Serpina7 (serpin family A member 7) - Rat Genome Database

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Gene: Serpina7 (serpin family A member 7) Rattus norvegicus
Analyze
Symbol: Serpina7
Name: serpin family A member 7
RGD ID: 619833
Description: Enables hormone binding activity. Involved in several processes, including response to corticosterone; response to prostaglandin E; and response to vitamin A. Located in extracellular space. Biomarker of hyperthyroidism and hypothyroidism. Orthologous to human SERPINA7 (serpin family A member 7); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 1-nitropropane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antipeptidase, antitrypsin), member 7; serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; serine (or cysteine) proteinase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 7; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; serpin A7; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; T4-binding globulin; Tbg; thyroxine-binding globulin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X102,663,242 - 102,722,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX102,663,405 - 102,669,040 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX104,795,940 - 104,801,575 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X108,294,677 - 108,300,314 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X105,866,090 - 105,871,723 (-)NCBIRnor_WKY
Rnor_6.0X110,226,565 - 110,232,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX110,226,572 - 110,232,179 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X110,265,668 - 110,271,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X126,739,203 - 126,744,763 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X126,812,635 - 126,816,664 (-)NCBI
CeleraX103,432,378 - 103,438,227 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,4-dioxane  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4',5,6'-Hexabromodiphenyl ether  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,5-dichlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
5-fluorouracil  (ISO)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
Aroclor 1254  (EXP)
azathioprine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethyl hydrogen phosphate  (EXP)
diiodine  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
flutamide  (EXP)
furan  (ISO)
hexachlorobenzene  (ISO)
isoprenaline  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
norgestimate  (ISO)
orphenadrine  (EXP)
oxycodone  (EXP)
paracetamol  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
succimer  (ISO)
tamoxifen  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thyroxine  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,IEA,TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Diminished thyroxine-binding globulin in pubertal diabetic children. Connors MH, etal., Diabetes Care. 1996 Mar;19(3):246-8.
2. Gene expression and serum thyroxine-binding globulin are regulated by adrenal status and corticosterone in the rat. Emerson CH, etal., Endocrinology. 1993 Sep;133(3):1192-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Alterations in circulating thyroid hormones and thyroxine-binding globulin levels during diabetic ketoacidosis. Glinoer D, etal., J Endocrinol Invest. 1980 Jan-Mar;3(1):67-9.
5. Molecular cloning and primary structure of rat thyroxine-binding globulin. Imamura S, etal., Biochemistry 1991 Jun 4;30(22):5406-11.
6. Goiter formation following prostaglandin administration in rats. Lupulescu A Am J Pathol. 1976 Oct;85(1):21-36.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Effects of vitamin A deficiency on thyroid function and serum thyroxine levels in the rat. Oba K and Kimura S, J Nutr Sci Vitaminol (Tokyo). 1980;26(4):327-34.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Re-expression of thyroxine-binding globulin in post-weaning rats during protein or energy malnutrition. Rouaze-Romet M, etal., Acta Endocrinol (Copenh). 1992 Nov;127(5):441-8.
14. Structural and functional microheterogeneity of rat thyroxine-binding globulin during ontogenesis. Rouaze-Romet M, etal., Biochem J. 1992 Aug 15;286 ( Pt 1):125-30.
15. Binding activities of thyroxine binding globulin versus thyroxine binding prealbumin in rat sera: differential modulation by thyroid hormone ligands, oleic acid and pharmacological drugs. Savu L, etal., Biochem Biophys Res Commun. 1989 Mar 31;159(3):919-26.
16. Thyroxine-binding globulin and thyroxine-binding prealbumin in hypothyroid and hyperthyroid developing rats. Savu L, etal., Biochim Biophys Acta. 1989 Sep 15;992(3):379-84.
17. A senescence up-regulated protein: the rat thyroxine-binding globulin (TBG). Savu L, etal., Biochim Biophys Acta. 1991 Jul 26;1097(1):19-22.
18. Euthyroid sick syndrome in type I diabetes mellitus in children and adolescents. Tahirovic H, etal., Acta Paediatr Hung. 1991;31(1):67-73.
19. Effect of dehydroepiandrosterone on rat thyroxine binding globulin, a protein upregulated during aging. Vranckx R, etal., Ann N Y Acad Sci. 1995 Dec 29;774:335-6.
20. The hepatic biosynthesis of rat thyroxine binding globulin (TBG): demonstration, ontogenesis, and up-regulation in experimental hypothyroidism. Vranckx R, etal., Biochem Biophys Res Commun. 1990 Feb 28;167(1):317-22.
21. Regulation of rat thyroxine-binding globulin and transthyretin: studies in thyroidectomized and hypophysectomized rats given tri-iodothyronine or/and growth hormone. Vranckx R, etal., J Endocrinol 1994 Jul;142(1):77-84.
