Pygm (glycogen phosphorylase, muscle associated) - Rat Genome Database

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Gene: Pygm (glycogen phosphorylase, muscle associated) Rattus norvegicus
Analyze
Symbol: Pygm
Name: glycogen phosphorylase, muscle associated
RGD ID: 3461
Description: Enables anion binding activity; carbohydrate binding activity; and glycogen phosphorylase activity. Involved in several processes, including cellular calcium ion homeostasis; glycogen catabolic process; and response to cAMP. Located in sarcoplasmic reticulum. Used to study cholestasis. Human ortholog(s) of this gene implicated in glycogen storage disease V. Orthologous to human PYGM (glycogen phosphorylase, muscle associated); PARTICIPATES IN glycogen degradation pathway; insulin signaling pathway; starch and sucrose metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,5-hexanedione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glycogen phosphorylase, muscle form; muscle (McArdle syndrome); muscle glycogen phosphorylase; Muscpho; myophosphorylase; Phosphorylase glycogen; Phosphorylase, glycogen; phosphorylase, glycogen, muscle
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21203,690,550 - 203,705,369 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1203,690,533 - 203,705,368 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,039,387 - 212,054,202 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01219,135,880 - 219,150,695 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01211,826,933 - 211,841,748 (+)NCBIRnor_WKY
Rnor_6.01221,756,325 - 221,771,142 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,756,286 - 221,771,143 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01228,737,461 - 228,758,937 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,166,701 - 209,181,588 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11209,325,179 - 209,340,017 (+)NCBI
Celera1201,223,967 - 201,238,784 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,5-hexanedione  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
astemizole  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
genistein  (EXP)
gentamycin  (EXP)
haloperidol  (ISO)
ketamine  (EXP)
lead diacetate  (EXP)
Licochalcone B  (ISO)
mercury dibromide  (ISO)
mitoxantrone  (ISO)
ochratoxin A  (EXP)
paraquat  (EXP)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
prednisone  (ISO)
progesterone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
sodium nitrate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors. Birch AM, etal., Bioorg Med Chem Lett. 2007 Jan 15;17(2):394-9. Epub 2006 Oct 19.
2. Brain-specific regulator of G-protein signaling 9-2 selectively interacts with alpha-actinin-2 to regulate calcium-dependent inactivation of NMDA receptors. Bouhamdan M, etal., J Neurosci. 2006 Mar 1;26(9):2522-30.
3. Structural relationships among regulated and unregulated phosphorylases. Buchbinder JL, etal., Annu Rev Biophys Biomol Struct. 2001;30:191-209.
4. Epinephrine regulation of skeletal muscle glycogen metabolism. Studies utilizing the perfused rat hindlimb preparation. Dietz MR, etal., J Biol Chem. 1980 Mar 25;255(6):2301-7.
5. Effects of electrostimulation on glycogenolysis in cultured rat myotubes. Elsner P, etal., Pflugers Arch. 2003 Dec;447(3):356-62. Epub 2003 Oct 25.
6. Alteration of glycogen and glucose metabolism in ischaemic and post-ischaemic working rat hearts by adenosine A1 receptor stimulation. Fraser H, etal., Br J Pharmacol. 1999 Sep;128(1):197-205.
7. Regulation of the rat muscle glycogen phosphorylase-encoding gene during muscle cell development. Froman BE, etal., Gene 1994 Nov 18;149(2):245-52.
8. The content of glycogen phosphorylase and glycogen in preparations of sarcoplasmic reticulum-glycogenolytic complex is enhanced in diabetic rat skeletal muscle. Garduno E, etal., Diabetologia. 2001 Oct;44(10):1238-46.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Botulinum-induced muscle paralysis alters metabolic gene expression and fatigue recovery. Gorin F, etal., Am J Physiol. 1996 Jan;270(1 Pt 2):R238-45.
12. Comparative analysis of species-independent, isozyme-specific amino-acid substitutions in mammalian muscle, brain and liver glycogen phosphorylases. Hudson JW, etal., Biochim Biophys Acta 1993 Jul 10;1164(2):197-208.
13. Adrenaline-mediated glycogen phosphorylase activation is enhanced in rat soleus muscle with increased glycogen content. Jensen J, etal., Biochim Biophys Acta. 1999 Oct 18;1472(1-2):215-21.
14. Glycogen phosphorylase: control by phosphorylation and allosteric effectors. Johnson LN FASEB J. 1992 Mar;6(6):2274-82.
15. Differential expression of the regulator of G protein signaling RGS9 protein in nociceptive pathways of different age rats. Kim KJ, etal., Brain Res Dev Brain Res. 2005 Nov 7;160(1):28-39. Epub 2005 Sep 8.
16. Molecular diagnosis of McArdle disease: revised genomic structure of the myophosphorylase gene and identification of a novel mutation. Kubisch C, etal., Hum Mutat. 1998;12(1):27-32.
17. Hepatic and skeletal muscle glycogen metabolism in rats with short-term cholestasis. Lang C, etal., J Hepatol. 2002 Jan;36(1):22-9.
18. Skeletal muscle sarcoplasmic reticulum glycogen status influences Ca2+ uptake supported by endogenously synthesized ATP. Lees SJ and Williams JH, Am J Physiol Cell Physiol. 2004 Jan;286(1):C97-104. Epub 2003 Sep 10.
19. Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. Li P, etal., Cell Mol Life Sci. 2003 Oct;60(10):2200-9.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Ca2+ uptake coupled to glycogen phosphorolysis in the glycogenolytic-sarcoplasmic reticulum complex from rat skeletal muscle. Nogues M, etal., Z Naturforsch C. 1996 Jul-Aug;51(7-8):591-8.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Isolation of partial cDNAs for rat liver and muscle glycogen phosphorylase isozymes. Osawa S, etal., FEBS Lett 1986 Jul 7;202(2):282-8.
25. Isozyme pattern of glycogen phosphorylase in the rat nervous system and rat astroglia-rich primary cultures: electrophoretic and polymerase chain reaction studies. Pfeiffer-Guglielmi B, etal., Neurochem Res. 2000 Nov;25(11):1485-91.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Glycogen-binding protein components of rat tissues. Satoh K and Sato K, Biochem Biophys Res Commun. 1980 Sep 16;96(1):28-33.
31. Electron microscopical study of a cytosolic enzyme in unfixed cryostat sections: demonstration of glycogen phosphorylase activity in rat liver and heart tissue. Schellens JP, etal., Histochem J. 1995 Aug;27(8):609-14.
32. Estrogen modulates RGS9 expression in the nucleus accumbens. Sharifi JL, etal., Neuroreport. 2004 Oct 25;15(15):2433-6.
33. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
34. Glycogen metabolism in rat heart muscle cultures after hypoxia. Vigoda A, etal., Mol Cell Biochem. 2003 Dec;254(1-2):311-8.
Additional References at PubMed
PMID:3209063   PMID:3840433   PMID:11596118   PMID:11785984   PMID:12477932   PMID:15282316   PMID:17689562   PMID:21700703   PMID:22206666   PMID:23533145   PMID:23904609   PMID:26945066  
PMID:27156240   PMID:30053369   PMID:32357304   PMID:33450132  


