Apoc3 (apolipoprotein C-III) - Rat Genome Database

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Gene: Apoc3 (apolipoprotein C-III) Mus musculus
Symbol: Apoc3
Name: apolipoprotein C-III
RGD ID: 10179
Description: Predicted to enable high-density lipoprotein particle receptor binding activity; lipase inhibitor activity; and phospholipid binding activity. Acts upstream of or within cholesterol metabolic process; triglyceride catabolic process; and triglyceride mobilization. Predicted to be located in extracellular space. Predicted to be part of chylomicron; spherical high-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Human ortholog(s) of this gene implicated in several diseases, including apolipoprotein C-III deficiency; chronic kidney disease; coronary artery disease; familial hyperlipidemia (multiple); and glucose metabolism disease (multiple). Orthologous to human APOC3 (apolipoprotein C3).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: apo-CIII; Apoc; apoC-III; apolipoprotein C3
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39946,144,348 - 46,146,934 (-)NCBIGRCm39mm39
GRCm39 Ensembl946,144,231 - 46,146,934 (-)Ensembl
GRCm38946,233,050 - 46,235,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,232,933 - 46,235,636 (-)EnsemblGRCm38mm10GRCm38
MGSCv37946,041,134 - 46,043,380 (-)NCBIGRCm37mm9NCBIm37
MGSCv36945,984,046 - 45,986,292 (-)NCBImm8
Celera943,522,002 - 43,524,237 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-ephedrine  (ISO)
1-methylphenanthrene  (ISO)
1-nitropropane  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,6-diaminotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-nitro-p-phenylenediamine  (ISO)
2-nitropropane  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-acetylaminofluorene  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitro-1,2-phenylenediamine  (ISO)
5-fluorouracil  (ISO)
acetamide  (ISO)
aconitine  (ISO)
aflatoxin B1  (ISO)
allopurinol  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
caffeine  (ISO)
calcium dichloride  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
chenodeoxycholic acid  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
dexamethasone  (EXP,ISO)
diamminedichloroplatinum  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
ethanol  (ISO)
fenofibrate  (EXP,ISO)
fluoranthene  (ISO)
folpet  (EXP)
furan  (ISO)
gemfibrozil  (ISO)
ginsenoside Rf  (EXP)
high-density lipoprotein cholesterol  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
indinavir  (ISO)
indometacin  (ISO)
L-methionine  (EXP)
linalool  (EXP,ISO)
menadione  (ISO)
mercaptopurine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
olanzapine  (ISO)
oleic acid  (ISO)
oxybenzone  (ISO)
p-toluidine  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
purine-6-thiol  (ISO)
quercetin  (ISO)
rifampicin  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sulindac  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
tetracycline  (EXP)
tetramethylpyrazine  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
transplatin  (ISO)
trichloroethene  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to glucose stimulus  (ISO)
cholesterol efflux  (ISO)
cholesterol homeostasis  (IBA,ISO)
cholesterol metabolic process  (IMP)
chylomicron remnant clearance  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
high-density lipoprotein particle remodeling  (ISO)
inflammatory response  (ISO)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
lipid transport  (IEA)
lipoprotein metabolic process  (IEA)
lipoprotein transport  (ISO)
negative regulation of cholesterol import  (ISO)
negative regulation of fatty acid biosynthetic process  (ISO)
negative regulation of high-density lipoprotein particle clearance  (IBA,ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of lipid metabolic process  (ISO)
negative regulation of lipoprotein lipase activity  (IBA,ISO)
negative regulation of low-density lipoprotein particle clearance  (IBA,ISO)
negative regulation of oxidative phosphorylation  (ISO)
negative regulation of receptor-mediated endocytosis  (ISO)
negative regulation of triglyceride catabolic process  (IBA,ISO)
negative regulation of very-low-density lipoprotein particle clearance  (IBA,ISO)
negative regulation of very-low-density lipoprotein particle remodeling  (ISO)
phospholipid efflux  (ISO)
positive regulation of triglyceride biosynthetic process  (ISO)
regulation of Cdc42 protein signal transduction  (ISO)
response to fatty acid  (ISO)
response to nutrient  (ISO)
response to peptide hormone  (ISO)
response to triglyceride  (ISO)
response to vitamin A  (ISO)
response to xenobiotic stimulus  (ISO)
triglyceride catabolic process  (IMP,ISO)
triglyceride homeostasis  (IBA,ISO)
triglyceride metabolic process  (IMP,ISO)
triglyceride mobilization  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Apolipoprotein A-I, A-II, B, C-II, and C-III in children with insulin-dependent diabetes mellitus. al Muhtaseb N, etal., Pediatrics. 1992 May;89(5 Pt 1):936-41.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes. Dallinga-Thie GM, etal., J Clin Invest. 1997 Mar 1;99(5):953-61.
4. Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men. Dallongeville J, etal., Int J Cardiol. 2006 Jan 13;106(2):152-6.
5. Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice. Duivenvoorden I, etal., Diabetes. 2005 Mar;54(3):664-71.
6. Increased apolipoprotein C-III levels associated with insulin resistance contribute to dyslipidemia in normoglycemic and diabetic subjects from a triethnic population. Florez H, etal., Atherosclerosis. 2006 Sep;188(1):134-41. Epub 2005 Nov 18.
7. ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression. Gerritsen G, etal., J Lipid Res. 2005 Jul;46(7):1466-73. Epub 2005 May 1.
8. Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans. Graham MJ, etal., Circ Res. 2013 May 24;112(11):1479-90. doi: 10.1161/CIRCRESAHA.111.300367. Epub 2013 Mar 29.
9. Association of a DNA polymorphism in the apolipoprotein C-III gene with diverse hyperlipidaemic phenotypes. Henderson HE, etal., Hum Genet. 1987 Jan;75(1):62-5.
10. Susceptibility to type 1 diabetes is associated with ApoCIII gene haplotypes. Hokanson JE, etal., Diabetes. 2006 Mar;55(3):834-8.
11. Lowering apolipoprotein CIII delays onset of type 1 diabetes. Holmberg R, etal., Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10685-9. doi: 10.1073/pnas.1019553108. Epub 2011 Jun 13.
12. Lipoprotein composition in insulin-dependent diabetes mellitus with chronic renal failure: effect of kidney and pancreas transplantation. Hughes TA, etal., Metabolism. 1994 Mar;43(3):333-47.
13. Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma. Inoue T, etal., Invest Ophthalmol Vis Sci. 2013 Aug 9;54(8):5353-8. doi: 10.1167/iovs.13-12245.
14. Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3. Jong MC, etal., Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):472-84.
15. Pattern of hyperlipoproteinemia in human nephrotic syndrome: influence of renal failure and diabetes mellitus. Joven J, etal., Nephron. 1993;64(4):565-9.
16. Effect of bile duct obstruction on the expression of intestinal mRNA related to cholesterol and bile acid metabolism in the rat. Kamisako T and Ogawa H, J Gastroenterol Hepatol. 2007 Jan;22(1):125-31.
17. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
18. Lack of association between genetic variations of apo A-I-C-III-A-IV gene cluster and myocardial infarction in a sample of European male: ECTIM study. Kee F, etal., Atherosclerosis. 1999 Jul;145(1):187-95.
19. Severely modified lipoprotein properties without a change in cholesteryl ester transfer protein activity in patients with acute renal failure secondary to Hantaan virus infection. Kim J, etal., BMB Rep. 2010 Aug;43(8):535-40.
20. Apolipoprotein C-III protein concentrations and gene polymorphisms in Type 1 diabetes: associations with microvascular disease complications in the DCCT/EDIC cohort. Klein RL, etal., J Diabetes Complications. 2005 Jan-Feb;19(1):18-25.
21. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics Konemori G, etal., Nippon Ronen Igakkai Zasshi. 1990 Jan;27(1):22-7.
22. Oxidative stress and inflammation in renal patients and healthy subjects. Lee DM, etal., PLoS One. 2011;6(7):e22360. doi: 10.1371/journal.pone.0022360. Epub 2011 Jul 28.
23. Role of thyroid hormone in the expression of apolipoprotein A-IV and C-III genes in rat liver. Lin-Lee YC, etal., J Lipid Res. 1993 Feb;34(2):249-59.
24. Association of Sst I polymorphism in apolipoprotein C3 gene with hypertriglyceridaemia in coronary atherosclerotic heart disease and type II diabetes mellitus in Chinese population. Liu HK, etal., Yi Chuan Xue Bao. 2005 Jan;32(1):11-8.
25. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
26. MGDs mouse GO annotations MGD data from the GO Consortium
28. APOC3 Promoter Polymorphisms C-482T and T-455C Are Associated with the Metabolic Syndrome. Miller M, etal., Arch Med Res. 2007 May;38(4):444-51. Epub 2007 Mar 26.
29. Serum protein oxidation and apolipoprotein CIII levels in people with systemic lupus erythematosus with and without nephritis. Morgan PE, etal., Free Radic Res. 2007 Dec;41(12):1301-12.
