Apoc3 (apolipoprotein C3) - Rat Genome Database

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Gene: Apoc3 (apolipoprotein C3) Rattus norvegicus
Analyze
Symbol: Apoc3
Name: apolipoprotein C3
RGD ID: 2136
Description: Predicted to enable high-density lipoprotein particle receptor binding activity; lipase inhibitor activity; and phospholipid binding activity. Involved in several processes, including lipoprotein transport; negative regulation of oxidative phosphorylation; and positive regulation of triglyceride biosynthetic process. Located in extracellular space. Used to study hyperthyroidism; hypothyroidism; and type 1 diabetes mellitus. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in several diseases, including apolipoprotein C-III deficiency; chronic kidney disease; familial hyperlipidemia (multiple); glucose metabolism disease (multiple); and hepatocellular carcinoma. Orthologous to human APOC3 (apolipoprotein C3); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (+)-schisandrin B; 1-nitropropane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apo-CIII; ApoC-III; apolipoprotein C-3; apolipoprotein C-III
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8855,428,172 - 55,430,352 (-)NCBIGRCr8
mRatBN7.2846,531,478 - 46,533,658 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,531,478 - 46,533,583 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx852,032,685 - 52,034,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0850,311,460 - 50,313,642 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0848,175,731 - 48,177,913 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,529,318 - 50,531,498 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,529,318 - 50,531,498 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,155,390 - 49,157,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.18159,618,812 - 159,618,833NCBI
Celera846,113,508 - 46,115,688 (-)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
apolipoprotein C-III deficiency  (ISO)
breast cancer  (ISO)
cardiovascular system disease  (ISO)
CD3epsilon deficiency  (ISO)
celiac disease  (ISO)
cholestasis  (IEP)
Chromosome 11, Partial Trisomy 11q  (ISO)
chronic kidney disease  (ISO)
cognitive disorder  (ISO)
colorectal cancer  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Drug Eruptions  (ISO)
Dwarfism  (ISO)
end stage renal disease  (ISO)
familial combined hyperlipidemia  (ISO)
familial hyperlipidemia  (ISO)
gastric adenocarcinoma  (ISO)
glucose intolerance  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
hepatocellular carcinoma  (ISO)
Hypercholesterolemia  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hyperlipoproteinemia type III  (ISO)
Hyperlipoproteinemias  (ISO)
hyperthyroidism  (IDA)
Hypertriglyceridemia  (ISO)
hypothyroidism  (IDA)
immunodeficiency 17  (ISO)
immunodeficiency 18  (ISO)
immunodeficiency 19  (ISO)
inflammatory bowel disease 28  (ISO)
Insulin Resistance  (IEP,ISO)
intellectual disability  (ISO)
isolated microphthalmia 5  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Metabolic Syndrome  (ISO)
myocardial infarction  (ISO)
nephroblastoma  (ISO)
nephronophthisis 15  (ISO)
nephrotic syndrome  (ISO)
obesity  (ISO)
open-angle glaucoma  (ISO)
primary hypoalphalipoproteinemia 2  (ISO)
RASopathy  (ISO)
renal artery obstruction  (ISO)
type 1 diabetes mellitus  (IMP,ISO)
Yin Deficiency  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-ephedrine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1-methylphenanthrene  (ISO)
1-nitropropane  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
5-fluorouracil  (ISO)
acetamide  (EXP)
aconitine  (EXP)
aflatoxin B1  (ISO)
allopurinol  (ISO)
alpha-Zearalanol  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
caffeine  (ISO)
calcium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
daunorubicin  (EXP)
dexamethasone  (EXP,ISO)
diamminedichloroplatinum  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
diquat  (ISO)
ethanol  (EXP)
fenofibrate  (EXP,ISO)
fluoranthene  (ISO)
folpet  (ISO)
furan  (EXP)
gemfibrozil  (EXP)
ginsenoside Rf  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
