RGD Reference Report - Resistance of MBL gene-knockout mice to experimental systemic aspergillosis. - Rat Genome Database

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Resistance of MBL gene-knockout mice to experimental systemic aspergillosis.

Authors: Clemons, KV  Martinez, M  Tong, AJ  Stevens, DA 
Citation: Clemons KV, etal., Immunol Lett. 2010 Feb 16;128(2):105-7. doi: 10.1016/j.imlet.2009.12.021. Epub 2010 Jan 12.
RGD ID: 8694071
Pubmed: (View Article at PubMed) PMID:20064561
DOI: Full-text: DOI:10.1016/j.imlet.2009.12.021

Mannose binding lectin (MBL) is a protein of the collectin family that appears important in resistance to invasive pulmonary aspergillosis. We assessed the role of MBL in experimental systemic aspergillosis. MBL-sufficient C57BL/6 (WT) mice and B6.129S4--Mb11(tm1Kata) Mb12(tm1Kata)/J MBL A and C gene-knockout (KO) mice were infected intravenously with different inocula of Aspergillus fumigatus conidia. WT and KO mice were dose-responsively susceptible. In no instance were the KO mice more susceptible than WT. At the highest inoculum, all WT and 90% of KO mice died on day 4 (P>0.05). Reduction of the inoculum to 5.5 x 10(6) conidia was lethal, but comparison showed KO mice less susceptible to lethal infection (P<0.015). At the lowest inoculum used, deaths of KO mice were delayed, but survival was not significantly different than WT (P>0.05). These results suggest MBL may play a deleterious role in systemic aspergillosis.

Annotation

Disease Annotations    
aspergillosis  (IMP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Mbl1  (mannose binding lectin 1)
Mbl2  (mannose binding lectin 2)

Genes (Mus musculus)
Mbl1  (mannose-binding lectin (protein A) 1)
Mbl2  (mannose-binding lectin (protein C) 2)

Genes (Homo sapiens)
MBL2  (mannose binding lectin 2)


Additional Information