Thbs2 (thrombospondin 2) - Rat Genome Database

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Gene: Thbs2 (thrombospondin 2) Rattus norvegicus
Analyze
Symbol: Thbs2
Name: thrombospondin 2
RGD ID: 1310979
Description: Predicted to enable calcium ion binding activity and heparin binding activity. Involved in negative regulation of angiogenesis and positive regulation of synapse assembly. Predicted to be located in basement membrane and platelet alpha granule. Predicted to be active in collagen-containing extracellular matrix. Orthologous to human THBS2 (thrombospondin 2); PARTICIPATES IN cell-extracellular matrix signaling pathway; malaria pathway; phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: thrombospondin-2; TSP-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2155,670,394 - 55,699,789 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl155,670,394 - 55,699,789 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx160,536,594 - 60,566,100 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0169,193,840 - 69,223,143 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0162,446,539 - 62,476,051 (-)NCBIRnor_WKY
Rnor_6.0156,653,929 - 56,683,571 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl156,653,938 - 56,683,731 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0157,842,346 - 57,871,988 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,584,406 - 53,613,652 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera151,888,359 - 51,917,750 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
barium sulfate  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
Cuprizon  (EXP)
D-glucose  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diethyl malate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
hexaconazole  (ISO)
ifosfamide  (ISO)
irinotecan  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
methylmercury chloride  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
panobinostat  (ISO)
paracetamol  (EXP)
pentane-2,3-dione  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
streptozocin  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction. Boekholdt SM, etal., Arterioscler Thromb Vasc Biol. 2002 Dec 1;22(12):e24-7.
2. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Christopherson KS, etal., Cell. 2005 Feb 11;120(3):421-33.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Differential regulation of thrombospondin-1 and thrombospondin-2 after focal cerebral ischemia/reperfusion. Lin TN, etal., Stroke. 2003 Jan;34(1):177-86.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Control of in vivo microvessel ingrowth by modulation of biomaterial local architecture and chemistry. Sanders JE, etal., J Biomed Mater Res. 2002 Apr;60(1):36-43.
13. Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. Schroen B, etal., Circ Res. 2004 Sep 3;95(5):515-22. Epub 2004 Jul 29.
14. Alteration of thrombospondin-1 and -2 in rat brains following experimental intracerebral hemorrhage. Zhou HJ, etal., J Neurosurg. 2010 Feb 5.
Additional References at PubMed
PMID:1737102   PMID:8889548   PMID:10669089   PMID:15748999   PMID:19189070   PMID:19571575   PMID:20714802   PMID:21124846   PMID:23043906   PMID:23541831   PMID:24006456   PMID:27068509  
PMID:28953973   PMID:31904090  


