Cdk5 (cyclin-dependent kinase 5) - Rat Genome Database

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Gene: Cdk5 (cyclin-dependent kinase 5) Rattus norvegicus
Symbol: Cdk5
Name: cyclin-dependent kinase 5
RGD ID: 70514
Description: Enables several functions, including ephrin receptor binding activity; protein kinase activity; and protein kinase binding activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of apoptotic process; and regulation of presynaptic cytosolic calcium ion concentration. Located in several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Part of protein kinase 5 complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and neuromuscular junction. Colocalizes with microtubule. Used to study brain ischemia; depressive disorder; and trigeminal neuralgia. Biomarker of Alzheimer's disease; transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5); PARTICIPATES IN dopamine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; Reelin signaling pathway; INTERACTS WITH (+)-schisandrin B; (S)-amphetamine; (S)-colchicine.
Type: protein-coding
Previously known as: cell division protein kinase 5; cyclin-dependent-like kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit; TPKII catalytic subunit
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2410,754,682 - 10,760,110 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,754,687 - 10,760,112 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,900,964 - 15,905,445 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,721,157 - 11,725,638 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,072,941 - 10,077,422 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,282,945 - 7,287,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,282,948 - 7,288,383 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,294,309 - 7,298,791 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,119,704 - 6,124,186 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,119,703 - 6,124,185 (+)NCBI
Celera46,369,255 - 6,373,737 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-amphetamine  (EXP)
(S)-colchicine  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alvocidib  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium dichloride  (EXP)
Calpeptin  (EXP)
camptothecin  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
deguelin  (ISO)
diarsenic trioxide  (EXP)
diazinon  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP,ISO)
lovastatin  (EXP)
lycopene  (ISO)
methamphetamine  (EXP,ISO)
methidathion  (ISO)
methoxyacetic acid  (EXP)
methylseleninic acid  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-D-aspartic acid  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel dichloride  (EXP)
oxidopamine  (EXP)
paracetamol  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
sarin  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tetrachloromethane  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
tolonium chloride  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
associative learning  (ISO)
axon extension  (TAS)
axonogenesis  (IBA,IEA,ISO)
behavioral response to cocaine  (IEA,ISO)
calcium ion import  (IEA,ISO)
cell division  (IEA)
cell migration  (ISO)
cell-matrix adhesion  (IEA,ISO)
cellular response to amyloid-beta  (IDA)
central nervous system neuron development  (IEA,ISO)
cerebellar cortex development  (ISO)
cerebellar cortex formation  (IEA,ISO)
cerebellum development  (ISO)
cerebral cortex development  (ISO)
chromatin remodeling  (IEA)
corpus callosum development  (IEA,ISO)
cortical actin cytoskeleton organization  (IMP)
dendrite morphogenesis  (IEA,ISO)
DNA damage response  (IMP)
establishment of localization in cell  (ISO)
excitatory postsynaptic potential  (IEA,ISO)
exocytosis  (IMP)
forebrain development  (ISO)
hippocampus development  (IEA,ISO)
intracellular protein transport  (IEA,ISO)
layer formation in cerebral cortex  (IEA,ISO)
mitochondrion organization  (IMP)
