RGD Reference Report - Effects of apolipoproteins C on oxidative phosphorylation in rat liver mitochondria. - Rat Genome Database

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Effects of apolipoproteins C on oxidative phosphorylation in rat liver mitochondria.

Authors: Panin, LE  Shalbueva, NI  Polyakov, LM 
Citation: Panin LE, etal., Bull Exp Biol Med. 2000 Aug;130(8):769-71.
RGD ID: 1599177
Pubmed: (View Article at PubMed) PMID:11177239

It is shown that apoC-III, but not other apoC proteins, components of very low density lipoproteins (apoC-I, apoC-II, apoC-III), reduced the rate of mitochondrial respiration in various metabolic states. This effect depended on the dose of apoprotein, type of oxidized substrate, and the presence of Ca ions in the incubation medium. ApoC-III completely blocked oxidative phosphorylation during oxidation of palmitoyl carnitine by mitochondria, while the respiration rate in metabolic state 4 remained unchanged.

Annotation

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Apoc3  (apolipoprotein C3)


Additional Information