Gene: Cdk5 (cyclin-dependent kinase 5) Rattus norvegicus
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Symbol:
Cdk5
Name:
cyclin-dependent kinase 5
Description:
Exhibits several functions, including ephrin receptor binding activity; protein kinase activity; and voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in several processes, including cellular response to amyloid-beta; positive regulation of apoptotic process; and protein phosphorylation. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and protein kinase 5 complex. Colocalizes with microtubule. Used to study brain ischemia; mental depression; and trigeminal neuralgia. Biomarker of Alzheimer's disease; transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly. Orthologous to human CDK5 (cyclin dependent kinase 5); PARTICIPATES IN dopamine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; Reelin signaling pathway; INTERACTS WITH (+)-schisandrin B; (S)-amphetamine; (S)-colchicine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
cell division protein kinase 5; cyclin-dependent-like kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit; TPKII catalytic subunit
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CDK5 (cyclin dependent kinase 5) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Cdk5 (cyclin-dependent kinase 5) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cdk5 (cyclin dependent kinase 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CDK5 (cyclin dependent kinase 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CDK5 (cyclin dependent kinase 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cdk5 (cyclin dependent kinase 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CDK5 (cyclin dependent kinase 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
CDK5 (cyclin dependent kinase 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Cdk5 (cyclin dependent kinase 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
CDK5 (cyclin dependent kinase 5)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Mus musculus (house mouse):
Cdk5 (cyclin-dependent kinase 5)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
cdk5 (cyclin-dependent kinase 5)
Alliance
DIOPT (PhylomeDB|TreeFam)
Saccharomyces cerevisiae (baker's yeast):
PHO85
Alliance
DIOPT (Hieranoid|OrthoFinder|PANTHER)
Drosophila melanogaster (fruit fly):
Cdk5
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Caenorhabditis elegans (roundworm):
cdk-5
Alliance
DIOPT (Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Is Marker For:
Strains:
BB/OK
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 4 7,282,945 - 7,287,427 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 4 7,282,948 - 7,288,383 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 4 7,294,309 - 7,298,791 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 4 6,119,704 - 6,124,186 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 4 6,119,703 - 6,124,185 (+) NCBI Celera 4 6,369,255 - 6,373,737 (+) NCBI Celera Cytogenetic Map 4 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Lissencephaly 7 with Cerebellar Hypoplasia ISO RGD:70825 8554872 ClinVar Annotator: match by term: Lissencephaly 7 with cerebellar hypoplasia ClinVar PMID:25560765 long QT syndrome ISO RGD:70825 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:28492532 long QT syndrome ISO RGD:70825 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:16470702 more ...
Imported Annotations - CTD
tauopathy ISO RGD:70825 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26945731 Imported Annotations - OMIM
