PTGDS (prostaglandin D2 synthase)

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Gene: PTGDS (prostaglandin D2 synthase) Sus scrofa

Analyze

Symbol:

PTGDS

Name:

prostaglandin D2 synthase

RGD ID:

14243220

Description:

ENCODES a protein that exhibits fatty acid binding (ortholog); prostaglandin-D synthase activity (ortholog); retinoid binding (ortholog); INVOLVED IN gene expression (ortholog); negative regulation of male germ cell proliferation (ortholog); prostaglandin biosynthetic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); arteriosclerosis (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog); INTERACTS WITH deoxynivalenol

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin-D synthase; PGD2 synthase; PGDS; PGDS2; prostaglandin D synthase; prostaglandin-H2 D-isomerase

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PTGDS (prostaglandin D2 synthase)	HGNC	Ensembl, Inparanoid, NCBI, OrthoDB, Panther
Mus musculus (house mouse):	Ptgds (prostaglandin D2 synthase (brain))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ptgds (prostaglandin D2 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ptgds (prostaglandin D2 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PTGDS (prostaglandin D2 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PTGDS (prostaglandin D2 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ptgds (prostaglandin D2 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PTGDS (prostaglandin D2 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ptgds (prostaglandin D2 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adams-Oliver Syndrome 5 (ISO)

arteriosclerosis (ISO)

autosomal dominant intellectual developmental disorder 8 (ISO)

autosomal dominant nocturnal frontal lobe epilepsy 5 (ISO)

carotid artery disease (ISO)

developmental and epileptic encephalopathy 14 (ISO)

Diabetic Nephropathies (ISO)

epilepsy (ISO)

hypertension (ISO)

Immunodeficiency 103 (ISO)

Insulin Resistance (ISO)

Joubert syndrome (ISO)

Kleefstra syndrome 1 (ISO)

Leigh disease (ISO)

nephrosclerosis (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Rafiq syndrome (ISO)

sensorineural hearing loss (ISO)

tuberous sclerosis 1 (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

deoxynivalenol (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid biosynthetic process (IEA)

fatty acid metabolic process (IEA)

gene expression (ISO)

lipid metabolic process (IEA)

mast cell degranulation (IEA)

negative regulation of male germ cell proliferation (ISO)

prostaglandin biosynthetic process (IEA,ISS)

prostaglandin metabolic process (IEA)

regulation of circadian sleep/wake cycle, sleep (ISS)

response to glucocorticoid (ISO)

Cellular Component

cytoplasm (IEA)

endoplasmic reticulum (IEA)

extracellular region (IEA,ISS)

extracellular space (IBA,ISO)

Golgi apparatus (IEA)

Golgi apparatus (ISS)

membrane (IEA)

nuclear membrane (IEA)

nucleus (IEA)

perinuclear region of cytoplasm (IEA)

rough endoplasmic reticulum (IEA)

rough endoplasmic reticulum (IEA,ISS)

rough endoplasmic reticulum (ISS)

Molecular Function

fatty acid binding (ISO)

isomerase activity (IEA)

prostaglandin-D synthase activity (IEA,ISS)

protein binding (ISO)

retinoid binding (ISS)

small molecule binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylsalicylic acid pharmacodynamics pathway (ISO)

antipyrine drug pathway (ISO)

arachidonic acid metabolic pathway (ISO)

celecoxib pharmacodynamics pathway (ISO)

diclofenac pharmacodynamics pathway (ISO)

diflunisal pharmacodynamics pathway (ISO)

etodolac pharmacodynamics pathway (ISO)

fenoprofen pharmacodynamics pathway (ISO)

flurbiprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

indometacin pharmacodynamics pathway (ISO)

ketoprofen pharmacodynamics pathway (ISO)

ketorolac pharmacodynamics pathway (ISO)

leukotriene C4 synthase deficiency pathway (ISO)

lornoxicam pharmacodynamics pathway (ISO)

magnesium salicylate pharmacodynamics pathway (ISO)

mefenamic acid pharmacodynamics pathway (ISO)

meloxicam pharmacodynamics pathway (ISO)

nabumetone pharmacodynamics pathway (ISO)

naproxen pharmacodynamics pathway (ISO)

paracetamol drug pathway (ISO)

piroxicam pharmacodynamics pathway (ISO)

prostaglandin biosynthetic pathway (ISO)

salicylic acid pharmacodynamics pathway (ISO)

sodium salicylate pharmacodynamics pathway (ISO)

sulindac pharmacodynamics pathway (ISO)

tenoxicam pharmacodynamics pathway (ISO)

tiaprofenic acid pharmacodynamics pathway (ISO)

tolmetin pharmacodynamics pathway (ISO)

valdecoxib pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:8761996	PMID:8908190	PMID:14681463	PMID:17145712

Genomics

Comparative Map Data

PTGDS
(Sus scrofa - pig)

No map positions available.

