APOC3 (apolipoprotein C3) - Rat Genome Database

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Gene: APOC3 (apolipoprotein C3) Sus scrofa
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Symbol: APOC3
Name: apolipoprotein C3
RGD ID: 14253123
Description: ENCODES a protein that exhibits enzyme regulator activity (inferred); high-density lipoprotein particle receptor binding (inferred); lipase inhibitor activity (inferred); INVOLVED IN cellular response to glucose stimulus (ortholog); cholesterol metabolic process (ortholog); inflammatory response (ortholog); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; ASSOCIATED WITH apolipoprotein C-III deficiency (ortholog); cardiovascular system disease (ortholog); celiac disease (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH ammonia
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apo-CIII; apoC-III; apolipoprotein C-III
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,211,194 - 44,213,533 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,211,171 - 44,213,538 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,283,407 - 49,285,786 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
ammonia  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to glucose stimulus  (ISO)
cholesterol efflux  (IEA)
cholesterol homeostasis  (IBA,IEA)
cholesterol metabolic process  (ISO)
chylomicron remnant clearance  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
high-density lipoprotein particle remodeling  (IEA)
inflammatory response  (ISO)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
lipid transport  (IEA)
lipoprotein metabolic process  (IEA)
lipoprotein transport  (ISO)
negative regulation of cholesterol import  (IEA)
negative regulation of fatty acid biosynthetic process  (IEA)
negative regulation of high-density lipoprotein particle clearance  (IBA,IEA)
negative regulation of lipid catabolic process  (IEA)
negative regulation of lipid metabolic process  (IEA)
negative regulation of lipoprotein lipase activity  (IBA,IEA)
negative regulation of low-density lipoprotein particle clearance  (IBA,IEA)
negative regulation of oxidative phosphorylation  (ISO)
negative regulation of receptor-mediated endocytosis  (IEA)
negative regulation of triglyceride catabolic process  (IBA,IEA)
negative regulation of very-low-density lipoprotein particle clearance  (IBA,IEA)
negative regulation of very-low-density lipoprotein particle remodeling  (IEA)
phospholipid efflux  (IEA)
positive regulation of triglyceride biosynthetic process  (ISO)
regulation of Cdc42 protein signal transduction  (IEA)
response to fatty acid  (ISO)
response to nutrient  (ISO)
response to peptide hormone  (ISO)
response to triglyceride  (ISO)
response to vitamin A  (ISO)
response to xenobiotic stimulus  (ISO)
triglyceride catabolic process  (IEA,ISO)
triglyceride homeostasis  (IBA,IEA)
triglyceride metabolic process  (IEA,ISO)
triglyceride mobilization  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:8428656   PMID:8468059   PMID:8661700   PMID:8661715   PMID:8672129   PMID:15878672   PMID:24085428  


Genomics

Comparative Map Data
APOC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,211,194 - 44,213,533 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,211,171 - 44,213,538 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,283,407 - 49,285,786 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p13NCBI
APOC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811116,829,907 - 116,833,072 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11116,829,706 - 116,833,072 (+)EnsemblGRCh38hg38GRCh38
GRCh3711116,700,623 - 116,703,788 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,205,834 - 116,208,997 (+)NCBINCBI36hg18NCBI36
Build 3411116,205,833 - 116,208,997NCBI
Celera11113,858,439 - 113,861,589 (+)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11112,632,897 - 112,636,045 (+)NCBIHuRef
CHM1_111116,585,371 - 116,588,539 (+)NCBICHM1_1
T2T-CHM13v2.011116,845,008 - 116,848,178 (+)NCBI
Apoc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,144,348 - 46,146,934 (-)NCBIGRCm39mm39
GRCm39 Ensembl946,144,231 - 46,146,934 (-)Ensembl
GRCm38946,233,050 - 46,235,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,232,933 - 46,235,636 (-)EnsemblGRCm38mm10GRCm38
MGSCv37946,041,134 - 46,043,380 (-)NCBIGRCm37mm9NCBIm37
