Eprs (glutamyl-prolyl-tRNA synthetase) - Rat Genome Database

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Gene: Eprs (glutamyl-prolyl-tRNA synthetase) Rattus norvegicus
Analyze
Symbol: Eprs
Name: glutamyl-prolyl-tRNA synthetase
RGD ID: 1310952
Description: Predicted to have several functions, including RNA stem-loop binding activity; proline-tRNA ligase activity; and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; cellular response to interferon-gamma; and prolyl-tRNA aminoacylation. Predicted to localize to several cellular components, including GAIT complex; aminoacyl-tRNA synthetase multienzyme complex; and cytosol. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; INTERACTS WITH (S)-colchicine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: bifunctional aminoacyl-tRNA synthetase; bifunctional glutamate/proline--tRNA ligase; LOC108351325; LOC289352; proline--tRNA ligase-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21396,901,548 - 96,971,966 (+)NCBI
Rnor_6.0 Ensembl13103,300,932 - 103,371,577 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.013103,300,911 - 103,371,651 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013107,973,665 - 108,044,298 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413101,375,656 - 101,448,175 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113101,564,698 - 101,637,217 (+)NCBI
Celera1396,415,061 - 96,484,921 (+)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
(S)-colchicine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B2  (ISO)
aldehydo-D-glucosamine  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
dioxygen  (ISO)
diuron  (EXP)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP)
fenofibrate  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
ibuprofen  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
levonorgestrel  (ISO)
menadione  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
p-toluidine  (EXP)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
rac-lactic acid  (ISO)
silicon dioxide  (ISO)
Soman  (EXP)
sunitinib  (ISO)
testosterone enanthate  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10791971   PMID:12060739   PMID:12477932   PMID:15479637   PMID:19131329   PMID:19289464   PMID:19946888   PMID:22082260   PMID:23071094   PMID:23263184   PMID:24100331   PMID:24337748  
PMID:28178239  


Genomics

Comparative Map Data
Eprs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21396,901,548 - 96,971,966 (+)NCBI
Rnor_6.0 Ensembl13103,300,932 - 103,371,577 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.013103,300,911 - 103,371,651 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013107,973,665 - 108,044,298 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413101,375,656 - 101,448,175 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113101,564,698 - 101,637,217 (+)NCBI
Celera1396,415,061 - 96,484,921 (+)NCBICelera
Cytogenetic Map13q26NCBI
EPRS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1219,968,600 - 220,046,530 (-)EnsemblGRCh38hg38GRCh38
GRCh381219,968,600 - 220,046,505 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371220,141,942 - 220,219,847 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361218,208,565 - 218,286,623 (-)NCBINCBI36hg18NCBI36
Build 341216,530,337 - 216,596,723NCBI
Celera1193,361,173 - 193,439,298 (-)NCBI
Cytogenetic Map1q41NCBI
HuRef1190,816,669 - 190,894,723 (-)NCBIHuRef
CHM1_11221,414,886 - 221,492,894 (-)NCBICHM1_1
Eprs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391185,093,614 - 185,160,557 (+)NCBIGRCm39mm39
GRCm39 Ensembl1185,095,241 - 185,160,557 (+)Ensembl
GRCm381185,361,417 - 185,428,360 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1185,363,044 - 185,428,360 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,186,974 - 187,252,234 (+)NCBIGRCm37mm9NCBIm37
MGSCv361187,063,883 - 187,129,143 (+)NCBImm8
MGSCv361186,479,177 - 186,544,604 (+)NCBImm8
Celera1192,317,193 - 192,381,950 (+)NCBICelera
Cytogenetic Map1H5NCBI
Eprs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555203,550,558 - 3,606,697 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555203,550,558 - 3,606,015 (+)NCBIChiLan1.0ChiLan1.0
EPRS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11200,575,257 - 200,655,958 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1200,575,259 - 200,656,197 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01195,537,319 - 195,618,257 (-)NCBIMhudiblu_PPA_v0panPan3
EPRS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13814,754,628 - 14,823,626 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3814,754,632 - 14,823,621 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3814,797,419 - 14,866,312 (-)NCBI
ROS_Cfam_1.03814,791,854 - 14,860,285 (-)NCBI
UMICH_Zoey_3.13814,800,874 - 14,869,666 (-)NCBI
UNSW_CanFamBas_1.03815,145,457 - 15,214,419 (-)NCBI
UU_Cfam_GSD_1.03815,435,096 - 15,504,056 (-)NCBI
Eprs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934456,897,415 - 56,971,602 (+)NCBI
SpeTri2.0NW_0049366502,145,614 - 2,219,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPRS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl109,579,301 - 9,648,414 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1109,579,301 - 9,648,416 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21011,663,038 - 11,730,358 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPRS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1259,534,747 - 9,618,119 (+)NCBI
ChlSab1.1 Ensembl259,534,114 - 9,618,141 (+)Ensembl
Eprs1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248353,635,829 - 3,695,875 (-)NCBI

