RGD Reference Report - Mannose binding lectin and ficolin-2 polymorphisms are associated with increased risk for bacterial infections in children with B acute lymphoblastic leukemia. - Rat Genome Database

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Mannose binding lectin and ficolin-2 polymorphisms are associated with increased risk for bacterial infections in children with B acute lymphoblastic leukemia.

Authors: Pana, ZD  Samarah, F  Papi, R  Antachopoulos, C  Papageorgiou, T  Farmaki, E  Hatzipantelis, E  Tragiannidis, A  Vavatsi-Christaki, N  Kyriakidis, D  Athanassiadou-Piperopoulou, F  Roilides, E 
Citation: Pana ZD, etal., Pediatr Blood Cancer. 2014 Jun;61(6):1017-22. doi: 10.1002/pbc.24951. Epub 2014 Jan 22.
RGD ID: 11530056
Pubmed: PMID:24453114   (View Abstract at PubMed)
DOI: DOI:10.1002/pbc.24951   (Journal Full-text)

BACKGROUND: We aimed to investigate whether the presence of mannose binding lectin (MBL2), ficolin 2 (FCN2) polymorphisms or the combined deficiency significantly influence the risk and subsequently the frequency of chemotherapy-induced bacterial infections in children with B acute lymphoblastic leukemia (B-ALL). PROCEDURE: MBL2 polymorphisms for exon 1 and FCN2 polymorphisms for promoter regions -986, -602, -557, -64, -4 and exon 8 regions +6,359, +6,424 were determined in children with B-ALL. FCN2 haplotype was determined by gene sequencing. Number and duration of FN episodes as well as number of bacterial infections were recorded during induction chemotherapy. RESULTS: Forty-four children with B-ALL (median age 4.3 years, 65.9% males) suffered from 142 FN episodes and 92 bacterial infections (40.2% Gram positive and 59.8% Gram negative). MBL2 low-risk genotype was found in 59.1%, medium-risk in 31.8% and high-risk in 9%. FCN2 low-risk haplotypes were detected in 38.2%, medium-risk in 44.1% and high-risk in 17.6%. MBL2 genotype and FCN2 haplotype were not associated with increased frequency of FN episodes. MBL2 medium/high-risk genotype and FCN2 medium/high-risk haplotype were associated with prolonged duration of FN (P = 0.007 and P = 0.001, respectively) and increased number of bacterial infections (P = 0.001 and P = 0.002, respectively). The combined MBL2/FCN2 medium/high-risk genotype was associated with an increased number of bacterial infections (P = 0.001). CONCLUSIONS: MBL2 and FCN2 single or combined deficiencies are associated with increased duration of FN episodes as well as increased number of bacterial infections in children with B-ALL suggesting a prognostic role of these genes.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MBL2Humanbacterial infectious disease susceptibilityIAGP associated with Precursor B-Cell Lymphoblastic Leukemia-Lymphoma and DNA:polymorphism:exon:RGD 
Mbl2Ratbacterial infectious disease susceptibilityISOMBL2 (Homo sapiens)associated with Precursor B-Cell Lymphoblastic Leukemia-Lymphoma and DNA:polymorphism:exon:RGD 
Mbl2Mousebacterial infectious disease susceptibilityISOMBL2 (Homo sapiens)associated with Precursor B-Cell Lymphoblastic Leukemia-Lymphoma and DNA:polymorphism:exon:RGD 
MBL2HumanChemotherapy-Induced Febrile Neutropenia disease progressionIAGP associated with Precursor B-Cell Lymphoblastic Leukemia-Lymphoma and DNA:polymorphisms:exon:RGD 
Mbl2RatChemotherapy-Induced Febrile Neutropenia disease progressionISOMBL2 (Homo sapiens)associated with Precursor B-Cell Lymphoblastic Leukemia-Lymphoma and DNA:polymorphisms:exon:RGD 
Mbl2MouseChemotherapy-Induced Febrile Neutropenia disease progressionISOMBL2 (Homo sapiens)associated with Precursor B-Cell Lymphoblastic Leukemia-Lymphoma and DNA:polymorphisms:exon:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbl2  (mannose binding lectin 2)

Genes (Mus musculus)
Mbl2  (mannose-binding lectin (protein C) 2)

Genes (Homo sapiens)
MBL2  (mannose binding lectin 2)


Additional Information