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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708417
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt2b7
Name: UDP glucuronosyltransferase family 2 member B7
Acc ID: CHEBI:76114
Term: benoxaprofen
Definition: A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals.
Chemical ID: MESH:C011677
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt2b7affects response to substanceISOUGT2B7 (Homo sapiens)6480464CTDUGT2B7 affects the susceptibility to benoxaprofenPMID:17880178
Ugt2b7increases glucuronidationISOUGT2B7 (Homo sapiens)6480464CTDUGT2B7 protein alternative form results in increased glucuronidation of benoxaprofenPMID:8423545
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