(S)-amphetamine increases expression ISO RGD:1553620 6480464 Dextroamphetamine results in increased expression of EPRS mRNA CTD PMID:12558987 (S)-colchicine increases expression EXP 6480464 Colchicine results in increased expression of EPRS mRNA CTD PMID:20624997 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression EXP 6480464 o, p'-DDT results in increased expression of EPRS mRNA CTD PMID:24096037 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression ISO RGD:1553620 6480464 o, p'-DDT results in increased expression of EPRS mRNA CTD PMID:24096037 17alpha-ethynylestradiol increases expression ISO RGD:1553620 6480464 Ethinyl Estradiol results in increased expression of EPRS mRNA CTD PMID:24096037 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of EPRS mRNA CTD PMID:24096037 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1553620 6480464 Tetrachlorodibenzodioxin affects the expression of EPRS mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of EPRS mRNA CTD PMID:32109520 2-amino-2-deoxy-D-glucopyranose decreases expression ISO RGD:1553620 6480464 Glucosamine results in decreased expression of EPRS mRNA CTD PMID:17178593 2-hydroxypropanoic acid decreases expression ISO RGD:1322145 6480464 Lactic Acid results in decreased expression of EPRS1 mRNA CTD PMID:30851411 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1553620 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of EPRS mRNA CTD PMID:20188158 , PMID:26251327 5-fluorouracil decreases expression ISO RGD:1322145 6480464 Fluorouracil results in decreased expression of EPRS1 mRNA CTD PMID:16709241 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of EPRS mRNA CTD PMID:31881176 aflatoxin B2 decreases methylation ISO RGD:1322145 6480464 aflatoxin B2 results in decreased methylation of EPRS1 intron CTD PMID:30157460 aldehydo-D-glucosamine decreases expression ISO RGD:1553620 6480464 Glucosamine results in decreased expression of EPRS mRNA CTD PMID:17178593 Aroclor 1254 decreases expression ISO RGD:1553620 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of EPRS mRNA CTD PMID:23650126 benzo[a]pyrene affects expression ISO RGD:1553620 6480464 Benzo(a)pyrene affects the expression of EPRS mRNA CTD PMID:21715664 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1322145 6480464 7 more ... CTD PMID:19150397 more ... beta-D-glucosamine decreases expression ISO RGD:1553620 6480464 Glucosamine results in decreased expression of EPRS mRNA CTD PMID:17178593 bisphenol A decreases expression ISO RGD:1322145 6480464 bisphenol A results in decreased expression of EPRS1 mRNA CTD PMID:20678512 bisphenol A affects expression ISO RGD:1322145 6480464 bisphenol A affects the expression of EPRS mRNA CTD PMID:30903817 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of EPRS gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of EPRS mRNA CTD PMID:30816183 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of EPRS mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:1553620 6480464 bisphenol A results in decreased expression of EPRS mRNA CTD PMID:23798566 cadmium dichloride decreases expression ISO RGD:1322145 6480464 Cadmium Chloride results in decreased expression of EPRS1 mRNA CTD PMID:25596134 cadmium dichloride increases expression ISO RGD:1322145 6480464 Cadmium Chloride results in increased expression of EPRS1 mRNA CTD PMID:26472689 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of EPRS mRNA CTD PMID:25993096 chloroacetaldehyde decreases expression ISO RGD:1322145 6480464 chloroacetaldehyde results in decreased expression of EPRS1 mRNA CTD PMID:25596134 chloropicrin affects expression ISO RGD:1322145 6480464 chloropicrin affects the expression of EPRS1 