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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cyclobenzaprine
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Accession:CHEBI:3996 term browser browse the term
Definition:5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its hydrochloride salt in the symptomatic treatment of painful muscle spasm.
Synonyms:exact_synonym: 3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine;   3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine
 related_synonym: (3-Dibenzo[a,d]cyclohepten-5-ylidene-propyl)-dimethyl-amine;   Formula=C20H21N;   InChI=1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3;   InChIKey=JURKNVYFZMSNLP-UHFFFAOYSA-N;   N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-Delta(5,gamma)-propylamine;   SMILES=CN(C)CCC=C1c2ccccc2C=Cc2ccccc12;   ciclobenzaprina;   cyclobenzaprinum
 alt_id: CHEBI:128119
 xref: Beilstein:2126383;   CAS:303-53-7;   DrugBank:DB00924;   Drug_Central:751;   KEGG:C06931;   KEGG:D07758;   LINCS:LSM-5537
 xref_mesh: MESH:C004704
 xref: PMID:17725338;   PMID:18027916;   Patent:GB858187;   Wikipedia:Cyclobenzaprine


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cyclobenzaprine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO cyclobenzaprine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      application 19741
        pharmaceutical 19579
          drug 19579
            neuromuscular agent 1324
              muscle relaxant 1319
                cyclobenzaprine 1
                  cyclobenzaprine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    main group molecular entity 19876
                      s-block molecular entity 19705
                        hydrogen molecular entity 19686
                          hydrides 19179
                            organic hydride 18717
                              organic fundamental parent 18717
                                hydrocarbon 18457
                                  cyclic hydrocarbon 17244
                                    arene 17225
                                      polycyclic arene 17050
                                        ortho-fused polycyclic arene 9848
                                          dibenzannulene 197
                                            dibenzo[a,d][7]annulene 197
                                              cyclobenzaprine 1
                                                cyclobenzaprine hydrochloride 0
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