Mbl2 (mannose binding lectin 2) - Rat Genome Database

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Gene: Mbl2 (mannose binding lectin 2) Heterocephalus glaber
Analyze
Symbol: Mbl2
Name: mannose binding lectin 2
RGD ID: 18929282
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); D-mannose binding (ortholog); INVOLVED IN antiviral innate immune response (ortholog); cell surface pattern recognition receptor signaling pathway (ortholog); complement activation, lectin pathway (ortholog); PARTICIPATES IN lectin complement pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); allergic bronchopulmonary aspergillosis (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular space (ortholog); protein-containing complex (ortholog); serine-type endopeptidase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Mannose-binding protein C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479110,881,268 - 10,886,297 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479110,881,319 - 10,886,294 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
Alzheimer's disease  (ISO)
Aneurysm  (ISO)
aortic valve insufficiency  (ISO)
Arterial Thrombosis  (ISO)
aspergillosis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autoimmune thyroiditis  (ISO)
Bacteremia  (ISO)
bacterial infectious disease  (ISO)
bacterial pneumonia  (ISO)
bacterial vaginosis  (ISO)
Behcet's disease  (ISO)
bipolar disorder  (ISO)
Birth Weight  (ISO)
Brain Injuries  (ISO)
bronchiectasis  (ISO)
bronchiolitis obliterans  (ISO)
bronchopneumonia  (ISO)
bronchopulmonary dysplasia  (ISO)
Chagas Cardiomyopathy  (ISO)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
chorioamnionitis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Rhinosinusitis  (ISO)
coccidioidomycosis  (ISO)
common variable immunodeficiency  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Crohn's disease  (ISO)
cryptococcal meningitis  (ISO)
cryptosporidiosis  (ISO)
cystic fibrosis  (ISO)
Cytomegalovirus Infections  (ISO)
dermatomyositis  (ISO)
Diabetic Foot  (ISO)
Diffuse Panbronchiolitis  (ISO)
disease by infectious agent  (ISO)
end stage renal disease  (ISO)
Familial Thoracic Aortic Aneurysm 8  (ISO)
fungal infectious disease  (ISO)
gestational diabetes  (ISO)
Hashimoto Disease  (ISO)
hemolytic-uremic syndrome  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Intestinal Reperfusion Injury  (ISO)
invasive aspergillosis  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kartagener syndrome  (ISO)
Kawasaki disease  (ISO)
Legionnaires' disease  (ISO)
lepromatous leprosy  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
lung cancer  (ISO)
lupus nephritis  (ISO)
Mannose-Binding Protein Deficiency  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
newborn respiratory distress syndrome  (ISO)
obesity  (ISO)
otitis media  (ISO)
ovarian cancer  (ISO)
panic disorder  (ISO)
pemphigus  (ISO)
peripheral nervous system disease  (ISO)
peripheral vascular disease  (ISO)
Plasmodium falciparum malaria  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyalgia rheumatica  (ISO)
Premature Birth  (ISO)
primary open angle glaucoma  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
respiratory failure  (ISO)
Respiratory Tract Infections  (ISO)
rhinitis  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
Smoke Inhalation Injury  (ISO)
Spontaneous Abortions  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
thrombocytopenia  (ISO)
toxic shock syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
Varicose Ulcer  (ISO)
Vaso-occlusive Crisis  (ISO)
visceral leishmaniasis  (ISO)
vitiligo  (ISO)
vulvovaginal candidiasis  (ISO)
Yin Deficiency  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Mbl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479110,881,268 - 10,886,297 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479110,881,319 - 10,886,294 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MBL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381052,765,380 - 52,772,784 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1052,765,380 - 52,772,784 (-)EnsemblGRCh38hg38GRCh38
GRCh371054,525,140 - 54,532,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361054,195,146 - 54,201,466 (-)NCBINCBI36Build 36hg18NCBI36
Build 341054,195,146 - 54,201,466NCBI
Celera1047,788,072 - 47,794,392 (-)NCBICelera
Cytogenetic Map10q21.1NCBI
HuRef1048,503,748 - 48,510,068 (-)NCBIHuRef
CHM1_11054,806,939 - 54,813,257 (-)NCBICHM1_1
T2T-CHM13v2.01053,612,365 - 53,619,761 (-)NCBIT2T-CHM13v2.0
Mbl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,210,306 - 30,217,087 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,210,342 - 30,217,087 (+)EnsemblGRCm39 Ensembl
GRCm381930,232,906 - 30,239,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,232,942 - 30,239,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv371930,307,447 - 30,314,172 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,298,954 - 30,305,679 (+)NCBIMGSCv36mm8
Celera1931,010,980 - 31,017,684 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.14NCBI
Mbl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,429,873 - 237,465,567 (+)NCBIGRCr8
mRatBN7.21228,016,439 - 228,024,736 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1236,419,619 - 236,424,489 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,349,309 - 243,354,179 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,171,876 - 236,176,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,435,069 - 248,442,669 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,723,397 - 248,729,962 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01255,681,084 - 255,688,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,978,931 - 233,983,824 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,140,682 - 234,147,846 (+)NCBI
Celera1225,160,772 - 225,165,665 (+)NCBICelera
Cytogenetic Map1q52NCBI
