Ptgds (prostaglandin D2 synthase) - Rat Genome Database

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Gene: Ptgds (prostaglandin D2 synthase) Rattus norvegicus
Analyze
Symbol: Ptgds
Name: prostaglandin D2 synthase
RGD ID: 3433
Description: Enables prostaglandin-D synthase activity and retinoid binding activity. Involved in prostaglandin biosynthetic process and response to glucocorticoid. Located in Golgi apparatus and extracellular space. Biomarker of sensorineural hearing loss and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PTGDS (prostaglandin D2 synthase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 2,5-hexanedione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin-D synthase; PGD2 synthase; PGDS; PGDS2; PH2DISO; Prostaglandin D synthase; prostaglandin D2 synthase (brain); prostaglandin D2 synthase, brain; prostaglandin-D2 synthase; prostaglandin-H2 D-isomerase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,680,044 - 28,682,978 (-)NCBIGRCr8
mRatBN7.238,281,899 - 8,284,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,281,899 - 8,284,833 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,386,994 - 11,389,928 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,973,218 - 19,976,152 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,163,066 - 18,166,000 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,686,125 - 2,689,059 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,686,123 - 2,689,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,667,538 - 2,670,472 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,632,683 - 3,635,617 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,632,682 - 3,635,617 (-)NCBI
Celera33,107,001 - 3,109,935 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,5-hexanedione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-anilinonaphthalene-1-sulfonic acid  (ISO)
Acetyl tributyl citrate  (ISO)
acrylamide  (ISO)
acteoside  (ISO)
alachlor  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
amentoflavone  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antipyrine  (ISO)
aristolochic acid A  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
cantharidin  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
celecoxib  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
clozapine  (ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
DAUDA  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enniatin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fluoxetine  (EXP,ISO)
genistein  (ISO)
glucose  (ISO)
glycidol  (EXP)
hinokiflavone  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP,ISO)
lead(0)  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotinic acid  (ISO)
nitroglycerin  (EXP)
ochratoxin A  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
phencyclidine  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
prostaglandin H2  (EXP)
raloxifene  (ISO)
ricinoleic acid  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
WIN 55212-2  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Binding of biliverdin, bilirubin, and thyroid hormones to lipocalin-type prostaglandin D synthase. Beuckmann CT, etal., Biochemistry. 1999 Jun 22;38(25):8006-13.
2. Cellular localization of lipocalin-type prostaglandin D synthase (beta-trace) in the central nervous system of the adult rat. Beuckmann CT, etal., J Comp Neurol. 2000 Dec 4;428(1):62-78.
3. Lipocalin-type prostaglandin D synthase (beta-trace) is located in pigment epithelial cells of rat retina and accumulates within interphotoreceptor matrix. Beuckmann CT, etal., J Neurosci. 1996 Oct 1;16(19):6119-24.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Prostaglandin D synthase in microvessels from the rat cerebral cortex. Gerritsen ME and Printz MP, Prostaglandins 1981 Oct;22(4):553-66.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Prostanoids as regulators of innate and adaptive immunity. Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
8. Lipocalin-type prostaglandin d synthase in essential hypertension. Hirawa N, etal., Hypertension. 2002 Feb;39(2 Pt 2):449-54.
9. Structural organization of the gene for prostaglandin D synthase in the rat brain. Igarashi M, etal., Proc Natl Acad Sci U S A 1992 Jun 15;89(12):5376-80.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Differential gene expression in the rat skeletal and heart muscle in glucocorticoid-induced myopathy: analysis by microarray. Komamura K, etal., Cardiovasc Drugs Ther. 2003 Jul;17(4):303-10.
12. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Japanese hypertensive patients. Miwa Y, etal., Biochem Biophys Res Commun. 2004 Sep 17;322(2):428-33.
15. Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins. Nagata A, etal., Proc Natl Acad Sci U S A 1991 May 1;88(9):4020-4.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Urinary excretions of lipocalin-type prostaglandin D2 synthase predict the development of proteinuria and renal injury in OLETF rats. Ogawa M, etal., Nephrol Dial Transplant. 2006 Apr;21(4):924-34. Epub 2005 Dec 29.
18. Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep. Pinzar E, etal., Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4903-7.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Accelerated glucose intolerance, nephropathy, and atherosclerosis in prostaglandin D2 synthase knock-out mice. Ragolia L, etal., J Biol Chem. 2005 Aug 19;280(33):29946-55. Epub 2005 Jun 21.
22. Post-translational modification regulates prostaglandin D2 synthase apoptotic activity: characterization by site-directed mutagenesis. Ragolia L, etal., Prostaglandins Other Lipid Mediat. 2007 Feb;83(1-2):25-32. Epub 2006 Nov 7.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Long-lasting changes in the cochlear K recycling structures after acute energy failure. Takiguchi Y, etal., Neurosci Res. 2013 Jul 1. pii: S0168-0102(13)00159-4. doi: 10.1016/j.neures.2013.06.003.
26. Lipocalin-type prostaglandin D synthase (beta-trace) is a newly recognized type of retinoid transporter. Tanaka T, etal., J Biol Chem. 1997 Jun 20;272(25):15789-95.
27. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
28. Primary structure of rat brain prostaglandin D synthetase deduced from cDNA sequence. Urade Y, etal., J Biol Chem 1989 Jan 15;264(2):1041-5.
29. Structural and functional significance of cysteine residues of glutathione-independent prostaglandin D synthase. Identification of Cys65 as an essential thiol. Urade Y, etal., J Biol Chem. 1995 Jan 20;270(3):1422-8.
Additional References at PubMed
PMID:1723819   PMID:7692978   PMID:8216319   PMID:8415655   PMID:8599604   PMID:8922532   PMID:9065498   PMID:9430563   PMID:9582446   PMID:9746734   PMID:10650953   PMID:11068878  
PMID:11565799   PMID:12488457   PMID:16730417   PMID:17715133   PMID:17951541   PMID:18590794   PMID:18619553   PMID:19451694   PMID:19878301   PMID:20667974   PMID:21334429   PMID:23376485  
PMID:23533145   PMID:25142465   PMID:28025147   PMID:29287795   PMID:31708494  