L-methionine  (ISO)
linalool  (ISO)
menadione  (ISO)
mercaptopurine  (EXP)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
olanzapine  (EXP)
oleic acid  (ISO)
oxybenzone  (EXP)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
purine-6-thiol  (EXP)
quercetin  (ISO)
rifampicin  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulindac  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
tetramethylpyrazine  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
transplatin  (ISO)
trichloroethene  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to glucose stimulus  (IDA)
cholesterol efflux  (ISO)
cholesterol homeostasis  (IBA,ISO)
cholesterol metabolic process  (ISO)
chylomicron remnant clearance  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
high-density lipoprotein particle remodeling  (ISO)
lipid catabolic process  (IEA)
lipid transport  (IEA,TAS)
lipoprotein metabolic process  (IEA)
lipoprotein transport  (IDA)
negative regulation of cholesterol import  (ISO)
negative regulation of fatty acid biosynthetic process  (ISO)
negative regulation of high-density lipoprotein particle clearance  (IBA,ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of lipid metabolic process  (ISO)
negative regulation of low-density lipoprotein particle clearance  (IBA,ISO)
negative regulation of oxidative phosphorylation  (IDA)
negative regulation of receptor-mediated endocytosis  (ISO)
negative regulation of triglyceride catabolic process  (IBA,ISO)
negative regulation of very-low-density lipoprotein particle clearance  (IBA,ISO)
negative regulation of very-low-density lipoprotein particle remodeling  (ISO)
phospholipid efflux  (ISO)
positive regulation of triglyceride biosynthetic process  (IMP)
regulation of Cdc42 protein signal transduction  (ISO)
response to fatty acid  (IEP)
response to nutrient  (IEP)
response to peptide hormone  (IDA)
response to triglyceride  (IEP)
response to vitamin A  (IEP)
response to xenobiotic stimulus  (IEP)
triglyceride catabolic process  (ISO)
triglyceride homeostasis  (IBA,ISO)
triglyceride metabolic process  (ISO)
triglyceride mobilization  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Apolipoprotein A-I, A-II, B, C-II, and C-III in children with insulin-dependent diabetes mellitus. al Muhtaseb N, etal., Pediatrics. 1992 May;89(5 Pt 1):936-41.
2. Developmental and pharmacological regulation of apolipoprotein C-II gene expression. Comparison with apo C-I and apo C-III gene regulation. Andersson Y, etal., Arterioscler Thromb Vasc Biol. 1999 Jan;19(1):115-21.
3. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
4. Biosynthesis of apolipoprotein C-III in rat liver and small intestinal mucosa. Blaufuss MC, etal., J Biol Chem. 1984 Feb 25;259(4):2452-6.
5. Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemia. Caron S, etal., Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):513-9. doi: 10.1161/ATVBAHA.110.220723. Epub 2010 Dec 23.
6. Effect of dietary saturated fatty acids on HNF-4alpha DNA binding activity and ApoCIII mRNA in sedentary rat liver. Ceccarelli V, etal., Mol Cell Biochem. 2011 Jan;347(1-2):29-39. doi: 10.1007/s11010-010-0609-0. Epub 2010 Oct 12.
7. Concurrent fatty liver increases risk of hepatocellular carcinoma among patients with chronic hepatitis B. Chan AW, etal., J Gastroenterol Hepatol. 2017 Mar;32(3):667-676. doi: 10.1111/jgh.13536.
8. Serum apolipoproteins C-I and C-III are reduced in stomach cancer patients: results from MALDI-based peptidome and immuno-based clinical assays. Cohen M, etal., PLoS One. 2011 Jan 18;6(1):e14540. doi: 10.1371/journal.pone.0014540.
9. Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes. Dallinga-Thie GM, etal., J Clin Invest. 1997 Mar 1;99(5):953-61.
10. Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men. Dallongeville J, etal., Int J Cardiol. 2006 Jan 13;106(2):152-6.
11. Alterations in rat serum lipids and apolipoproteins following clofibrate treatment. Dashti N and Ontko JA, Atherosclerosis. 1983 Dec;49(3):255-66.
12. Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice. Duivenvoorden I, etal., Diabetes. 2005 Mar;54(3):664-71.
