Mbl2 (mannose-binding lectin (protein C) 2) - Rat Genome Database

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Gene: Mbl2 (mannose-binding lectin (protein C) 2) Mus musculus
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Symbol: Mbl2
Name: mannose-binding lectin (protein C) 2
RGD ID: 731472
MGI Page MGI
Description: Predicted to enable several functions, including calcium-dependent protein binding activity; monosaccharide binding activity; and phosphatidylinositol-4-phosphate binding activity. Acts upstream of or within defense response to other organism and positive regulation of phagocytosis. Located in extracellular space. Is expressed in early conceptus and embryo. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bacterial infectious disease (multiple); fungal infectious disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MBL2 (mannose binding lectin 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: L-MBP; mannan-binding protein; mannose binding lectin (C); mannose binding lectin, liver (C); mannose-binding protein C; MB; MBL; MBL-; MBL-C; MBP-; MBP-C; RA-reactive factor P28A subunit; RARF/P28A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,210,306 - 30,217,087 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,210,342 - 30,217,087 (+)EnsemblGRCm39 Ensembl
GRCm381930,232,906 - 30,239,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,232,942 - 30,239,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv371930,307,447 - 30,314,172 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,298,954 - 30,305,679 (+)NCBIMGSCv36mm8
Celera1931,010,980 - 31,017,684 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
Alzheimer's disease  (ISO)
Aneurysm  (ISO)
aortic valve insufficiency  (ISO)
Arterial Thrombosis  (ISO)
aspergillosis  (IMP)
asthma  (ISO)
atopic dermatitis  (ISO)
autoimmune thyroiditis  (ISO)
Bacteremia  (ISO)
bacterial infectious disease  (ISO)
bacterial pneumonia  (ISO)
bacterial vaginosis  (ISO)
Behcet's disease  (ISO)
bipolar disorder  (ISO)
Birth Weight  (ISO)
Brain Injuries  (IMP)
bronchiectasis  (ISO)
bronchiolitis obliterans  (ISO)
bronchopneumonia  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Chagas Cardiomyopathy  (ISO)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
chorioamnionitis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Rhinosinusitis  (ISO)
coccidioidomycosis  (ISO)
common variable immunodeficiency  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Crohn's disease  (ISO)
cryptococcal meningitis  (ISO)
cryptosporidiosis  (ISO)
cystic fibrosis  (ISO)
Cytomegalovirus Infections  (ISO)
dermatomyositis  (ISO)
Diabetic Foot  (ISO)
Diffuse Panbronchiolitis  (ISO)
disease by infectious agent  (ISO)
end stage renal disease  (ISO)
Familial Thoracic Aortic Aneurysm 8  (ISO)
fungal infectious disease  (ISO)
gestational diabetes  (ISO)
Hashimoto Disease  (ISO)
hemolytic-uremic syndrome  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Intestinal Reperfusion Injury  (ISO)
invasive aspergillosis  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kartagener syndrome  (ISO)
Kawasaki disease  (IEP,ISO)
Legionnaires' disease  (ISO)
lepromatous leprosy  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
lung cancer  (ISO)
lupus nephritis  (ISO)
Mannose-Binding Protein Deficiency  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
newborn respiratory distress syndrome  (ISO)
obesity  (ISO)
otitis media  (ISO)
ovarian cancer  (ISO)
panic disorder  (ISO)
pemphigus  (ISO)
peripheral nervous system disease  (ISO)
peripheral vascular disease  (ISO)
Plasmodium falciparum malaria  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyalgia rheumatica  (ISO)
Premature Birth  (ISO)
primary open angle glaucoma  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (IEP,ISO)
respiratory allergy  (ISO)
respiratory failure  (ISO)
Respiratory Tract Infections  (ISO)
rhinitis  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
Smoke Inhalation Injury  (ISO)
Spontaneous Abortions  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
thrombocytopenia  (ISO)
toxic shock syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
Varicose Ulcer  (ISO)
Vaso-occlusive Crisis  (ISO)
visceral leishmaniasis  (ISO)
vitiligo  (ISO)
vulvovaginal candidiasis  (ISO)
Yin Deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-amphetamine  (ISO)
1,1-dichloroethene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
aflatoxin B1  (ISO)
all-trans-retinol  (ISO)
ammonium chloride  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buspirone  (ISO)
buta-1,3-diene  (EXP)
cannabidiol  (EXP)
carbon nanotube  (EXP)
cerium trichloride  (ISO)
CGP 52608  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
endosulfan  (ISO)
flutamide  (ISO)
furan  (ISO)
glafenine  (ISO)
Lasiocarpine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
metam  (EXP)
methapyrilene  (ISO)
methidathion  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (EXP)
parathion  (EXP)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
senecionine  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MBL2 gene polymorphisms protect against development of thrombocytopenia associated with severe dengue phenotype. Acioli-Santos B, etal., Hum Immunol. 2008 Feb;69(2):122-8. doi: 10.1016/j.humimm.2008.01.005. Epub 2008 Feb 12.