30. Association of lipoprotein lipase S447X, apolipoprotein E exon 4, and apoC3 -455T>C polymorphisms on the susceptibility to diabetic nephropathy. Ng MC, etal., Clin Genet. 2006 Jul;70(1):20-8.
31. Lipoprotein abnormalities in patients with atherosclerotic renovascular disease. Nowakowska Fortuna E, etal., Kidney Blood Press Res. 2011;34(5):311-9. doi: 10.1159/000325648. Epub 2011 May 26.
32. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. Plasma apolipoprotein C-III metabolism in patients with chronic kidney disease. Ooi EM, etal., J Lipid Res. 2011 Apr;52(4):794-800. doi: 10.1194/jlr.M011163. Epub 2011 Feb 6.
35. Mouse MP Annotation Import Pipeline RGD automated import pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Association between the SstI polymorphism of the apolipoprotein C-III gene, glucose intolerance and cardiovascular risk in renal transplant recipients. Rodrigo E, etal., Transplant Proc. 2002 Feb;34(1):379.
39. Isotretinoin and fenofibrate induce adiposity with distinct effect on metabolic profile in a rat model of the insulin resistance syndrome. Sedova L, etal., Int J Obes Relat Metab Disord. 2004 May;28(5):719-25.
40. Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia. Shimokata K, etal., Atherosclerosis. 2004 Jan;172(1):167-73.
41. The ApoAI-CIII-AIV gene cluster and its relation to lipid levels in type 2 diabetes mellitus and coronary heart disease: determination of a novel susceptible haplotype. Singh P, etal., Diab Vasc Dis Res. 2007 Jun;4(2):124-9.
42. Apolipoprotein C3 polymorphisms, cognitive function and diabetes in Caribbean origin Hispanics. Smith CE, etal., PLoS One. 2009;4(5):e5465. doi: 10.1371/journal.pone.0005465. Epub 2009 May 8.
43. Haplotypes of the ApoA-I/C-III/A-IV gene cluster and familial combined hyperlipidemia. Tahvanainen E, etal., Arterioscler Thromb Vasc Biol. 1998 Nov;18(11):1810-7.
44. The usefulness of measuring body fat deposition for detecting obesity and atherogenesity in Japanese school children. Takahashi H, etal., Acta Paediatr Jpn. 1996 Dec;38(6):634-9.
45. [Apolipoprotein C-II and C-III anomalies in normolipemic and hyperlipemic patients with chronic kidney failure]. Tornero F, etal., Nefrologia. 2000 Jan-Feb;20(1):47-53.
46. Identification of potential serum biomarkers for Wilms tumor after excluding confounding effects of common systemic inflammatory factors. Wang J, etal., Mol Biol Rep. 2012 May;39(5):5095-104. doi: 10.1007/s11033-011-1305-1. Epub 2011 Dec 8.
47. Genetic risk for coronary artery disease in individuals with or without type 2 diabetes. Yamada Y, etal., Mol Genet Metab. 2004 Apr;81(4):282-90.
48. An apolipoprotein CIII marker associated with hypertriglyceridemia in Caucasians also confers increased risk in a west Japanese population. Zeng Q, etal., Hum Genet. 1995 Apr;95(4):371-5.
