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Gene: Eprs (glutamyl-prolyl-tRNA synthetase) Rattus norvegicus
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Symbol: Eprs
Name: glutamyl-prolyl-tRNA synthetase
Description: Predicted to have several functions, including proline-tRNA ligase activity; protein homodimerization activity; and zinc ion binding activity. Predicted to be involved in several processes, including cellular response to interferon-gamma; long-chain fatty acid import into cell; and prolyl-tRNA aminoacylation. Predicted to localize to several cellular components, including the GAIT complex; aminoacyl-tRNA synthetase multienzyme complex; and cytosol. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human EPRS (glutamyl-prolyl-tRNA synthetase); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-colchicine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: bifunctional aminoacyl-tRNA synthetase; bifunctional glutamate/proline--tRNA ligase; LOC289352
Orthologs:
Homo sapiens (human) : EPRS1 (glutamyl-prolyl-tRNA synthetase 1)  HGNC  Alliance
Mus musculus (house mouse) : Eprs (glutamyl-prolyl-tRNA synthetase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eprs1 (glutamyl-prolyl-tRNA synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EPRS1 (glutamyl-prolyl-tRNA synthetase 1)
Canis lupus familiaris (dog) : EPRS1 (glutamyl-prolyl-tRNA synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Eprs1 (glutamyl-prolyl-tRNA synthetase 1)
Sus scrofa (pig) : EPRS1 (glutamyl-prolyl-tRNA synthetase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.013103,300,911 - 103,371,651 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013107,973,665 - 108,044,298 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413101,375,656 - 101,448,175 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113101,564,698 - 101,637,217 (+)NCBI
Celera1396,415,061 - 96,484,921 (+)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Eprs
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310952
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-01
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.