Genomics

Comparative Map Data
Pygm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21203,690,550 - 203,705,369 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1203,690,533 - 203,705,368 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,039,387 - 212,054,202 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01219,135,880 - 219,150,695 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01211,826,933 - 211,841,748 (+)NCBIRnor_WKY
Rnor_6.01221,756,325 - 221,771,142 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,756,286 - 221,771,143 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01228,737,461 - 228,758,937 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,166,701 - 209,181,588 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11209,325,179 - 209,340,017 (+)NCBI
Celera1201,223,967 - 201,238,784 (+)NCBICelera
Cytogenetic Map1q43NCBI
PYGM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,746,389 - 64,760,715 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1164,746,389 - 64,759,974 (-)EnsemblGRCh38hg38GRCh38
GRCh371164,513,861 - 64,528,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,270,606 - 64,284,763 (-)NCBINCBI36Build 36hg18NCBI36
Build 341164,270,605 - 64,284,763NCBI
Celera1161,840,305 - 61,854,685 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,840,630 - 60,855,032 (-)NCBIHuRef
CHM1_11164,397,556 - 64,411,957 (-)NCBICHM1_1
T2T-CHM13v2.01164,739,618 - 64,754,020 (-)NCBIT2T-CHM13v2.0
Pygm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,434,438 - 6,448,494 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,434,429 - 6,448,489 (+)EnsemblGRCm39 Ensembl
GRCm38196,384,408 - 6,398,464 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,384,399 - 6,398,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv37196,384,429 - 6,398,459 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36196,384,429 - 6,398,459 (+)NCBIMGSCv36mm8
Celera196,257,446 - 6,271,476 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.53NCBI
Pygm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,411,480 - 20,424,931 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,411,480 - 20,424,676 (+)NCBIChiLan1.0ChiLan1.0
PYGM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11163,443,609 - 63,457,012 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,443,609 - 63,457,430 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01160,101,810 - 60,115,813 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PYGM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,398,192 - 52,410,731 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,398,056 - 52,410,464 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,005,808 - 51,018,059 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01853,439,715 - 53,451,957 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,439,257 - 53,451,957 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,534,631 - 52,546,873 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,120,553 - 52,132,799 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01852,904,684 - 52,916,934 (+)NCBIUU_Cfam_GSD_1.0
Pygm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,108,815 - 8,121,764 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,551,032 - 4,564,154 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365994,551,164 - 4,564,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PYGM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,409,116 - 7,421,254 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,409,330 - 7,421,256 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,540,079 - 6,553,856 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PYGM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,474,539 - 9,490,612 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,475,622 - 9,491,500 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038106,864,368 - 106,879,692 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pygm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476721,626,740 - 21,640,161 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476721,626,740 - 21,639,963 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pygm
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:116
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000028636
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat

