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Gene: APOC3 (apolipoprotein C3) Homo sapiens
Symbol: APOC3
Name: apolipoprotein C3
Description: Exhibits high-density lipoprotein particle receptor binding activity; lipase inhibitor activity; and phospholipid binding activity. Involved in several processes, including lipid homeostasis; negative regulation of lipid metabolic process; and negative regulation of lipoprotein particle clearance. Localizes to the chylomicron; spherical high-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Implicated in chronic kidney disease; cognitive disorder; coronary artery disease; familial hyperlipidemia (multiple); and glucose metabolism disease (multiple). Biomarker of several diseases, including chronic kidney disease (multiple); diabetes mellitus (multiple); lupus nephritis; obesity; and renal artery obstruction.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apo-CIII; apoC-III; APOCIII; apolipoprotein C-III; HALP2; MGC150353
Mus musculus (house mouse) : Apoc3 (apolipoprotein C-III)  MGI  Alliance
Rattus norvegicus (Norway rat) : Apoc3 (apolipoprotein C3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apoc3 (apolipoprotein C3)
Pan paniscus (bonobo/pygmy chimpanzee) : APOC3 (apolipoprotein C3)
Canis lupus familiaris (dog) : APOC3 (apolipoprotein C3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apoc3 (apolipoprotein C3)
Sus scrofa (pig) : APOC3 (apolipoprotein C3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811116,829,907 - 116,833,072 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711116,700,624 - 116,703,787 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,205,834 - 116,208,997 (+)NCBINCBI36hg18NCBI36
Build 3411116,205,833 - 116,208,997NCBI
Celera11113,858,439 - 113,861,589 (+)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11112,632,897 - 112,636,045 (+)NCBIHuRef
CHM1_111116,585,371 - 116,588,539 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on APOC3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737569
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.