Cd24 (CD24 molecule) - Rat Genome Database

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Gene: Cd24 (CD24 molecule) Rattus norvegicus
Analyze
Symbol: Cd24
Name: CD24 molecule
RGD ID: 2298
Description: Predicted to enable several functions, including heat shock protein binding activity; protein kinase binding activity; and protein tyrosine kinase activator activity. Involved in immune response. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human CD24 (CD24 molecule); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD24 antigen; Cd24a; heat-stable antigen; HSA; MGC93641; nectadrin heat stable antigen; nectadrin, heat stable antigen; signal transducer CD24
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82048,655,549 - 48,661,786 (+)NCBIGRCr8
mRatBN7.22047,074,353 - 47,079,662 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2047,073,512 - 47,079,662 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2048,789,167 - 48,794,459 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02048,439,001 - 48,444,293 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02049,123,655 - 49,128,973 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02048,335,540 - 48,340,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2048,335,540 - 48,340,846 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02049,989,320 - 49,994,627 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42047,502,354 - 47,507,663 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12047,531,055 - 47,536,352 (+)NCBI
Celera2052,908,730 - 52,914,027 (-)NCBICelera
RH 3.4 Map20495.52RGD
RH 3.4 Map20493.45RGD
Cytogenetic Map20q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-Nitrobenzanthrone  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
bacitracin  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium atom  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
Didecyldimethylammonium  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
eugenol  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
griseofulvin  (ISO)
hexachlorobenzene  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
iron dichloride  (ISO)
isobutanol  (ISO)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lapatinib  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin-LR  (EXP)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
ochratoxin A  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP,ISO)
ozone  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (ISO)
PhIP  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP,ISO)
Trapidil  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
ubiquinone-0  (ISO)
valproic acid  (ISO)
vancomycin  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic mitochondrial changes  (ISO)
apoptotic nuclear changes  (ISO)
apoptotic signaling pathway  (ISO)
B cell apoptotic process  (ISO)
B cell proliferation  (ISO)
B cell receptor transport into membrane raft  (ISO,ISS)
calcium-mediated signaling  (ISO)
CD4-positive, alpha-beta T cell proliferation  (ISO)
cell activation  (IBA,ISO,ISS)
cell adhesion  (IEA)
cell migration  (ISO,ISS)
cell surface receptor signaling pathway  (ISO)
chemokine receptor transport out of membrane raft  (ISO,ISS)
cholesterol homeostasis  (ISO,ISS)
glomerular parietal epithelial cell differentiation  (ISO,ISS)
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  (ISO)
homotypic cell-cell adhesion  (ISO)
immune response  (IEP)
integrin activation  (ISO)
leukocyte cell-cell adhesion  (ISO)
leukocyte migration involved in inflammatory response  (ISO)
negative regulation of B cell proliferation  (ISO)
negative regulation of erythrocyte aggregation  (ISO)
negative regulation of erythrocyte clearance  (ISO)
negative regulation of inflammatory response to wounding  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of monocyte chemotactic protein-1 production  (ISO)
negative regulation of neuroblast proliferation  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of T cell homeostatic proliferation  (ISO)
negative regulation of transforming growth factor beta3 production  (ISO,ISS)
negative regulation of tumor necrosis factor production  (ISO)
neuroblast proliferation  (ISO)
neuromuscular synaptic transmission  (ISO)
neuron projection development  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
podocyte differentiation  (ISO,ISS)
positive regulation of activated T cell proliferation  (ISO,ISS)
positive regulation of alpha-beta T cell proliferation  (ISO)
positive regulation of B cell apoptotic process  (ISO)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of cell-cell adhesion mediated by integrin  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO,ISS)
positive regulation of inflammatory response to antigenic stimulus  (ISO)
positive regulation of inflammatory response to wounding  (ISO)
positive regulation of integrin activation  (ISO)
positive regulation of MAP kinase activity  (ISO,ISS)
positive regulation of nephron tubule epithelial cell differentiation  (ISO,ISS)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of T cell homeostatic proliferation  (ISO)
positive regulation of T cell mediated immune response to tumor cell  (ISO)
pre-B cell differentiation  (ISO)
regulation of B cell differentiation  (ISO)
regulation of cell-cell adhesion  (IBA,ISO)
regulation of cell-cell adhesion mediated by integrin  (ISO)
regulation of cytokine-mediated signaling pathway  (ISO,ISS)
regulation of MAPK cascade  (ISO,ISS)
regulation of phosphorylation  (ISO,ISS)
respiratory burst  (ISO,ISS)
response to estrogen  (ISO,ISS)
response to hypoxia  (ISO,ISS)
response to molecule of bacterial origin  (ISO,ISS)
synaptic vesicle endocytosis  (ISO)
T cell costimulation  (ISO,ISS)
T cell homeostatic proliferation  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Signal transduction in lymphocytic and myeloid cells via CD24, a new member of phosphoinositol-anchored membrane molecules. Fischer GF, etal., J Immunol. 1990 Jan 15;144(2):638-41.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Lipid rafts clustering and signalling by listeriolysin O. Gekara NO and Weiss S, Biochem Soc Trans. 2004 Nov;32(Pt 5):712-4.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Expression of HIS50 Ag: a rat homologue of mouse heat-stable antigen and human CD24 on B lymphoid cells in the rat. Hermans MH, etal., Immunology. 1997 Jan;90(1):14-22.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. CD24 and myosin light polypeptide 2 are involved in prevention of experimental autoimmune encephalomyelitis by myelin basic protein-pulsed dendritic cells. Liu X, etal., J Neuroimmunol. 2006 Mar;172(1-2):137-44. Epub 2005 Dec 27.
8. Activation of human monocytes and granulocytes by monoclonal antibodies to glycosylphosphatidylinositol-anchored antigens. Lund-Johansen F, etal., Eur J Immunol. 1993 Nov;23(11):2782-91.
9. CD24 (heat stable antigen, nectadrin), a novel keratinocyte differentiation marker, is preferentially expressed in areas of the hair follicle containing the colony-forming cells. Magnaldo T and Barrandon Y, J Cell Sci 1996 Dec;109 ( Pt 13):3035-45.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Antibodies recognizing CD24 LAP epitope on human T cells enhance CD28 and IL-2 T cell proliferation. Salamone MC, etal., J Leukoc Biol. 2001 Feb;69(2):215-23.
15. CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells. Schabath H, etal., J Cell Sci. 2006 Jan 15;119(Pt 2):314-25. Epub 2006 Jan 3.
16. Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study. Scheurer SB, etal., Proteomics. 2004 Jun;4(6):1737-60.
17. Gene expression of CD24 core peptide molecule in developing brain and developing non-neural tissues. Shirasawa T, etal., Dev Dyn 1993 Sep;198(1):1-13.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system. Suzuki T, etal., J Immunol. 2001 May 1;166(9):5567-77.
20. Pre-B cell antigen receptor-mediated signal inhibits CD24-induced apoptosis in human pre-B cells. Taguchi T, etal., J Immunol. 2003 Jan 1;170(1):252-60.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes. Yang GP, etal., Nucleic Acids Res. 1999 Mar 15;27(6):1517-23.
23. Regulation of E-cadherin and TGF-beta3 expression by CD24 in cultured oral epithelial cells. Ye P, etal., Biochem Biophys Res Commun. 2006 Oct 13;349(1):229-35. Epub 2006 Aug 14.
24. Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line. Zarn JA, etal., Biochem Biophys Res Commun. 1996 Aug 14;225(2):384-91.
25. CD24 is a genetic modifier for risk and progression of multiple sclerosis. Zhou Q, etal., Proc Natl Acad Sci U S A 2003 Dec 9;100(25):15041-6. Epub 2003 Dec 1.