2. Relation among mannose-binding lectin 2 genotype, beta-cell autoantibodies, and risk for type 1 diabetes in Finnish children. Aittoniemi J, etal., Hum Immunol. 2008 Feb;69(2):108-11. doi: 10.1016/j.humimm.2008.01.007. Epub 2008 Feb 20.
3. Genotypes of the mannan-binding lectin gene and susceptibility to visceral leishmaniasis and clinical complications. Alonso DP, etal., J Infect Dis. 2007 Apr 15;195(8):1212-7. Epub 2007 Mar 5.
4. Mannan-binding lectin MBL2 gene polymorphism in chronic hepatitis C: association with the severity of liver fibrosis and response to interferon therapy. Alves Pedroso ML, etal., Clin Exp Immunol. 2008 May;152(2):258-64. doi: 10.1111/j.1365-2249.2008.03614.x. Epub 2008 Mar 10.
5. Mannose-binding lectin serum levels are low in persons with clinically active coccidioidomycosis. Ampel NM, etal., Mycopathologia. 2009 Apr;167(4):173-80. Epub 2008 Dec 14.
6. Polymorphisms in immunoregulatory genes and the risk of histologic chorioamnionitis in Caucasoid women: a case control study. Annells MF, etal., BMC Pregnancy Childbirth. 2005 Feb 21;5(1):4.
7. Mannan-binding lectin deficiency in pediatric patients with inflammatory bowel disease. Bak-Romaniszyn L, etal., Scand J Gastroenterol. 2011 Oct;46(10):1275-8. doi: 10.3109/00365521.2011.594087. Epub 2011 Jun 27.
8. The polymorphisms of the MBL2 and MIF genes associated with Pediatric Cochlear Implant Patients. Baysal E, etal., Int J Pediatr Otorhinolaryngol. 2013 Mar;77(3):338-40. doi: 10.1016/j.ijporl.2012.11.020. Epub 2012 Dec 14.
9. Polymorphisms in the mannose-binding lectin gene as determinants of age-defined risk of coronary artery lesions in Kawasaki disease. Biezeveld MH, etal., Arthritis Rheum. 2006 Jan;54(1):369-76.
10. Association of the wild-type A/A genotype of MBL2 codon 54 with asthma in a North Indian population. Birbian N, etal., Dis Markers. 2012;32(5):301-8. doi: 10.3233/DMA-2012-0892.
11. Epidemiology of chronic wound patients and relation to serum levels of mannan-binding lectin. Bitsch M, etal., Acta Derm Venereol. 2009 Nov;89(6):607-11. doi: 10.2340/00015555-0730.
12. Association between bronchopulmonary dysplasia and MBL2 and IL1-RN polymorphisms. Cakmak BC, etal., Pediatr Int. 2012 Dec;54(6):863-8. doi: 10.1111/j.1442-200X.2012.03714.x. Epub 2012 Nov 21.
13. Role played by human mannose-binding lectin polymorphisms in pulmonary tuberculosis. Capparelli R, etal., J Infect Dis. 2009 Mar 1;199(5):666-72.
14. Prevalence of atopic symptoms among blood donor carriers of mannose-binding lectin variant alleles. Cardinale F, etal., Int J Immunopathol Pharmacol. 2008 Jul-Sep;21(3):735-8.
15. Deficient serum mannose-binding lectin levels and MBL2 polymorphisms increase the risk of single and recurrent Cryptosporidium infections in young children. Carmolli M, etal., J Infect Dis. 2009 Nov 15;200(10):1540-7. doi: 10.1086/606013.
16. High polymorphism of the MBL2 gene in patients with atopic dermatitis. Carrera MC, etal., Ann Allergy Asthma Immunol. 2010 Jul;105(1):39-42. doi: 10.1016/j.anai.2010.03.017.
17. L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children. Cedzynski M, etal., Mol Immunol. 2009 Dec;47(2-3):415-9. Epub 2009 Sep 19.
18. Influence of mannose-binding lectin gene polymorphisms on the invasiveness of cytomegalovirus disease after solid organ transplantation. Cervera C, etal., Transplant Proc. 2009 Jul-Aug;41(6):2259-61.
19. Mannose-binding lectin polymorphisms and recurrent respiratory tract infection in Chinese children. Chen J, etal., Eur J Pediatr. 2009 Nov;168(11):1305-13. Epub 2009 Jan 24.
20. Modulating effects of mannose binding lectin genotype on arterial stiffness in children after Kawasaki disease. Cheung YF, etal., Pediatr Res. 2004 Oct;56(4):591-6. Epub 2004 Aug 4.
21. Mannose-binding lectin in chronic hepatitis B virus infection. Chong WP, etal., Hepatology. 2005 Nov;42(5):1037-45. doi: 10.1002/hep.20891.
22. Mannose-binding lectin-2 genotypes and recurrent late pregnancy losses. Christiansen OB, etal., Hum Reprod. 2009 Feb;24(2):291-9. doi: 10.1093/humrep/den377. Epub 2008 Oct 16.