Lissencephaly 7 with Cerebellar Hypoplasia ISO RGD:70825 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CDK5 mRNA] CTD PMID:31150632 (S)-amphetamine increases activity EXP 6480464 Dextroamphetamine results in increased activity of CDK5 protein CTD PMID:18991853 (S)-colchicine increases expression EXP 6480464 Colchicine results in increased expression of CDK5 protein CTD PMID:12941380 (S)-colchicine multiple interactions EXP 6480464 alvocidib inhibits the reaction [Colchicine results in increased expression of CDK5 protein] CTD PMID:12941380 1,2-dimethylhydrazine increases expression ISO RGD:70826 6480464 1, 2-Dimethylhydrazine results in increased expression of CDK5 mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO RGD:70826 6480464 Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of CDK5 mRNA] CTD PMID:22206623 1,3-dinitrobenzene increases expression EXP 6480464 3-dinitrobenzene results in increased expression of CDK5 mRNA CTD PMID:21983209 2,3',4,4',5-Pentachlorobiphenyl increases expression ISO RGD:70826 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDK5 mRNA] CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CDK5 mRNA CTD PMID:21215274 3,4-methylenedioxymethamphetamine increases expression ISO RGD:70826 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of CDK5 mRNA CTD PMID:20188158 3H-1,2-dithiole-3-thione increases expression EXP 6480464 1, 2-dithiol-3-thione results in increased expression of CDK5 mRNA CTD PMID:19162173 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of CDK5 protein CTD PMID:30096436 acrylamide multiple interactions EXP 6480464 calpeptin inhibits the reaction [Acrylamide results in increased expression of CDK5 protein] CTD PMID:30096436 all-trans-retinoic acid increases expression ISO RGD:70825 6480464 Tretinoin results in increased expression of CDK5 protein CTD PMID:16149052 alvocidib multiple interactions EXP 6480464 alvocidib inhibits the reaction [Colchicine results in increased expression of CDK5 protein] CTD PMID:12941380 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CDK5 mRNA CTD PMID:16483693 ammonium chloride affects response to substance EXP 6480464 CDK5 protein affects the susceptibility to Ammonium Chloride CTD PMID:18722528 ammonium chloride increases cleavage EXP 6480464 Ammonium Chloride results in increased cleavage of CDK5 protein CTD PMID:18722528 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein], pyrazolanthrone inhibits the reaction [troglitazone results in increased phosphorylation of CDK5 protein] CTD PMID:24481447 arsane increases expression ISO RGD:70825 6480464 Arsenic results in increased expression of CDK5 mRNA CTD PMID:20654705 arsane affects methylation ISO RGD:70825 6480464 Arsenic affects the methylation of CDK5 gene CTD PMID:25304211 arsenic atom increases expression ISO RGD:70825 6480464 Arsenic results in increased expression of CDK5 mRNA CTD PMID:20654705 arsenic atom affects methylation ISO RGD:70825 6480464 Arsenic affects the methylation of CDK5 gene CTD PMID:25304211 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of CDK5 mRNA, Arsenic Trioxide results in increased expression of CDK5 protein CTD PMID:22801079 , PMID:24641850 atrazine decreases expression ISO RGD:70825 6480464 Atrazine results in decreased expression of CDK5 mRNA CTD PMID:22378314 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CDK5 mRNA CTD PMID:25181051 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CDK5 mRNA CTD PMID:30816183 bisphenol F decreases expression EXP 6480464 4, 4'-bisphenol F results in decreased expression of CDK5 mRNA CTD PMID:26186136 cadmium dichloride increases methylation EXP 6480464 Cadmium Chloride results in increased methylation of CDK5 promoter CTD PMID:22457795 cadmium dichloride multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein] more ... CTD PMID:24481447 Calpeptin multiple interactions EXP 6480464 calpeptin inhibits the reaction [Acrylamide results in increased expression of CDK5 protein] CTD PMID:30096436 carbamazepine affects expression ISO RGD:70825 6480464 Carbamazepine affects the expression of CDK5 mRNA CTD PMID:24752500 carbon nanotube decreases expression ISO RGD:70826 6480464 Nanotubes, Carbon analog results in decreased expression of CDK5 mRNA CTD PMID:25554681 chlorpromazine decreases expression ISO RGD:70825 6480464 Chlorpromazine analog results in decreased expression of CDK5 mRNA CTD PMID:15924885 cisplatin multiple interactions ISO RGD:70825 