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Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients.

Authors: Filho, CB  Rodrigues, FF  Segat, L  Fonseca, AM  Araujo, J  Arahata, C  Pontes, L  Vilar, L  De Lima Filho, JL  Crovella, S 
Citation: Filho CB, etal., Int J Immunogenet. 2012 Aug;39(4):357-61. doi: 10.1111/j.1744-313X.2012.01102.x. Epub 2012 Feb 23.
Pubmed: (View Article at PubMed) PMID:22360648
DOI: Full-text: DOI:10.1111/j.1744-313X.2012.01102.x

We investigated the association between MBL2 gene exon 1 functional polymorphisms and autoimmune thyroid disease (AITD) in 163 Brazilian patients (87 with Hashimoto thyroiditis, HT; 76 with Graves' disease) and 214 healthy controls. Individuals carrying MBL2 O allele are at higher risk of developing AITD (OR = 1.58, 95% CI: 1.11-2.26; P-value = 0.009) and HT (OR = 1.67, 95% CI: 1.09-2.55; P-value = 0.013) as suggesting a possible role for mannose-binding lectin in influencing disease susceptibility.

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RGD Object Information
RGD ID: 8693703
Created: 2014-07-18
Species: All species
Last Modified: 2014-07-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.