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Gene: Fcgr2b (Fc fragment of IgG receptor IIb) Rattus norvegicus
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Symbol: Fcgr2b
Name: Fc fragment of IgG receptor IIb
Description: Exhibits IgG binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to lipopolysaccharide; and negative regulation of neutrophil apoptotic process. Localizes to the cell surface; membrane raft; and recycling endosome. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); autoimmune hypersensitivity disease (multiple); dengue disease (multiple); hematologic cancer (multiple); and leukopenia (multiple). Orthologous to several human genes including FCGR2A (Fc fragment of IgG receptor IIa) and FCGR2B (Fc fragment of IgG receptor IIb); PARTICIPATES IN clathrin-mediated endocytosis pathway; adaptive immune response pathway; B cell receptor signaling pathway; INTERACTS WITH (S)-colchicine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CD32; Fc fragment of IgG, low affinity IIb, receptor; Fc receptor, IgG, low affinity IIb; FC-gamma RII; FcgammaRIIB2; Fcgr2; FCRII; igG Fc receptor II beta; low affinity immunoglobulin gamma Fc region receptor II; low affinity immunoglobulin gamma FC region receptor II precursor; low affinity immunoglobulin gamma Fc region receptor II-b
Orthologs:
Homo sapiens (human) : FCGR2B (Fc fragment of IgG receptor IIb)  HGNC  Alliance
Mus musculus (house mouse) : Fcgr2b (Fc receptor, IgG, low affinity IIb)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fcgr2b (Fc fragment of IgG receptor IIb)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100984838 (low affinity immunoglobulin gamma Fc region receptor II-b)
Canis lupus familiaris (dog) : LOC100856270 (low affinity immunoglobulin gamma Fc region receptor II)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fcgr2b (Fc fragment of IgG receptor IIb)
Sus scrofa (pig) : FCGR2B (Fc fragment of IgG, low affinity IIb, receptor (CD32))
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01389,329,298 - 89,343,916 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,327,794 - 89,433,815 (-)Ensembl
Rnor_5.01393,968,425 - 93,983,043 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,809,011 - 86,823,599NCBIRGSC3.4rn4RGSC3.4
Celera1382,845,906 - 82,860,494 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Fcgr2b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 631331
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.