23. Resistance of MBL gene-knockout mice to experimental systemic aspergillosis. Clemons KV, etal., Immunol Lett. 2010 Feb 16;128(2):105-7. doi: 10.1016/j.imlet.2009.12.021. Epub 2010 Jan 12.
24. Mannose-binding lectin gene polymorphisms as a susceptibility factor for chronic necrotizing pulmonary aspergillosis. Crosdale DJ, etal., J Infect Dis. 2001 Sep 1;184(5):653-6. Epub 2001 Jul 24.
25. Increased serum complement component 3 and mannose-binding lectin levels in adult Chinese patients with chronic rhinosinusitis. Cui YH, etal., Rhinology. 2009 Jun;47(2):187-91.
26. Mannan-binding lectin and ficolin deposition in skin lesions of pemphigus. de Messias-Reason IJ, etal., Arch Dermatol Res. 2011 Sep;303(7):521-5. doi: 10.1007/s00403-011-1132-1. Epub 2011 Feb 16.
27. The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injury. de Vries B, etal., Am J Pathol. 2004 Nov;165(5):1677-88.
28. Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study. Dolman KM, etal., Arthritis Res Ther. 2008;10(2):R32. doi: 10.1186/ar2386. Epub 2008 Mar 11.
29. Serum levels and H/L gene polymorphism of mannose-binding lectin in primary open angle glaucoma. Dursun O, etal., Curr Eye Res. 2012 Mar;37(3):212-7. doi: 10.3109/02713683.2011.639124.
30. Lack of genetic association of promoter and structural variants of mannan-binding lectin (MBL2) gene with susceptibility to generalized vitiligo. Dwivedi M, etal., Br J Dermatol. 2009 Jul;161(1):63-9. doi: 10.1111/j.1365-2133.2009.09140.x. Epub 2009 Apr 16.
31. Mannose-binding lectin in chronic hepatitis C in children. Dzwonek AB, etal., Scand J Gastroenterol. 2015;50(10):1276-84. doi: 10.3109/00365521.2015.1006673. Epub 2015 May 8.
32. Mannose-binding lectin genotypes in susceptibility to community-acquired pneumonia. Endeman H, etal., Chest. 2008 Dec;134(6):1135-40. Epub 2008 Jul 18.
33. Association of mannose-binding lectin-2 gene polymorphism with the development of hepatitis C-induced hepatocellular carcinoma. Eurich D, etal., Liver Int. 2011 Aug;31(7):1006-12. doi: 10.1111/j.1478-3231.2011.02522.x. Epub 2011 Apr 15.
34. Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin. Fernandez-Real JM, etal., Diabetologia. 2006 Oct;49(10):2402-11. Epub 2006 Aug 29.
35. Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanism. Fidler KJ, etal., Thorax. 2009 Feb;64(2):150-5. Epub 2008 Nov 6.
36. Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients. Filho CB, etal., Int J Immunogenet. 2012 Aug;39(4):357-61. doi: 10.1111/j.1744-313X.2012.01102.x. Epub 2012 Feb 23.
37. Bipolar and panic disorders may be associated with hereditary defects in the innate immune system. Foldager L, etal., J Affect Disord. 2014 Aug;164:148-54. doi: 10.1016/j.jad.2014.04.017. Epub 2014 Apr 19.
38. Association of mannose-binding lectin gene polymorphisms with antiphospholipid syndrome, cardiovascular disease and chronic damage in patients with systemic lupus erythematosus. Font J, etal., Rheumatology (Oxford). 2007 Jan;46(1):76-80. Epub 2006 Jun 26.
39. Mannan-binding lectin modulates the response to HSV-2 infection. Gadjeva M, etal., Clin Exp Immunol. 2004 Nov;138(2):304-11.
40. Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults. Garcia-Laorden MI, etal., J Allergy Clin Immunol. 2008 Aug;122(2):368-74, 374.e1-2. Epub 2008 Jun 25.
41. Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis. Garred P, etal., J Clin Invest. 1999 Aug;104(4):431-7.
42. Complement defects in patients with chronic rhinosinusitis. Gaunsbaek MQ, etal., PLoS One. 2012;7(11):e47383. doi: 10.1371/journal.pone.0047383. Epub 2012 Nov 7.
43. Mannose-binding lectin gene polymorphism, vulvovaginal candidiasis, and bacterial vaginosis. Giraldo PC, etal., Obstet Gynecol. 2007 May;109(5):1123-8.
44. Mannose-binding lectin gene polymorphism is a modulating factor in repeated respiratory infections. Gomi K, etal., Chest. 2004 Jul;126(1):95-9.
45. Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome. Gong MN, etal., Crit Care Med. 2007 Jan;35(1):48-56.
46. Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factors. Gregersen S, etal., Ann Allergy Asthma Immunol. 2010 Jun;104(6):503-10.
47. Genetic variants of mannose-binding lectin 2 gene influence progression and prognosis of patients with hepatitis B virus infection in China. Gu X, etal., Clin Res Hepatol Gastroenterol. 2016 Nov;40(5):614-621. doi: 10.1016/j.clinre.2015.12.015. Epub 2016 Feb 5.