MGSCv36945,984,046 - 45,986,292 (-)NCBImm8
Celera943,522,002 - 43,524,237 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
Apoc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2846,531,478 - 46,533,658 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl846,531,478 - 46,533,583 (-)Ensembl
Rnor_6.0850,529,318 - 50,531,498 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,529,318 - 50,531,498 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,155,390 - 49,157,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.18159,618,812 - 159,618,833NCBI
Celera846,113,508 - 46,115,688 (-)NCBICelera
Cytogenetic Map8q22NCBI
Apoc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,165,667 - 18,168,015 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,165,667 - 18,168,015 (+)NCBIChiLan1.0ChiLan1.0
APOC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111115,600,416 - 115,603,460 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,600,416 - 115,603,460 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011111,667,816 - 111,670,861 (+)NCBIMhudiblu_PPA_v0panPan3
APOC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,744,423 - 16,746,992 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,744,423 - 16,746,992 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,796,585 - 16,799,154 (-)NCBI
ROS_Cfam_1.0516,690,907 - 16,693,492 (-)NCBI
ROS_Cfam_1.0 Ensembl516,690,907 - 16,693,492 (-)Ensembl
UMICH_Zoey_3.1516,828,006 - 16,830,575 (-)NCBI
UNSW_CanFamBas_1.0516,730,571 - 16,733,151 (-)NCBI
UU_Cfam_GSD_1.0516,773,507 - 16,776,068 (-)NCBI
Apoc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,184,897 - 99,187,178 (+)NCBI
SpeTri2.0NW_0049365422,106,927 - 2,108,412 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,196,283 - 108,199,274 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,196,939 - 108,199,342 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604317,851,374 - 17,853,839 (-)NCBIVero_WHO_p1.0
Apoc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,244,646 - 12,246,790 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462478412,244,565 - 12,246,790 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system musculoskeletal system renal system
High
Medium 4 2
Low 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000016435   ⟹   ENSSSCP00000015993
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl944,211,194 - 44,213,533 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000054422   ⟹   ENSSSCP00000045185
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl944,211,245 - 44,213,533 (+)Ensembl
RefSeq Acc Id: NM_001002801   ⟹   NP_001002801
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1944,211,902 - 44,213,370 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005667372   ⟹   XP_005667429
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1944,211,171 - 44,213,538 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021102247   ⟹   XP_020957906
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1944,211,199 - 44,213,538 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021102248   ⟹   XP_020957907
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1944,211,250 - 44,213,538 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001002801 (Get FASTA)   NCBI Sequence Viewer  
  XP_005667429 (Get FASTA)   NCBI Sequence Viewer  
  XP_020957906 (Get FASTA)   NCBI Sequence Viewer  
  XP_020957907 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA30993 (Get FASTA)   NCBI Sequence Viewer  
  P27917 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005667429   ⟸   XM_005667372
- Peptide Label: isoform X1
- UniProtKB: P27917 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_020957906   ⟸   XM_021102247
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020957907   ⟸   XM_021102248
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001002801   ⟸   NM_001002801
- Peptide Label: precursor
- UniProtKB: P27917 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000015993   ⟸   ENSSSCT00000016435
RefSeq Acc Id: ENSSSCP00000045185   ⟸   ENSSSCT00000054422


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015069 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005022280 UniProtKB/Swiss-Prot
  ENSSSCG00015078430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00025006471 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00030064837 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00035023450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00040025123 UniProtKB/Swiss-Prot