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of CDK5 mRNA CTD PMID:27392435 clobetasol increases expression ISO RGD:70826 6480464 Clobetasol results in increased expression of CDK5 mRNA CTD PMID:27462272 clofibrate decreases expression ISO RGD:70826 6480464 Clofibrate results in decreased expression of CDK5 mRNA CTD PMID:17585979 clozapine increases expression EXP 6480464 Clozapine results in increased expression of CDK5 mRNA CTD PMID:15860345 cobalt dichloride decreases expression ISO RGD:70825 6480464 cobaltous chloride results in decreased expression of CDK5 mRNA CTD PMID:19376846 cocaine affects expression EXP 6480464 Cocaine affects the expression of CDK5 mRNA, Cocaine affects the expression of CDK5 protein CTD PMID:12787079 more ... cocaine increases expression EXP 6480464 Cocaine results in increased expression of CDK5 mRNA, Cocaine results in increased expression of CDK5 protein CTD PMID:11268215 cocaine decreases expression EXP 6480464 Cocaine results in decreased expression of CDK5 protein CTD PMID:16263094 copper(II) sulfate decreases expression ISO RGD:70825 6480464 Copper Sulfate results in decreased expression of CDK5 mRNA CTD PMID:19549813 curcumin decreases expression ISO RGD:70825 6480464 Curcumin analog results in decreased expression of CDK5 mRNA CTD PMID:26409325 cyclosporin A decreases expression ISO RGD:70825 6480464 Cyclosporine results in decreased expression of CDK5 mRNA CTD PMID:20106945 , PMID:25562108 cyhalothrin increases expression EXP 6480464 cyhalothrin results in increased expression of CDK5 protein CTD PMID:28487251 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of CDK5 mRNA, Arsenic Trioxide results in increased expression of CDK5 protein CTD PMID:22801079 , PMID:24641850 diazinon affects expression EXP 6480464 Diazinon affects the expression of CDK5 mRNA CTD PMID:22546817 diclofenac affects expression ISO RGD:70825 6480464 Diclofenac affects the expression of CDK5 mRNA CTD PMID:24752500 diethylstilbestrol increases expression ISO RGD:70825 6480464 Diethylstilbestrol results in increased expression of CDK5 mRNA CTD PMID:15766595 disodium selenite decreases expression ISO RGD:70825 6480464 Sodium Selenite results in decreased expression of CDK5 mRNA CTD PMID:16705456 doxorubicin increases expression ISO RGD:70826 6480464 Doxorubicin results in increased expression of CDK5 mRNA CTD PMID:22008532 fluoxetine decreases expression ISO RGD:70826 6480464 Fluoxetine results in decreased expression of CDK5 mRNA CTD PMID:17105902 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of CDK5 mRNA CTD PMID:24793618 folic acid multiple interactions ISO RGD:70826 6480464 Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of CDK5 mRNA] CTD PMID:22206623 genistein increases expression ISO RGD:70825 6480464 Genistein results in increased expression of CDK5 protein CTD PMID:16149052 genistein decreases expression ISO RGD:70825 6480464 Genistein results in decreased expression of CDK5 mRNA CTD PMID:22228119 haloperidol increases expression EXP 6480464 Haloperidol results in increased expression of CDK5 mRNA CTD PMID:15860345 hydrogen peroxide affects expression ISO RGD:70825 6480464 Hydrogen Peroxide affects the expression of CDK5 mRNA CTD PMID:20044591 isotretinoin decreases expression ISO RGD:70825 6480464 Isotretinoin results in decreased expression of CDK5 mRNA CTD PMID:20436886 lead diacetate increases cleavage EXP 6480464 lead acetate results in increased cleavage of CDK5 protein CTD PMID:27012722 lead diacetate increases expression ISO RGD:70826 6480464 lead acetate results in increased expression of CDK5 mRNA, lead acetate results in increased expression of CDK5 protein CTD PMID:24954411 , PMID:27293183 lead diacetate multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein] more ... CTD PMID:24481447 lovastatin decreases cleavage EXP 6480464 Lovastatin results in decreased cleavage of CDK5 protein CTD PMID:19741129 lycopene decreases expression ISO RGD:70825 6480464 lycopene results in decreased expression of CDK5 protein CTD PMID:17337101 