48. Association of hepatitis C virus infection and liver fibrosis severity with the variants alleles of MBL2 gene in a Brazilian population. Halla MC, etal., Hum Immunol. 2010 Sep;71(9):883-7. doi: 10.1016/j.humimm.2010.05.021. Epub 2010 Jun 1.
49. A variant in the promoter of MBL2 is associated with protection against visceral leishmaniasis in Morocco. Hamdi S, etal., Infect Genet Evol. 2013 Jan;13:162-7. doi: 10.1016/j.meegid.2012.09.002. Epub 2012 Sep 18.
50. Deficient mannose-binding lectin-mediated complement activation despite mannose-binding lectin-sufficient genotypes in an outbreak of Legionella pneumophila pneumonia. Herpers BL, etal., Hum Immunol. 2009 Feb;70(2):125-9. doi: 10.1016/j.humimm.2008.11.002. Epub 2008 Dec 13.
51. Therapeutic role for mannose-binding lectin in cigarette smoke-induced lung inflammation? Evidence from a murine model. Hodge S, etal., Am J Respir Cell Mol Biol. 2010 Feb;42(2):235-42. Epub 2009 May 1.
52. Mannose-binding lectin variant associated with severe malaria in young African children. Holmberg V, etal., Microbes Infect. 2008 Apr;10(4):342-8. doi: 10.1016/j.micinf.2007.12.008. Epub 2007 Dec 28.
53. Association between mannose-binding lectin gene polymorphism and pediatric cytomegalovirus infection. Hu Y, etal., Viral Immunol. 2010 Aug;23(4):443-7.
54. Serum mannose-binding lectin levels are decreased in behcet's disease and associated with disease severity. Inanc N, etal., J Rheumatol. 2005 Feb;32(2):287-91.
55. Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection. Ip WK, etal., J Infect Dis. 2005 May 15;191(10):1697-704. Epub 2005 Apr 11.
56. Mannose-binding lectin variant alleles and HLA-DR4 alleles are associated with giant cell arteritis. Jacobsen S, etal., J Rheumatol. 2002 Oct;29(10):2148-53.
57. Elevated levels of mannan-binding lectin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL. Kaur S, etal., Clin Exp Immunol. 2006 Mar;143(3):414-9.
58. Protective role of mannan-binding lectin in a murine model of invasive pulmonary aspergillosis. Kaur S, etal., Clin Exp Immunol. 2007 May;148(2):382-9. Epub 2007 Mar 5.
59. Association of MBL2 polymorphism with asthma after bronchiolitis in infancy. Koponen P, etal., Pediatr Int. 2012 Oct;54(5):619-22. doi: 10.1111/j.1442-200X.2012.03651.x. Epub 2012 Jul 19.
60. Mannan-binding lectin in human serum, cerebrospinal fluid and brain tissue and its role in Alzheimer's disease. Lanzrein AS, etal., Neuroreport. 1998 May 11;9(7):1491-5.
61. Infections during induction therapy of childhood acute lymphoblastic leukemia--no association to mannose-binding lectin deficiency. Lausen B, etal., Eur J Haematol. 2006 Jun;76(6):481-7. Epub 2006 Feb 23.
62. Mannose-Binding Lectin Gene Polymorphism Contributes to Recurrence of Infective Exacerbation in COPD Patients. Lin CL, etal., Chest. 2010 Aug 5.
63. Impact of mannose-binding lectin 2 polymorphism on the risk of hepatocellular carcinoma: a case-control study in Chinese Han population. Lin Y, etal., J Epidemiol. 2015;25(5):387-91. doi: 10.2188/jea.JE20140194. Epub 2015 Mar 14.
64. Mannose-binding lectin gene polymorphic variants predispose to the development of bronchopulmonary complications but have no influence on other clinical and laboratory symptoms or signs of common variable immunodeficiency. Litzman J, etal., Clin Exp Immunol. 2008 Sep;153(3):324-30. Epub 2008 Jul 11.
65. The Chinese herbal formula Zhibai Dihuang Granule treat Yin-deficiency-heat syndrome rats by regulating the immune responses. Liu CM, etal., J Ethnopharmacol. 2018 Oct 28;225:271-278. doi: 10.1016/j.jep.2018.05.001. Epub 2018 May 2.
66. Genetically Determined MBL Deficiency Is Associated with Protection against Chronic Cardiomyopathy in Chagas Disease. Luz PR, etal., PLoS Negl Trop Dis. 2016 Jan 8;10(1):e0004257. doi: 10.1371/journal.pntd.0004257. eCollection 2016 Jan.
67. Mannose-binding lectin null alleles are associated with preserved epithelial cell integrity following intestinal ischemia reperfusion in man. Matthijsen RA, etal., Mol Immunol. 2009 Jul;46(11-12):2244-8. doi: 10.1016/j.molimm.2009.04.010. Epub 2009 May 23.
