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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:8825
Term: Rhein
Definition: A dihydroxyanthraquinone that has formula C15H8O6.
Chemical ID: MESH:C020491
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1adecreases expressionISOHIF1A (Homo sapiens)6480464CTDrhein results in decreased expression of HIF1A proteinPMID:21457705
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTDrhein inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]PMID:21457705
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