methamphetamine multiple interactions EXP 6480464 CDK5 protein affects the reaction [Methamphetamine results in increased expression of CASP12 protein] more ... CTD PMID:29705343 methamphetamine multiple interactions ISO RGD:70826 6480464 SNCA gene mutant form inhibits the reaction [Methamphetamine results in increased expression of CDK5 protein] CTD PMID:32278788 methamphetamine increases expression ISO RGD:70826 6480464 Methamphetamine results in increased expression of CDK5 protein CTD PMID:32278788 methamphetamine increases expression ISO RGD:70825 6480464 Methamphetamine results in increased expression of CDK5 protein CTD PMID:29705343 methamphetamine multiple interactions ISO RGD:70825 6480464 CDK5 protein affects the reaction [Methamphetamine results in increased expression of CASP12 protein] more ... CTD PMID:29705343 methoxyacetic acid affects expression EXP 6480464 methoxyacetic acid affects the expression of CDK5 mRNA CTD PMID:20864626 methylseleninic acid increases expression ISO RGD:70825 6480464 methylselenic acid results in increased expression of CDK5 mRNA CTD PMID:11830524 monosodium L-glutamate multiple interactions ISO RGD:70826 6480464 [Sodium Glutamate co-treated with Trans Fatty Acids] results in increased expression of CDK5 mRNA CTD PMID:19001666 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:70825 6480464 CDK5 protein affects the reaction [LRRK2 protein mutant form results in increased susceptibility to 1-Methyl-4-phenylpyridinium] CTD PMID:26930193 N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO RGD:70825 6480464 Methylnitronitrosoguanidine results in increased expression of CDK5 mRNA CTD PMID:12634122 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of CDK5 mRNA CTD PMID:22546817 oxidopamine multiple interactions EXP 6480464 [Oxidopamine co-treated with Levodopa] results in increased expression of CDK5 protein CTD PMID:17188499 paracetamol decreases expression ISO RGD:70825 6480464 Acetaminophen results in decreased expression of CDK5 mRNA CTD PMID:29067470 resveratrol multiple interactions ISO RGD:70826 6480464 resveratrol inhibits the reaction [TNF protein results in increased activity of CDK5 protein], resveratrol results in decreased expression of and results in decreased activity of CDK5 protein CTD PMID:21736731 , PMID:23129026 resveratrol decreases activity ISO RGD:70826 6480464 resveratrol results in decreased activity of CDK5 protein CTD PMID:21736731 resveratrol decreases activity EXP 6480464 resveratrol results in decreased activity of CDK5 protein CTD PMID:21736731 resveratrol multiple interactions EXP 6480464 [resveratrol results in decreased expression of CDK5R1 protein] which results in decreased activity of CDK5 protein CTD PMID:21736731 ritonavir decreases expression ISO RGD:70825 6480464 Ritonavir results in decreased expression of CDK5 mRNA CTD PMID:19386116 sarin decreases expression ISO RGD:70825 6480464 Sarin results in decreased expression of CDK5 mRNA CTD PMID:19522546 sarin increases expression ISO RGD:70825 6480464 Sarin results in increased expression of CDK5 mRNA CTD PMID:19522546 simvastatin increases expression ISO RGD:70825 6480464 Simvastatin results in increased expression of CDK5 CTD PMID:19461118 sodium arsenate increases expression ISO RGD:70826 6480464 sodium arsenate results in increased expression of CDK5 mRNA CTD PMID:30953684 sodium arsenite increases expression ISO RGD:70825 6480464 sodium arsenite results in increased expression of CDK5 mRNA CTD PMID:17879257 sodium arsenite affects methylation ISO RGD:70825 6480464 sodium arsenite affects the methylation of CDK5 gene CTD PMID:28589171 sodium arsenite multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein] more ... CTD PMID:24481447 sunitinib decreases expression ISO RGD:70825 6480464 Sunitinib results in decreased expression of CDK5 mRNA CTD PMID:31533062 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of CDK5 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CDK5 mRNA] CTD PMID:31150632 troglitazone multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Troglitazone results in increased phosphorylation of CDK5 protein] more ... CTD PMID:24481447 tunicamycin decreases expression ISO RGD:70825 6480464 Tunicamycin results in decreased expression of CDK5 mRNA CTD PMID:22378314 valproic acid affects expression ISO RGD:70825 6480464 Valproic Acid affects the expression of CDK5 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:70825 6480464 Valproic Acid results in increased expression of CDK5 mRNA CTD PMID:23179753 more ...
