UGT2B15 (UDP glucuronosyltransferase family 2 member B15) - Rat Genome Database
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Gene: UGT2B15 (UDP glucuronosyltransferase family 2 member B15) Homo sapiens
Analyze
Symbol: UGT2B15
Name: UDP glucuronosyltransferase family 2 member B15
RGD ID: 1343349
HGNC Page HGNC
Description: Exhibits glucuronosyltransferase activity. Involved in cellular glucuronidation. Predicted to localize to intracellular membrane-bounded organelle.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HLUG4; UDP glucuronosyltransferase 2 family, member 15; UDP glucuronosyltransferase 2 family, member B8; UDP glucuronosyltransferase 2 family, polypeptide B15; udp glycosyltransferase 2 family, polypeptide b15; UDP glycosyltransferase 2B15; UDP gycosyltransferase 2 family, member B15; UDP-glucuronosyltransferase 2B15; UDP-glucuronosyltransferase 2B8; UDP-glucuronosyltransferase UGT2B15; UDP-glucuronyltransferase, family 2, beta-15; UDPGT 2B15; UDPGT 2B8; UDPGT2B15; UDPGTh-3; UDPGTH3; UGT2B8; uridine diphosphate glucuronosyltransferase 2 family, member B8; uridine diphosphate glycosyltransferase 2 family, member B15
RGD Orthologs
Pig
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC728807   LOC728811  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl468,646,597 - 68,670,652 (-)EnsemblGRCh38hg38GRCh38
GRCh38468,646,597 - 68,670,652 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37469,512,315 - 69,536,494 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36469,546,932 - 69,571,114 (-)NCBINCBI36hg18NCBI36
Build 34469,693,144 - 69,717,122NCBI
Celera466,854,004 - 66,878,059 (-)NCBI
Cytogenetic Map4q13.2NCBI
HuRef465,308,273 - 65,332,364 (-)NCBIHuRef
CHM1_1469,549,031 - 69,573,207 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-naringenin  (EXP)
1-naphthol  (EXP)
16alpha-hydroxytestosterone  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-hydroxyestrone  (EXP)
2-naphthol  (EXP)
4-hydroxy-17beta-estradiol  (EXP)
4-hydroxyestrone  (EXP)
4-hydroxyphenytoin  (EXP)
4-methylumbelliferone  (EXP)
4-methylumbelliferone beta-D-glucuronide  (EXP)
4-nitrophenol  (EXP)
4-tert-Octylphenol  (EXP)
7-hydroxycoumarin O(7)-glucosiduronic acid  (EXP)
7-hydroxyflavone  (EXP)
aflatoxin B1  (EXP)
aflatoxin M1  (EXP)
alizarin  (EXP)
amobarbital  (EXP)
androstane  (EXP)
androstane-3,17-diol  (EXP)
anthraflavic acid  (EXP)
apigenin  (EXP)
Aroclor 1254  (EXP)
atrazine  (EXP)
baicalein  (EXP)
benzo[a]pyrene  (EXP)
beta-naphthoflavone  (EXP)
bilirubin IXalpha  (EXP)
biphenyl-4-ol  (EXP)
bisphenol A  (EXP)
bucladesine  (EXP)
butanal  (EXP)
Butylparaben  (EXP)
calcitriol  (EXP)
carbamazepine  (EXP)
carvacrol  (EXP)
chrysin  (EXP)
coumestrol  (EXP)
cycloheximide  (EXP)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
diclofenac  (EXP)
dienestrol  (EXP)
emodin  (EXP)
equol  (EXP)
esculetin  (EXP)
estriol  (EXP)
eugenol  (EXP)
ezetimibe  (EXP)
flunitrazepam  (EXP)
fluorescein  (EXP)
formaldehyde  (EXP)
fulvestrant  (EXP)
galangin  (EXP)
genistein  (EXP)
glabridin  (EXP)
ibuprofen  (EXP)
L-ascorbic acid  (EXP)
lorcaserin  (EXP)
medroxyprogesterone acetate  (EXP)
methoxychlor  (EXP)
N-Nitrosopyrrolidine  (EXP)
O-methyleugenol  (EXP)
obeticholic acid  (EXP)
oxazepam  (EXP)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP)
perfluorononanoic acid  (EXP)
phenobarbital  (EXP)
phenol red  (EXP)
phenolphthalein  (EXP)
pterostilbene  (EXP)
quercetin  (EXP)
quinolin-6-ol  (EXP)
quinolin-8-ol  (EXP)
resveratrol  (EXP)
SCH 23390  (EXP)
scopoletin  (EXP)
silibinin  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
testosterone  (EXP)
testosterone 17-glucosiduronic acid  (EXP)
theophylline  (EXP)
umbelliferone  (EXP)