  ENSSSCG00045014192 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00050065822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00055013290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00060012997 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00065005643 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00070005639 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000015993 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00000045185 ENTREZGENE
  ENSSSCP00000045185.2 UniProtKB/TrEMBL
  ENSSSCP00000063050.1 UniProtKB/TrEMBL
  ENSSSCP00005021468 UniProtKB/Swiss-Prot
  ENSSSCP00005021487 UniProtKB/Swiss-Prot
  ENSSSCP00005021507 UniProtKB/Swiss-Prot
  ENSSSCP00005021529 UniProtKB/Swiss-Prot
  ENSSSCP00015044584.1 UniProtKB/TrEMBL
  ENSSSCP00015044612 UniProtKB/Swiss-Prot
  ENSSSCP00015044628.1 UniProtKB/TrEMBL
  ENSSSCP00025003367 UniProtKB/Swiss-Prot
  ENSSSCP00025003372.1 UniProtKB/TrEMBL
  ENSSSCP00025003374.1 UniProtKB/TrEMBL
  ENSSSCP00030041753.1 UniProtKB/TrEMBL
  ENSSSCP00030041772 UniProtKB/Swiss-Prot
  ENSSSCP00030041792.1 UniProtKB/TrEMBL
  ENSSSCP00035012006 UniProtKB/Swiss-Prot
  ENSSSCP00035012010.1 UniProtKB/TrEMBL
  ENSSSCP00035012012.1 UniProtKB/TrEMBL
  ENSSSCP00040013969 UniProtKB/Swiss-Prot
  ENSSSCP00040014101 UniProtKB/Swiss-Prot
  ENSSSCP00040014115 UniProtKB/Swiss-Prot
  ENSSSCP00040014128 UniProtKB/Swiss-Prot
  ENSSSCP00045016668 UniProtKB/Swiss-Prot
  ENSSSCP00045016690.1 UniProtKB/TrEMBL
  ENSSSCP00045016699.1 UniProtKB/TrEMBL
  ENSSSCP00050038492 UniProtKB/Swiss-Prot
  ENSSSCP00050038494.1 UniProtKB/TrEMBL
  ENSSSCP00050038496.1 UniProtKB/TrEMBL
  ENSSSCP00055020805 UniProtKB/Swiss-Prot
  ENSSSCP00055020849.1 UniProtKB/TrEMBL
  ENSSSCP00055020873.1 UniProtKB/TrEMBL
  ENSSSCP00060006774 UniProtKB/Swiss-Prot
  ENSSSCP00060006777.1 UniProtKB/TrEMBL
  ENSSSCP00060006780.1 UniProtKB/TrEMBL
  ENSSSCP00065003241 UniProtKB/Swiss-Prot
  ENSSSCP00065003243.1 UniProtKB/TrEMBL
  ENSSSCP00070008797 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000016435 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00000054422 ENTREZGENE
  ENSSSCT00000054422.2 UniProtKB/TrEMBL
  ENSSSCT00000075550.1 UniProtKB/TrEMBL
  ENSSSCT00005035249 UniProtKB/Swiss-Prot
  ENSSSCT00005035285 UniProtKB/Swiss-Prot
  ENSSSCT00005035313 UniProtKB/Swiss-Prot
  ENSSSCT00005035342 UniProtKB/Swiss-Prot
  ENSSSCT00015106133.1 UniProtKB/TrEMBL
  ENSSSCT00015106164 UniProtKB/Swiss-Prot
  ENSSSCT00015106186.1 UniProtKB/TrEMBL
  ENSSSCT00025008549 UniProtKB/Swiss-Prot
  ENSSSCT00025008560.1 UniProtKB/TrEMBL
  ENSSSCT00025008566.1 UniProtKB/TrEMBL
  ENSSSCT00030090651.1 UniProtKB/TrEMBL
  ENSSSCT00030090701 UniProtKB/Swiss-Prot
  ENSSSCT00030090757.1 UniProtKB/TrEMBL
  ENSSSCT00035030741 UniProtKB/Swiss-Prot
  ENSSSCT00035030747.1 UniProtKB/TrEMBL
  ENSSSCT00035030750.1 UniProtKB/TrEMBL
  ENSSSCT00040033903 UniProtKB/Swiss-Prot
  ENSSSCT00040034204 UniProtKB/Swiss-Prot
  ENSSSCT00040034236 UniProtKB/Swiss-Prot
  ENSSSCT00040034260 UniProtKB/Swiss-Prot
  ENSSSCT00045024167 UniProtKB/Swiss-Prot
  ENSSSCT00045024199.1 UniProtKB/TrEMBL
  ENSSSCT00045024211.1 UniProtKB/TrEMBL
  ENSSSCT00050089653 UniProtKB/Swiss-Prot
  ENSSSCT00050089655.1 UniProtKB/TrEMBL
  ENSSSCT00050089658.1 UniProtKB/TrEMBL
  ENSSSCT00055026185 UniProtKB/Swiss-Prot
  ENSSSCT00055026240.1 UniProtKB/TrEMBL
  ENSSSCT00055026267.1 UniProtKB/TrEMBL
  ENSSSCT00060017063 UniProtKB/Swiss-Prot
  ENSSSCT00060017071.1 UniProtKB/TrEMBL
  ENSSSCT00060017076.1 UniProtKB/TrEMBL
  ENSSSCT00065007617 UniProtKB/Swiss-Prot
  ENSSSCT00065007622.1 UniProtKB/TrEMBL
  ENSSSCT00070010689 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Apo-CIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Apo_CIII_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:406187 UniProtKB/Swiss-Prot
NCBI Gene APOC3 ENTREZGENE
PANTHER PTHR14225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Apo-CIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5G2QLU1_PIG UniProtKB/TrEMBL
  A0A5S6HRA3_PIG UniProtKB/TrEMBL
  A0A8D0QF44_PIG UniProtKB/TrEMBL
  A0A8D1HE80_PIG UniProtKB/TrEMBL
  APOC3_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q29208 UniProtKB/Swiss-Prot
VGNC ID VGNC:85421 ENTREZGENE