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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclobenzaprine
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Accession:CHEBI:3996 term browser browse the term
Definition:5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its hydrochloride salt in the symptomatic treatment of painful muscle spasm.
Synonyms:exact_synonym: 3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine;   3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine
 related_synonym: (3-Dibenzo[a,d]cyclohepten-5-ylidene-propyl)-dimethyl-amine;   Formula=C20H21N;   InChI=1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3;   InChIKey=JURKNVYFZMSNLP-UHFFFAOYSA-N;   N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-Delta(5,gamma)-propylamine;   SMILES=CN(C)CCC=C1c2ccccc2C=Cc2ccccc12;   ciclobenzaprina;   cyclobenzaprinum
 alt_id: CHEBI:128119
 xref: Beilstein:2126383;   CAS:303-53-7;   DrugBank:DB00924;   Drug_Central:751;   KEGG:C06931;   KEGG:D07758;   LINCS:LSM-5537
 xref_mesh: MESH:C004704
 xref: PMID:17725338;   PMID:18027916;   Patent:GB858187;   Wikipedia:Cyclobenzaprine


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cyclobenzaprine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO cyclobenzaprine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            neuromuscular agent 1291
              muscle relaxant 1286
                cyclobenzaprine 1
                  cyclobenzaprine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  cyclic hydrocarbon 17065
                                    arene 17061
                                      polycyclic arene 16882
                                        ortho-fused polycyclic arene 9643
                                          dibenzannulene 185
                                            dibenzo[a,d][7]annulene 185
                                              cyclobenzaprine 1
                                                cyclobenzaprine hydrochloride 0
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