13. Increased apolipoprotein C-III levels associated with insulin resistance contribute to dyslipidemia in normoglycemic and diabetic subjects from a triethnic population. Florez H, etal., Atherosclerosis. 2006 Sep;188(1):134-41. Epub 2005 Nov 18.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression. Gerritsen G, etal., J Lipid Res. 2005 Jul;46(7):1466-73. Epub 2005 May 1.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans. Graham MJ, etal., Circ Res. 2013 May 24;112(11):1479-90. doi: 10.1161/CIRCRESAHA.111.300367. Epub 2013 Mar 29.
18. Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes. Haddad IA, etal., J Biol Chem 1986 Oct 5;261(28):13268-77.
19. Association of a DNA polymorphism in the apolipoprotein C-III gene with diverse hyperlipidaemic phenotypes. Henderson HE, etal., Hum Genet. 1987 Jan;75(1):62-5.
20. Susceptibility to type 1 diabetes is associated with ApoCIII gene haplotypes. Hokanson JE, etal., Diabetes. 2006 Mar;55(3):834-8.
21. Lowering apolipoprotein CIII delays onset of type 1 diabetes. Holmberg R, etal., Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10685-9. doi: 10.1073/pnas.1019553108. Epub 2011 Jun 13.
22. Lipoprotein composition in insulin-dependent diabetes mellitus with chronic renal failure: effect of kidney and pancreas transplantation. Hughes TA, etal., Metabolism. 1994 Mar;43(3):333-47.
23. Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma. Inoue T, etal., Invest Ophthalmol Vis Sci. 2013 Aug 9;54(8):5353-8. doi: 10.1167/iovs.13-12245.
24. Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3. Jong MC, etal., Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):472-84.
25. Pattern of hyperlipoproteinemia in human nephrotic syndrome: influence of renal failure and diabetes mellitus. Joven J, etal., Nephron. 1993;64(4):565-9.
26. Effect of bile duct obstruction on the expression of intestinal mRNA related to cholesterol and bile acid metabolism in the rat. Kamisako T and Ogawa H, J Gastroenterol Hepatol. 2007 Jan;22(1):125-31.
27. Lack of association between genetic variations of apo A-I-C-III-A-IV gene cluster and myocardial infarction in a sample of European male: ECTIM study. Kee F, etal., Atherosclerosis. 1999 Jul;145(1):187-95.
28. Severely modified lipoprotein properties without a change in cholesteryl ester transfer protein activity in patients with acute renal failure secondary to Hantaan virus infection. Kim J, etal., BMB Rep. 2010 Aug;43(8):535-40.
29. Apolipoprotein C-III protein concentrations and gene polymorphisms in Type 1 diabetes: associations with microvascular disease complications in the DCCT/EDIC cohort. Klein RL, etal., J Diabetes Complications. 2005 Jan-Feb;19(1):18-25.
30. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics Konemori G, etal., Nippon Ronen Igakkai Zasshi. 1990 Jan;27(1):22-7.
31. Oxidative stress and inflammation in renal patients and healthy subjects. Lee DM, etal., PLoS One. 2011;6(7):e22360. doi: 10.1371/journal.pone.0022360. Epub 2011 Jul 28.
32. Role of thyroid hormone in the expression of apolipoprotein A-IV and C-III genes in rat liver. Lin-Lee YC, etal., J Lipid Res. 1993 Feb;34(2):249-59.
33. Serum Protein KNG1, APOC3, and PON1 as Potential Biomarkers for Yin-Deficiency-Heat Syndrome. Liu C, etal., Evid Based Complement Alternat Med. 2016;2016:5176731. doi: 10.1155/2016/5176731. Epub 2016 Oct 24.
34. Association of Sst I polymorphism in apolipoprotein C3 gene with hypertriglyceridaemia in coronary atherosclerotic heart disease and type II diabetes mellitus in Chinese population. Liu HK, etal., Yi Chuan Xue Bao. 2005 Jan;32(1):11-8.