Additional References at PubMed
PMID:1450516   PMID:1478650   PMID:6099394   PMID:7035547   PMID:7868970   PMID:8089130   PMID:8689583   PMID:8864964   PMID:8994037   PMID:9616220   PMID:9873036   PMID:10349636  
PMID:11002334   PMID:11042159   PMID:11076861   PMID:11478940   PMID:11551841   PMID:11557675   PMID:11590213   PMID:11814582   PMID:11983814   PMID:12477932   PMID:12810823   PMID:14610273  
PMID:14974682   PMID:14983036   PMID:15117734   PMID:15489334   PMID:15649902   PMID:16141072   PMID:16141073   PMID:16461842   PMID:16478678   PMID:16497661   PMID:16498401   PMID:17916774  
PMID:18243209   PMID:18263930   PMID:18678879   PMID:18722179   PMID:19121312   PMID:19542564   PMID:20889132   PMID:21183731   PMID:21793029   PMID:21873635   PMID:23949443   PMID:24449835  
PMID:24929016   PMID:25209997   PMID:25941406   PMID:25969427   PMID:26160324   PMID:27226540   PMID:27400128   PMID:28115523   PMID:28159868   PMID:28739253   PMID:28825717   PMID:28887372  
PMID:29449313   PMID:30223835   PMID:31092690   PMID:31295146   PMID:33639183   PMID:34051224  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39946,144,348 - 46,146,934 (-)NCBIGRCm39mm39
GRCm39 Ensembl946,144,231 - 46,146,934 (-)Ensembl
GRCm38946,233,050 - 46,235,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,232,933 - 46,235,636 (-)EnsemblGRCm38mm10GRCm38
MGSCv37946,041,134 - 46,043,380 (-)NCBIGRCm37mm9NCBIm37
MGSCv36945,984,046 - 45,986,292 (-)NCBImm8
Celera943,522,002 - 43,524,237 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811116,829,907 - 116,833,072 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11116,829,706 - 116,833,072 (+)EnsemblGRCh38hg38GRCh38
GRCh3711116,700,623 - 116,703,788 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,205,834 - 116,208,997 (+)NCBINCBI36hg18NCBI36
Build 3411116,205,833 - 116,208,997NCBI
Celera11113,858,439 - 113,861,589 (+)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11112,632,897 - 112,636,045 (+)NCBIHuRef
CHM1_111116,585,371 - 116,588,539 (+)NCBICHM1_1
T2T-CHM13v2.011116,845,008 - 116,848,178 (+)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2846,531,478 - 46,533,658 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl846,531,478 - 46,533,583 (-)Ensembl
Rnor_6.0850,529,318 - 50,531,498 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,529,318 - 50,531,498 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,155,390 - 49,157,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.18159,618,812 - 159,618,833NCBI
Celera846,113,508 - 46,115,688 (-)NCBICelera
Cytogenetic Map8q22NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541218,165,667 - 18,168,015 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,165,667 - 18,168,015 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.111115,600,416 - 115,603,460 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,600,416 - 115,603,460 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011111,667,816 - 111,670,861 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1516,744,423 - 16,746,992 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,744,423 - 16,746,992 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,796,585 - 16,799,154 (-)NCBI
ROS_Cfam_1.0516,690,907 - 16,693,492 (-)NCBI
ROS_Cfam_1.0 Ensembl516,690,907 - 16,693,492 (-)Ensembl
UMICH_Zoey_3.1516,828,006 - 16,830,575 (-)NCBI
UNSW_CanFamBas_1.0516,730,571 - 16,733,151 (-)NCBI
UU_Cfam_GSD_1.0516,773,507 - 16,776,068 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494799,184,897 - 99,187,178 (+)NCBI
SpeTri2.0NW_0049365422,106,927 - 2,108,412 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1944,211,171 - 44,213,538 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,283,407 - 49,285,786 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p13NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11108,196,283 - 108,199,274 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,196,939 - 108,199,342 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604317,851,374 - 17,853,839 (-)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462478412,244,646 - 12,246,790 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462478412,244,565 - 12,246,790 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38946,233,355 - 46,233,567UniSTSGRCm38
MGSCv37946,041,438 - 46,041,650UniSTSGRCm37
Celera943,522,306 - 43,522,506UniSTS
Cytogenetic Map9A5.2UniSTS
cM Map927.0UniSTS
Whitehead Genetic920.8UniSTS
Whitehead_YAC9 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38946,232,846 - 46,233,270UniSTSGRCm38
MGSCv37946,040,929 - 46,041,353UniSTSGRCm37
Celera943,521,797 - 43,522,221UniSTS
Cytogenetic Map9A5.2UniSTS

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93673624349420511Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93694340650111140Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94041959451808670Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94064537448351476Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