Position Markers
RH142520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21396,953,292 - 96,953,555 (+)MAPPER
Rnor_6.013103,352,979 - 103,353,241NCBIRnor6.0
Rnor_5.013108,025,626 - 108,025,888UniSTSRnor5.0
RGSC_v3.413101,429,697 - 101,429,959UniSTSRGSC3.4
Celera1396,466,443 - 96,466,705UniSTS
RH 3.4 Map13656.8UniSTS
Cytogenetic Map13q26UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1362975663107975663Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1366971778111971778Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1371230858114033958Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1371230858114033958Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1372583716114033958Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)777694986114033958Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1379567081103613733Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1380403559108770687Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1386833393114033958Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:61
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000038264
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000038264   ⟹   ENSRNOP00000033323
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13103,301,074 - 103,371,457 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085214   ⟹   ENSRNOP00000071057
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13103,300,932 - 103,371,577 (+)Ensembl
RefSeq Acc Id: NM_001024238   ⟹   NP_001019409
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21396,901,703 - 96,971,772 (+)NCBI
Rnor_6.013103,301,074 - 103,371,457 (+)NCBI
Rnor_5.013107,973,665 - 108,044,298 (+)NCBI
RGSC_v3.413101,375,656 - 101,448,175 (+)RGD
Celera1396,415,061 - 96,484,921 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250425   ⟹   XP_006250487
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21396,901,548 - 96,971,966 (+)NCBI
Rnor_6.013103,300,911 - 103,371,651 (+)NCBI
Rnor_5.013107,973,665 - 108,044,298 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250426   ⟹   XP_006250488
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21396,901,548 - 96,971,966 (+)NCBI
Rnor_6.013103,300,912 - 103,371,651 (+)NCBI
Rnor_5.013107,973,665 - 108,044,298 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250427   ⟹   XP_006250489
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013103,313,177 - 103,371,651 (+)NCBI
Rnor_5.013107,973,665 - 108,044,298 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090582   ⟹   XP_038946510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21396,901,552 - 96,971,966 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001019409   ⟸   NM_001024238
- UniProtKB: Q6TXE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250487   ⟸   XM_006250425
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006250488   ⟸   XM_006250426
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JZI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250489   ⟸   XM_006250427
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000071057   ⟸   ENSRNOT00000085214
RefSeq Acc Id: ENSRNOP00000033323   ⟸   ENSRNOT00000038264
RefSeq Acc Id: XP_038946510   ⟸   XM_039090582
- Peptide Label: isoform X3
Protein Domains
AA_TRNA_LIGASE_II   WHEP-TRS