68. Use of a modeling framework to evaluate the effect of a modifier gene (MBL2) on variation in cystic fibrosis. McDougal KE, etal., Eur J Hum Genet. 2010 Jun;18(6):680-4. Epub 2010 Jan 13.
69. Structural polymorphism of the mannose-binding lectin 2 (MBL2 ) gene in HCV-infected patients with a serological marker for thyroid autoimmunity. Melo FM, etal., Int J Immunogenet. 2009 Dec;36(6):377-81. doi: 10.1111/j.1744-313X.2009.00871.x. Epub 2009 Aug 24.
70. Association of variant alleles of MBL2 gene with vasoocclusive crisis in children with sickle cell anemia. Mendonca TF, etal., Blood Cells Mol Dis. 2010 Apr 15;44(4):224-8. doi: 10.1016/j.bcmd.2010.02.004. Epub 2010 Feb 20.
71. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
72. MGDs mouse GO annotations MGD data from the GO Consortium
73. MGD IEA MGD IEA
74. High levels of serum mannose-binding lectin are associated with the severity of clinical signs of leptospirosis. Miranda KA, etal., Braz J Med Biol Res. 2009 Apr;42(4):353-7.
75. Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis. Mishra A, etal., Parasitol Int. 2015 Dec;64(6):591-6. doi: 10.1016/j.parint.2015.08.003. Epub 2015 Aug 19.
76. MBL2 polymorphism and risk of severe infections in multiple myeloma patients receiving high-dose melphalan and autologous stem cell transplantation. Molle I, etal., Bone Marrow Transplant. 2006 Oct;38(8):555-60. Epub 2006 Sep 4.
77. Mannan-binding lectin recognizes structures on ischaemic reperfused mouse kidneys and is implicated in tissue injury. Moller-Kristensen M, etal., Scand J Immunol. 2005 May;61(5):426-34.
78. Mannose-binding lectin gene variants and infections in patients receiving autologous stem cell transplantation. Moreto A, etal., BMC Immunol. 2014 May 3;15:17. doi: 10.1186/1471-2172-15-17.
79. Association between mannan-binding lectin and impaired lung function in cystic fibrosis may be age-dependent. Muhlebach MS, etal., Clin Exp Immunol. 2006 Aug;145(2):302-7.
80. Mannose binding lectin polymorphisms are associated with early age of disease onset and autoimmunity in common variable immunodeficiency. Mullighan CG, etal., Scand J Immunol. 2000 Feb;51(2):111-22.
81. Association between donor MBL promoter haplotype and graft survival and the development of BOS after lung transplantation. Munster JM, etal., Transplantation. 2008 Dec 27;86(12):1857-63.
82. Involvement of mannose-binding lectin in the pathogenesis of Kawasaki disease-like murine vasculitis. Nakamura A, etal., Clin Immunol. 2014 Jul;153(1):64-72. doi: 10.1016/j.clim.2014.03.019. Epub 2014 Apr 8.
83. Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994. Ned RM, etal., BMC Med Genet. 2010 Nov 5;11:155.
84. Mannan-binding lectin deficiency increases the risk of recurrent infections in children with Down's syndrome. Nisihara RM, etal., Hum Immunol. 2010 Jan;71(1):63-6. Epub .
85. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
86. Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk. Olivo-Marston SE, etal., Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3375-83.
87. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
88. Might there be a link between mannose binding lectin and vitiligo? Onay H, etal., Eur J Dermatol. 2007 Mar-Apr;17(2):146-8. Epub 2007 Mar 2.
89. Genotypes coding for mannose-binding lectin deficiency correlated with cryptococcal meningitis in HIV-uninfected Chinese patients. Ou XT, etal., J Infect Dis. 2011 Jun 1;203(11):1686-91. doi: 10.1093/infdis/jir152.
90. Human mannose-binding lectin inhibitor prevents Shiga toxin-induced renal injury. Ozaki M, etal., Kidney Int. 2016 Jul 1. pii: S0085-2538(16)30202-2. doi: 10.1016/j.kint.2016.05.011.
91. Mannose binding lectin and ficolin-2 polymorphisms are associated with increased risk for bacterial infections in children with B acute lymphoblastic leukemia. Pana ZD, etal., Pediatr Blood Cancer. 2014 Jun;61(6):1017-22. doi: 10.1002/pbc.24951. Epub 2014 Jan 22.
92. Association of HYPA haplotype in the mannose-binding lectin gene-2 with Behcet's disease. Park KS, etal., Tissue Antigens. 2005 Mar;65(3):260-5.
93. Human mannose-binding lectin inhibitor prevents myocardial injury and arterial thrombogenesis in a novel animal model. Pavlov VI, etal., Am J Pathol. 2015 Feb;185(2):347-55. doi: 10.1016/j.ajpath.2014.10.015. Epub 2014 Dec 4.