35. Identification and Validation of Stage-Associated Serum Biomarkers in Colorectal Cancer Using MS-Based Procedures. Marín-Vicente C, etal., Proteomics Clin Appl. 2020 Jan;14(1):e1900052. doi: 10.1002/prca.201900052. Epub 2019 Sep 18.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. APOC3 Promoter Polymorphisms C-482T and T-455C Are Associated with the Metabolic Syndrome. Miller M, etal., Arch Med Res. 2007 May;38(4):444-51. Epub 2007 Mar 26.
38. Serum protein oxidation and apolipoprotein CIII levels in people with systemic lupus erythematosus with and without nephritis. Morgan PE, etal., Free Radic Res. 2007 Dec;41(12):1301-12.
39. Vitamin A regulates the expression of apolipoprotein AI and CIII genes in the rat. Nagasaki A, etal., Biochem Biophys Res Commun. 1994 Dec 30;205(3):1510-7.
40. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. Association of lipoprotein lipase S447X, apolipoprotein E exon 4, and apoC3 -455T>C polymorphisms on the susceptibility to diabetic nephropathy. Ng MC, etal., Clin Genet. 2006 Jul;70(1):20-8.
42. Lipoprotein abnormalities in patients with atherosclerotic renovascular disease. Nowakowska Fortuna E, etal., Kidney Blood Press Res. 2011;34(5):311-9. doi: 10.1159/000325648. Epub 2011 May 26.
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. Plasma apolipoprotein C-III metabolism in patients with chronic kidney disease. Ooi EM, etal., J Lipid Res. 2011 Apr;52(4):794-800. doi: 10.1194/jlr.M011163. Epub 2011 Feb 6.
45. Effects of apolipoproteins C on oxidative phosphorylation in rat liver mitochondria. Panin LE, etal., Bull Exp Biol Med. 2000 Aug;130(8):769-71.
46. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
47. GOA pipeline RGD automated data pipeline
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Association between the SstI polymorphism of the apolipoprotein C-III gene, glucose intolerance and cardiovascular risk in renal transplant recipients. Rodrigo E, etal., Transplant Proc. 2002 Feb;34(1):379.
51. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors reduce serum triglyceride levels through modulation of apolipoprotein C-III and lipoprotein lipase. Schoonjans K, etal., FEBS Lett. 1999 Jun 11;452(3):160-4.
52. Isotretinoin and fenofibrate induce adiposity with distinct effect on metabolic profile in a rat model of the insulin resistance syndrome. Sedova L, etal., Int J Obes Relat Metab Disord. 2004 May;28(5):719-25.
53. Alteration in rat apolipoprotein C-III gene expression and lipoprotein composition during inflammation. Shen P and Howlett GJ, Inflammation. 1993 Apr;17(2):153-66.
54. Apolipoproteins as Differentiating and Predictive Markers for Assessing Clinical Outcomes in Patients with Small Cell Lung Cancer. Shi J, etal., Yonsei Med J. 2016 May;57(3):549-56. doi: 10.3349/ymj.2016.57.3.549.
55. Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia. Shimokata K, etal., Atherosclerosis. 2004 Jan;172(1):167-73.
56. The ApoAI-CIII-AIV gene cluster and its relation to lipid levels in type 2 diabetes mellitus and coronary heart disease: determination of a novel susceptible haplotype. Singh P, etal., Diab Vasc Dis Res. 2007 Jun;4(2):124-9.
57. Apolipoprotein C3 polymorphisms, cognitive function and diabetes in Caribbean origin Hispanics. Smith CE, etal., PLoS One. 2009;4(5):e5465. doi: 10.1371/journal.pone.0005465. Epub 2009 May 8.
58. Diagnostic and prognostic role of serum protein peak at 6449 m/z in gastric adenocarcinoma based on mass spectrometry. Song D, etal., Br J Cancer. 2016 Apr 12;114(8):929-38. doi: 10.1038/bjc.2016.52. Epub 2016 Mar 22.
59. Detection and identification of serum protein peak at 6648 m/z as a novel indicator in breast cancer based on mass spectrometry. Song D, etal., Discov Med. 2017 May;23(128):283-294.
60. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
61. Haplotypes of the ApoA-I/C-III/A-IV gene cluster and familial combined hyperlipidemia. Tahvanainen E, etal., Arterioscler Thromb Vasc Biol. 1998 Nov;18(11):1810-7.
62. The usefulness of measuring body fat deposition for detecting obesity and atherogenesity in Japanese school children. Takahashi H, etal., Acta Paediatr Jpn. 1996 Dec;38(6):634-9.
63. [Clinical consideration with special reference to autopsy cases of malignant tumor in the oral cavity, treated with Bleomycin (author's transl)] Tanaka S, etal., Hiroshima Daigaku Shigaku Zasshi 1975;8(2):168-75.
64. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
65. [Apolipoprotein C-II and C-III anomalies in normolipemic and hyperlipemic patients with chronic kidney failure]. Tornero F, etal., Nefrologia. 2000 Jan-Feb;20(1):47-53.
66. Targeted serum glycoproteomics for the discovery of lung cancer-associated glycosylation disorders using lectin-coupled ProteinChip arrays. Ueda K, etal., Proteomics. 2009 Apr;9(8):2182-92. doi: 10.1002/pmic.200800374.
67. Identification of potential serum biomarkers for Wilms tumor after excluding confounding effects of common systemic inflammatory factors. Wang J, etal., Mol Biol Rep. 2012 May;39(5):5095-104. doi: 10.1007/s11033-011-1305-1. Epub 2011 Dec 8.
68. Diagnostic and prognostic significance of mRNA expressions of apolipoprotein A and C family genes in hepatitis B virus-related hepatocellular carcinoma. Wang X, etal., J Cell Biochem. 2019 Oct;120(10):18246-18265. doi: 10.1002/jcb.29131. Epub 2019 Jun 18.
69. Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver. Windler E and Havel RJ, J Lipid Res. 1985 May;26(5):556-65.
70. Genetic risk for coronary artery disease in individuals with or without type 2 diabetes. Yamada Y, etal., Mol Genet Metab. 2004 Apr;81(4):282-90.
71. An apolipoprotein CIII marker associated with hypertriglyceridemia in Caucasians also confers increased risk in a west Japanese population. Zeng Q, etal., Hum Genet. 1995 Apr;95(4):371-5.
Additional References at PubMed
PMID:182536   PMID:1917954   PMID:3973011   PMID:4066713   PMID:8089130   PMID:8245722   PMID:8864964   PMID:9254056   PMID:11060345   PMID:11162594   PMID:11551841   PMID:11590213  
PMID:15576844   PMID:15778093   PMID:16443932   PMID:16935699   PMID:17142127   PMID:17154273   PMID:17336988   PMID:17438339   PMID:18635818   PMID:18767813   PMID:23376485   PMID:23533145  
PMID:24234421   PMID:24804986   PMID:27068509   PMID:27559042   PMID:28255847   PMID:28473603   PMID:37675633   PMID:38441531  


Genomics

Comparative Map Data
Apoc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8855,428,172 - 55,430,352 (-)NCBIGRCr8
mRatBN7.2846,531,478 - 46,533,658 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,531,478 - 46,533,583 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx852,032,685 - 52,034,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0850,311,460 - 50,313,642 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0848,175,731 - 48,177,913 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,529,318 - 50,531,498 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,529,318 - 50,531,498 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,155,390 - 49,157,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.18159,618,812 - 159,618,833NCBI
Celera846,113,508 - 46,115,688 (-)NCBICelera
Cytogenetic Map8q22NCBI
APOC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811116,829,907 - 116,833,072 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11116,829,706 - 116,833,072 (+)EnsemblGRCh38hg38GRCh38
GRCh3711116,700,623 - 116,703,788 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,205,834 - 116,208,997 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411116,205,833 - 116,208,997NCBI
Celera11113,858,439 - 113,861,589 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11112,632,897 - 112,636,045 (+)NCBIHuRef
CHM1_111116,585,371 - 116,588,539 (+)NCBICHM1_1
T2T-CHM13v2.011116,845,008 - 116,848,178 (+)NCBIT2T-CHM13v2.0
Apoc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,144,348 - 46,146,934 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl946,144,231 - 46,146,934 (-)EnsemblGRCm39 Ensembl
