Gabra2 (gamma-aminobutyric acid type A receptor subunit alpha 2) - Rat Genome Database
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Gene: Gabra2 (gamma-aminobutyric acid type A receptor subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Gabra2
Name: gamma-aminobutyric acid type A receptor subunit alpha 2
RGD ID: 61856
Description: Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Predicted to be involved in several processes, including GABAergic synaptic transmission; gamma-aminobutyric acid signaling pathway; and inhibitory synapse assembly. Localizes to GABA-ergic synapse; dendrite membrane; and integral component of postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in alcohol use disorder; autistic disorder; and early infantile epileptic encephalopathy. Orthologous to human GABRA2 (gamma-aminobutyric acid type A receptor subunit alpha2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; Alphaxolone; amitriptyline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GABA(A) receptor subunit alpha-2; gamma-aminobutyric acid (GABA) A receptor, alpha 2; gamma-aminobutyric acid (GABA-A) receptor subunit alpha 2; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2; gamma-aminobutyric acid A receptor, alpha 2; gamma-aminobutyric acid receptor A2 subunit; gamma-aminobutyric acid receptor subunit alpha-2; gamma-aminobutyric acid type A receptor alpha2 subunit; similar to Gamma-aminobutyric-acid receptor alpha-2 subunit precursor (GABA(A) receptor)
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01439,662,411 - 39,801,082 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1439,661,968 - 39,798,302 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01439,473,078 - 39,610,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41439,568,677 - 39,705,897 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11439,574,531 - 39,707,830 (+)NCBI
Celera1436,313,034 - 36,444,629 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:1312131   PMID:1312132   PMID:1379501   PMID:1849552   PMID:8391122   PMID:9039914   PMID:9682826   PMID:11389177   PMID:12354299   PMID:12763608   PMID:14627650   PMID:14729731  
PMID:17113954   PMID:17483577   PMID:18256255   PMID:18292084   PMID:18360306   PMID:20833253   PMID:21219474   PMID:21368176   PMID:22044189   PMID:22215379   PMID:22666188   PMID:22871113  
PMID:23916758   PMID:23962649   PMID:24554721   PMID:25896802   PMID:26164299   PMID:26469128   PMID:27129275  


Genomics

Comparative Map Data
Gabra2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01439,662,411 - 39,801,082 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1439,661,968 - 39,798,302 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01439,473,078 - 39,610,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41439,568,677 - 39,705,897 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11439,574,531 - 39,707,830 (+)NCBI
Celera1436,313,034 - 36,444,629 (+)NCBICelera
Cytogenetic Map14p11NCBI
GABRA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl446,248,427 - 46,475,230 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl446,243,548 - 46,475,230 (-)EnsemblGRCh38hg38GRCh38
GRCh38446,243,548 - 46,390,300 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37446,246,470 - 46,392,056 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36445,946,463 - 46,086,702 (-)NCBINCBI36hg18NCBI36
Build 34446,092,633 - 46,232,873NCBI
Celera446,700,624 - 46,841,051 (-)NCBI
Cytogenetic Map4p12NCBI
HuRef445,569,699 - 45,710,166 (-)NCBIHuRef
CHM1_1446,248,463 - 46,389,517 (-)NCBICHM1_1
Gabra2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39571,115,735 - 71,253,192 (-)NCBI
GRCm38570,958,392 - 71,095,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl570,957,597 - 71,095,849 (-)EnsemblGRCm38mm10GRCm38
MGSCv37571,352,296 - 71,487,088 (-)NCBIGRCm37mm9NCBIm37
MGSCv36571,240,192 - 71,374,984 (-)NCBImm8
Celera568,229,777 - 68,364,499 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map537.59NCBI
Gabra2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554432,042,151 - 2,179,174 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554432,042,202 - 2,176,589 (+)NCBIChiLan1.0ChiLan1.0
GABRA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1486,491,841 - 86,641,878 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl486,491,837 - 86,638,166 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0475,762,568 - 75,913,708 (+)NCBIMhudiblu_PPA_v0panPan3
GABRA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1342,368,949 - 42,488,075 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11342,367,988 - 42,488,069 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gabra2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648212,555,222 - 12,685,122 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl836,347,023 - 36,502,460 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1836,344,633 - 36,474,840 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2838,215,163 - 38,344,937 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GABRA2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl273,858,910 - 4,006,582 (+)Ensembl
ChlSab1.1273,858,741 - 4,013,385 (+)NCBI
Gabra2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476120,688,819 - 20,819,487 (+)NCBI