94. Gene polymorphisms and febrile neutropenia in acute leukemia--no association with IL-4, CCR-5, IL-1RA, but the MBL-2, ACE, and TLR-4 are associated with the disease in Turkish patients: a preliminary study. Pehlivan M, etal., Genet Test Mol Biomarkers. 2014 Jul;18(7):474-81. doi: 10.1089/gtmb.2014.0004. Epub 2014 May 12.
95. Mannose-binding lectin 2 gene polymorphism and lung damage in primary ciliary dyskinesia. Pifferi M, etal., Pediatr Pulmonol. 2015 Feb;50(2):179-86. doi: 10.1002/ppul.23026. Epub 2014 Apr 19.
96. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
97. Association of mannose-binding lectin gene polymorphism but not of mannose-binding serine protease 2 with chronic severe aortic regurgitation of rheumatic etiology. Ramasawmy R, etal., Clin Vaccine Immunol. 2008 Jun;15(6):932-6. doi: 10.1128/CVI.00324-07. Epub 2008 Apr 9.
98. Mouse MP Annotation Import Pipeline RGD automated import pipeline
99. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
100. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
101. MBL genotype and risk of invasive pneumococcal disease: a case-control study. Roy S, etal., Lancet. 2002 May 4;359(9317):1569-73.
102. High rate of early restenosis after carotid eversion endarterectomy in homozygous carriers of the normal mannose-binding lectin genotype. Rugonfalvi-Kiss S, etal., Stroke. 2005 May;36(5):944-8. Epub 2005 Mar 24.
103. Mannose binding lectin gene (MBL2) functional polymorphisms are associated with systemic lupus erythematosus in southern Brazilians. Sandrin-Garcia P, etal., Hum Immunol. 2011 Jun;72(6):516-21. Epub 2011 Apr 8.
104. Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes. Sapkota BR, etal., Hum Immunol. 2010 Oct;71(10):992-8. doi: 10.1016/j.humimm.2010.07.001. Epub 2010 Aug 1.
105. MBL2 and MASP2 gene polymorphisms in patients with hepatocellular carcinoma. Segat L, etal., J Viral Hepat. 2008 May;15(5):387-91. doi: 10.1111/j.1365-2893.2007.00965.x.
106. Mannose-binding lectin 2 gene polymorphism in recurrent herpes simplex virus 2 infection. Seppanen M, etal., Hum Immunol. 2009 Apr;70(4):218-21. doi: 10.1016/j.humimm.2009.01.022. Epub 2009 Feb 4.
107. Functional mannose-binding lectin haplotype variants are associated with Alzheimer's disease. Sjölander A, etal., J Alzheimers Dis. 2013;35(1):121-7. doi: 10.3233/JAD-122044.
108. Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli. Smithson A, etal., Clin Vaccine Immunol. 2007 Mar;14(3):256-61. Epub 2007 Jan 3.
109. MBL2 genotypes and their associations with MBL levels and NICU morbidity in a cohort of Greek neonates. Speletas M, etal., J Immunol Res. 2015;2015:478412. doi: 10.1155/2015/478412. Epub 2015 Mar 24.
110. Association study between mannose-binding lectin haplotypes and X gene mutation of hepatitis B virus from treatment naïve patients. Su C, etal., Aging (Albany NY). 2016 Nov 7;8(11):2862-2870. doi: 10.18632/aging.101097.
111. Association between mannose-binding lectin variants, haplotypes and risk of hepatocellular carcinoma: A case-control study. Su C, etal., Sci Rep. 2016 Aug 25;6:32147. doi: 10.1038/srep32147.
112. Mannose-Binding Lectin (MBL) and MBL-associated serine protease-2 (MASP-2) in women with malignant and benign ovarian tumours. Swierzko AS, etal., Cancer Immunol Immunother. 2014 Nov;63(11):1129-40. doi: 10.1007/s00262-014-1579-y. Epub 2014 Jul 20.
113. Association between mannose-binding lectin and HIV infection and progression in a Chinese population. Tan Y, etal., Mol Immunol. 2009 Dec;47(2-3):632-8. doi: 10.1016/j.molimm.2009.08.020. Epub 2009 Sep 30.
114. MBL2 gene variants coding for mannose-binding lectin deficiency are associated with increased risk of nephritis in Danish patients with systemic lupus erythematosus. Tanha N, etal., Lupus. 2014 Oct;23(11):1105-11. doi: 10.1177/0961203314536478. Epub 2014 May 21.
115. Genetic polymorphisms and serum levels of mannose-binding lectin in Chinese pediatric patients with common infectious diseases. Tao R, etal., Int J Infect Dis. 2012 May;16(5):e403-7. doi: 10.1016/j.ijid.2012.01.014. Epub 2012 Mar 22.
116. An MBL2 haplotype and ABCB4 variants modulate the risk of liver disease in cystic fibrosis patients: a multicentre study. Tomaiuolo R, etal., Dig Liver Dis. 2009 Nov;41(11):817-22. Epub 2009 May 20.
117. Does MBL2 codon 54 polymorphism play a role in the pathogenesis of psoriasis? Turan H, etal., Int J Dermatol. 2014 Jan;53(1):34-8. doi: 10.1111/j.1365-4632.2012.5657.x. Epub 2012 Nov 1.