GRCm38946,233,050 - 46,235,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,232,933 - 46,235,636 (-)EnsemblGRCm38mm10GRCm38
MGSCv37946,041,134 - 46,043,380 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36945,984,046 - 45,986,292 (-)NCBIMGSCv36mm8
Celera943,522,002 - 43,524,237 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
Apoc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,165,667 - 18,168,015 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,165,667 - 18,168,015 (+)NCBIChiLan1.0ChiLan1.0
APOC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29117,533,589 - 117,536,588 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111118,638,797 - 118,641,800 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011111,667,816 - 111,670,861 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111115,600,416 - 115,603,460 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,600,416 - 115,603,460 (+)Ensemblpanpan1.1panPan2
APOC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,744,423 - 16,746,992 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,744,423 - 16,746,992 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,796,585 - 16,799,154 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0516,690,907 - 16,693,492 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl516,690,907 - 16,693,492 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1516,828,006 - 16,830,575 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0516,730,571 - 16,733,151 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0516,773,507 - 16,776,068 (-)NCBIUU_Cfam_GSD_1.0
Apoc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,184,897 - 99,187,178 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,106,318 - 2,108,603 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,106,927 - 2,108,412 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,211,194 - 44,213,533 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,211,171 - 44,213,538 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,283,407 - 49,285,786 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p13NCBI
APOC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,196,283 - 108,199,274 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,196,939 - 108,199,342 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604317,851,374 - 17,853,839 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,244,646 - 12,246,790 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478412,244,565 - 12,246,790 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apoc3
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:36
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000074942
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84269268450095447Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat

Markers in Region
D8Mit7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,531,639 - 46,531,840 (+)MAPPERmRatBN7.2
Rnor_6.0850,529,480 - 50,529,680NCBIRnor6.0
Rnor_5.0849,155,552 - 49,155,752UniSTSRnor5.0
Celera846,113,670 - 46,113,870UniSTS
RH 3.4 Map8469.8RGD
RH 3.4 Map8469.8UniSTS
RH 2.0 Map8368.2RGD
Cytogenetic Map8q23-q24UniSTS
D8Wox4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,531,722 - 46,531,840 (+)MAPPERmRatBN7.2
Rnor_6.0850,529,563 - 50,529,680NCBIRnor6.0
Rnor_5.0849,155,635 - 49,155,752UniSTSRnor5.0
Celera846,113,753 - 46,113,870UniSTS
RH 3.4 Map8474.2RGD
RH 3.4 Map8474.2UniSTS
RH 2.0 Map8359.1RGD
Cytogenetic Map8q23-q24UniSTS
D8Rat85  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,531,718 - 46,531,839 (+)MAPPERmRatBN7.2
Rnor_6.0850,529,559 - 50,529,679NCBIRnor6.0
Rnor_5.0849,155,631 - 49,155,751UniSTSRnor5.0
Celera846,113,749 - 46,113,869UniSTS
RH 3.4 Map8474.3UniSTS
RH 3.4 Map8474.3RGD
RH 2.0 Map8357.5RGD
FHH x ACI Map839.2299RGD
Cytogenetic Map8q23-q24UniSTS
D8Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,531,733 - 46,531,902 (+)MAPPERmRatBN7.2
Rnor_6.0850,529,574 - 50,529,742NCBIRnor6.0
Rnor_5.0849,155,646 - 49,155,814UniSTSRnor5.0
Celera846,113,764 - 46,113,932UniSTS
SHRSP x BN Map836.96RGD
SHRSP x BN Map836.96UniSTS
FHH x ACI Map839.2199RGD
Cytogenetic Map8q23-q24UniSTS