motor neuron axon guidance  (IEA,ISO)
negative regulation of axon extension  (IEA,ISO)
negative regulation of cell cycle  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of protein export from nucleus  (IEA,ISO)
negative regulation of protein ubiquitination  (IEA,ISO)
negative regulation of proteolysis  (IEA,ISO)
negative regulation of synaptic plasticity  (IEA,ISO)
neuron apoptotic process  (IBA,IEA,IMP,ISO)
neuron differentiation  (IDA,ISO)
neuron migration  (IEA,ISO)
neuron projection development  (IMP)
neuron projection morphogenesis  (IMP)
nucleocytoplasmic transport  (IMP)
oligodendrocyte differentiation  (IEA,ISO)
peptidyl-serine phosphorylation  (IDA)
phosphorylation  (IEA,ISO)
positive regulation of calcium ion-dependent exocytosis  (IEA,ISO)
positive regulation of glial cell apoptotic process  (IMP)
positive regulation of neuron apoptotic process  (IDA)
positive regulation of presynaptic cytosolic calcium concentration  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of protein targeting to membrane  (IEA,ISO)
protein autophosphorylation  (IDA)
protein localization to synapse  (IEA,ISO)
protein phosphorylation  (IDA)
receptor catabolic process  (IEA,ISO)
receptor clustering  (IEA,ISO)
regulated exocytosis  (IMP)
regulation of cell migration  (IEA,ISO)
regulation of dendritic spine morphogenesis  (IEA,ISO,ISS)
regulation of postsynaptic membrane potential  (ISO)
regulation of presynaptic cytosolic calcium ion concentration  (IDA,IMP)
regulation of protein localization to plasma membrane  (IEA,ISO)
regulation of synapse pruning  (EXP,IDA,IMP)
regulation of synaptic plasticity  (IMP)
regulation of synaptic transmission, glutamatergic  (IEA,ISO)
response to cocaine  (ISO)
rhythmic process  (IEA)
Schwann cell development  (IEA,ISO)
sensory perception of pain  (IEA,ISO)
skeletal muscle tissue development  (IEA,IEP,ISO,TAS)
synapse assembly  (IEA,ISO)
synaptic transmission, dopaminergic  (IEA,ISO)
synaptic transmission, glutamatergic  (IEA,ISO)
synaptic vesicle endocytosis  (IMP)
synaptic vesicle transport  (IBA,IEA)
telencephalon development  (ISO)
vesicle-mediated transport  (IEA)
visual learning  (IEA,ISO)

Cellular Component
axon  (IDA,IEA,ISO)
cell junction  (ISO,TAS)
cyclin-dependent protein kinase holoenzyme complex  (IEA,ISO)
cytoplasm  (IBA,IDA,IEA,ISO)
cytosol  (IEA,ISO,TAS)
dendrite  (IDA)
filopodium  (IEA,ISO)
glutamatergic synapse  (EXP,IDA,IMP)
growth cone  (IDA)
lamellipodium  (IEA,ISO)
membrane  (IDA)
microtubule  (IDA)
neuromuscular junction  (IDA)
neuron projection  (IDA)
neuronal cell body  (IDA)
nucleolus  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)
perikaryon  (IEA)
plasma membrane  (IEA,ISO)
postsynapse  (IDA)
postsynaptic density  (IDA,IEA)
presynapse  (IMP)
protein kinase 5 complex  (IDA,IEA,ISO)
Schaffer collateral - CA1 synapse  (EXP,IDA,IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins. Bhaskar K, etal., Neurochem Int. 2004 Jan;44(1):35-44.
2. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Bibb JA, etal., Nature 2001 Mar 15;410(6826):376-80.
3. c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice. Cancino GI, etal., Neurobiol Aging. 2011 Jul;32(7):1249-61. doi: 10.1016/j.neurobiolaging.2009.07.007. Epub 2009 Aug 22.
4. The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats. Cao Y, etal., Acta Biochim Biophys Sin (Shanghai). 2016 May;48(5):437-46. doi: 10.1093/abbs/gmw024.
5. Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35. Cheng K, etal., J Biol Chem 2002 Aug 30;277(35):31988-93.
6. Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. Cheung ZH, etal., PLoS Biol. 2007 Apr;5(4):e63.
7. Neuronal Cell Death and Degeneration through Increased Nitroxidative Stress and Tau Phosphorylation in HIV-1 Transgenic Rats. Cho YE, etal., PLoS One. 2017 Jan 20;12(1):e0169945. doi: 10.1371/journal.pone.0169945. eCollection 2017.
8. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. Dhavan R, etal., J Neurosci. 2002 Sep 15;22(18):7879-91.
9. Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Fu AK, etal., Nat Neurosci. 2001 Apr;4(4):374-81.
10. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Fu WY, etal., Nat Neurosci. 2007 Jan;10(1):67-76. Epub 2006 Dec 3.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Gong X, etal., Neuron. 2003 Apr 10;38(1):33-46.
14. Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression. Hellmich MR, etal., Proc Natl Acad Sci U S A 1992 Nov 15;89(22):10867-71.
15. Microtubule association of the neuronal p35 activator of Cdk5. Hou Z, etal., J Biol Chem. 2007 Jun 29;282(26):18666-70. Epub 2007 May 9.
16. The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect. Huang M, etal., Behav Brain Res. 2018 Jan 30;337:280-286. doi: 10.1016/j.bbr.2017.07.047. Epub 2017 Aug 4.
17. p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. Humbert S, etal., J Cell Sci. 2000 Mar;113 ( Pt 6):975-83.
18. CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus. Hyun HW, etal., Neurosci Res. 2017 Jun;119:24-37. doi: 10.1016/j.neures.2017.01.006. Epub 2017 Jan 30.
19. Balance of calcineurin Aa and CDK5 activities sets release probability at nerve terminals. Kim SH and Ryan TA, J Neurosci. 2013 May 22;33(21):8937-50. doi: 10.1523/JNEUROSCI.4288-12.2013.
20. Regulation of NMDA receptors by cyclin-dependent kinase-5. Li BS, etal., Proc Natl Acad Sci U S A 2001 Oct 23;98(22):12742-7.
21. Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. Li T, etal., J Biol Chem. 2007 Mar 2;282(9):6619-28. Epub 2007 Jan 3.
22. [Expression and activity of Cdk5/p35 in a rat model of trigeminal neuropathic pain]. Li W, etal., Shanghai Kou Qiang Yi Xue. 2010 Oct;19(5):545-8.
23. Ischemic stroke injury is mediated by aberrant Cdk5. Meyer DA, etal., J Neurosci. 2014 Jun 11;34(24):8259-67. doi: 10.1523/JNEUROSCI.4368-13.2014.
24. A family of human cdc2-related protein kinases. Meyerson M, etal., EMBO J 1992 Aug;11(8):2909-17.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability. Moy LY and Tsai LH, J Biol Chem. 2004 Dec 24;279(52):54487-93. Epub 2004 Oct 7.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Nguyen MD, etal., Neuron 2001 Apr;30(1):135-47.
29. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Nikolic M, etal., Genes Dev. 1996 Apr 1;10(7):816-25.
30. Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5. Norrholm SD, etal., Neuroscience. 2003;116(1):19-22.
31. Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death. O'Hare MJ, etal., J Neurosci. 2005 Sep 28;25(39):8954-66.
32. Na, K-ATPase a3 is a death target of Alzheimer patient amyloid-ß assembly. Ohnishi T, etal., Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4465-74. doi: 10.1073/pnas.1421182112. Epub 2015 Jul 29.
33. Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5). Pant AC, etal., Brain Res. 1997 Aug 15;765(2):259-66.
34. Cyclin-dependent kinase 5 activity regulates pain signaling. Pareek TK, etal., Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):791-6. doi: 10.1073/pnas.0510405103. Epub 2006 Jan 9.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
37. Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer's Disease. Prema A, etal., J Alzheimers Dis. 2017;60(s1):S209-S220. doi: 10.3233/JAD-161103.
38. Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. Rademakers R, etal., Neurobiol Aging. 2005 Aug-Sep;26(8):1145-51. doi: 10.1016/j.neurobiolaging.2004.10.003. Epub 2004 Dec 22.
39. GOA pipeline RGD automated data pipeline
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. Sahlgren CM, etal., EMBO J. 2006 Oct 18;25(20):4808-19. Epub 2006 Oct 12.
42. Cdk5 regulates the organization of Nestin and its association with p35. Sahlgren CM, etal., Mol Cell Biol 2003 Jul;23(14):5090-106.
43. Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39. Sakaue F, etal., J Biol Chem. 2005 Sep 9;280(36):31522-9. Epub 2005 Jul 1.
44. A novel, extraneuronal role for cyclin-dependent protein kinase 5 (CDK5): modulation of cAMP-induced apoptosis in rat leukemia cells.PG - 20783-93 Sandal T, etal., J Biol Chem 2002 Jun 7;277(23):20783-93.
45. L6 myoblast differentiation is modulated by Cdk5 via the PI3K-AKT-p70S6K signaling pathway. Sarker KP and Lee KY, Oncogene. 2004 Aug 12;23(36):6064-70.
46. Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35. Sato K, etal., J Neurosci Res. 2007 Nov 1;85(14):3071-8. doi: 10.1002/jnr.21438.
47. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity. Seeburg DP, etal., Neuron. 2008 May 22;58(4):571-83. doi: 10.1016/j.neuron.2008.03.021.
48. TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice. Shukla V, etal., J Alzheimers Dis. 2017;56(1):335-349. doi: 10.3233/JAD-160916.
49. Phosphorylation of the high molecular weight neurofilament protein (NF-H) by Cdk5 and p35. Sun D, etal., J Biol Chem 1996 Jun 14;271(24):14245-51.
50. Cdk5 is essential for synaptic vesicle endocytosis. Tan TC, etal., Nat Cell Biol 2003 Aug;5(8):701-10.
51. Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. Tian B, etal., Nat Cell Biol. 2009 Feb;11(2):211-8. doi: 10.1038/ncb1829. Epub 2009 Jan 18.
52. The neuroprotective mechanism of puerarin in the treatment of acute spinal ischemia-reperfusion injury is linked to cyclin-dependent kinase 5. Tian F, etal., Neurosci Lett. 2015 Jan 1;584:50-5. doi: 10.1016/j.neulet.2014.09.049. Epub 2014 Oct 7.
53. Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity. Ubeda M, etal., J Biol Chem. 2006 Sep 29;281(39):28858-64. Epub 2006 Aug 3.
54. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
55. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
56. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Wang J, etal., Nat Neurosci 2003 Oct;6(10):1039-47. Epub 2003 Sep 21.
57. Cdk5 and Trio modulate endocrine cell exocytosis. Xin X, etal., J Cell Sci. 2004 Sep 15;117(Pt 20):4739-48. Epub 2004 Aug 25.
58. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Xiong Y, etal., Cell 1992 Oct 30;71(3):505-14.
59. Cdk5 inhibitor roscovitine alleviates neuropathic pain in the dorsal root ganglia by downregulating N-methyl-D-aspartate receptor subunit 2A. Yang L, etal., Neurol Sci. 2014 Sep;35(9):1365-71. doi: 10.1007/s10072-014-1713-9.
60. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
61. Cdk5 is required for the neuroprotective effect of transforming growth factor-ß1 against cerebral ischemia-reperfusion. Zhao W, etal., Biochem Biophys Res Commun. 2017 Apr 15;485(4):775-781. doi: 10.1016/j.bbrc.2017.02.130. Epub 2017 Feb 27.
62. Regulation of cyclin-dependent kinase 5 and calcium/calmodulin-dependent protein kinase II by phosphatidylinositol-linked dopamine receptor in rat brain. Zhen X, etal., Mol Pharmacol. 2004 Dec;66(6):1500-7. Epub 2004 Jul 30.
63. A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons. Zheng YL, etal., EMBO J. 2005 Jan 12;24(1):209-20. Epub 2004 Dec 9.
64. Increased Cdk5/p35 activity in the dentate gyrus mediates depressive-like behaviour in rats. Zhu WL, etal., Int J Neuropsychopharmacol. 2012 Jul;15(6):795-809. doi: 10.1017/S1461145711000915. Epub 2011 Jun 20.
65. Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation. Zhu YS, etal., J Neurochem. 2005 Sep;94(6):1535-45. Epub 2005 Jun 30.
Additional References at PubMed
PMID:3627430   PMID:8855328   PMID:8891282   PMID:9126296   PMID:9191048   PMID:9202329   PMID:9698328   PMID:10407039   PMID:11163260   PMID:11226314   PMID:11517264   PMID:11978846  
PMID:12056836   PMID:12077184   PMID:12372285   PMID:12393264   PMID:12496365   PMID:12941275   PMID:14521924   PMID:14704270   PMID:14769920   PMID:15067135   PMID:15096606   PMID:15123626  
PMID:15342635   PMID:15489224   PMID:16203963   PMID:16237170   PMID:16996690   PMID:17060449   PMID:17108320   PMID:17113760   PMID:17121855   PMID:17150266   PMID:17194758   PMID:17327227  
PMID:17360491   PMID:17400554   PMID:17401652   PMID:17498664   PMID:17517623   PMID:17529984   PMID:17591690   PMID:17694053   PMID:17699587   PMID:17728463   PMID:17965932   PMID:18032654  
PMID:18032670   PMID:18042622   PMID:18054859   PMID:18351461   PMID:18385322   PMID:18460467   PMID:18480410   PMID:18616564   PMID:18625302   PMID:18628310   PMID:18662245   PMID:18701695  
PMID:18771616   PMID:18818692   PMID:18991853   PMID:19049962   PMID:19141975   PMID:19158499   PMID:19295160   PMID:19304511   PMID:19514269   PMID:19522735   PMID:19531642   PMID:19776350  
PMID:19782753   PMID:20213743   PMID:20357208   PMID:20684275   PMID:20720012   PMID:20826311   PMID:20886068   PMID:21145489   PMID:21187058   PMID:21378178   PMID:21389115   PMID:21457712  
PMID:21554958   PMID:21712386   PMID:21756775   PMID:21978141   PMID:22451679   PMID:22573681   PMID:22778260   PMID:22801079   PMID:22833568   PMID:22870316   PMID:22871113   PMID:22874667  
PMID:22899714   PMID:23000950   PMID:23022559   PMID:23056393   PMID:23077056   PMID:23123677   PMID:23164613   PMID:23415811   PMID:23786497   PMID:23816988   PMID:23954626   PMID:24189275  
PMID:24465591   PMID:24498195   PMID:24548080   PMID:24607229   PMID:24662752   PMID:24766160   PMID:24880860   PMID:25012575   PMID:25055140   PMID:25093719   PMID:25234403   PMID:25533468  
PMID:25598508   PMID:25819553   PMID:25831123   PMID:25843720   PMID:25864429   PMID:25903132   PMID:25931508   PMID:26088971   PMID:26104286   PMID:26179626   PMID:26503494   PMID:26658992  
PMID:26806339   PMID:26902776   PMID:27145370   PMID:27316643   PMID:27461471   PMID:27549397   PMID:28445771   PMID:28559121   PMID:28595035   PMID:28760951   PMID:28941293   PMID:29476059  
PMID:29564811   PMID:29705343   PMID:30537069   PMID:30562750   PMID:30875016   PMID:31156174   PMID:31163256   PMID:31186372   PMID:31403945   PMID:31744861   PMID:31786229   PMID:31983427  
PMID:32310180   PMID:32571373   PMID:32666227   PMID:32883957   PMID:33423166   PMID:35795154   PMID:36854738  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2410,754,682 - 10,760,110 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,754,687 - 10,760,112 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,900,964 - 15,905,445 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,721,157 - 11,725,638 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,072,941 - 10,077,422 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,282,945 - 7,287,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,282,948 - 7,288,383 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,294,309 - 7,298,791 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,119,704 - 6,124,186 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,119,703 - 6,124,185 (+)NCBI
Celera46,369,255 - 6,373,737 (+)NCBICelera
Cytogenetic Map4q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387151,053,815 - 151,057,897 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7151,053,815 - 151,057,897 (-)EnsemblGRCh38hg38GRCh38
GRCh377150,750,902 - 150,754,984 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,381,832 - 150,385,929 (-)NCBINCBI36Build 36hg18NCBI36
Build 347150,188,546 - 150,192,644NCBI
Celera7145,308,208 - 145,312,361 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,563,235 - 144,567,388 (-)NCBIHuRef
CHM1_17150,759,247 - 150,763,400 (-)NCBICHM1_1
