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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclobenzaprine
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Accession:CHEBI:3996 term browser browse the term
Definition:5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its hydrochloride salt in the symptomatic treatment of painful muscle spasm.
Synonyms:exact_synonym: 3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine;   3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine
 related_synonym: (3-Dibenzo[a,d]cyclohepten-5-ylidene-propyl)-dimethyl-amine;   Formula=C20H21N;   InChI=1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3;   InChIKey=JURKNVYFZMSNLP-UHFFFAOYSA-N;   N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-Delta(5,gamma)-propylamine;   SMILES=CN(C)CCC=C1c2ccccc2C=Cc2ccccc12;   ciclobenzaprina;   cyclobenzaprinum
 alt_id: CHEBI:128119
 xref: Beilstein:2126383;   CAS:303-53-7;   DrugBank:DB00924;   Drug_Central:751;   KEGG:C06931;   KEGG:D07758;   LINCS:LSM-5537
 xref_mesh: MESH:C004704
 xref: PMID:17725338;   PMID:18027916;   Patent:GB858187;   Wikipedia:Cyclobenzaprine



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cyclobenzaprine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO cyclobenzaprine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19730
    role 19703
      application 19534
        pharmaceutical 19410
          drug 19410
            neuromuscular agent 1314
              muscle relaxant 1309
                cyclobenzaprine 1
                  cyclobenzaprine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19730
    subatomic particle 19728
      composite particle 19728
        hadron 19728
          baryon 19728
            nucleon 19728
              atomic nucleus 19728
                atom 19728
                  main group element atom 19676
                    main group molecular entity 19676
                      s-block molecular entity 19531
                        hydrogen molecular entity 19523
                          hydrides 19007
                            organic hydride 18616
                              organic fundamental parent 18616
                                hydrocarbon 18355
                                  cyclic hydrocarbon 17189
                                    arene 17169
                                      polycyclic arene 16995
                                        ortho-fused polycyclic arene 9734
                                          dibenzannulene 197
                                            dibenzo[a,d][7]annulene 197
                                              cyclobenzaprine 1
                                                cyclobenzaprine hydrochloride 0
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