Biological Process apoptotic process ISO RGD:70826 1624291 (MGI:MGI:87730, PMID:9126296) RGD MGI:MGI:87730 , PMID:9126296 associative learning ISO RGD:70826 1624291 (MGI:MGI:2178910, PMID:11978846) RGD MGI:MGI:2178910 , PMID:11978846 axon extension TAS 8554712 PMID:11276227 UniProt axonogenesis ISO RGD:70826 1624291 (MGI:MGI:1928548, PMID:11163260) RGD MGI:MGI:1928548 , PMID:11163260 axonogenesis IBA FB:FBgn0013762 more ... 13792537 PMID:21873635 GO_Central behavioral response to cocaine ISO RGD:70826 1624291 MGI:MGI:3531299 more ... RGD MGI:MGI:3764563 , PMID:18032670 calcium ion import ISO RGD:70826 1624291 (MGI:MGI:4941854, PMID:18054859) RGD MGI:MGI:4941854 , PMID:18054859 cell division IEA UniProtKB-KW:KW-0132 1600115 GO_REF:0000043 UniProt GO_REF:0000043 cell migration ISO RGD:70826 1624291 MGI:MGI:1861809 more ... RGD MGI:MGI:2446382 more ... cell-matrix adhesion ISO RGD:70826 1624291 (MGI:MGI:2446382, PMID:12496365) RGD MGI:MGI:2446382 , PMID:12496365 cellular response to amyloid-beta IDA 11576284 PMID:26224839 ARUK-UCL central nervous system development TAS 632377 RGD central nervous system neuron development ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:1889058 , PMID:8855328) RGD MGI:MGI:1889058 , PMID:8855328 cerebellar cortex development ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:1889058 , PMID:8855328) RGD MGI:MGI:1889058 , PMID:8855328 cerebellar cortex formation ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:1340775 , PMID:10407039) RGD MGI:MGI:1340775 , PMID:10407039 cerebellum development ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:1931637 , PMID:11226314) RGD MGI:MGI:1931637 , PMID:11226314 cerebral cortex development ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:1277606 , PMID:9698328) RGD MGI:MGI:1277606 , PMID:9698328 corpus callosum development ISO RGD:70826 1624291 MGI:MGI:1928281 more ... RGD MGI:MGI:3764566 , PMID:18032654 cortical actin cytoskeleton organization IMP 1598417 RGD dendrite morphogenesis ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:3621856 more ... RGD MGI:MGI:3621856 more ... excitatory postsynaptic potential ISO RGD:70826 1624291 MGI:MGI:3720892 more ... RGD MGI:MGI:3720432 , PMID:17529984 exocytosis IMP 1598417 RGD forebrain development ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:3763708 , PMID:17694053) RGD MGI:MGI:3763708 , PMID:17694053 hippocampus development ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:2149271 , PMID:11517264) RGD MGI:MGI:2149271 , PMID:11517264 histone phosphorylation IMP 13782383 RGD induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration IEA GO:0099635 1600115 GO_REF:0000108 GOC GO_REF:0000108 intracellular protein transport ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:1889058 , PMID:8855328) RGD MGI:MGI:1889058 , PMID:8855328 layer formation in cerebral cortex ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:2149271 , PMID:11517264) RGD MGI:MGI:2149271 , PMID:11517264 mitochondrion organization IMP 13506926 RGD motor neuron axon guidance ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:3607648 , PMID:16203963) RGD MGI:MGI:3607648 , PMID:16203963 negative regulation of axon extension ISO RGD:70826 1624291 MGI:MGI:1197518 (MGI:MGI:5426470 , PMID:22573681) RGD MGI:MGI:5426470 , PMID:22573681 negative regulation of cell cycle ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:3607011 , PMID:16237170) RGD MGI:MGI:3607011 , PMID:16237170 negative regulation of neuron death ISO