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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708417
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt2b7
Name: UDP glucuronosyltransferase family 2 member B7
Acc ID: CHEBI:5855
Term: ibuprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Chemical ID: MESH:D007052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt2b7increases expressionISOUgt2b34 (Mus musculus)6480464CTDIbuprofen results in increased expression of UGT2B34 mRNAPMID:29222744
Ugt2b7increases glucuronidationISOUGT2B7 (Homo sapiens)6480464CTDUGT2B7 protein alternative form results in increased glucuronidation of Ibuprofen; UGT2B7 protein results in increased glucuronidation of IbuprofenPMID:15843492 PMID:8423545 PMID:8517101
Ugt2b7multiple interactionsISOUGT2B7 (Homo sapiens)6480464CTDIbuprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ibuprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]PMID:19740398
Ugt2b7multiple interactionsISOUgt2b34 (Mus musculus)6480464CTD[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT2B34 mRNAPMID:29222744
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