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Gene: Got2 (glutamic-oxaloacetic transaminase 2) Rattus norvegicus
Symbol: Got2
Name: glutamic-oxaloacetic transaminase 2
RGD ID: 2722
Description: Exhibits several functions, including L-aspartate:2-oxoglutarate aminotransferase activity; anion binding activity; and identical protein binding activity. Involved in several processes, including dicarboxylic acid metabolic process; lactation; and response to morphine. Localizes to several cellular components, including T-tubule; mitochondrial inner membrane; and perikaryon. Biomarker of acute kidney failure; neurodegenerative disease; obesity; and schizophrenia. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2); PARTICIPATES IN gluconeogenesis pathway; 2-hydroxyglutaric aciduria pathway; argininosuccinic aciduria pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: aspartate aminotransferase; aspartate aminotransferase, mitochondrial; ASPATA; FABP-1; FABPpm; fatty acid-binding protein; glutamate oxaloacetate transaminase 2; Glutamate oxaloacetate transaminase 2 mitochondrial (aspartate aminotransferase 2); glutamate oxaloacetate transaminase 2, mitochondrial; Glutamate oxaloacetate transaminase 2, mitochondrial (aspartate aminotransferase 2); glutamic-oxaloacetic transaminase 2, mitochondrial; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); kynurenine aminotransferase 4; kynurenine aminotransferase IV; kynurenine--oxoglutarate transaminase 4; kynurenine--oxoglutarate transaminase IV; mAAT; mAspAT; plasma membrane-associated fatty acid-binding protein; transaminase A
Homo sapiens (human) : GOT2 (glutamic-oxaloacetic transaminase 2)  HGNC  Alliance
Mus musculus (house mouse) : Got2 (glutamatic-oxaloacetic transaminase 2, mitochondrial)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Got2 (glutamic-oxaloacetic transaminase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GOT2 (glutamic-oxaloacetic transaminase 2)
Canis lupus familiaris (dog) : GOT2 (glutamic-oxaloacetic transaminase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Got2 (glutamic-oxaloacetic transaminase 2)
Sus scrofa (pig) : GOT2 (glutamic-oxaloacetic transaminase 2)
Chlorocebus sabaeus (African green monkey) : GOT2 (glutamic-oxaloacetic transaminase 2)
Heterocephalus glaber (naked mole-rat) : Got2 (glutamic-oxaloacetic transaminase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0199,587,637 - 9,613,323 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,587,653 - 9,613,340 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0199,572,757 - 9,598,443 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4199,629,687 - 9,655,336 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1199,634,512 - 9,660,162 (+)NCBI
Celera199,072,871 - 9,098,515 (+)NCBICelera
Cytogenetic Map19p13NCBI
RH 3.4 Map1972.43RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Got2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2722
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.