1048,503,748 - 48,510,068 (-)NCBIHuRef
CHM1_11054,806,939 - 54,813,257 (-)NCBICHM1_1
T2T-CHM13v2.01053,612,365 - 53,619,761 (-)NCBIT2T-CHM13v2.0
Mbl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,429,873 - 237,465,567 (+)NCBIGRCr8
mRatBN7.21228,016,439 - 228,024,736 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1236,419,619 - 236,424,489 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,349,309 - 243,354,179 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,171,876 - 236,176,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,435,069 - 248,442,669 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,723,397 - 248,729,962 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01255,681,084 - 255,688,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,978,931 - 233,983,824 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,140,682 - 234,147,846 (+)NCBI
Celera1225,160,772 - 225,165,665 (+)NCBICelera
Cytogenetic Map1q52NCBI
Mbl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554257,702,137 - 7,709,006 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554257,704,371 - 7,708,951 (-)NCBIChiLan1.0ChiLan1.0
MBL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2865,063,616 - 65,068,335 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11065,070,156 - 65,073,657 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01049,401,364 - 49,409,328 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11051,537,129 - 51,543,041 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1051,527,758 - 51,543,432 (-)Ensemblpanpan1.1panPan2
MBL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1429,419,886 - 29,424,377 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha429,544,300 - 29,548,802 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0429,721,980 - 29,726,589 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl429,721,981 - 29,726,540 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1429,591,559 - 29,596,084 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0429,794,211 - 29,798,774 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0430,148,194 - 30,152,765 (-)NCBIUU_Cfam_GSD_1.0
MBL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,102,823 - 97,108,083 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,103,926 - 97,107,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214105,632,322 - 105,636,031 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MBL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1978,389,534 - 78,394,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl978,389,947 - 78,396,079 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604839,340,958 - 39,345,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mbl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479110,881,268 - 10,886,297 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479110,881,319 - 10,886,294 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Mbl2
212 total Variants

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:67
Interacting mature miRNAs:72
Transcripts:ENSMUST00000025797
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 31 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192198409132912719Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse

1 to 10 of 31 rows
D11440  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,239,514 - 30,239,593UniSTSGRCm38
MGSCv371930,314,004 - 30,314,083UniSTSGRCm37
Celera1931,017,516 - 31,017,595UniSTS
Cytogenetic Map19C1UniSTS
cM Map1925.0UniSTS
Whitehead/MRC_RH19304.24UniSTS
Mbl2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C1UniSTS
cM Map1925.14UniSTS







Ensembl Acc Id: ENSMUST00000025797   ⟹   ENSMUSP00000025797
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1930,210,342 - 30,217,087 (+)Ensembl
GRCm38.p6 Ensembl1930,232,942 - 30,239,687 (+)Ensembl
RefSeq Acc Id: NM_001365058   ⟹   NP_001351987
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391930,210,328 - 30,217,087 (+)NCBI
GRCm381930,232,928 - 30,239,687 (+)NCBI
Sequence:
RefSeq Acc Id: NM_010776   ⟹   NP_034906
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391930,210,328 - 30,217,087 (+)NCBI
GRCm381930,232,928 - 30,239,687 (+)NCBI
MGSCv371930,307,447 - 30,314,172 (+)RGD
Celera1931,010,980 - 31,017,684 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526730   ⟹   XP_006526793
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391930,210,306 - 30,217,086 (+)NCBI
GRCm381930,232,906 - 30,239,686 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034906   ⟸   NM_010776
- Peptide Label: precursor
- UniProtKB: P41317 (UniProtKB/Swiss-Prot),   Q3UEK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006526793   ⟸   XM_006526730
- Peptide Label: isoform X1
- UniProtKB: P41317 (UniProtKB/Swiss-Prot),   Q3UEK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001351987   ⟸   NM_001365058
- Peptide Label: precursor
- UniProtKB: P41317 (UniProtKB/Swiss-Prot),   Q3UEK1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000025797   ⟸   ENSMUST00000025797
C-type lectin   Collagen-like

Name Modeler Protein Id AA Range Protein Structure
AF-P41317-F1-model_v2 AlphaFold P41317 1-244 view protein structure

RGD ID:13679248
Promoter ID:EPDNEW_M23772
Type:multiple initiation site
Name:Mbl2_1
Description:Mus musculus mannose-binding lectin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381930,232,933 - 30,232,993EPDNEW
RGD ID:6830191
Promoter ID:MM_KWN:26822
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000025797
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361930,307,166 - 30,307,666 (+)MPROMDB
RGD ID:6847569
Promoter ID:MM_ACW:26534
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:MBL2.CSEP07,   MBL2.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361930,309,166 - 30,309,666 (+)MPROMDB


1 to 24 of 24 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000024863 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025797 ENTREZGENE
  ENSMUST00000025797.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  C-type_lectin_CS UniProtKB/Swiss-Prot
  Ca-dependent_lectin UniProtKB/Swiss-Prot
  Collagen UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
KEGG Report mmu:17195 UniProtKB/Swiss-Prot
MGD MGI:96924 ENTREZGENE
NCBI Gene 17195 ENTREZGENE
PANTHER PTHR24024:SF34 UniProtKB/Swiss-Prot
  PULMONARY SURFACTANT-ASSOCIATED PROTEIN A UniProtKB/Swiss-Prot
Pfam Collagen UniProtKB/Swiss-Prot
  Lectin_C UniProtKB/Swiss-Prot
PhenoGen Mbl2 PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
SMART CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
UniProt MBL2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UEK1 ENTREZGENE, UniProtKB/TrEMBL
1 to 24 of 24 rows