Genomics

Comparative Map Data
Ptgds
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,680,044 - 28,682,978 (-)NCBIGRCr8
mRatBN7.238,281,899 - 8,284,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,281,899 - 8,284,833 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,386,994 - 11,389,928 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,973,218 - 19,976,152 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,163,066 - 18,166,000 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,686,125 - 2,689,059 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,686,123 - 2,689,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,667,538 - 2,670,472 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,632,683 - 3,635,617 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,632,682 - 3,635,617 (-)NCBI
Celera33,107,001 - 3,109,935 (-)NCBICelera
Cytogenetic Map3p13NCBI
PTGDS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,977,504 - 136,981,742 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,975,092 - 136,981,742 (+)EnsemblGRCh38hg38GRCh38
GRCh379139,871,956 - 139,876,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,991,777 - 138,996,015 (+)NCBINCBI36Build 36hg18NCBI36
Build 349137,147,792 - 137,152,030NCBI
Celera9110,384,087 - 110,388,329 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,331,058 - 109,335,300 (+)NCBIHuRef
CHM1_19140,020,562 - 140,024,952 (+)NCBICHM1_1
T2T-CHM13v2.09149,211,911 - 149,216,153 (+)NCBIT2T-CHM13v2.0
Ptgds
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,356,723 - 25,360,080 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,356,721 - 25,360,058 (-)EnsemblGRCm39 Ensembl
GRCm38225,466,709 - 25,470,110 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,466,709 - 25,470,046 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,322,232 - 25,325,269 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,288,721 - 25,291,740 (-)NCBIMGSCv36mm8
Celera225,194,223 - 25,197,258 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.28NCBI
Ptgds
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,009,625 - 5,012,781 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,009,530 - 5,012,781 (+)NCBIChiLan1.0ChiLan1.0
PTGDS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,417,107 - 2,421,310 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,419,441 - 2,423,510 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,037,994 - 108,042,136 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,006,601 - 137,010,582 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,006,601 - 137,009,680 (+)Ensemblpanpan1.1panPan2
PTGDS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,647,334 - 48,650,608 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,646,255 - 48,669,814 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,860,991 - 47,864,203 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,525,429 - 49,528,641 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,526,341 - 49,528,664 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,301,642 - 48,304,854 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,600,355 - 48,603,569 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,647,517 - 48,650,729 (-)NCBIUU_Cfam_GSD_1.0
Ptgds
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,410,468 - 202,413,812 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669961,034 - 965,136 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936669961,246 - 964,584 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGDS
(Sus scrofa - pig)
No map positions available.
PTGDS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,210,567 - 1,214,631 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,211,487 - 1,214,531 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,086,821 - 4,090,925 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgds
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760920,877 - 923,283 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760920,292 - 923,174 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptgds
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:93
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000020926
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat

Markers in Region
D3Arb28  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,286,133 - 8,286,419 (+)MAPPERmRatBN7.2
Rnor_6.032,690,360 - 2,690,645NCBIRnor6.0
Rnor_5.032,671,773 - 2,672,058UniSTSRnor5.0
RGSC_v3.433,636,917 - 3,637,203RGDRGSC3.4
RGSC_v3.433,636,918 - 3,637,203UniSTSRGSC3.4
RGSC_v3.133,636,917 - 3,637,203RGD
Celera33,111,236 - 3,111,521UniSTS
Cytogenetic Map3p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 13
Medium 11 39 19 19
Low 30 32 19 17 19 8 8 10 16 20 11 8
Below cutoff 2 2 14 12 2 12 3 2 2

Sequence


RefSeq Acc Id: ENSRNOT00000020926   ⟹   ENSRNOP00000020926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,281,899 - 8,284,833 (-)Ensembl
Rnor_6.0 Ensembl32,686,123 - 2,689,084 (-)Ensembl
RefSeq Acc Id: NM_013015   ⟹   NP_037147
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,680,044 - 28,682,978 (-)NCBI
mRatBN7.238,281,899 - 8,284,833 (-)NCBI
Rnor_6.032,686,125 - 2,689,059 (-)NCBI
Rnor_5.032,667,538 - 2,670,472 (-)NCBI
RGSC_v3.433,632,683 - 3,635,617 (-)RGD
Celera33,107,001 - 3,109,935 (-)RGD
Sequence:
RefSeq Acc Id: NP_037147   ⟸   NM_013015
- Peptide Label: precursor
- UniProtKB: P22057 (UniProtKB/Swiss-Prot),   A6JT70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020926   ⟸   ENSRNOT00000020926
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22057-F1-model_v2 AlphaFold P22057 1-189 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691882
Promoter ID:EPDNEW_R2405
Type:single initiation site
Name:Ptgds_1
Description:prostaglandin D2 synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,689,098 - 2,689,158EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3433 AgrOrtholog
BioCyc Gene G2FUF-50450 BioCyc
BioCyc Pathway PWY66-374 [C20 prostanoid biosynthesis] BioCyc
BioCyc Pathway Image PWY66-374 BioCyc
Ensembl Genes ENSRNOG00000015550 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055000514 UniProtKB/Swiss-Prot
  ENSRNOG00060026230 UniProtKB/Swiss-Prot
  ENSRNOG00065025596 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020926 ENTREZGENE
  ENSRNOT00000020926.6 UniProtKB/Swiss-Prot
  ENSRNOT00055000890 UniProtKB/Swiss-Prot
  ENSRNOT00060045439 UniProtKB/Swiss-Prot
  ENSRNOT00065044097 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25526 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25526 ENTREZGENE
PANTHER LIPOCALIN UniProtKB/TrEMBL
  PROSTAGLANDIN-H2 D-ISOMERASE UniProtKB/TrEMBL
  PTHR11430 UniProtKB/Swiss-Prot
  PTHR11430:SF86 UniProtKB/Swiss-Prot
Pfam Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PTGDS RGD
PhenoGen Ptgds PhenoGen
PRINTS LIPOCALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGNDSYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOCALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015550 RatGTEx
  ENSRNOG00055000514 RatGTEx
  ENSRNOG00060026230 RatGTEx
  ENSRNOG00065025596 RatGTEx
Superfamily-SCOP Lipocalins UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC205197
UniProt A6JT70 ENTREZGENE, UniProtKB/TrEMBL
  A6JT72_RAT UniProtKB/TrEMBL
  P22057 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Ptgds  prostaglandin D2 synthase  Ptgds  prostaglandin D2 synthase (brain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Ptgds  prostaglandin D2 synthase (brain)  Ptgds  prostaglandin D2 synthase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-06-26 Ptgds  prostaglandin D2 synthase  Ptgds  prostaglandin D2 synthase (brain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Ptgds  prostaglandin D2 synthase (brain)  Ptgds  prostaglandin D2 synthase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ptgds  Prostaglandin D synthase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to the cytosol 1358962
gene_process may mediate maturation and maintenance of central nervous system 729601