Additional References at PubMed
PMID:1346270   PMID:1383383   PMID:1385153   PMID:2118158   PMID:7477352   PMID:7534304   PMID:7613634   PMID:7669058   PMID:7774619   PMID:7795661   PMID:7807014   PMID:7908303  
PMID:8117278   PMID:8125140   PMID:8145052   PMID:8543797   PMID:8557754   PMID:8562500   PMID:8889548   PMID:8920854   PMID:8943715   PMID:9028339   PMID:9177270   PMID:9324354  
PMID:9368605   PMID:10365441   PMID:10601245   PMID:10791997   PMID:10943842   PMID:11283023   PMID:11978835   PMID:12657681   PMID:12882831   PMID:12940824   PMID:14707049   PMID:14990792  
PMID:15314074   PMID:15477346   PMID:15489334   PMID:15633604   PMID:15737737   PMID:16288985   PMID:16532032   PMID:16606832   PMID:16769998   PMID:16885410   PMID:17545040   PMID:18776904  
PMID:18958875   PMID:19092120   PMID:19103603   PMID:19264983   PMID:19299737   PMID:19458237   PMID:19487454   PMID:20103531   PMID:21323829   PMID:22732588   PMID:26935354  


Genomics

Comparative Map Data
Cd24
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82048,655,549 - 48,661,786 (+)NCBIGRCr8
mRatBN7.22047,074,353 - 47,079,662 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2047,073,512 - 47,079,662 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2048,789,167 - 48,794,459 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02048,439,001 - 48,444,293 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02049,123,655 - 49,128,973 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02048,335,540 - 48,340,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2048,335,540 - 48,340,846 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02049,989,320 - 49,994,627 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42047,502,354 - 47,507,663 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12047,531,055 - 47,536,352 (+)NCBI
Celera2052,908,730 - 52,914,027 (-)NCBICelera
RH 3.4 Map20495.52RGD
RH 3.4 Map20493.45RGD
Cytogenetic Map20q13NCBI
CD24
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386106,969,831 - 106,976,855 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6106,969,831 - 106,975,627 (-)EnsemblGRCh38hg38GRCh38
GRCh37619,611,914 - 19,614,093 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36621,152,527 - 21,154,705NCBINCBI36Build 36hg18NCBI36
Build 34Y19,540,683 - 19,542,776NCBI
CeleraY6,620,552 - 6,622,554 (+)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6104,864,115 - 104,868,879 (-)NCBIHuRef
T2T-CHM13v2.06108,145,896 - 108,152,920 (-)NCBIT2T-CHM13v2.0
Cd24a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391043,454,433 - 43,460,261 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1043,454,280 - 43,460,261 (+)EnsemblGRCm39 Ensembl
GRCm381043,579,169 - 43,584,265 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1043,578,284 - 43,584,265 (+)EnsemblGRCm38mm10GRCm38
MGSCv371043,298,975 - 43,304,071 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361043,267,584 - 43,272,680 (+)NCBIMGSCv36mm8
Celera1044,451,209 - 44,456,305 (+)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1023.01NCBI
Cd24
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541132,270,881 - 32,275,236 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541132,270,881 - 32,275,236 (-)NCBIChiLan1.0ChiLan1.0
LOC100982539
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25126,990,812 - 126,994,802 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16124,877,952 - 124,882,093 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06104,783,720 - 104,789,509 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11535,991,289 - 35,993,436 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6108,655,624 - 108,657,847 (-)NCBIpanpan1.1panPan2
CD24
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11264,239,957 - 64,245,114 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1264,026,788 - 64,032,059 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01265,083,676 - 65,088,953 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11264,443,727 - 64,448,980 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01264,287,882 - 64,293,144 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01264,561,114 - 64,566,403 (-)NCBIUU_Cfam_GSD_1.0
LOC101968601
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629211,864,267 - 11,864,552 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649116,706,745 - 16,707,010 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100519934
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1173,119,758 - 73,124,368 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2182,267,687 - 82,273,306 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD24
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11366,863,164 - 66,868,951 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604039,191,025 - 39,196,629 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd24
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478015,287,433 - 15,292,292 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478015,287,426 - 15,292,292 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd24