mRNA CTD PMID:26352163 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of EPRS mRNA CTD PMID:23125180 chromium(6+) affects expression ISO RGD:1553620 6480464 chromium hexavalent ion affects the expression of EPRS mRNA CTD PMID:28472532 cidofovir anhydrous decreases expression ISO RGD:1322145 6480464 Cidofovir results in decreased expression of EPRS1 mRNA CTD PMID:25596134 cisplatin decreases expression ISO RGD:1322145 6480464 Cisplatin results in decreased expression of EPRS1 mRNA CTD PMID:25596134 clodronic acid decreases expression ISO RGD:1322145 6480464 Clodronic Acid results in decreased expression of EPRS1 mRNA CTD PMID:25596134 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of EPRS mRNA CTD PMID:25596134 cyclosporin A increases expression ISO RGD:1322145 6480464 Cyclosporine results in increased expression of EPRS1 mRNA CTD PMID:20106945 more ... dioxygen decreases expression ISO RGD:1322145 6480464 Oxygen deficiency results in decreased expression of EPRS1 mRNA CTD PMID:25596134 diuron decreases expression EXP 6480464 Diuron results in decreased expression of EPRS mRNA CTD PMID:25152437 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of EPRS mRNA CTD PMID:29391264 enzyme inhibitor multiple interactions ISO RGD:1322145 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of EPRS1 protein CTD PMID:23301498 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of EPRS protein CTD PMID:19609968 fenofibrate increases expression ISO RGD:1322145 6480464 Fenofibrate results in increased expression of EPRS1 mRNA CTD PMID:25596134 fenofibrate increases expression EXP 6480464 Fenofibrate results in increased expression of EPRS mRNA CTD PMID:25596134 flutamide increases expression EXP 6480464 Flutamide results in increased expression of EPRS mRNA CTD PMID:24136188 geldanamycin increases expression ISO RGD:1322145 6480464 geldanamycin results in increased expression of EPRS1 mRNA CTD PMID:26705709 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of EPRS mRNA CTD PMID:22061828 glafenine increases expression EXP 6480464 Glafenine results in increased expression of EPRS mRNA CTD PMID:24136188 hydralazine multiple interactions ISO RGD:1322145 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of EPRS1 mRNA CTD PMID:17183730 hydrogen peroxide affects expression ISO RGD:1322145 6480464 Hydrogen Peroxide affects the expression of EPRS1 mRNA CTD PMID:20044591 hydrogen sulfide decreases expression ISO RGD:1553620 6480464 Hydrogen Sulfide results in decreased expression of EPRS protein CTD PMID:29932956 ibuprofen increases expression ISO RGD:1322145 6480464 Ibuprofen results in increased expression of EPRS1 mRNA CTD PMID:25596134 L-ascorbic acid decreases expression ISO RGD:1322145 6480464 Ascorbic Acid results in decreased expression of EPRS1 mRNA CTD PMID:19197388 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of EPRS mRNA CTD PMID:11578147 levonorgestrel multiple interactions ISO RGD:1322145 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of EPRS1 mRNA CTD PMID:19074003 menadione affects expression ISO RGD:1322145 6480464 Vitamin K 3 affects the expression of EPRS1 mRNA CTD PMID:20044591 metformin increases expression EXP 6480464 Metformin results in increased expression of EPRS mRNA CTD PMID:25596134 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of EPRS mRNA CTD PMID:30467583 methotrexate affects response to substance ISO RGD:1322145 6480464 EPRS1 protein affects the susceptibility to Methotrexate CTD PMID:16217747 N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of EPRS mRNA CTD PMID:28801915 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of EPRS mRNA CTD PMID:24136188 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of