valproic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:2116769   PMID:3100939   PMID:7574722   PMID:7835232   PMID:7835904   PMID:8399210   PMID:9202245   PMID:9295060   PMID:10024527   PMID:10468930   PMID:10748067   PMID:11129427  
PMID:12010866   PMID:12376738   PMID:12386133   PMID:12477932   PMID:12646996   PMID:12695355   PMID:12880121   PMID:15044558   PMID:15065092   PMID:15126881   PMID:15318931   PMID:15618667  
PMID:15666817   PMID:15815621   PMID:15952058   PMID:15961980   PMID:16344560   PMID:16513443   PMID:16690804   PMID:16859836   PMID:17244352   PMID:17507624   PMID:17576806   PMID:17687269  
PMID:17698910   PMID:17848572   PMID:17988216   PMID:18161889   PMID:18281521   PMID:18302198   PMID:18496127   PMID:18719240   PMID:19343046   PMID:19487245   PMID:19572376   PMID:19847790  
PMID:19898482   PMID:19916996   PMID:19956635   PMID:20056724   PMID:20142249   PMID:20308471   PMID:20736324   PMID:21365123   PMID:21404072   PMID:21666065   PMID:21873635   PMID:22170718  
PMID:22532564   PMID:22579593   PMID:22829776   PMID:22960998   PMID:23223495   PMID:23404680   PMID:23951298   PMID:24121496   PMID:24214217   PMID:24267955   PMID:24822274   PMID:24980262  
PMID:25795461   PMID:26163549   PMID:26176234   PMID:26238215   PMID:26385605   PMID:27098059   PMID:27383482   PMID:27496708   PMID:27622723   PMID:28514442   PMID:28882566   PMID:28962835  
PMID:29367276   PMID:30066917   PMID:32176075  


Genomics

Comparative Map Data
UGT2B15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl468,646,597 - 68,670,652 (-)EnsemblGRCh38hg38GRCh38
GRCh38468,646,597 - 68,670,652 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37469,512,315 - 69,536,494 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36469,546,932 - 69,571,114 (-)NCBINCBI36hg18NCBI36
Build 34469,693,144 - 69,717,122NCBI
Celera466,854,004 - 66,878,059 (-)NCBI
Cytogenetic Map4q13.2NCBI
HuRef465,308,273 - 65,332,364 (-)NCBIHuRef
CHM1_1469,549,031 - 69,573,207 (-)NCBICHM1_1
LOC100515741
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1866,251,785 - 66,297,861 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2870,563,803 - 70,570,430 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Position Markers
SHGC-68230  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37469,512,408 - 69,512,563UniSTSGRCh37
Build 36469,195,003 - 69,195,158RGDNCBI36
Celera466,854,097 - 66,854,253RGD
Cytogenetic Map4q13UniSTS
HuRef465,308,366 - 65,308,522UniSTS
GeneMap99-GB4 RH Map4422.02UniSTS
NCBI RH Map4817.2UniSTS
SHGC-59737  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37469,512,777 - 69,513,036UniSTSGRCh37
Build 36469,195,372 - 69,195,631RGDNCBI36
Celera466,854,468 - 66,854,727RGD
Cytogenetic Map4q13UniSTS
HuRef465,308,737 - 65,308,996UniSTS
GeneMap99-GB4 RH Map4408.17UniSTS
G60251  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37469,527,719 - 69,527,847UniSTSGRCh37
GRCh37469,425,241 - 69,425,369UniSTSGRCh37
Celera466,869,402 - 66,869,530UniSTS
Cytogenetic Map4q13UniSTS
HuRef465,323,679 - 65,323,807UniSTS
TNG Radiation Hybrid Map438105.0UniSTS
G42996  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q13UniSTS
D4S2612  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37469,425,241 - 69,425,375UniSTSGRCh37
GRCh37469,527,719 - 69,527,853UniSTSGRCh37
Celera466,869,402 - 66,869,536UniSTS
Cytogenetic Map4q13UniSTS
HuRef465,323,679 - 65,323,813UniSTS
Whitehead-RH Map4470.3UniSTS
Whitehead-YAC Contig Map4 UniSTS
NCBI RH Map4817.2UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:123
Interacting mature miRNAs:124
Transcripts:ENST00000338206
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High 6 6 6
Medium 480 1 389 389 86 391 2 5 8
Low 418 68 48 51 495 44 15 10 9 20 287 42 7 10 8
Below cutoff 568 776 357 144 618 11 991 470 671 139 589 534 135 275 592