RGD:70825 1624291 (PMID:24548080) RGD PMID:24548080 negative regulation of protein export from nucleus ISO RGD:70826 1624291 (MGI:MGI:3720993, PMID:17591690) RGD MGI:MGI:3720993 , PMID:17591690 negative regulation of protein ubiquitination ISO RGD:70826 1624291 (MGI:MGI:3720993, PMID:17591690) RGD MGI:MGI:3720993 , PMID:17591690 negative regulation of proteolysis ISO RGD:70825 1624291 (PMID:24548080) RGD PMID:24548080 negative regulation of synaptic plasticity ISO RGD:70826 1624291 MGI:MGI:3720892 more ... RGD MGI:MGI:3720432 , PMID:17529984 negative regulation of transcription, DNA-templated ISO RGD:70825 1624291 (PMID:20357208) RGD PMID:20357208 neuron apoptotic process ISO RGD:70826 1624291 (MGI:MGI:3720993, PMID:17591690) RGD MGI:MGI:3720993 , PMID:17591690 neuron apoptotic process IBA MGI:MGI:101765 more ... 13792537 PMID:21873635 GO_Central neuron apoptotic process IMP 1598414 RGD neuron differentiation ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:3607011 , PMID:16237170) RGD MGI:MGI:3607011 , PMID:16237170 neuron differentiation IDA 8554279 PMID:8846918 UniProt neuron migration ISO RGD:70826 1624291 MGI:MGI:1861809 more ... RGD MGI:MGI:1340775 more ... neuron projection development IMP 8554279 PMID:8846918 UniProt neuron projection morphogenesis IMP 1598432 RGD nucleocytoplasmic transport IMP 2311183 transport of Pdx-1 RGD oligodendrocyte differentiation ISO RGD:70825 1624291 (PMID:18042622) RGD PMID:18042622 peptidyl-serine phosphorylation IDA 734740 ; 1598431 RGD peptidyl-serine phosphorylation ISO RGD:70826 1624291 MGI:MGI:2179066 more ... RGD MGI:MGI:4941854 more ... peptidyl-serine phosphorylation ISO RGD:70825 1624291 (PMID:21145489) RGD PMID:21145489 peptidyl-threonine phosphorylation ISO RGD:70826 1624291 (MGI:MGI:4941854 more ... RGD MGI:MGI:4941854 more ... phosphorylation ISO RGD:70825 1624291 (PMID:20357208) RGD PMID:20357208 positive regulation of calcium ion-dependent exocytosis ISO RGD:70826 1624291 (MGI:MGI:3709145, PMID:15123626) RGD MGI:MGI:3709145 , PMID:15123626 positive regulation of glial cell apoptotic process IMP 13506926 RGD positive regulation of neuron apoptotic process IDA 8553388 PMID:16192386 UniProt positive regulation of neuron death IMP 10053571 RGD positive regulation of presynaptic cytosolic calcium concentration IMP 13792535 PMID:23699505 ARUK-UCL positive regulation of protein binding ISO RGD:70826 1624291 MGI:MGI:4941830 (MGI:MGI:4941854 , PMID:18054859) RGD MGI:MGI:4941854 , PMID:18054859 positive regulation of protein kinase activity ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:3607648 , PMID:16203963) RGD MGI:MGI:3607648 , PMID:16203963 positive regulation of protein phosphorylation IMP 13506926 RGD positive regulation of protein targeting to membrane ISO RGD:70826 1624291 MGI:MGI:4941830 (MGI:MGI:4941854 , PMID:18054859) RGD MGI:MGI:4941854 , PMID:18054859 positive regulation of voltage-gated calcium channel activity IMP 13792535 PMID:23699505 ARUK-UCL protein autophosphorylation IDA 1598412 RGD protein localization to synapse ISO RGD:70826 1624291 (MGI:MGI:4941854, PMID:18054859) RGD MGI:MGI:4941854 , PMID:18054859 protein phosphorylation IDA 1598414 ; 632374 ; 1598417 RGD protein phosphorylation IBA CGD:CAL0000191263 more ... 13792537 PMID:21873635 GO_Central protein phosphorylation IDA 8553329 PMID:17202132 MGI protein phosphorylation ISO RGD:70826 1624291 MGI:MGI:894678 (MGI:MGI:2149271 more ... RGD MGI:MGI:2149271 more ... receptor catabolic process ISO RGD:70826 1624291 MGI:MGI:3720892 more ... RGD MGI:MGI:3720432 , PMID:17529984 receptor clustering ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:3607648 , PMID:16203963) RGD MGI:MGI:3607648 , PMID:16203963 regulated exocytosis IMP 1598417 RGD regulation of cell migration ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:2673122 , PMID:12941275) RGD MGI:MGI:2673122 , PMID:12941275 regulation of dendritic spine morphogenesis ISO RGD:70826 1624291 (MGI:MGI:3696283, PMID:17143272) RGD MGI:MGI:3696283 , PMID:17143272 regulation of dendritic