Genomics

Comparative Map Data
Thbs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2155,670,394 - 55,699,789 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl155,670,394 - 55,699,789 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx160,536,594 - 60,566,100 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0169,193,840 - 69,223,143 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0162,446,539 - 62,476,051 (-)NCBIRnor_WKY
Rnor_6.0156,653,929 - 56,683,571 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl156,653,938 - 56,683,731 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0157,842,346 - 57,871,988 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,584,406 - 53,613,652 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera151,888,359 - 51,917,750 (-)NCBICelera
Cytogenetic Map1q12NCBI
THBS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386169,215,785 - 169,253,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6169,215,780 - 169,254,050 (-)EnsemblGRCh38hg38GRCh38
GRCh376169,615,880 - 169,653,941 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366169,357,800 - 169,396,062 (-)NCBINCBI36Build 36hg18NCBI36
Build 346169,433,507 - 169,471,769NCBI
Celera6170,328,643 - 170,365,927 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6167,041,671 - 167,078,465 (-)NCBIHuRef
CHM1_16169,878,047 - 169,916,199 (-)NCBICHM1_1
T2T-CHM13v2.06170,567,396 - 170,606,595 (-)NCBIT2T-CHM13v2.0
Thbs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391714,885,762 - 14,914,524 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1714,885,762 - 14,914,497 (-)EnsemblGRCm39 Ensembl
GRCm381714,665,500 - 14,694,262 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1714,665,500 - 14,694,235 (-)EnsemblGRCm38mm10GRCm38
MGSCv371714,802,507 - 14,831,269 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361714,403,747 - 14,430,687 (-)NCBIMGSCv36mm8
Celera1715,465,975 - 15,494,741 (-)NCBICelera
Cytogenetic Map17A2NCBI
cM Map178.95NCBI
Thbs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554114,314,984 - 4,347,383 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554114,315,055 - 4,347,044 (+)NCBIChiLan1.0ChiLan1.0
THBS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16172,131,476 - 172,169,026 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6172,130,727 - 172,169,028 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06167,290,482 - 167,329,319 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
THBS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,402,519 - 56,429,975 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,402,524 - 56,451,892 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha157,194,281 - 57,221,451 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0156,586,312 - 56,613,645 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl156,584,696 - 56,613,622 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1156,481,253 - 56,508,431 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,328,999 - 56,356,324 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0156,956,445 - 56,983,636 (-)NCBIUU_Cfam_GSD_1.0
Thbs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946150,622,058 - 150,655,464 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648917,874,064 - 17,907,255 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THBS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1855,389 - 882,473 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11854,473 - 882,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.211,590,783 - 1,617,082 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THBS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11397,033,791 - 97,066,274 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604068,988,667 - 69,052,256 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thbs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248505,071,512 - 5,105,074 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248505,072,070 - 5,104,865 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Thbs2
251 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:179
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000014552
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 32 5 5 4 5 6 6 20 21 4 6
Low 3 7 47 31 15 31 2 5 74 15 16 7 2
Below cutoff 4 5 5 5 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014552   ⟹   ENSRNOP00000014552
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl155,670,394 - 55,699,789 (-)Ensembl
Rnor_6.0 Ensembl156,653,938 - 56,683,731 (-)Ensembl
RefSeq Acc Id: NM_001169138   ⟹   NP_001162609
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2155,670,394 - 55,699,789 (-)NCBI
Rnor_6.0156,653,929 - 56,683,571 (-)NCBI
Rnor_5.0157,842,346 - 57,871,988 (-)NCBI
RGSC_v3.4153,584,406 - 53,613,652 (-)RGD
Celera151,888,359 - 51,917,750 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001162609 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001162609   ⟸   NM_001169138
- Peptide Label: precursor
- UniProtKB: D4A2G6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014552   ⟸   ENSRNOT00000014552
Protein Domains
EGF-like   TSP C-terminal   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2G6-F1-model_v2 AlphaFold D4A2G6 1-1172 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689637
Promoter ID:EPDNEW_R162
Type:single initiation site
Name:Thbs2_1
Description:thrombospondin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0156,683,567 - 56,683,627EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310979 AgrOrtholog
BioCyc Gene G2FUF-61335 BioCyc
Ensembl Genes ENSRNOG00000010529 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014552 ENTREZGENE
  ENSRNOP00000014552.6 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014552 ENTREZGENE
  ENSRNOT00000014552.8 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  4.10.1080.10 UniProtKB/TrEMBL
InterPro ConA-like_subgrp UniProtKB/TrEMBL
  EGF-like_Ca-bd UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_dom_MSP1-like UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
  Thrombospondin_1_rpt UniProtKB/TrEMBL
  Thrombospondin_2 UniProtKB/TrEMBL
  Thrombospondin_3-like_rpt UniProtKB/TrEMBL
  Thrombospondin_3_rpt UniProtKB/TrEMBL
  Thrombospondin_C UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
  TSP_type-3_rpt UniProtKB/TrEMBL
  VWF_C UniProtKB/TrEMBL
KEGG Report rno:292406 UniProtKB/TrEMBL
NCBI Gene 292406 ENTREZGENE
PANTHER PTHR10199:SF10 UniProtKB/TrEMBL
Pfam EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
  TSP_3 UniProtKB/TrEMBL
  TSP_C UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
PhenoGen Thbs2 PhenoGen
PROSITE EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  TSP3 UniProtKB/TrEMBL
  TSP_CTER UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  TSPN UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  SSF103647 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
UniProt D4A2G6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Thbs2  thrombospondin 2  Thbs2_predicted  thrombospondin 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Thbs2_predicted  thrombospondin 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED