Ugt2b7 (UDP glucuronosyltransferase family 2 member B7) - Rat Genome Database

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Gene: Ugt2b7 (UDP glucuronosyltransferase family 2 member B7) Rattus norvegicus
Analyze
Symbol: Ugt2b7
Name: UDP glucuronosyltransferase family 2 member B7
RGD ID: 708417
Description: Predicted to enable glucuronosyltransferase activity. Predicted to be involved in androgen metabolic process; cellular glucuronidation; and estrogen metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human UGT2B7 (UDP glucuronosyltransferase family 2 member B7); PARTICIPATES IN artemether pharmacokinetics pathway; codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC286989; UDP glucuronosyltransferase 2 family, polypeptide B7; UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 2B7; UDP-glucuronosyltransferase 2B8; UDPGT 2B7; UDPGT 2B8; UGT2B-RH4; Ugt2b8
RGD Orthologs
Human
Mouse
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21420,896,682 - 20,919,604 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,896,682 - 20,919,604 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1421,234,855 - 21,257,777 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01422,553,786 - 22,576,709 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01421,084,881 - 21,107,803 (+)NCBIRnor_WKY
Rnor_6.01422,597,103 - 22,619,968 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01422,498,982 - 22,521,751 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41422,499,152 - 22,522,842 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11422,499,151 - 22,522,842 (+)NCBI
Celera1420,401,346 - 20,422,368 (+)NCBICelera
Cytogenetic Map14p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-isoborneol  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-indene  (ISO)
1H-pyrazole  (ISO)
2,2-Bis(bromomethyl)propane-1,3-diol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-tert-butylhydroquinone  (ISO)
20-HETE  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one  (ISO)
4-hydroxy-3-[1-(4-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one  (ISO)
4-hydroxyestrone  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylumbelliferone  (ISO)
4-methylumbelliferone beta-D-glucuronide  (ISO)
4-tert-Octylphenol  (ISO)
7-Hydroxywarfarin  (ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (EXP,ISO)
alclofenac  (ISO)
aldosterone  (ISO)
Aldosterone 18-glucuronide  (ISO)
aminoguanidine  (ISO)
ammonium chloride  (EXP)
amobarbital  (ISO)
androsterone  (ISO)
arachidonic acid  (ISO)
aristolochic acid  (EXP,ISO)
Aroclor 1254  (ISO)
belinostat  (ISO)
benoxaprofen  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (ISO)
bisphenol A  (EXP,ISO)
bromfenac  (ISO)
buta-1,3-diene  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calycosin  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
denopamine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenzo[a,l]pyrene  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
diflunisal  (ISO)
disodium selenite  (ISO)
emodin  (EXP,ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
erythrosin B  (ISO)
estriol  (ISO)
estrone  (ISO)
etodolac  (ISO)
ezetimibe  (ISO)
farnesol  (ISO)
fenoprofen  (ISO)
fluconazole  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
furan  (EXP)
galangin  (ISO)
glabridin  (ISO)
hyodeoxycholic acid  (ISO)
ibuprofen  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
kaempferol  (ISO)
ketoprofen  (ISO)
ketorolac  (ISO)
labetalol  (ISO)
Licochalcone A  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lorcaserin  (ISO)
mangiferin  (ISO)
meclofenamic acid  (ISO)
mefenamic acid  (ISO)
mercury dichloride  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (ISO)
morphine  (ISO)
myricetin  (ISO)
N-nitrosodiethylamine  (EXP)
naloxone  (ISO)
naproxen  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oltipraz  (ISO)
osimertinib  (ISO)
oxazepam  (ISO)
Oxazepam glucuronide  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pirprofen  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (ISO)
propanal  (ISO)
propiconazole  (ISO)
prostaglandin B1  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sertraline  (ISO)
Shikonin  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulindac  (ISO)
sulindac sulfone  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
tiaprofenic acid  (ISO)
titanium dioxide  (ISO)
topiramate  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
UDP-alpha-D-glucuronic acid  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
warfarin  (ISO)
zidovudine  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:17442341   PMID:18052087   PMID:20056724   PMID:20308471   PMID:22028316   PMID:22579593   PMID:23376485   PMID:28770824   PMID:30347696  