13432191Actrse4_mactivity response to saline/ethanol 4 (mouse)94370321448603195Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:827
Count of miRNA genes:377
Interacting mature miRNAs:416
Transcripts:ENSMUST00000034586, ENSMUST00000118649, ENSMUST00000121916, ENSMUST00000145672
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000034586   ⟹   ENSMUSP00000034586
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,144,349 - 46,146,597 (-)Ensembl
GRCm38.p6 Ensembl946,233,051 - 46,235,299 (-)Ensembl
RefSeq Acc Id: ENSMUST00000118649   ⟹   ENSMUSP00000113058
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,144,496 - 46,146,934 (-)Ensembl
GRCm38.p6 Ensembl946,233,198 - 46,235,636 (-)Ensembl
RefSeq Acc Id: ENSMUST00000121916   ⟹   ENSMUSP00000113126
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,144,231 - 46,146,558 (-)Ensembl
GRCm38.p6 Ensembl946,232,933 - 46,235,260 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145672   ⟹   ENSMUSP00000115025
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,145,735 - 46,146,767 (-)Ensembl
GRCm38.p6 Ensembl946,234,437 - 46,235,469 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214729
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,144,358 - 46,146,597 (-)Ensembl
GRCm38.p6 Ensembl946,233,060 - 46,235,299 (-)Ensembl
RefSeq Acc Id: NM_001289755   ⟹   NP_001276684
RefSeq Status: REVIEWED
Mouse AssemblyChrPosition (strand)Source
GRCm39946,144,348 - 46,146,597 (-)NCBI
GRCm38946,233,050 - 46,235,299 (-)NCBI
Celera943,522,001 - 43,524,576 (-)NCBI
RefSeq Acc Id: NM_001289756   ⟹   NP_001276685
RefSeq Status: REVIEWED
Mouse AssemblyChrPosition (strand)Source
GRCm39946,144,348 - 46,146,934 (-)NCBI
GRCm38946,233,050 - 46,235,636 (-)NCBI
Celera943,522,001 - 43,524,576 (-)NCBI
RefSeq Acc Id: NM_001289833   ⟹   NP_001276762
RefSeq Status: REVIEWED
Mouse AssemblyChrPosition (strand)Source
GRCm39946,144,348 - 46,146,597 (-)NCBI
GRCm38946,233,050 - 46,235,299 (-)NCBI
Celera943,522,001 - 43,524,576 (-)NCBI
RefSeq Acc Id: NM_023114   ⟹   NP_075603
RefSeq Status: REVIEWED
Mouse AssemblyChrPosition (strand)Source
GRCm39946,144,348 - 46,146,597 (-)NCBI
GRCm38946,233,050 - 46,235,299 (-)NCBI
MGSCv37946,041,134 - 46,043,380 (-)RGD
Celera943,522,001 - 43,524,576 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_075603   ⟸   NM_023114
- Peptide Label: isoform b precursor
- UniProtKB: P33622 (UniProtKB/Swiss-Prot),   A0A0R4J1N3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276685   ⟸   NM_001289756
- Peptide Label: isoform b precursor
- UniProtKB: P33622 (UniProtKB/Swiss-Prot),   A0A0R4J1N3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276762   ⟸   NM_001289833
- Peptide Label: isoform c
- Sequence:
RefSeq Acc Id: NP_001276684   ⟸   NM_001289755
- Peptide Label: isoform a
- UniProtKB: E9QP56 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000113058   ⟸   ENSMUST00000118649
RefSeq Acc Id: ENSMUSP00000034586   ⟸   ENSMUST00000034586
RefSeq Acc Id: ENSMUSP00000115025   ⟸   ENSMUST00000145672
RefSeq Acc Id: ENSMUSP00000113126   ⟸   ENSMUST00000121916

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33622-F1-model_v2 AlphaFold P33622 1-99 view protein structure

RGD ID:6849264
Promoter ID:MM_XEF:7428
SO ACC ID:SO:0000170
Tissues & Cell Lines:Liver
Transcripts:NM_000040,   NM_001003369,   NM_012501
Mouse AssemblyChrPosition (strand)Source
MGSCv36946,042,436 - 46,042,936 (-)MPROMDB
RGD ID:6844175
Promoter ID:MM_KWN:57218
SO ACC ID:SO:0000170
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000118649,   ENSMUST00000121916,   OTTMUST00000071084,   OTTMUST00000071087
Mouse AssemblyChrPosition (strand)Source
MGSCv36946,043,036 - 46,043,536 (-)MPROMDB
RGD ID:8669478
Promoter ID:EPDNEW_M12770
Type:initiation region
Description:Mus musculus apolipoprotein C-III , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38946,235,299 - 46,235,359EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88055 AgrOrtholog
Ensembl Genes ENSMUSG00000032081 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034586 ENTREZGENE
  ENSMUSP00000034586.3 UniProtKB/TrEMBL
  ENSMUSP00000113058.2 UniProtKB/TrEMBL
  ENSMUSP00000113126.2 UniProtKB/TrEMBL
  ENSMUSP00000115025.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034586 ENTREZGENE
  ENSMUST00000034586.9 UniProtKB/TrEMBL
  ENSMUST00000118649.8 UniProtKB/TrEMBL
  ENSMUST00000121916.8 UniProtKB/TrEMBL
  ENSMUST00000145672.2 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Apo-CIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Apo_CIII_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR14225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Apo-CIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Apoc3 PhenoGen
  APOC3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8VC58 UniProtKB/Swiss-Prot
  Q9CPP9 UniProtKB/Swiss-Prot