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000338206   ⟹   ENSP00000341045
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl468,646,597 - 68,670,652 (-)Ensembl
RefSeq Acc Id: NM_001076   ⟹   NP_001067
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38468,646,597 - 68,670,652 (-)NCBI
GRCh37469,512,315 - 69,536,494 (-)NCBI
Build 36469,546,932 - 69,571,114 (-)NCBI Archive
HuRef465,308,273 - 65,332,364 (-)NCBI
CHM1_1469,549,031 - 69,573,207 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001067   ⟸   NM_001076
- Peptide Label: precursor
- UniProtKB: P54855 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000341045   ⟸   ENST00000338206
Protein Domains
UDPGT

Promoters
RGD ID:6867588
Promoter ID:EPDNEW_H6959
Type:multiple initiation site
Name:UGT2B15_1
Description:UDP glucuronosyltransferase family 2 member B15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38468,670,652 - 68,670,712EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q13.2-13.3(chr4:66842408-70831557)x1 copy number loss See cases [RCV000050704] Chr4:66842408..70831557 [GRCh38]
Chr4:67708126..71697274 [GRCh37]
Chr4:67390721..71916138 [NCBI36]
Chr4:4q13.2-13.3
pathogenic
GRCh38/hg38 4q13.2(chr4:65873016-68743024)x3 copy number gain See cases [RCV000051038] Chr4:65873016..68743024 [GRCh38]
Chr4:66738734..69608742 [GRCh37]
Chr4:66421329..69643331 [NCBI36]
Chr4:4q13.2
uncertain significance
GRCh38/hg38 4q12-22.3(chr4:51831622-97505618)x3 copy number gain See cases [RCV000051772] Chr4:51831622..97505618 [GRCh38]
Chr4:52697788..98426769 [GRCh37]
Chr4:52392545..98645792 [NCBI36]
Chr4:4q12-22.3
pathogenic
GRCh38/hg38 4q13.2-21.23(chr4:67869564-85517308)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|See cases [RCV000053294] Chr4:67869564..85517308 [GRCh38]
Chr4:68735282..86438461 [GRCh37]
Chr4:68417877..86657485 [NCBI36]
Chr4:4q13.2-21.23
pathogenic
GRCh38/hg38 4q13.1-13.3(chr4:65454562-72313693)x1 copy number loss See cases [RCV000053293] Chr4:65454562..72313693 [GRCh38]
Chr4:66320280..73179410 [GRCh37]
Chr4:66002875..73398274 [NCBI36]
Chr4:4q13.1-13.3
pathogenic
NM_001076.4(UGT2B15):c.253T>G (p.Tyr85Asp) single nucleotide variant lorazepam response - Other [RCV000417167]|oxazepam response - Other [RCV000211302] Chr4:68670366 [GRCh38]
Chr4:69536084 [GRCh37]
Chr4:4q13.2
drug response
GRCh38/hg38 4q13.2(chr4:68410654-68727128)x3 copy number gain See cases [RCV000134766] Chr4:68410654..68727128 [GRCh38]
Chr4:69276372..69592846 [GRCh37]
Chr4:68958967..69477169 [NCBI36]
Chr4:4q13.2
benign
GRCh38/hg38 4q13.2-13.3(chr4:68537073-69610311)x3 copy number gain See cases [RCV000137009] Chr4:68537073..69610311 [GRCh38]
Chr4:69402791..70476029 [GRCh37]
Chr4:69085386..70510618 [NCBI36]
Chr4:4q13.2-13.3
benign
GRCh38/hg38 4q13.2-13.3(chr4:67799665-74240920)x1 copy number loss See cases [RCV000137622] Chr4:67799665..74240920 [GRCh38]
Chr4:68665383..75106637 [GRCh37]
Chr4:68347978..75325501 [NCBI36]
Chr4:4q13.2-13.3
likely pathogenic
GRCh38/hg38 4q13.2(chr4:68508935-68647669)x3 copy number gain See cases [RCV000138744] Chr4:68508935..68647669 [GRCh38]
Chr4:69374653..69513387 [GRCh37]
Chr4:69057248..69195982 [NCBI36]
Chr4:4q13.2
likely benign
GRCh38/hg38 4q13.2-13.3(chr4:67744481-70267689)x1 copy number loss See cases [RCV000142366] Chr4:67744481..70267689 [GRCh38]
Chr4:68610199..71133406 [GRCh37]
Chr4:68292794..71167995 [NCBI36]
Chr4:4q13.2-13.3
uncertain significance
GRCh38/hg38 4q13.2(chr4:68501374-69255507)x3 copy number gain See cases [RCV000143578] Chr4:68501374..69255507 [GRCh38]
Chr4:69367092..70121225 [GRCh37]
Chr4:69049687..70155814 [NCBI36]
Chr4:4q13.2
uncertain significance
GRCh38/hg38 4q13.2(chr4:68626601-68646936)x1 copy number loss Premature ovarian failure [RCV000225267] Chr4:68626601..68646936 [GRCh38]