PTGDS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	136,977,504 - 136,981,742 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	9	136,975,092 - 136,981,742 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	139,871,956 - 139,876,194 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	138,991,777 - 138,996,015 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	137,147,792 - 137,152,030	NCBI
Celera	9	110,384,087 - 110,388,329 (+)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	109,331,058 - 109,335,300 (+)	NCBI		HuRef
CHM1_1	9	140,020,562 - 140,024,952 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	149,211,911 - 149,216,153 (+)	NCBI		T2T-CHM13v2.0

Ptgds
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	25,356,721 - 25,360,141 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	25,356,721 - 25,360,058 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	25,466,709 - 25,470,110 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	25,466,709 - 25,470,046 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	25,322,232 - 25,325,269 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	25,288,721 - 25,291,740 (-)	NCBI		MGSCv36	mm8
Celera	2	25,194,223 - 25,197,258 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	17.28	NCBI

Ptgds
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	8,281,899 - 8,284,833 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,281,899 - 8,284,833 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,386,994 - 11,389,928 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	19,973,218 - 19,976,152 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	18,163,066 - 18,166,000 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	2,686,125 - 2,689,059 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,686,123 - 2,689,084 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,667,538 - 2,670,472 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,632,683 - 3,635,617 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,632,682 - 3,635,617 (-)	NCBI
Celera	3	3,107,001 - 3,109,935 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

Ptgds
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	5,009,625 - 5,012,781 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	5,009,530 - 5,012,781 (+)	NCBI	ChiLan1.0	ChiLan1.0

PTGDS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	9	137,006,601 - 137,010,582 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	137,006,601 - 137,009,680 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	9	108,037,994 - 108,042,136 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

PTGDS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	48,647,334 - 48,650,608 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	48,646,255 - 48,669,814 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	47,860,991 - 47,864,203 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,525,429 - 49,528,641 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	49,526,341 - 49,528,664 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	48,301,642 - 48,304,854 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	48,600,355 - 48,603,569 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	48,647,517 - 48,650,729 (-)	NCBI		UU_Cfam_GSD_1.0

Ptgds
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	202,410,468 - 202,413,812 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	961,034 - 965,136 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936669	961,246 - 964,584 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTGDS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	1,210,567 - 1,214,631 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	1,211,487 - 1,214,531 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	4,086,821 - 4,090,925 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ptgds
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	920,877 - 923,283 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	920,292 - 923,174 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	endocrine system	hemolymphoid system	nervous system	reproductive system
High
Medium
Low	1			16	1
Below cutoff	1	3	2	7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_214228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB115763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AEMK02000682	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK392469	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01082889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X92979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Protein Sequences


Protein RefSeqs	NP_999393	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAC99052	(Get FASTA)	NCBI Sequence Viewer
	CAA63556	(Get FASTA)	NCBI Sequence Viewer
	Q29095	(Get FASTA)	NCBI Sequence Viewer

Additional Information

External Database Links

Database	Acc Id	Source(s)
Gene3D-CATH	2.40.128.20	UniProtKB/Swiss-Prot
InterPro	Calycin	UniProtKB/Swiss-Prot
	Lipocalin	UniProtKB/Swiss-Prot
	Lipocln_cytosolic_FA-bd_dom	UniProtKB/Swiss-Prot
KEGG Report	ssc:397456	UniProtKB/Swiss-Prot
NCBI Gene	PTGDS	ENTREZGENE
PANTHER	PTHR11430	UniProtKB/Swiss-Prot
	PTHR11430:SF86	UniProtKB/Swiss-Prot
Pfam	Lipocalin	UniProtKB/Swiss-Prot
PRINTS	LIPOCALIN	UniProtKB/Swiss-Prot
	PGNDSYNTHASE	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50814	UniProtKB/Swiss-Prot
UniProt	PTGDS_PIG	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

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Imported Annotations - SMPDB