Markers in Region
D1Mgh11  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11537.2RGD
RH 3.4 Map11537.2UniSTS
FHH x ACI Map198.97UniSTS
FHH x ACI Map198.97RGD
Cytogenetic Map1q43UniSTS
D1Wox28  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11523.1UniSTS
RH 3.4 Map11523.1RGD
RH 2.0 Map11152.8RGD
Cytogenetic Map1q43UniSTS
RH128350  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,705,131 - 203,705,337 (+)MAPPERmRatBN7.2
Rnor_6.01221,770,905 - 221,771,110NCBIRnor6.0
Rnor_5.01228,758,694 - 228,758,899UniSTSRnor5.0
RGSC_v3.41209,181,351 - 209,181,556UniSTSRGSC3.4
Celera1201,238,547 - 201,238,752UniSTS
RH 3.4 Map11536.3UniSTS
Cytogenetic Map1q43UniSTS
RH140670  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,696,040 - 203,697,095 (+)MAPPERmRatBN7.2
Rnor_6.01221,761,816 - 221,762,870NCBIRnor6.0
Rnor_5.01228,749,605 - 228,750,659UniSTSRnor5.0
RGSC_v3.41209,172,192 - 209,173,246UniSTSRGSC3.4
Celera1201,229,458 - 201,230,512UniSTS
RH 3.4 Map11537.7UniSTS
Cytogenetic Map1q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 8 11 8
Medium 2 43 3 27 20 31 11
Low 1 57 41 16 41 47 15 10
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB766603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB803241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK357376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK358095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR754132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR754647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L10669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L18752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X03032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000028636   ⟹   ENSRNOP00000028636
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1203,690,533 - 203,705,360 (+)Ensembl
Rnor_6.0 Ensembl1221,756,286 - 221,771,143 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094854   ⟹   ENSRNOP00000089298
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1203,690,597 - 203,705,368 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097542   ⟹   ENSRNOP00000085985
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1203,690,533 - 203,705,360 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099163   ⟹   ENSRNOP00000081606
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1203,690,533 - 203,704,922 (+)Ensembl
RefSeq Acc Id: NM_012638   ⟹   NP_036770
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21203,690,550 - 203,705,369 (+)NCBI
Rnor_6.01221,756,325 - 221,771,142 (+)NCBI
Rnor_5.01228,737,461 - 228,758,937 (+)NCBI
RGSC_v3.41209,166,701 - 209,181,588 (+)RGD
Celera1201,223,967 - 201,238,784 (+)RGD
Sequence:
RefSeq Acc Id: XM_039100805   ⟹   XP_038956733
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21203,691,339 - 203,705,369 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036770   ⟸   NM_012638
- UniProtKB: G3V8V3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028636   ⟸   ENSRNOT00000028636
RefSeq Acc Id: XP_038956733   ⟸   XM_039100805
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000081606   ⟸   ENSRNOT00000099163
RefSeq Acc Id: ENSRNOP00000085985   ⟸   ENSRNOT00000097542
RefSeq Acc Id: ENSRNOP00000089298   ⟸   ENSRNOT00000094854

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09812-F1-model_v2 AlphaFold P09812 1-842 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690701
Promoter ID:EPDNEW_R1224
Type:single initiation site
Name:Pygm_1
Description:glycogen phosphorylase, muscle associated
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01221,756,235 - 221,756,295EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3461 AgrOrtholog
BioCyc Gene G2FUF-56595 BioCyc
BioCyc Pathway PWY-5941 [glycogen degradation II] BioCyc
Ensembl Genes ENSRNOG00000021090 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028636 ENTREZGENE
  ENSRNOP00000028636.4 UniProtKB/TrEMBL
  ENSRNOP00000081606.1 UniProtKB/TrEMBL
  ENSRNOP00000085985.1 UniProtKB/TrEMBL
  ENSRNOP00000089298.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028636 ENTREZGENE
  ENSRNOT00000028636.6 UniProtKB/TrEMBL
  ENSRNOT00000094854.1 UniProtKB/TrEMBL
  ENSRNOT00000097542.1 UniProtKB/TrEMBL
  ENSRNOT00000099163.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8366912 IMAGE-MGC_LOAD
InterPro Glycg_phsphrylas UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_trans_35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyridoxal_P_attach_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24701 UniProtKB/TrEMBL
MGC_CLONE MGC:187616 IMAGE-MGC_LOAD
NCBI Gene 24701 ENTREZGENE
PANTHER PTHR11468 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Phosphorylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pygm PhenoGen
PIRSF Pprylas_GlgP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PHOSPHORYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204701
TIGRFAMs P_ylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A2T3_RAT UniProtKB/TrEMBL
  A0A8I6A9J1_RAT UniProtKB/TrEMBL
  A0A8I6G867_RAT UniProtKB/TrEMBL
  B1WBU9_RAT UniProtKB/TrEMBL
  G3V8V3 ENTREZGENE, UniProtKB/TrEMBL
  P09812 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-18 Pygm  glycogen phosphorylase, muscle associated  Pygm  phosphorylase, glycogen, muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-30 Pygm  phosphorylase, glycogen, muscle  Pygm  muscle glycogen phosphorylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pygm  Phosphorylase, glycogen; muscle (McArdle syndrome)      Symbol and Name status set to approved 70586 APPROVED