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Gene: APOC3 (apolipoprotein C3) Homo sapiens
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Symbol: APOC3
Name: apolipoprotein C3
Description: Exhibits high-density lipoprotein particle receptor binding activity; lipase inhibitor activity; and phospholipid binding activity. Involved in several processes, including lipid homeostasis; negative regulation of lipid metabolic process; and negative regulation of lipoprotein particle clearance. Localizes to the chylomicron; spherical high-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Implicated in chronic kidney disease; cognitive disorder; coronary artery disease; familial hyperlipidemia (multiple); and glucose metabolism disease (multiple). Biomarker of several diseases, including chronic kidney disease (multiple); diabetes mellitus (multiple); lupus nephritis; obesity; and renal artery obstruction.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apo-CIII; apoC-III; APOCIII; apolipoprotein C-III; HALP2; MGC150353
Orthologs:
Mus musculus (house mouse) : Apoc3 (apolipoprotein C-III)  MGI  Alliance
Rattus norvegicus (Norway rat) : Apoc3 (apolipoprotein C3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apoc3 (apolipoprotein C3)
Pan paniscus (bonobo/pygmy chimpanzee) : APOC3 (apolipoprotein C3)
Canis lupus familiaris (dog) : APOC3 (apolipoprotein C3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apoc3 (apolipoprotein C3)
Sus scrofa (pig) : APOC3 (apolipoprotein C3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811116,829,907 - 116,833,072 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711116,700,624 - 116,703,787 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,205,834 - 116,208,997 (+)NCBINCBI36hg18NCBI36
Build 3411116,205,833 - 116,208,997NCBI
Celera11113,858,439 - 113,861,589 (+)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11112,632,897 - 112,636,045 (+)NCBIHuRef
CHM1_111116,585,371 - 116,588,539 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on APOC3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737569
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.