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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708417
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt2b7
Name: UDP glucuronosyltransferase family 2 member B7
Acc ID: CHEBI:39669
Term: diflunisal
Definition: An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.
Chemical ID: MESH:D004061
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt2b7increases glucuronidationISORGD:13515426480464CTDUGT2B7 protein alternative form results in increased glucuronidation of Diflunisal UGT2B7 protein results in increased glucuronidation of Diflunisal

PMID:8423545 PMID:8517101
Ugt2b7multiple interactionsISORGD:13515426480464CTDDiflunisal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide] Diflunisal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]

PMID:19740398
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