spine morphogenesis ISS UniProtKB:P49615 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of neurotransmitter receptor activity IEA GO:0030549 1600115 GO_REF:0000108 GOC GO_REF:0000108 regulation of postsynaptic membrane potential ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:3607648 , PMID:16203963) RGD MGI:MGI:3607648 , PMID:16203963 regulation of protein localization to plasma membrane ISO RGD:70826 1624291 (MGI:MGI:6094501, PMID:24607229) RGD MGI:MGI:6094501 , PMID:24607229 regulation of synaptic plasticity IMP 69667 RGD regulation of synaptic plasticity IMP 8553496 PMID:18498738 UniProt regulation of synaptic transmission, glutamatergic ISO RGD:70826 1624291 (MGI:MGI:6094501, PMID:24607229) RGD MGI:MGI:6094501 , PMID:24607229 regulation of transcription involved in G1/S transition of mitotic cell cycle IBA PANTHER:PTN002373304 more ... 13792537 PMID:21873635 GO_Central response to cocaine ISO RGD:70826 1624291 (MGI:MGI:3033267, PMID:14769920) RGD MGI:MGI:3033267 , PMID:14769920 response to wounding IMP 734740 RGD rhythmic process IEA UniProtKB-KW:KW-0090 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Schwann cell development ISO RGD:70826 1624291 MGI:MGI:1861809 (MGI:MGI:3607648 , PMID:16203963) RGD MGI:MGI:3607648 , PMID:16203963 sensory perception of pain ISO RGD:70826 1624291 MGI:MGI:3042874 more ... RGD MGI:MGI:3701155 , PMID:17194758 serine phosphorylation of STAT protein ISO RGD:70826 1624291 (MGI:MGI:3040789, PMID:15096606) RGD MGI:MGI:3040789 , PMID:15096606 skeletal muscle tissue development IEP 1598429 RGD skeletal muscle tissue development TAS 8554712 PMID:11276227 UniProt skeletal muscle tissue development ISO RGD:70826 1624291 (MGI:MGI:892714, PMID:9191048) RGD MGI:MGI:892714 , PMID:9191048 synapse assembly ISO RGD:70826 1624291 (MGI:MGI:4941854, PMID:18054859) RGD MGI:MGI:4941854 , PMID:18054859 synaptic transmission, dopaminergic ISO RGD:70826 1624291 (MGI:MGI:3033267, PMID:14769920) RGD MGI:MGI:3033267 , PMID:14769920 synaptic transmission, glutamatergic ISO RGD:70826 1624291 (MGI:MGI:3033267, PMID:14769920) RGD MGI:MGI:3033267 , PMID:14769920 synaptic vesicle endocytosis IMP 1358501 RGD synaptic vesicle transport IBA PANTHER:PTN000623852 , WB:WBGene00000407 13792537 PMID:21873635 GO_Central telencephalon development ISO RGD:70826 1624291 MGI:MGI:1928281 more ... RGD MGI:MGI:3764566 , PMID:18032654 visual learning ISO RGD:70826 1624291 MGI:MGI:3720892 more ... RGD MGI:MGI:3720432 , PMID:17529984 Cellular Component axon ISO RGD:70826 1624291 (MGI:MGI:84679, PMID:3627430) RGD MGI:MGI:84679 , PMID:3627430 axon IDA 8554279 PMID:8846918 UniProt cell junction TAS 632377 RGD cytoplasm IDA 1598431 RGD cytoplasm IBA MGI:MGI:101765 more ... 13792537 PMID:21873635 GO_Central cytoplasm IDA 13601989 PMID:10683146 ARUK-UCL cytoplasm IDA 13461746 PMID:17491008 ARUK-UCL cytoplasm ISO RGD:70826 1624291 (MGI:MGI:3040789 more ... RGD MGI:MGI:3040789 more ... cytoplasm IDA 8554712 PMID:11276227 UniProt cytoskeleton IDA 1598430 RGD cytosol TAS 1600115 Reactome:R-NUL-9032908 Reactome Reactome:R-NUL-9032908 cytosol ISO RGD:70826 1624291 (MGI:MGI:2446382 more ... RGD MGI:MGI:2446382 more ... cytosol TAS 1600115 Reactome:R-NUL-9032961 Reactome Reactome:R-NUL-9032961 dendrite IDA 8554161 PMID:12223541 UniProt dendrite IDA 8554279 PMID:8846918 UniProt filopodium ISO RGD:70826 1624291 (MGI:MGI:2446382, PMID:12496365) RGD MGI:MGI:2446382 , PMID:12496365 growth cone IDA 8554279 PMID:8846918 UniProt growth cone IDA 13601989 PMID:10683146 ARUK-UCL lamellipodium ISO RGD:70826 1624291 (MGI:MGI:2446382, PMID:12496365) RGD MGI:MGI:2446382 , PMID:12496365 membrane IDA 8554712 PMID:11276227 UniProt membrane IDA 13782381 RGD membrane IDA 13601989 PMID:10683146 ARUK-UCL microtubule colocalizes_with IDA 13461746 PMID:17491008 ARUK-UCL neuromuscular junction IDA 8554712 PMID:11276227 UniProt neuron projection IDA 13601989 PMID:10683146 ARUK-UCL neuronal cell body IDA 8554279 PMID:8846918 UniProt nucleolus NOT ISO RGD:70826 1624291 (MGI:MGI:84679, PMID:3627430) RGD