Gene: Fst (follistatin) Rattus norvegicus
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Symbol: Fst
Name: follistatin
Description: ENCODES a protein that exhibits heparan sulfate proteoglycan binding; activin binding (ortholog); activin receptor antagonist activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); female gonad development (ortholog); gamete generation (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Breast Neoplasms (ortholog); hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine
AGR Description: Exhibits heparan sulfate proteoglycan binding activity; predicted to be involved in several processes, including animal organ development, gamete generation, and regulation of cellular biosynthetic process; predicted to localize to the cytoplasm and nucleus; orthologous to human FST (follistatin).
Merged Description: Exhibits heparan sulfate proteoglycan binding activity; predicted to be involved in several processes, including animal organ development, gamete generation, and regulation of cellular biosynthetic process; predicted to localize to the cytoplasm and nucleus; orthologous to human FST (follistatin); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activin-binding protein; FOL1; follistatin-A; FS; Fst-288; LOC686745; RATFOL1; similar to follistatin
Orthologs:
Homo sapiens (human) : FST (follistatin)  HGNC  Alliance
Mus musculus (house mouse) : Fst (follistatin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fst (follistatin)
Pan paniscus (bonobo/pygmy chimpanzee) : FST (follistatin)
Canis lupus familiaris (dog) : FST (follistatin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fst (follistatin)
Sus scrofa (pig) : FST (follistatin)
more info ...
Is Marker For: Strains:   SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc   WKY.SHRSP-(Fst-Pklr)/Gcrc   SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc  
QTLs:   Bp132  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0246,537,589 - 46,544,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0265,576,721 - 65,583,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,542,246 - 46,550,678 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1246,470,478 - 46,478,911 (-)NCBI
Celera241,883,386 - 41,889,989 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Fst
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2633
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.