RGD Reference Report - Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Japanese hypertensive patients.

General

Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Japanese hypertensive patients.
Authors:	Miwa, Y Takiuchi, S Kamide, K Yoshii, M Horio, T Tanaka, C Banno, M Miyata, T Sasaguri, T Kawano, Y
Citation:	Miwa Y, etal., Biochem Biophys Res Commun. 2004 Sep 17;322(2):428-33.
RGD ID:	1642582
Pubmed:	PMID:15325247 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.bbrc.2004.07.143 (Journal Full-text)
Recent reports suggested that lipocalin-type prostaglandin D synthase (L-PGDS) is implicated in atherogenesis. In the present study, we investigated the polymorphism of the L-PGDS gene and examined its relationship with the severity of carotid atherosclerosis which is determined as the maximum intima-media thickness in the common carotid artery (C-IMT(max)). We identified 6 single nucleotide polymorphisms (SNPs) of the L-PGDS gene in Japanese. A rare SNP with an amino acid change (1535C>G in exon 4, Leu79Val) and a common SNP (4111 A>C in 3'-untranslated region) were selected for genotyping in 782 Japanese hypertensive subjects. There was no significant difference among genotypes in 1535C>G, however, in 4111 A>C, serum levels of high-density lipoprotein (HDL) cholesterol were significantly higher in subjects with A/A genotype than those with A/C and C/C genotypes. C-IMT(max) was significantly smaller in subjects with A/A genotype than those with A/C and C/C. Logistic regression analysis revealed that the presence of A/A genotype significantly reduced the risk for increased C-IMT(max), even after adjustment for other known risk factors [adjusted odds ratio: 0.71 (95% CI: 0.58-0.88)]. Our results suggested that 4111 A>C polymorphism in the L-PGDS gene contributes to the development of carotid atherosclerosis in Japanese hypertensive patients.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
carotid artery disease	susceptibility	IAGP		1642582	associated with Hypertension and DNA:polymorphism:3'utr:4111A>C	RGD
carotid artery disease	susceptibility	ISO	PTGDS (Homo sapiens)	1642582; 1642582	associated with Hypertension and DNA:polymorphism:3'utr:4111A>C	RGD

Objects Annotated

Genes (Rattus norvegicus)

Ptgds (prostaglandin D2 synthase)

Genes (Mus musculus)

Ptgds (prostaglandin D2 synthase (brain))

Genes (Homo sapiens)

PTGDS (prostaglandin D2 synthase)

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Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Japanese hypertensive patients.