St8sia1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1) - Rat Genome Database

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Gene: St8sia1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1) Rattus norvegicus
Analyze
Symbol: St8sia1
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
RGD ID: 3679
Description: Enables sialyltransferase activity. Involved in protein glycosylation. Predicted to be located in Golgi apparatus and membrane. Orthologous to human ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1); PARTICIPATES IN ganglioside metabolic pathway; globoside metabolic pathway; lacto-series glycosphingolipid metabolic pathway; INTERACTS WITH acetamide; ammonium chloride; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-2, 8-sialytransferase; alpha-2,8-sialyltransferase; alpha-N-acetylneuraminate: alpha-2,8-sialytransferase; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; GD3 synthase; sialyltransferase 8 (alpha-2 8-sialytransferase) A; Sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-28-sialytransferase GD3 synthase); sialyltransferase 8 A; Sialyltransferase 8 A (alpha-N-acetylneuraminate: alpha-28-sialytransferase GD3 synthase) GenBank no: U53883; Sialyltransferase 8a; Siat8; Siat8a; ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24175,782,989 - 175,921,338 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,789,947 - 175,920,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4182,084,919 - 182,215,399 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04177,869,195 - 177,999,668 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04176,489,766 - 176,620,240 (-)NCBIRnor_WKY
Rnor_6.04177,065,266 - 177,195,942 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4177,065,168 - 177,196,180 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04241,274,072 - 241,403,150 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44180,722,382 - 180,852,639 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14180,967,505 - 181,097,763 (-)NCBI
Celera4164,320,658 - 164,451,184 (-)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons. Copani A, etal., J Neurosci 2002 May 15;22(10):3963-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
9. The molecular cloning and expression of alpha 2,8-sialyltransferase (GD3 synthase) in a rat brain. Watanabe Y, etal., J Biochem (Tokyo) 1996 Nov;120(5):1020-7.
10. Molecular cloning of cDNA for rat brain GD3-synthase. Zeng G, etal., Biochem Biophys Res Commun 1996 Sep 13;226(2):319-23.
Additional References at PubMed
PMID:15645117   PMID:15748692   PMID:18755693  


