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Gene: Cdk5 (cyclin-dependent kinase 5) Rattus norvegicus
Symbol: Cdk5
Name: cyclin-dependent kinase 5
Description: Exhibits several functions, including ephrin receptor binding activity; protein kinase activity; and voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in several processes, including cellular response to amyloid-beta; positive regulation of apoptotic process; and protein phosphorylation. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and protein kinase 5 complex. Colocalizes with microtubule. Used to study brain ischemia; mental depression; and trigeminal neuralgia. Biomarker of Alzheimer's disease; transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly. Orthologous to human CDK5 (cyclin dependent kinase 5); PARTICIPATES IN dopamine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; Reelin signaling pathway; INTERACTS WITH (+)-schisandrin B; (S)-amphetamine; (S)-colchicine.
Type: protein-coding
Also known as: cell division protein kinase 5; cyclin-dependent-like kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit; TPKII catalytic subunit
Homo sapiens (human) : CDK5 (cyclin dependent kinase 5)  HGNC  Alliance
Mus musculus (house mouse) : Cdk5 (cyclin-dependent kinase 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk5 (cyclin dependent kinase 5)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK5 (cyclin dependent kinase 5)
Canis lupus familiaris (dog) : CDK5 (cyclin dependent kinase 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk5 (cyclin dependent kinase 5)
Sus scrofa (pig) : CDK5 (cyclin dependent kinase 5)
Chlorocebus sabaeus (African green monkey) : CDK5 (cyclin dependent kinase 5)
Heterocephalus glaber (naked mole-rat) : Cdk5 (cyclin dependent kinase 5)
more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.047,282,945 - 7,287,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,282,948 - 7,288,383 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,294,309 - 7,298,791 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,119,704 - 6,124,186 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.146,119,703 - 6,124,185 (+)NCBI
Celera46,369,255 - 6,373,737 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cdk5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70514
Created: 2002-05-02
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.