Position Markers
M86567  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01439,798,275 - 39,798,395NCBIRnor6.0
Rnor_5.01439,609,556 - 39,609,676UniSTSRnor5.0
RGSC_v3.41439,705,244 - 39,705,364UniSTSRGSC3.4
Celera1436,443,976 - 36,444,096UniSTS
Cytogenetic Map14p11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14141333960Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14141333960Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14142766285Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14975643572854397Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin141053997755539977Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)141053997755539977Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)141072926861873323Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1412680424106641756Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141916189343957503Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141919154143957628Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)142018938665189386Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)142026622343957628Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)142145756566457565Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143259392686191589Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143303991261783215Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143316331673391571Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:26
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000003197, ENSRNOT00000064779
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 64
Low 16 10 12 30 3
Below cutoff 3 20 25 10 19 10 8 9 17 9 8 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001135779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001841016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07014929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07014930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01079243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01079244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01079245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01079246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01079247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01079248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01079249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF334587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L08491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000003197   ⟹   ENSRNOP00000003197
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1439,663,421 - 39,798,106 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000064779   ⟹   ENSRNOP00000060621
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1439,661,968 - 39,798,302 (+)Ensembl
RefSeq Acc Id: NM_001135779   ⟹   NP_001129251
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01439,662,441 - 39,798,928 (+)NCBI
Rnor_5.01439,473,078 - 39,610,209 (+)NCBI
RGSC_v3.41439,568,677 - 39,705,897 (+)RGD
Celera1436,313,034 - 36,444,629 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250931   ⟹   XP_006250993
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01439,662,411 - 39,799,626 (+)NCBI
Rnor_5.01439,473,078 - 39,610,209 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599106   ⟹   XP_017454595
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01439,662,852 - 39,799,626 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001841016
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01439,662,852 - 39,801,082 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001129251   ⟸   NM_001135779
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_006250993   ⟸   XM_006250931
- Peptide Label: isoform X2
- UniProtKB: F1LMU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454595   ⟸   XM_017599106
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000003197   ⟸   ENSRNOT00000003197
RefSeq Acc Id: ENSRNOP00000060621   ⟸   ENSRNOT00000064779
Protein Domains
Neur_chan_LBD   Neur_chan_memb

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61856 AgrOrtholog
Ensembl Genes ENSRNOG00000002349 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003197 UniProtKB/TrEMBL
  ENSRNOP00000060621 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003197 UniProtKB/TrEMBL
  ENSRNOT00000064779 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAAa_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABBAa2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 289606 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18945:SF218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gabra2 PhenoGen
PRINTS GABAARALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARALPHA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs LIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LMU7 ENTREZGENE, UniProtKB/TrEMBL
  F1LNE8_RAT UniProtKB/TrEMBL
  GBRA2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabra2  gamma-aminobutyric acid type A receptor subunit alpha 2  Gabra2  gamma-aminobutyric acid type A receptor alpha2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabra2  gamma-aminobutyric acid type A receptor alpha2 subunit  Gabra2  gamma-aminobutyric acid (GABA) A receptor, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabra2  gamma-aminobutyric acid type A receptor alpha2 subunit  Gabra2  gamma-aminobutyric acid type A receptor alpha2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-20 Gabra2  gamma-aminobutyric acid (GABA) A receptor, alpha 2  Gabra2  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-21 Gabra2  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2  LOC289606  similar to Gamma-aminobutyric-acid receptor alpha-2 subunit precursor (GABA(A) receptor)  Data Merged 737654 APPROVED
2008-03-11 Gabra2  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2  Gabra2  gamma-aminobutyric acid (GABA) A receptor, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Gabra2  gamma-aminobutyric acid (GABA) A receptor, alpha 2  Gabra2  gamma-aminobutyric acid A receptor, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC289606  similar to Gamma-aminobutyric-acid receptor alpha-2 subunit precursor (GABA(A) receptor)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Gabra2  gamma-aminobutyric acid A receptor, alpha 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in low amounts in NTS and protein expression is weak in most areas of the medulla except the olivary, lateral reticular, cuneate, vestibular and spinal trigeminal nuclei 625528
gene_process may mediate inhibitory GABA responses in nucleus tractus solitarii (NTS) in the brain 625528