EPRS mRNA CTD PMID:24136188 ochratoxin A decreases expression ISO RGD:1322145 6480464 ochratoxin A results in decreased expression of EPRS1 mRNA CTD PMID:30559759 oxaliplatin multiple interactions EXP 6480464 [Oxaliplatin co-treated with Topotecan] results in decreased expression of EPRS mRNA CTD PMID:25729387 p-toluidine increases expression EXP 6480464 4-toluidine results in increased expression of EPRS mRNA CTD PMID:27638505 phenobarbital affects expression ISO RGD:1553620 6480464 Phenobarbital affects the expression of EPRS mRNA CTD PMID:23091169 rac-lactic acid decreases expression ISO RGD:1322145 6480464 Lactic Acid results in decreased expression of EPRS1 mRNA CTD PMID:30851411 silicon dioxide decreases expression ISO RGD:1322145 6480464 Silicon Dioxide results in decreased expression of EPRS1 mRNA CTD PMID:25351596 Soman increases expression EXP 6480464 Soman results in increased expression of EPRS mRNA CTD PMID:19281266 sunitinib increases expression ISO RGD:1322145 6480464 Sunitinib results in increased expression of EPRS1 mRNA CTD PMID:31533062 testosterone enanthate affects expression ISO RGD:1322145 6480464 testosterone enanthate affects the expression of EPRS1 mRNA CTD PMID:17440010 testosterone undecanoate multiple interactions ISO RGD:1322145 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of EPRS1 mRNA CTD PMID:19074003 thapsigargin increases expression ISO RGD:1553620 6480464 Thapsigargin results in increased expression of EPRS protein CTD PMID:24648495 thapsigargin increases expression ISO RGD:1322145 6480464 Thapsigargin results in increased expression of EPRS1 mRNA CTD PMID:22378314 thimerosal decreases expression ISO RGD:1322145 6480464 Thimerosal results in decreased expression of EPRS1 mRNA CTD PMID:27188386 titanium dioxide increases expression ISO RGD:1322145 6480464 titanium dioxide results in increased expression of EPRS1 protein CTD PMID:30910687 topotecan multiple interactions EXP 6480464 [Oxaliplatin co-treated with Topotecan] results in decreased expression of EPRS mRNA CTD PMID:25729387 triphenyl phosphate affects expression EXP 6480464 triphenyl phosphate affects the expression of EPRS mRNA CTD PMID:30589522 tungsten decreases expression ISO RGD:1553620 6480464 Tungsten results in decreased expression of EPRS mRNA CTD PMID:30912803 tunicamycin increases expression ISO RGD:1322145 6480464 Tunicamycin results in increased expression of EPRS1 mRNA, Tunicamycin results in increased expression of EPRS1 protein CTD PMID:22378314 , PMID:29453283 valproic acid multiple interactions ISO RGD:1322145 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of EPRS1 mRNA CTD PMID:17183730 valproic acid decreases expression ISO RGD:1322145 6480464 Valproic Acid results in decreased expression of EPRS1 mRNA CTD PMID:23179753 , PMID:27188386 vincaleukoblastine increases expression EXP 6480464 Vinblastine results in increased expression of EPRS mRNA CTD PMID:20624997 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of EPRS mRNA CTD PMID:19015723 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of EPRS mRNA CTD PMID:20566332 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of EPRS mRNA CTD PMID:20566332 vincristine increases expression EXP 6480464 Vincristine results in increased expression of EPRS mRNA CTD PMID:20624997 vorinostat decreases expression ISO RGD:1322145 6480464 Vorinostat results in decreased expression of EPRS1 mRNA CTD PMID:27188386 zoledronic acid decreases expression ISO RGD:1322145 6480464 Zoledronic Acid results in decreased expression of EPRS1 mRNA CTD PMID:25596134