118. Distinct alleles of mannose-binding lectin (MBL) and surfactant proteins A (SP-A) in patients with chronic cavitary pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. Vaid M, etal., Clin Chem Lab Med. 2007;45(2):183-6.
119. Effects of mannose-binding lectin polymorphisms on irinotecan-induced febrile neutropenia. van der Bol JM, etal., Oncologist. 2010;15(10):1063-72. doi: 10.1634/theoncologist.2010-0033. Epub 2010 Oct 7.
120. Mannose binding lectin and FcgammaRIIa (CD32) polymorphism in Spanish systemic lupus erythematosus patients. Villarreal J, etal., Rheumatology (Oxford). 2001 Sep;40(9):1009-12.
121. Mannose-binding lectin 2 rs11003123 polymorphism is associated with the development of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis in the Chinese population. Wang PS, etal., Hepatobiliary Pancreat Dis Int. 2016 Jun;15(3):282-8.
122. Mannose binding lectin (MBL) polymorphisms associated with low MBL production in patients with dermatomyositis. Werth VP, etal., J Invest Dermatol. 2002 Dec;119(6):1394-9.
123. Functional polymorphisms in the mannan-binding lectin 2 gene: effect on MBL levels and otitis media. Wiertsema SP, etal., J Allergy Clin Immunol. 2006 Jun;117(6):1344-50. Epub 2006 Apr 27.
124. Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in mice. Yager PH, etal., J Cereb Blood Flow Metab. 2008 May;28(5):1030-9. doi: 10.1038/sj.jcbfm.9600605. Epub 2008 Jan 9.
125. [Correlation between mannose-binding lectin gene codon 54 polymorphism and susceptibility of Kawasaki disease]. Yang J, etal., Zhonghua Er Ke Za Zhi. 2004 Mar;42(3):176-9.
126. HIV-1 Disease Progression and Survival in an Adult Population in Zimbabwe: Is There an Effect of the Mannose Binding Lectin Deficiency? Zinyama-Gutsire RB, etal., OMICS. 2015 Sep;19(9):542-52. doi: 10.1089/omi.2015.0047.
Additional References at PubMed
PMID:1637828   PMID:1712818   PMID:7592984   PMID:7766991   PMID:7894166   PMID:8702911   PMID:8961631   PMID:9107690   PMID:9525630   PMID:10047541   PMID:10349636   PMID:10922068  
PMID:11042159   PMID:11076861   PMID:11217851   PMID:11309157   PMID:12471128   PMID:12477932   PMID:14761934   PMID:15115753   PMID:15148336   PMID:15489334   PMID:15749852   PMID:15879138  
PMID:15972690   PMID:16141072   PMID:16141073   PMID:16299314   PMID:16424207   PMID:17015433   PMID:17015738   PMID:17114482   PMID:17363917   PMID:17475881   PMID:17646356   PMID:17785849  
PMID:18180310   PMID:18493734   PMID:18501966   PMID:18672286   PMID:18996748   PMID:19021581   PMID:19112490   PMID:19380618   PMID:19476514   PMID:19684159   PMID:19749170   PMID:19843088  
PMID:19854517   PMID:20140243   PMID:20305659   PMID:20375621   PMID:20585009   PMID:20810984   PMID:20870940   PMID:21182784   PMID:21257205   PMID:21305474   PMID:21677750   PMID:21873635  
PMID:21943708   PMID:22079428   PMID:22156595   PMID:22457620   PMID:22792067   PMID:23032324   PMID:23139754   PMID:23350727   PMID:23350935   PMID:23427256   PMID:23478320   PMID:23526211  
PMID:23936347   PMID:24167262   PMID:24743949   PMID:25008177   PMID:26367533   PMID:26442658   PMID:26603976   PMID:26631482   PMID:27106289   PMID:27689697   PMID:28378742   PMID:28700732  
PMID:28819174   PMID:29497373   PMID:30351498   PMID:30354247   PMID:30573546   PMID:30706943   PMID:30723261   PMID:30967639   PMID:31175160   PMID:31260126   PMID:31578522   PMID:31869396  
PMID:32325033   PMID:33927296   PMID:34031614   PMID:34547288   PMID:35021101  


Genomics

Comparative Map Data
Mbl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,210,306 - 30,217,087 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,210,342 - 30,217,087 (+)EnsemblGRCm39 Ensembl
GRCm381930,232,906 - 30,239,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,232,942 - 30,239,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv371930,307,447 - 30,314,172 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,298,954 - 30,305,679 (+)NCBIMGSCv36mm8
Celera1931,010,980 - 31,017,684 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.14NCBI
MBL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381052,765,380 - 52,772,784 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1052,765,380 - 52,772,784 (-)EnsemblGRCh38hg38GRCh38
GRCh371054,525,140 - 54,532,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361054,195,146 - 54,201,466 (-)NCBINCBI36Build 36hg18NCBI36
Build 341054,195,146 - 54,201,466NCBI
Celera1047,788,072 - 47,794,392 (-)NCBICelera
Cytogenetic Map10q21.1NCBI
HuRef1048,503,748 - 48,510,068 (-)NCBIHuRef
CHM1_11054,806,939 - 54,813,257 (-)NCBICHM1_1
T2T-CHM13v2.01053,612,365 - 53,619,761 (-)NCBIT2T-CHM13v2.0
Mbl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21228,016,439 - 228,024,736 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1236,419,619 - 236,424,489 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01243,349,309 - 243,354,179 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01236,171,876 - 236,176,773 (+)NCBIRnor_WKY
Rnor_6.01248,435,069 - 248,442,669 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,723,397 - 248,729,962 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01255,681,084 - 255,688,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,978,931 - 233,983,824 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,140,682 - 234,147,846 (+)NCBI
Celera1225,160,772 - 225,165,665 (+)NCBICelera
Cytogenetic Map1q52NCBI