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:511
Count of miRNA genes:266
Interacting mature miRNAs:332
Transcripts:ENSRNOT00000000352
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat

Markers in Region
RH94631  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2821,018,517 - 21,018,694 (+)MAPPERmRatBN7.2
mRatBN7.22047,079,150 - 47,079,328 (+)MAPPERmRatBN7.2
Rnor_6.0823,497,113 - 23,497,289NCBIRnor6.0
Rnor_6.02048,340,337 - 48,340,513NCBIRnor6.0
Rnor_5.02049,994,117 - 49,994,293UniSTSRnor5.0
Rnor_5.0823,544,800 - 23,544,976UniSTSRnor5.0
RGSC_v3.42047,507,152 - 47,507,329UniSTSRGSC3.4
Celera2052,909,064 - 52,909,241UniSTS
Cytogenetic Map20q13UniSTS
RH142320  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,079,038 - 47,079,191 (+)MAPPERmRatBN7.2
mRatBN7.22047,079,038 - 47,079,191 (-)MAPPERmRatBN7.2
mRatBN7.2821,018,653 - 21,018,804 (+)MAPPERmRatBN7.2
Rnor_6.02048,340,226 - 48,340,377NCBIRnor6.0
Rnor_6.0823,497,249 - 23,497,399NCBIRnor6.0
Rnor_5.02049,994,006 - 49,994,157UniSTSRnor5.0
Rnor_5.0823,544,936 - 23,545,086UniSTSRnor5.0
RGSC_v3.42047,507,040 - 47,507,192UniSTSRGSC3.4
Celera2052,909,201 - 52,909,353UniSTS
RH 3.4 Map20495.52UniSTS
Cytogenetic Map20q13UniSTS
BE116382  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,075,580 - 47,075,760 (+)MAPPERmRatBN7.2
Rnor_6.02048,336,768 - 48,336,947NCBIRnor6.0
Rnor_5.02049,990,548 - 49,990,727UniSTSRnor5.0
RGSC_v3.42047,503,582 - 47,503,761UniSTSRGSC3.4
Celera2052,912,632 - 52,912,811UniSTS
RH 3.4 Map20495.9UniSTS
Cytogenetic Map20q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000000352   ⟹   ENSRNOP00000000352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2047,075,216 - 47,079,662 (+)Ensembl
Rnor_6.0 Ensembl2048,335,540 - 48,340,846 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109979   ⟹   ENSRNOP00000085201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2047,073,512 - 47,079,654 (+)Ensembl
RefSeq Acc Id: NM_012752   ⟹   NP_036884
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82048,656,477 - 48,661,786 (+)NCBI
mRatBN7.22047,074,353 - 47,079,662 (+)NCBI
Rnor_6.02048,335,540 - 48,340,847 (+)NCBI
Rnor_5.02049,989,320 - 49,994,627 (+)NCBI
RGSC_v3.42047,502,354 - 47,507,663 (+)RGD
Celera2052,908,730 - 52,914,027 (-)RGD
Sequence:
RefSeq Acc Id: XM_063278972   ⟹   XP_063135042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82048,655,549 - 48,661,781 (+)NCBI
RefSeq Acc Id: NP_036884   ⟸   NM_012752
- Peptide Label: precursor
- UniProtKB: Q0P5T1 (UniProtKB/Swiss-Prot),   Q07490 (UniProtKB/Swiss-Prot),   A6K6W7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000352   ⟸   ENSRNOT00000000352
Ensembl Acc Id: ENSRNOP00000085201   ⟸   ENSRNOT00000109979
RefSeq Acc Id: XP_063135042   ⟸   XM_063278972
- Peptide Label: isoform X1
- UniProtKB: Q0P5T1 (UniProtKB/Swiss-Prot),   Q07490 (UniProtKB/Swiss-Prot),   A6K6W7 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07490-F1-model_v2 AlphaFold Q07490 1-76 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701677
Promoter ID:EPDNEW_R12201
Type:single initiation site
Name:Cd24_1
Description:CD24 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02048,335,532 - 48,335,592EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2298 AgrOrtholog
BioCyc Gene G2FUF-3339 BioCyc
Ensembl Genes ENSRNOG00000000321 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000352.6 UniProtKB/TrEMBL
  ENSRNOT00000109979.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623514 IMAGE-MGC_LOAD
  IMAGE:7110912 IMAGE-MGC_LOAD
InterPro CD24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25145 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72544 IMAGE-MGC_LOAD
  MGC:93641 IMAGE-MGC_LOAD
NCBI Gene 25145 ENTREZGENE
PANTHER PTHR16676 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIGNAL TRANSDUCER CD24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CD24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd24 PhenoGen
RatGTEx ENSRNOG00000000321 RatGTEx
TIGR TC216491
  TC216492
UniProt A0A8I6A2R9_RAT UniProtKB/TrEMBL
  A0A8L2PZU1_RAT UniProtKB/TrEMBL
  A6K6W7 ENTREZGENE, UniProtKB/TrEMBL
  CD24_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q0P5T1 ENTREZGENE
UniProt Secondary Q0P5T1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-06-27 Cd24  CD24 molecule  Cd24  CD24 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Cd24  CD24 antigen      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization transmembrane glycoprotein anchored in membrane via GPI anchor 634713
gene_expression expressed in keratinocytes 634712
gene_expression expressed in postmitotic cells of spinal cord, hindbrain, midbrain, and forebrain in embryos; expression is strongly downregulated in adult brain 634713
gene_process involved in cell-cell adhesion and signaling 634712
gene_process may be involved in migration of neurons on astroglial processes during development 634713