Biological Process cellular response to insulin stimulus ISO RGD:1553620 1624291 (MGI:MGI:5913528, PMID:28178239) RGD MGI:MGI:5913528 , PMID:28178239 cellular response to interferon-gamma ISO RGD:1553620 1624291 (MGI:MGI:5466658, PMID:23071094) RGD MGI:MGI:5466658 , PMID:23071094 cellular response to interferon-gamma ISO RGD:1322145 1624291 (PMID:15479637) RGD PMID:15479637 glutamyl-tRNA aminoacylation IEA InterPro:IPR004526 1600115 GO_REF:0000002 InterPro GO_REF:0000002 negative regulation of translation ISO RGD:1322145 1624291 (PMID:15479637), (PMID:23071094) RGD PMID:15479637 , PMID:23071094 negative regulation of translation ISO RGD:1553620 1624291 (MGI:MGI:5466658, PMID:23071094) RGD MGI:MGI:5466658 , PMID:23071094 prolyl-tRNA aminoacylation ISO RGD:1322145 1624291 (PMID:24100331) RGD PMID:24100331 prolyl-tRNA aminoacylation IBA MGI:MGI:97838 more ... 13792537 PMID:21873635 GO_Central prolyl-tRNA aminoacylation ISO RGD:1553620 1624291 (MGI:MGI:3055639, PMID:12060739) RGD MGI:MGI:3055639 , PMID:12060739 regulation of long-chain fatty acid import into cell ISO RGD:1553620 1624291 (MGI:MGI:5913528, PMID:28178239) RGD MGI:MGI:5913528 , PMID:28178239 regulation of long-chain fatty acid import into cell ISO RGD:1322145 1624291 (PMID:28178239) RGD PMID:28178239 Cellular Component aminoacyl-tRNA synthetase multienzyme complex ISO RGD:1322145 1624291 (PMID:10791971), (PMID:19131329) RGD PMID:10791971 , PMID:19131329 aminoacyl-tRNA synthetase multienzyme complex IBA FB:FBgn0005674 more ... 13792537 PMID:21873635 GO_Central aminoacyl-tRNA synthetase multienzyme complex ISO RGD:1553620 1624291 (MGI:MGI:3055639 more ... RGD MGI:MGI:3055639 more ... cytoplasm ISO RGD:1322145 1624291 (PMID:10791971) RGD PMID:10791971 cytoplasm IBA PANTHER:PTN000155236 more ... 13792537 PMID:21873635 GO_Central cytosol ISO RGD:1322145 1624291 (PMID:19289464) RGD GO_REF:0000052, PMID:19289464 cytosol IEA UniProtKB:P07814 , ensembl:ENSP000003558901600115 GO_REF:0000107 Ensembl GO_REF:0000107 GAIT complex ISO RGD:1553620 1624291 (MGI:MGI:5466658, PMID:23071094) RGD MGI:MGI:5466658 , PMID:23071094 GAIT complex ISO RGD:1322145 1624291 (PMID:15479637), (PMID:23071094) RGD PMID:15479637 , PMID:23071094 GAIT complex NOT ISO RGD:1553620 1624291 (MGI:MGI:5466658, PMID:23071094) RGD MGI:MGI:5466658 , PMID:23071094 plasma membrane ISO RGD:1553620 1624291 (MGI:MGI:5913528, PMID:28178239) RGD MGI:MGI:5913528 , PMID:28178239 ribonucleoprotein complex ISO RGD:1322145 1624291 (PMID:15479637) RGD PMID:15479637 Molecular Function ATP binding IEA InterPro:IPR000738 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 ATP binding IEA InterPro:IPR000738 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 glutamate-tRNA ligase activity IEA InterPro:IPR004526 1600115 GO_REF:0000002 InterPro GO_REF:0000002 GTPase binding ISO RGD:1322145 1624291 UniProtKB:P32455 (PMID:24337748) RGD PMID:24337748 identical protein binding ISO RGD:1322145 1624291 UniProtKB:P07814 (PMID:23263184) RGD PMID:23263184 proline-tRNA ligase activity ISO RGD:1322145 1624291 (PMID:24100331) RGD PMID:24100331 proline-tRNA ligase activity IBA MGI:MGI:97838 more ... 13792537 PMID:21873635 GO_Central proline-tRNA ligase activity ISO RGD:1553620 1624291 (MGI:MGI:3055639, PMID:12060739) RGD MGI:MGI:3055639 , PMID:12060739 protein binding ISO RGD:1553620 1624291 UniProtKB:Q60714 (MGI:MGI:5913528 , PMID:28178239) RGD MGI:MGI:5913528 , PMID:28178239 protein binding ISO RGD:1322145 1624291 UniProtKB:A2RTX5 more ... RGD PMID:10913161 more ... protein homodimerization activity ISO RGD:1322145 1624291 UniProtKB:P07814 (PMID:24100331) RGD PMID:24100331 RNA stem-loop binding ISO RGD:1322145 1624291 (PMID:15479637) RGD PMID:15479637 zinc ion binding ISO RGD:1322145 1624291 (PMID:24100331) RGD PMID:24100331
Gene-Chemical Interaction Annotations