Chr4:69492319..69512654 [GRCh37]
Chr4:4q13.2
benign
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q13.2(chr4:69256219-69908707)x3 copy number gain See cases [RCV000510245] Chr4:69256219..69908707 [GRCh37]
Chr4:4q13.2
uncertain significance
GRCh37/hg19 4q13.1-21.1(chr4:66017575-76772947)x1 copy number loss See cases [RCV000510445] Chr4:66017575..76772947 [GRCh37]
Chr4:4q13.1-21.1
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q13.1-13.3(chr4:64705501-73469716)x3 copy number gain not provided [RCV000682409] Chr4:64705501..73469716 [GRCh37]
Chr4:4q13.1-13.3
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q12-13.3(chr4:58332294-71587615)x1 copy number loss not provided [RCV000743602] Chr4:58332294..71587615 [GRCh37]
Chr4:4q12-13.3
pathogenic
GRCh37/hg19 4q13.2(chr4:69310506-69544238)x3 copy number gain not provided [RCV000743653] Chr4:69310506..69544238 [GRCh37]
Chr4:4q13.2
benign
GRCh37/hg19 4q13.2(chr4:69382080-70371555)x3 copy number gain not provided [RCV000743655] Chr4:69382080..70371555 [GRCh37]
Chr4:4q13.2
benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
NM_001076.4(UGT2B15):c.1408C>T (p.Arg470Cys) single nucleotide variant not provided [RCV000963433] Chr4:68647289 [GRCh38]
Chr4:69513007 [GRCh37]
Chr4:4q13.2
likely benign
NM_001076.4(UGT2B15):c.174T>G (p.Ser58=) single nucleotide variant not provided [RCV000894323] Chr4:68670445 [GRCh38]
Chr4:69536163 [GRCh37]
Chr4:4q13.2
benign
GRCh37/hg19 4q13.2-21.22(chr4:68242784-82991431)x3 copy number gain not provided [RCV000845944] Chr4:68242784..82991431 [GRCh37]
Chr4:4q13.2-21.22
pathogenic
GRCh37/hg19 4q13.2(chr4:67392949-69837294)x3 copy number gain not provided [RCV001005552] Chr4:67392949..69837294 [GRCh37]
Chr4:4q13.2
uncertain significance
NM_001076.4(UGT2B15):c.1580A>G (p.Lys527Arg) single nucleotide variant not provided [RCV000974405] Chr4:68647117 [GRCh38]
Chr4:69512835 [GRCh37]
Chr4:4q13.2
benign
NM_001076.4(UGT2B15):c.873+9A>G single nucleotide variant not provided [RCV000956217] Chr4:68668031 [GRCh38]
Chr4:69533749 [GRCh37]
Chr4:4q13.2
benign
GRCh37/hg19 4q13.2-21.21(chr4:68950363-79738598)x1 copy number loss not provided [RCV001005553] Chr4:68950363..79738598 [GRCh37]
Chr4:4q13.2-21.21
pathogenic
GRCh37/hg19 4q13.2(chr4:66969699-69462438)x3 copy number gain Cognitive impairment [RCV001004821] Chr4:66969699..69462438 [GRCh37]
Chr4:4q13.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12546 AgrOrtholog
COSMIC UGT2B15 COSMIC
Ensembl Genes ENSG00000196620 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000277132 UniProtKB/TrEMBL
Ensembl Protein ENSP00000341045 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000480287 UniProtKB/TrEMBL
Ensembl Transcript ENST00000338206 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000611777 UniProtKB/TrEMBL
GTEx ENSG00000196620 GTEx
  ENSG00000277132 GTEx
HGNC ID HGNC:12546 ENTREZGENE
Human Proteome Map UGT2B15 Human Proteome Map
InterPro UDP_glucos_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7366 UniProtKB/Swiss-Prot
NCBI Gene 7366 ENTREZGENE
OMIM 600069 OMIM
Pfam UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA37188 PharmGKB, RGD
PROSITE UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JMZ5_HUMAN UniProtKB/TrEMBL
  P54855 ENTREZGENE
  Q9UHH3_HUMAN UniProtKB/TrEMBL
  UDB15_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A6NDX0 UniProtKB/Swiss-Prot
  A6NNJ4 UniProtKB/Swiss-Prot
  A8K054 UniProtKB/Swiss-Prot
  P23765 UniProtKB/Swiss-Prot
  Q9UK63 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 UGT2B15  UDP glucuronosyltransferase family 2 member B15    UDP glucuronosyltransferase 2 family, polypeptide B15  Symbol and/or name change 5135510 APPROVED