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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:patchouli alcohol
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Accession:CHEBI:7940 term browser browse the term
Definition:A carbotricyclic compound and sesquiterpenoid tertiary alcohol that is tricyclo[5.3.1.0(3,8)]undecan-3-ol which is substituted at positions 2, 2, 6 and 8 by methyl groups (the 1R,3R,6S,7S,8S-diastereoisomer).
Synonyms:exact_synonym: (1R,4S,4aS,6R,8aS)-4,8a,9,9-tetramethyloctahydro-1,6-methanonaphthalen-1(2H)-ol
 related_synonym: (-)-(1R,3R,6S,7S,8S)-2,2,6,8-tetramethyltricyclo[5.3.1.0(3,8)]undecan-3-ol;   Formula=C15H26O;   InChI=1S/C15H26O/c1-10-5-8-15(16)13(2,3)11-6-7-14(15,4)12(10)9-11/h10-12,16H,5-9H2,1-4H3/t10-,11+,12-,14-,15+/m0/s1;   InChIKey=GGHMUJBZYLPWFD-CUZKYEQNSA-N;   SMILES=[H][C@@]12CC[C@@]3(C)[C@@]([H])(C1)[C@@H](C)CC[C@@]3(O)C2(C)C;   [1R-(1alpha,4beta,4aalpha,6beta,8aalpha)]-octahydro-4,8a,9,9-tetramethyl-1,6-methano-1(2H)-naphthol;   patchoulanol;   patchouli camphor;   patchoulic alcohol;   patchoulol
 xref: CAS:5986-55-0;   KEGG:C09705;   KNApSAcK:C00003168
 xref_mesh: MESH:C052983
 xref: MetaCyc:CPD-11399;   PMID:20148554;   PMID:3038029;   Reaxys:5730219


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patchouli alcohol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP patchouli alcohol inhibits the reaction [Ethanol results in decreased activity of CAT protein] CTD PMID:25168850 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Il10 interleukin 10 multiple interactions EXP patchouli alcohol inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:25168850 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
patchouli alcohol inhibits the reaction [Ethanol results in increased expression of IL6 protein]
patchouli alcohol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of IL6 protein]
CTD PMID:23348408, PMID:25168850 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein modified form]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of MAPK1 protein modified form] CTD PMID:23348408 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein modified form]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of MAPK3 protein modified form] CTD PMID:23348408 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
patchouli alcohol inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]
CTD PMID:23348408 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO patchouli alcohol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of NOS2 protein]
patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:23348408 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP patchouli alcohol inhibits the reaction [Indomethacin results in decreased expression of PTGS1 mRNA] CTD PMID:25168850 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP patchouli alcohol inhibits the reaction [Indomethacin results in decreased expression of PTGS2 mRNA] CTD PMID:25168850 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO patchouli alcohol inhibits the reaction [TNF protein affects the localization of RELA protein]
patchouli alcohol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
CTD PMID:23348408 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
patchouli alcohol inhibits the reaction [TNF protein affects the localization of RELA protein]; patchouli alcohol inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of IL6 protein]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of NOS2 protein]
patchouli alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein]
patchouli alcohol inhibits the reaction [TNF protein results in increased expression of MAPK1 protein modified form]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of MAPK3 protein modified form]
CTD PMID:23348408, PMID:25168850 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          carbon atom 19588
            organic molecular entity 19588
              isoprenoid 9609
                terpenoid 9593
                  sesquiterpenoid 2694
                    patchouli alcohol 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            organic hydride 18265
                              organic fundamental parent 18265
                                hydrocarbon 17986
                                  terpene 9609
                                    sesquiterpene 2694
                                      sesquiterpenoid 2694
                                        patchouli alcohol 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.