Additional References at PubMed
PMID:7988464   PMID:19056867   PMID:19415532   PMID:19429849   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Serpina7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X102,663,242 - 102,722,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX102,663,405 - 102,669,040 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX104,795,940 - 104,801,575 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X108,294,677 - 108,300,314 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X105,866,090 - 105,871,723 (-)NCBIRnor_WKY
Rnor_6.0X110,226,565 - 110,232,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX110,226,572 - 110,232,179 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X110,265,668 - 110,271,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X126,739,203 - 126,744,763 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X126,812,635 - 126,816,664 (-)NCBI
CeleraX103,432,378 - 103,438,227 (-)NCBICelera
Cytogenetic MapXq32NCBI
SERPINA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X106,032,435 - 106,038,727 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX106,032,435 - 106,038,727 (-)EnsemblGRCh38hg38GRCh38
GRCh37X105,276,426 - 105,282,718 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X105,163,853 - 105,167,722 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X105,083,341 - 105,087,530NCBI
CeleraX105,751,759 - 105,757,289 (-)NCBICelera
Cytogenetic MapXq22.3NCBI
HuRefX94,904,096 - 94,909,653 (-)NCBIHuRef
CHM1_1X105,188,486 - 105,194,014 (-)NCBICHM1_1
T2T-CHM13v2.0X104,464,373 - 104,470,665 (-)NCBIT2T-CHM13v2.0
Serpina7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X137,979,998 - 137,985,985 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX137,980,006 - 137,985,985 (-)EnsemblGRCm39 Ensembl
GRCm38X139,079,249 - 139,085,236 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX139,079,257 - 139,085,236 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X135,613,788 - 135,619,775 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X134,426,520 - 134,430,065 (-)NCBIMGSCv36mm8
CeleraX122,347,375 - 122,353,362 (-)NCBICelera
Cytogenetic MapXF1NCBI
Serpina7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555482,855,111 - 2,861,952 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555482,855,377 - 2,861,946 (-)NCBIChiLan1.0ChiLan1.0
SERPINA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X105,542,386 - 105,547,774 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX105,541,475 - 105,548,132 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X95,163,842 - 95,169,230 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SERPINA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X79,571,169 - 79,589,199 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX79,571,169 - 79,576,759 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX65,715,739 - 65,719,634 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X81,203,615 - 81,207,510 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX81,203,618 - 81,237,679 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X78,685,978 - 78,689,873 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X80,374,716 - 80,378,611 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X80,165,549 - 80,169,444 (-)NCBIUU_Cfam_GSD_1.0
Serpina7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X79,084,151 - 79,089,667 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364998,568,309 - 8,573,764 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX86,708,632 - 86,714,329 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X86,708,624 - 86,714,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X101,067,043 - 101,072,645 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X93,895,103 - 93,899,718 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX93,894,788 - 93,898,738 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606518,924,778 - 18,930,070 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpina7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480310,622,140 - 10,630,845 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480310,622,181 - 10,627,652 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serpina7
144 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:117
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000014739
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 18 18 18
Low 9 7 7 1 1 4 1 1
Below cutoff 2 9 4 8 4 1 1 3 8 12 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001054915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_343823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000014739   ⟹   ENSRNOP00000014739
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX102,663,405 - 102,669,040 (-)Ensembl
Rnor_6.0 EnsemblX110,226,572 - 110,232,179 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093401   ⟹   ENSRNOP00000076228
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX102,663,405 - 102,669,020 (-)Ensembl
Rnor_6.0 EnsemblX110,226,582 - 110,230,610 (-)Ensembl
RefSeq Acc Id: NM_031128   ⟹   NP_112390
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X102,663,405 - 102,669,040 (-)NCBI
RefSeq Acc Id: XM_039100091   ⟹   XP_038956019
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X102,663,242 - 102,668,963 (-)NCBI
RefSeq Acc Id: XM_039100092   ⟹   XP_038956020
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X102,663,242 - 102,669,053 (-)NCBI
RefSeq Acc Id: XM_039100093   ⟹   XP_038956021
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X102,663,988 - 102,669,748 (-)NCBI
RefSeq Acc Id: XM_039100094   ⟹   XP_038956022
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X102,665,766 - 102,669,748 (-)NCBI
RefSeq Acc Id: XM_039100095   ⟹   XP_038956023
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X102,663,243 - 102,722,319 (-)NCBI
RefSeq Acc Id: XM_039100096   ⟹   XP_038956024
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X102,663,243 - 102,667,373 (-)NCBI
Reference Sequences
RefSeq Acc Id: ENSRNOP00000014739   ⟸   ENSRNOT00000014739
RefSeq Acc Id: ENSRNOP00000076228   ⟸   ENSRNOT00000093401
RefSeq Acc Id: XP_038956020   ⟸   XM_039100092
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038956019   ⟸   XM_039100091
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038956023   ⟸   XM_039100095
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038956024   ⟸   XM_039100096
- Peptide Label: isoform X5
RefSeq Acc Id: NP_112390   ⟸   NM_031128
- Peptide Label: precursor
- UniProtKB: A0A140TAB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956021   ⟸   XM_039100093
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038956022   ⟸   XM_039100094
- Peptide Label: isoform X4
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35577-F1-model_v2 AlphaFold P35577 1-418 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701949
Promoter ID:EPDNEW_R12473
Type:single initiation site
Name:Serpina7_1
Description:serpin family A member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X110,232,164 - 110,232,224EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619833 AgrOrtholog
BioCyc Gene G2FUF-1569 BioCyc
Ensembl Genes ENSRNOG00000011081 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014739 ENTREZGENE
  ENSRNOP00000014739.5 UniProtKB/TrEMBL
  ENSRNOP00000076228 ENTREZGENE
  ENSRNOP00000076228.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014739 ENTREZGENE
  ENSRNOT00000014739.7 UniProtKB/TrEMBL
  ENSRNOT00000093401 ENTREZGENE
  ENSRNOT00000093401.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 81806 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Serpina7 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAB0 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2Q6F2_RAT UniProtKB/TrEMBL
  P35577 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpina7  serpin family A member 7  Serpina7  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-01-19 Serpina7  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7  Serpina7  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Serpina7  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7  Serpina7  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antipeptidase, antitrypsin), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Serpina7  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antipeptidase, antitrypsin), member 7    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7  Name updated 1299863 APPROVED
2002-08-07 Serpina7  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7      Symbol and Name status set to provisional 70820 PROVISIONAL