Genomics

Comparative Map Data
St8sia1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24175,782,989 - 175,921,338 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,789,947 - 175,920,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4182,084,919 - 182,215,399 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04177,869,195 - 177,999,668 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04176,489,766 - 176,620,240 (-)NCBIRnor_WKY
Rnor_6.04177,065,266 - 177,195,942 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4177,065,168 - 177,196,180 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04241,274,072 - 241,403,150 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44180,722,382 - 180,852,639 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14180,967,505 - 181,097,763 (-)NCBI
Celera4164,320,658 - 164,451,184 (-)NCBICelera
Cytogenetic Map4q44NCBI
ST8SIA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381222,193,391 - 22,334,707 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1222,063,773 - 22,437,041 (-)EnsemblGRCh38hg38GRCh38
GRCh371222,346,325 - 22,487,641 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361222,245,200 - 22,378,915 (-)NCBINCBI36Build 36hg18NCBI36
Celera1227,500,769 - 27,642,080 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1222,119,372 - 22,260,647 (-)NCBIHuRef
CHM1_11222,311,335 - 22,452,993 (-)NCBICHM1_1
T2T-CHM13v2.01222,071,418 - 22,212,735 (-)NCBIT2T-CHM13v2.0
St8sia1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,767,267 - 142,935,247 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6142,767,271 - 142,910,178 (-)EnsemblGRCm39 Ensembl
GRCm386142,821,541 - 142,989,528 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,821,545 - 142,964,452 (-)EnsemblGRCm38mm10GRCm38
MGSCv376142,770,061 - 142,912,972 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366142,778,763 - 142,921,674 (-)NCBIMGSCv36mm8
Celera6145,883,284 - 146,020,842 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map674.78NCBI
St8sia1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541317,672,460 - 17,805,623 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541317,667,434 - 17,810,671 (-)NCBIChiLan1.0ChiLan1.0
ST8SIA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11266,578,598 - 66,712,240 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1266,578,949 - 66,712,240 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01263,972,127 - 64,112,083 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ST8SIA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12724,879,103 - 25,027,014 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2724,879,380 - 25,023,618 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2721,333,527 - 21,483,378 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02725,096,491 - 25,246,504 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2725,096,525 - 25,238,358 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12724,894,560 - 25,045,533 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02724,918,605 - 25,068,657 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02721,502,984 - 21,653,212 (-)NCBIUU_Cfam_GSD_1.0
St8sia1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494586,748,403 - 86,880,894 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365484,671,284 - 4,796,426 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365484,671,257 - 4,797,917 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ST8SIA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl551,211,336 - 51,358,144 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1551,211,312 - 51,364,226 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ST8SIA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11122,035,111 - 22,172,244 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1122,035,661 - 22,170,548 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606912,973,699 - 13,108,791 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
St8sia1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475216,483,378 - 16,633,776 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475216,483,168 - 16,633,938 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in St8sia1
695 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:29
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000018999
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
D4Wox46  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,921,306 - 175,921,441 (+)MAPPERmRatBN7.2
Rnor_6.04177,196,672 - 177,196,806NCBIRnor6.0
Rnor_5.04241,403,880 - 241,404,014UniSTSRnor5.0
RGSC_v3.44180,853,618 - 180,853,752UniSTSRGSC3.4
Celera4164,451,883 - 164,452,017UniSTS
Cytogenetic Map4q44UniSTS
GDB:455130  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,386,550 - 33,386,634 (+)MAPPERmRatBN7.2
mRatBN7.24175,792,841 - 175,793,184 (+)MAPPERmRatBN7.2
Rnor_6.04177,068,161 - 177,068,503NCBIRnor6.0
Rnor_6.01238,833,759 - 38,833,842NCBIRnor6.0
Rnor_5.01240,734,471 - 40,734,554UniSTSRnor5.0
Rnor_5.04241,276,967 - 241,277,309UniSTSRnor5.0
RGSC_v3.44180,725,277 - 180,725,619UniSTSRGSC3.4
RGSC_v3.41234,552,174 - 34,552,257UniSTSRGSC3.4
Celera1235,067,439 - 35,067,522UniSTS
Celera4164,323,553 - 164,323,938UniSTS
Cytogenetic Map12q16UniSTS
Cytogenetic Map4q44UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 15 69 4
Low 3 27 42 34 4 34 5 35 36 11
Below cutoff 16 6 6 6 8 10 1 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018999   ⟹   ENSRNOP00000018999
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4175,789,947 - 175,920,577 (-)Ensembl
Rnor_6.0 Ensembl4177,065,168 - 177,196,180 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100059   ⟹   ENSRNOP00000081373
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4175,878,573 - 175,920,708 (-)Ensembl
RefSeq Acc Id: NM_012813   ⟹   NP_036945
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24175,789,947 - 175,920,577 (-)NCBI
Rnor_6.04177,065,266 - 177,195,942 (-)NCBI
Rnor_5.04241,274,072 - 241,403,150 (-)NCBI
RGSC_v3.44180,722,382 - 180,852,639 (-)RGD
Celera4164,320,658 - 164,451,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107103   ⟹   XP_038963031
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24175,782,989 - 175,921,338 (-)NCBI
RefSeq Acc Id: XM_039107104   ⟹   XP_038963032
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24175,782,989 - 175,867,514 (-)NCBI
Protein Sequences
Protein RefSeqs NP_036945 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963031 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963032 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC27541 (Get FASTA)   NCBI Sequence Viewer  
  BAA08213 (Get FASTA)   NCBI Sequence Viewer  
  EDM01472 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036945   ⟸   NM_012813
- UniProtKB: G3V7T2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018999   ⟸   ENSRNOT00000018999
RefSeq Acc Id: XP_038963031   ⟸   XM_039107103
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038963032   ⟸   XM_039107104
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000081373   ⟸   ENSRNOT00000100059

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7T2-F1-model_v2 AlphaFold G3V7T2 1-356 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3679 AgrOrtholog
BioCyc Gene G2FUF-42486 BioCyc
Ensembl Genes ENSRNOG00000014018 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018999 ENTREZGENE
  ENSRNOP00000018999.4 UniProtKB/TrEMBL
  ENSRNOP00000081373.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018999 ENTREZGENE
  ENSRNOT00000018999.6 UniProtKB/TrEMBL
  ENSRNOT00000100059.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.1480.20 UniProtKB/TrEMBL
InterPro Glyco_trans_29 UniProtKB/TrEMBL
  GT29-like_sf UniProtKB/TrEMBL
  Sialyl_trans UniProtKB/TrEMBL
KEGG Report rno:25280 UniProtKB/TrEMBL
NCBI Gene 25280 ENTREZGENE
Pfam Glyco_transf_29 UniProtKB/TrEMBL
PhenoGen St8sia1 PhenoGen
PIRSF Sialyl_trans UniProtKB/TrEMBL
TIGR TC202136
UniProt A0A8I5ZSU8_RAT UniProtKB/TrEMBL
  G3V7T2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-05 St8sia1  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1  St8sia1  ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-16 St8sia1  ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1  St8sia1  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 St8sia1  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1      Symbol and Name updated 1299863 APPROVED
2001-06-20 Siat8  Sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialytransferase, GD3 synthase)      Symbol withdrawn, duplicate of Siat8a (RGD:3679) 67952 WITHDRAWN
2001-06-20 Siat8a  Sialyltransferase 8a      Name updated 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may be involved in Alzheimers Disease and Creutzfeldt-Jakob disease since elevated GD3 levels have been seen in the brains from these patients 625459
gene_expression expressed in cerebral cortex, hippocampus, thalamus, cerebellum and spleen 633966
gene_process activity is necessary for beta-amyloid peptide induced GD3 upregulation which leads to induction of neuronal apoptosis 625459