Mbl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554257,702,137 - 7,709,006 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554257,704,371 - 7,708,951 (-)NCBIChiLan1.0ChiLan1.0
MBL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11051,537,129 - 51,543,041 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1051,527,758 - 51,543,432 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01049,401,364 - 49,409,328 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MBL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1429,419,886 - 29,424,377 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha429,544,300 - 29,548,802 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0429,721,980 - 29,726,589 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl429,721,981 - 29,726,540 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1429,591,559 - 29,596,084 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0429,794,211 - 29,798,774 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0430,148,194 - 30,152,765 (-)NCBIUU_Cfam_GSD_1.0
MBL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,102,823 - 97,108,083 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,103,926 - 97,107,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214105,632,322 - 105,636,031 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MBL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1978,389,534 - 78,394,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl978,389,947 - 78,396,079 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604839,340,958 - 39,345,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mbl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479110,881,268 - 10,886,297 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479110,881,319 - 10,886,294 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:67
Interacting mature miRNAs:72
Transcripts:ENSMUST00000025797
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192198409132912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
1357568Tgct4_mtesticular germ cell tumor 4 (mouse)Not determined192777198535295381Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse

Markers in Region
D11440  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,239,514 - 30,239,593UniSTSGRCm38
MGSCv371930,314,004 - 30,314,083UniSTSGRCm37
Celera1931,017,516 - 31,017,595UniSTS
Cytogenetic Map19C1UniSTS
cM Map1925.0UniSTS
Whitehead/MRC_RH19304.24UniSTS
Mbl2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C1UniSTS
cM Map1925.14UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000025797   ⟹   ENSMUSP00000025797
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1930,210,342 - 30,217,087 (+)Ensembl
GRCm38.p6 Ensembl1930,232,942 - 30,239,687 (+)Ensembl
RefSeq Acc Id: NM_001365058   ⟹   NP_001351987
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391930,210,328 - 30,217,087 (+)NCBI
GRCm381930,232,928 - 30,239,687 (+)NCBI
Sequence:
RefSeq Acc Id: NM_010776   ⟹   NP_034906
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391930,210,328 - 30,217,087 (+)NCBI
GRCm381930,232,928 - 30,239,687 (+)NCBI
MGSCv371930,307,447 - 30,314,172 (+)RGD
Celera1931,010,980 - 31,017,684 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526730   ⟹   XP_006526793
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391930,210,306 - 30,217,086 (+)NCBI
GRCm381930,232,906 - 30,239,686 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034906   ⟸   NM_010776
- Peptide Label: precursor
- UniProtKB: P41317 (UniProtKB/Swiss-Prot),   Q3UEK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006526793   ⟸   XM_006526730
- Peptide Label: isoform X1
- UniProtKB: P41317 (UniProtKB/Swiss-Prot),   Q3UEK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001351987   ⟸   NM_001365058
- Peptide Label: precursor
- UniProtKB: P41317 (UniProtKB/Swiss-Prot),   Q3UEK1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000025797   ⟸   ENSMUST00000025797
Protein Domains
C-type lectin   Collagen-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41317-F1-model_v2 AlphaFold P41317 1-244 view protein structure

Promoters
RGD ID:13679248
Promoter ID:EPDNEW_M23772
Type:multiple initiation site
Name:Mbl2_1
Description:Mus musculus mannose-binding lectin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381930,232,933 - 30,232,993EPDNEW
RGD ID:6830191
Promoter ID:MM_KWN:26822
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000025797
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361930,307,166 - 30,307,666 (+)MPROMDB
RGD ID:6847569
Promoter ID:MM_ACW:26534
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:MBL2.CSEP07,   MBL2.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361930,309,166 - 30,309,666 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96924 AgrOrtholog
Ensembl Genes ENSMUSG00000024863 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000025797 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025797 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mannose-binding_protein_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17195 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96924 ENTREZGENE
NCBI Gene 17195 ENTREZGENE
PANTHER PTHR24024:SF34 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mbl2 PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MBL2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UEK1 ENTREZGENE, UniProtKB/TrEMBL