RH134356  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,531,619 - 46,532,796 (+)MAPPERmRatBN7.2
Rnor_6.0850,529,460 - 50,530,636NCBIRnor6.0
Rnor_5.0849,155,532 - 49,156,708UniSTSRnor5.0
Celera846,113,650 - 46,114,826UniSTS
RH 3.4 Map8471.9UniSTS
Cytogenetic Map8q23-q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 21 21 21
Medium 20 18 18 2 2 13 2 2 2
Low 3 18 16 2 18 2 5 6 15 16 22 9 5
Below cutoff 22 1 1 2 29 6 15 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AW917416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000074942   ⟹   ENSRNOP00000067045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl846,531,478 - 46,533,583 (-)Ensembl
Rnor_6.0 Ensembl850,529,318 - 50,531,498 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090985   ⟹   ENSRNOP00000074692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl850,529,318 - 50,531,423 (-)Ensembl
RefSeq Acc Id: NM_001271053   ⟹   NP_001257982
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8855,428,172 - 55,430,277 (-)NCBI
mRatBN7.2846,531,478 - 46,533,583 (-)NCBI
Rnor_6.0850,529,318 - 50,531,423 (-)NCBI
Rnor_5.0849,155,390 - 49,157,779 (-)NCBI
Celera846,113,508 - 46,115,613 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012501   ⟹   NP_036633
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8855,428,172 - 55,430,352 (-)NCBI
mRatBN7.2846,531,478 - 46,533,658 (-)NCBI
Rnor_6.0850,529,318 - 50,531,498 (-)NCBI
Rnor_5.0849,155,390 - 49,157,779 (-)NCBI
Celera846,113,508 - 46,115,688 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001257982 (Get FASTA)   NCBI Sequence Viewer  
  NP_036633 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95395 (Get FASTA)   NCBI Sequence Viewer  
  EDL95396 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067045.3
GenBank Protein P06759 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036633   ⟸   NM_012501
- Peptide Label: precursor
- UniProtKB: P06759 (UniProtKB/Swiss-Prot),   A6J472 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257982   ⟸   NM_001271053
- Peptide Label: precursor
- UniProtKB: P06759 (UniProtKB/Swiss-Prot),   A6J472 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074692   ⟸   ENSRNOT00000090985
Ensembl Acc Id: ENSRNOP00000067045   ⟸   ENSRNOT00000074942

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06759-F1-model_v2 AlphaFold P06759 1-101 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695927
Promoter ID:EPDNEW_R6452
Type:initiation region
Name:Apoc3_1
Description:apolipoprotein C3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0850,531,467 - 50,531,527EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2136 AgrOrtholog
BioCyc Gene G2FUF-30651 BioCyc
Ensembl Genes ENSRNOG00000047503 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074942.3 UniProtKB/TrEMBL
Gene3D-CATH 6.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Apo-CIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Apo_CIII_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24207 UniProtKB/TrEMBL
NCBI Gene 24207 ENTREZGENE
PANTHER APOLIPOPROTEIN C-III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Apo-CIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB APOC3 RGD
PhenoGen Apoc3 PhenoGen
RatGTEx ENSRNOG00000047503 RatGTEx
TIGR TC218485
UniProt A0A0H2UI39_RAT UniProtKB/TrEMBL
  A6J472 ENTREZGENE, UniProtKB/TrEMBL
  A6J473_RAT UniProtKB/TrEMBL
  APOC3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Apoc3  apolipoprotein C3  Apoc3  apolipoprotein C-III  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Apoc3  apolipoprotein C-III    apolipoprotein C-3  Name updated 629478 APPROVED
2002-06-10 Apoc3  apolipoprotein C-3      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease increase in levels induces development of hypertriglyceridemia  
gene_expression expressed in liver and intestion in adulthood and during the aging process 634656
gene_expression expressed in liver and intestine in adulthood and during the aging process 634656
gene_function very low density lipoprotein (VLDL) protein that inhibits the enzymatic activity of lipoprotein lipase and hepatic lipase  
gene_process may delay catabolism of triglyceride-rich particles  
gene_process major component of lipid transport system 634656