RGD Reference Report - Diagnostic and prognostic role of serum protein peak at 6449 m/z in gastric adenocarcinoma based on mass spectrometry. - Rat Genome Database

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Diagnostic and prognostic role of serum protein peak at 6449 m/z in gastric adenocarcinoma based on mass spectrometry.

Authors: Song, Dongjian  Yue, Lifang  Li, Hao  Zhang, Junjie  Yan, Zechen  Fan, Yingzhong  Yang, Heying  Liu, Qiuliang  Zhang, Da  Xia, Ziqiang  Qin, Pan  Jia, Jia  Yue, Ming  Yu, Jiekai  Zheng, Shu  Yang, Fuquan  Wang, Jiaxiang 
Citation: Song D, etal., Br J Cancer. 2016 Apr 12;114(8):929-38. doi: 10.1038/bjc.2016.52. Epub 2016 Mar 22.
RGD ID: 153350083
Pubmed: PMID:27002935   (View Abstract at PubMed)
PMCID: PMC4984799   (View Article at PubMed Central)
DOI: DOI:10.1038/bjc.2016.52   (Journal Full-text)


BACKGROUND: Gastric cancer (GC) is a highly aggressive cancer type associated with significant mortality owing to delayed diagnosis and non-specific symptoms observed in the early stages. Therefore, identification of novel specific GC serum biomarkers for screening purposes is an urgent clinical requirement.
METHODS: This study recruited a total of 432 serum samples from 296 GC patients split into the mining and testing sets. We aimed to screen for reliable protein biomarkers from matched serum samples based on mass spectrometry, followed by comparison with three representative conventional markers using receiver operating characteristic and survival curve analyses to ascertain their potential values as diagnostic and prognostic biomarkers for GC.
RESULTS: We identified an apoC-III fragment with confirmation in an independent test set from a second hospital. We found that the diagnostic ability of this fragment performed better than current standard GC diagnostic biomarkers both individually and in combination in distinguishing patients with GC from healthy individuals. Moreover, we found that this apoC-III protein fragment represents a more robust potential prognostic factor for GC than the three conventional markers.
CONCLUSIONS: In view of these findings, we suggest that apoC-III protein fragment is a novel diagnostic and prognostic biomarker, a complement to conventional biomarkers in detecting GC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
APOC3Humangastric adenocarcinoma disease_progressionIEP  RGD 
Apoc3Ratgastric adenocarcinoma disease_progressionISOAPOC3 (Homo sapiens) RGD 
Apoc3Mousegastric adenocarcinoma disease_progressionISOAPOC3 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoc3  (apolipoprotein C3)

Genes (Mus musculus)
Apoc3  (apolipoprotein C-III)

Genes (Homo sapiens)
APOC3  (apolipoprotein C3)


Additional Information