MGI:MGI:84679 , PMID:3627430 nucleoplasm ISO RGD:70825 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:Q00535 , ensembl:ENSP000004197821600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm IEA UniProtKB:A0A090N7W4 , ensembl:ENSP000004197821600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus IDA 1598431 RGD nucleus IBA FB:FBgn0015618 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:70826 1624291 (MGI:MGI:3040789 more ... RGD MGI:MGI:3040789 more ... nucleus IDA 8553388 PMID:16192386 UniProt perikaryon IEA UniProtKB-SubCell:SL-0197 1600115 GO_REF:0000044 UniProt GO_REF:0000044 plasma membrane ISO RGD:70825 1624291 RGD GO_REF:0000052 plasma membrane IEA UniProtKB-SubCell:SL-0039 1600115 GO_REF:0000044 UniProt GO_REF:0000044 postsynaptic density IDA 8554385 PMID:17143272 UniProt presynapse IMP 13792535 PMID:23699505 ARUK-UCL protein kinase 5 complex IDA 632374 RGD Molecular Function acetylcholine receptor activator activity ISO RGD:70826 1624291 (MGI:MGI:3688080, PMID:11276227) RGD MGI:MGI:3688080 , PMID:11276227 acetylcholine receptor activator activity ISS UniProtKB:P49615 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000043 UniProt GO_REF:0000043 cyclin-dependent protein serine/threonine kinase activity IDA 69667 ; 1598416 ; 1598414 ; 1598412 ; 1598417 ; 734740 ; 1598428 ; 1598431 RGD cyclin-dependent protein serine/threonine kinase activity IBA FB:FBgn0004106 more ... 13792537 PMID:21873635 GO_Central cyclin-dependent protein serine/threonine kinase activity IDA 8553496 PMID:18498738 UniProt cytoskeletal protein binding IPI UniProtKB:P12036 8553816 PMID:9313898 BHF-UCL ephrin receptor binding IPI UniProtKB:D3ZZK3 8554385 PMID:17143272 UniProt ErbB-2 class receptor binding ISO RGD:70826 1624291 (MGI:MGI:3688080, PMID:11276227) RGD MGI:MGI:3688080 , PMID:11276227 ErbB-2 class receptor binding ISS UniProtKB:P49615 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ErbB-3 class receptor binding ISO RGD:70826 1624291 (MGI:MGI:3688080, PMID:11276227) RGD MGI:MGI:3688080 , PMID:11276227 ErbB-3 class receptor binding ISS UniProtKB:P49615 1600115 GO_REF:0000024 UniProt GO_REF:0000024 Hsp90 protein binding ISO RGD:70826 1624291 UniProtKB:P11499 (MGI:MGI:6148636 , PMID:17517623) RGD MGI:MGI:6148636 , PMID:17517623 kinase activity IDA 8554279 PMID:8846918 UniProt p53 binding ISO RGD:70826 1624291 PR:P02340 (MGI:MGI:3720993, PMID:17591690) RGD MGI:MGI:3720993 , PMID:17591690 protein binding IPI RGD:3785 1598430 RGD protein binding IPI UniProtKB:Q63604 13432345 PMID:17341134 IntAct protein binding IPI UniProtKB:Q16620 13432345 PMID:17341134 IntAct protein binding IPI UniProtKB:Q03351 13432345 PMID:17341134 IntAct protein binding IPI UniProtKB:P61810 13432345 PMID:17341134 IntAct protein binding IPI UniProtKB:P61810 13432229 PMID:17036052 IntAct protein binding ISO RGD:70825 1624291 UniProtKB:A6NLX3 more ... RGD PMID:12223541 more ... protein binding ISO RGD:70826 1624291 PR:O35350 more ... RGD MGI:MGI:2446382 more ... protein binding IPI UniProtKB:P61810 8554279 PMID:8846918 UniProt protein binding IPI UniProtKB:O35412 8553496 PMID:18498738 UniProt protein kinase activity IDA 632377 RGD protein kinase activity ISO RGD:70826 1624291 MGI:MGI:1861809 more ... RGD MGI:MGI:1931637 more ... protein kinase activity IDA 8553329 PMID:17202132 MGI protein kinase binding IPI RGD:1584969 8693570 RGD protein serine/threonine kinase activity IDA 632374 RGD protein serine/threonine kinase activity ISO RGD:70826 1624291 (MGI:MGI:2673122 more ... RGD MGI:MGI:2673122 more ... protein serine/threonine kinase activity IDA 8553752 PMID:15994305 UniProt protein serine/threonine kinase activity ISO RGD:70825 1624291 (PMID:20357208), (PMID:21145489) RGD PMID:20357208 , PMID:21145489 tau-protein kinase activity IDA 8553752 PMID:15994305 UniProt voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels IDA 13792535 PMID:23699505 SynGO voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels IMP 13792535 PMID:23699505 SynGO
Gene-Chemical Interaction Annotations