Genomics

Comparative Map Data
Ugt2b7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21420,896,682 - 20,919,604 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,896,682 - 20,919,604 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1421,234,855 - 21,257,777 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01422,553,786 - 22,576,709 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01421,084,881 - 21,107,803 (+)NCBIRnor_WKY
Rnor_6.01422,597,103 - 22,619,968 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01422,498,982 - 22,521,751 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41422,499,152 - 22,522,842 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11422,499,151 - 22,522,842 (+)NCBI
Celera1420,401,346 - 20,422,368 (+)NCBICelera
Cytogenetic Map14p21NCBI
UGT2B7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38469,051,375 - 69,112,987 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl469,051,363 - 69,112,987 (+)EnsemblGRCh38hg38GRCh38
GRCh37469,917,093 - 69,978,705 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36469,996,814 - 70,013,293 (+)NCBINCBI36Build 36hg18NCBI36
Build 34470,142,984 - 70,159,464NCBI
Celera467,303,842 - 67,320,327 (+)NCBICelera
Cytogenetic Map4q13.2NCBI
HuRef465,757,832 - 65,774,338 (+)NCBIHuRef
CHM1_1469,998,516 - 70,014,999 (+)NCBICHM1_1
T2T-CHM13v2.0472,492,136 - 72,553,482 (+)NCBIT2T-CHM13v2.0
Ugt2b34
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39587,037,629 - 87,054,796 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl587,037,626 - 87,054,796 (-)EnsemblGRCm39 Ensembl
GRCm38586,889,770 - 86,906,937 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl586,889,767 - 86,906,937 (-)EnsemblGRCm38mm10GRCm38
MGSCv37587,318,795 - 87,335,962 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36587,964,331 - 87,981,498 (-)NCBIMGSCv36mm8
Celera584,109,778 - 84,126,936 (-)NCBICelera
Cytogenetic Map5E1NCBI
LOC100623255
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1865,915,718 - 65,936,113 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2870,337,489 - 70,357,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Ugt2b7
312 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:104
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000002716
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000048482   ⟹   ENSRNOP00000050445
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1420,896,682 - 20,919,604 (+)Ensembl
RefSeq Acc Id: NM_173323   ⟹   NP_775445
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21420,896,682 - 20,919,604 (+)NCBI
Rnor_6.01422,597,103 - 22,619,968 (+)NCBI
Rnor_5.01422,498,982 - 22,521,751 (+)NCBI
RGSC_v3.41422,499,152 - 22,522,842 (+)RGD
Celera1420,401,346 - 20,422,368 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_775445 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA86833 (Get FASTA)   NCBI Sequence Viewer  
  Q62789 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_775445   ⟸   NM_173323
- Peptide Label: precursor
- UniProtKB: F1LLV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050445   ⟸   ENSRNOT00000048482
Protein Domains
UDPGT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62789-F1-model_v2 AlphaFold Q62789 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708417 AgrOrtholog
BioCyc Gene G2FUF-16099 BioCyc
Ensembl Genes ENSRNOG00000070682 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000050445 ENTREZGENE
  ENSRNOP00000050445.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048482 ENTREZGENE
  ENSRNOT00000048482.5 UniProtKB/TrEMBL
InterPro UDP_glucos_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:286989 UniProtKB/Swiss-Prot
NCBI Gene 286989 ENTREZGENE
Pfam UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB UGT2B7 RGD
PhenoGen Ugt2b7 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LLV5 ENTREZGENE, UniProtKB/TrEMBL
  Q62789 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ugt2b7  UDP glucuronosyltransferase family 2 member B7  Ugt2b7  UDP glucuronosyltransferase 2 family, polypeptide B7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-03-12 Ugt2b7  UDP glucuronosyltransferase 2 family, polypeptide B7  LOC286989  UDP-glucuronosyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-28 LOC286989        Symbol and Name status set to provisional 70820 PROVISIONAL