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699099
Promoter ID:EPDNEW_R9617
Type:initiation region
Name:Eprs_1
Description:glutamyl-prolyl-tRNA synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013103,300,951 - 103,301,011EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
13 108028751 108028752 A G snv ACI/EurMcwi (MCW), FHH/EurMcwi (MCW), SR/JrHsd (MCW)
13 108031045 108031046 G A snv DOB/Oda (KyushuU)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
13 103356104 103356105 A G snv LEW/NCrlBR (RGD)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
13 101432822 101432823 A G snv ACI/EurMcwi (MCW), SR/JrHsd (MCW), FHH/EurMcwi (MCW)
13 101435103 101435104 G A snv FHL/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310952 AgrOrtholog
Ensembl Genes ENSRNOG00000002393 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000033323 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000071057 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038264 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000085214 UniProtKB/TrEMBL
Gene3D-CATH 2.40.240.10 UniProtKB/TrEMBL
  3.30.110.30 UniProtKB/TrEMBL
  3.40.50.620 UniProtKB/TrEMBL
  3.40.50.800 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7364865 IMAGE-MGC_LOAD
InterPro aa-tRNA-synt_IIb_cons-dom UniProtKB/TrEMBL
  aa-tRNA-synth_I_CS UniProtKB/TrEMBL
  Aminoacyl-tRNA-synth_II UniProtKB/TrEMBL
  Anticodon-bd UniProtKB/TrEMBL
  Anticodon-bd_dom_sf UniProtKB/TrEMBL
  Glu-tRNA-synth_arc/euk UniProtKB/TrEMBL
  Glu/Gln-tRNA-synth_Ib_cat-dom UniProtKB/TrEMBL
  Glu/Gln-tRNA-synth_Ib_codon-bd UniProtKB/TrEMBL
  Glu/Gln-tRNA-synth_Ic UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  Pro-tRNA-ligase_IIa UniProtKB/TrEMBL
  Pro-tRNA-synth_IIa_arc-type UniProtKB/TrEMBL
  Pro-tRNA_synth_II UniProtKB/TrEMBL
  Pro-tRNA_synth_II_C UniProtKB/TrEMBL
  ProRS_core_arch_euk UniProtKB/TrEMBL
  Rbsml_L25/Gln-tRNA_synth_b-brl UniProtKB/TrEMBL
  Ribosomal_L25/Gln-tRNA_synth UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/TrEMBL
  S15_NS1_RNA-bd UniProtKB/TrEMBL
  WHEP-TRS UniProtKB/TrEMBL
KEGG Report rno:289352 UniProtKB/TrEMBL
MGC_CLONE MGC:109566 IMAGE-MGC_LOAD
NCBI Gene 289352 ENTREZGENE
PANTHER PTHR43382 UniProtKB/TrEMBL
Pfam HGTP_anticodon UniProtKB/TrEMBL
  ProRS-C_1 UniProtKB/TrEMBL
  tRNA-synt_1c UniProtKB/TrEMBL
  tRNA-synt_1c_C UniProtKB/TrEMBL
  tRNA-synt_2b UniProtKB/TrEMBL
  WHEP-TRS UniProtKB/TrEMBL
PhenoGen Eprs PhenoGen
PRINTS TRNASYNTHGLU UniProtKB/TrEMBL
  TRNASYNTHPRO UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_I UniProtKB/TrEMBL
  AA_TRNA_LIGASE_II UniProtKB/TrEMBL
  WHEP_TRS_1 UniProtKB/TrEMBL
  WHEP_TRS_2 UniProtKB/TrEMBL
SMART ProRS-C_1 UniProtKB/TrEMBL
  WHEP-TRS UniProtKB/TrEMBL
Superfamily-SCOP GST_C_like UniProtKB/TrEMBL
  Pro-tRNA_synth_II_C UniProtKB/TrEMBL
  Ribosomal_L25rel UniProtKB/TrEMBL
  S15/NS1_bind UniProtKB/TrEMBL
TIGRFAMs gltX_arch UniProtKB/TrEMBL
  ProS_fam_I UniProtKB/TrEMBL
UniProt A0A0G2JZI2 ENTREZGENE, UniProtKB/TrEMBL
  Q5I0H2_RAT UniProtKB/TrEMBL
  Q6TXE9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Eprs  glutamyl-prolyl-tRNA synthetase  LOC108351325  proline--tRNA ligase-like  Data Merged 737654 PROVISIONAL
2016-08-02 LOC108351325  proline--tRNA ligase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Eprs  glutamyl-prolyl-tRNA synthetase  Eprs_predicted  glutamyl-prolyl-tRNA synthetase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Eprs_predicted  glutamyl-prolyl-tRNA synthetase (predicted)      Symbol and Name status set to approved 70820 APPROVED