Mbl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554257,702,137 - 7,709,006 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554257,704,371 - 7,708,951 (-)NCBIChiLan1.0ChiLan1.0
MBL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2865,063,616 - 65,068,335 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11065,070,156 - 65,073,657 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01049,401,364 - 49,409,328 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11051,537,129 - 51,543,041 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1051,527,758 - 51,543,432 (-)Ensemblpanpan1.1panPan2
MBL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1429,419,886 - 29,424,377 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha429,544,300 - 29,548,802 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0429,721,980 - 29,726,589 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl429,721,981 - 29,726,540 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1429,591,559 - 29,596,084 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0429,794,211 - 29,798,774 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0430,148,194 - 30,152,765 (-)NCBIUU_Cfam_GSD_1.0
MBL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,102,823 - 97,108,083 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,103,926 - 97,107,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214105,632,322 - 105,636,031 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MBL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1978,389,534 - 78,394,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl978,389,947 - 78,396,079 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604839,340,958 - 39,345,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000004471   ⟹   ENSHGLP00000004409
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462479110,881,268 - 10,886,297 (+)Ensembl
RefSeq Acc Id: XM_004858315   ⟹   XP_004858372
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479110,881,322 - 10,886,294 (+)NCBI
RefSeq Acc Id: XM_004858316   ⟹   XP_004858373
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479110,881,323 - 10,886,294 (+)NCBI
RefSeq Acc Id: XM_004858318   ⟹   XP_004858375
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479110,881,320 - 10,886,294 (+)NCBI
RefSeq Acc Id: XM_004858319   ⟹   XP_004858376
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479110,881,323 - 10,886,294 (+)NCBI
RefSeq Acc Id: XM_013077224   ⟹   XP_012932678
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479110,881,322 - 10,886,294 (+)NCBI
RefSeq Acc Id: XM_021239178   ⟹   XP_021094837
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479110,881,323 - 10,886,294 (+)NCBI
RefSeq Acc Id: XM_021239179   ⟹   XP_021094838
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479110,881,322 - 10,886,294 (+)NCBI
RefSeq Acc Id: XM_021239180   ⟹   XP_021094839
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479110,881,319 - 10,886,294 (+)NCBI
RefSeq Acc Id: XM_021239181   ⟹   XP_021094840
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479110,881,323 - 10,886,294 (+)NCBI
RefSeq Acc Id: XM_021239182   ⟹   XP_021094841
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479110,881,323 - 10,886,294 (+)NCBI
RefSeq Acc Id: XM_021239183   ⟹   XP_021094842
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479110,881,323 - 10,886,294 (+)NCBI
RefSeq Acc Id: XP_021094839   ⟸   XM_021239180
- Peptide Label: isoform X2
- UniProtKB: G5CAB8 (UniProtKB/TrEMBL),   A0AAX6RET5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004858375   ⟸   XM_004858318
- Peptide Label: isoform X2
- UniProtKB: G5CAB8 (UniProtKB/TrEMBL),   A0AAX6RET5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012932678   ⟸   XM_013077224
- Peptide Label: isoform X1
- UniProtKB: G5CAB8 (UniProtKB/TrEMBL),   A0AAX6PTL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004858372   ⟸   XM_004858315
- Peptide Label: isoform X1
- UniProtKB: G5CAB8 (UniProtKB/TrEMBL),   A0AAX6PTL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021094838   ⟸   XM_021239179
- Peptide Label: isoform X1
- UniProtKB: G5CAB8 (UniProtKB/TrEMBL),   A0AAX6PTL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021094841   ⟸   XM_021239182
- Peptide Label: isoform X2
- UniProtKB: G5CAB8 (UniProtKB/TrEMBL),   A0AAX6RET5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021094840   ⟸   XM_021239181
- Peptide Label: isoform X2
- UniProtKB: G5CAB8 (UniProtKB/TrEMBL),   A0AAX6RET5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021094837   ⟸   XM_021239178
- Peptide Label: isoform X1
- UniProtKB: G5CAB8 (UniProtKB/TrEMBL),   A0AAX6PTL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021094842   ⟸   XM_021239183
- Peptide Label: isoform X2
- UniProtKB: G5CAB8 (UniProtKB/TrEMBL),   A0AAX6RET5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004858373   ⟸   XM_004858316
- Peptide Label: isoform X1
- UniProtKB: G5CAB8 (UniProtKB/TrEMBL),   A0AAX6PTL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004858376   ⟸   XM_004858319
- Peptide Label: isoform X2
- UniProtKB: G5CAB8 (UniProtKB/TrEMBL),   A0AAX6RET5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000004409   ⟸   ENSHGLT00000004471


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003224 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000004471 ENTREZGENE
Gene3D-CATH 3.10.100.10 UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/TrEMBL
  Ca-dependent_lectin UniProtKB/TrEMBL
  Collagen UniProtKB/TrEMBL
  CTDL_fold UniProtKB/TrEMBL
NCBI Gene Mbl2 ENTREZGENE
PANTHER PTHR24024:SF34 UniProtKB/TrEMBL
  PULMONARY SURFACTANT-ASSOCIATED PROTEIN A UniProtKB/TrEMBL
Pfam Collagen UniProtKB/TrEMBL
  Lectin_C UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_1 UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/TrEMBL
SMART CLECT UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/TrEMBL
UniProt A0AAX6PTL5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RET5 ENTREZGENE, UniProtKB/TrEMBL
  G5CAB8 ENTREZGENE, UniProtKB/TrEMBL