T2T-CHM13v2.07152,226,903 - 152,230,985 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27150,080,438 - 150,084,591 (-)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39524,612,595 - 24,628,737 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl524,623,239 - 24,628,528 (-)EnsemblGRCm39 Ensembl
GRCm38524,407,597 - 24,423,587 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,418,241 - 24,423,530 (-)EnsemblGRCm38mm10GRCm38
MGSCv37523,924,060 - 23,929,348 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36523,928,307 - 23,933,595 (-)NCBIMGSCv36mm8
Celera521,368,049 - 21,373,342 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map511.73NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554915,491,744 - 5,497,280 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,491,744 - 5,497,280 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1739,485,994 - 39,490,148 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,640,630 - 142,644,785 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,793,344 - 154,797,499 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,793,344 - 154,797,499 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11615,105,177 - 15,113,085 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,101,230 - 15,109,269 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,713,427 - 15,717,637 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,827,407 - 16,831,617 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1616,827,546 - 16,831,537 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,199,846 - 15,204,056 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,781,300 - 15,785,509 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,832,007 - 15,836,217 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244051186,419,559 - 6,424,495 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,478,982 - 6,483,866 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,478,934 - 6,483,848 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1186,166,914 - 6,171,157 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,536,973 - 6,541,192 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap18q12-q13NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.121119,235,687 - 119,240,163 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607215,206,191 - 15,211,917 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248005,562,462 - 5,569,937 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248005,562,468 - 5,566,458 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cdk5
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:120
Interacting mature miRNAs:131
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,755,427 - 10,755,743 (+)MAPPERmRatBN7.2
Rnor_6.047,283,686 - 7,284,001NCBIRnor6.0
Rnor_5.047,295,050 - 7,295,365UniSTSRnor5.0
RGSC_v3.446,120,445 - 6,120,760UniSTSRGSC3.4
Celera46,369,996 - 6,370,311UniSTS
Cytogenetic Map4q11UniSTS

Related Rat Strains
The following Strains have been annotated to Cdk5


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 29 22 6 18 6 74 29 35 11
Low 14 35 35 1 35 8 11 6 6 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000011052   ⟹   ENSRNOP00000011052
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,754,690 - 10,760,112 (+)Ensembl
Rnor_6.0 Ensembl47,282,948 - 7,288,383 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095452   ⟹   ENSRNOP00000078022
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,754,687 - 10,759,166 (+)Ensembl
RefSeq Acc Id: NM_080885   ⟹   NP_543161
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,754,687 - 10,759,169 (+)NCBI
Rnor_6.047,282,945 - 7,287,427 (+)NCBI
Rnor_5.047,294,309 - 7,298,791 (+)NCBI
RGSC_v3.446,119,704 - 6,124,186 (+)RGD
Celera46,369,255 - 6,373,737 (+)RGD
RefSeq Acc Id: XR_005503144
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,754,682 - 10,760,110 (+)NCBI
Protein Sequences
Protein RefSeqs NP_543161 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40902 (Get FASTA)   NCBI Sequence Viewer  
  EDL99365 (Get FASTA)   NCBI Sequence Viewer  
  EDL99366 (Get FASTA)   NCBI Sequence Viewer  
  EDL99367 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011052.3
GenBank Protein Q03114 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_543161   ⟸   NM_080885
- UniProtKB: Q03114 (UniProtKB/Swiss-Prot),   A6K556 (UniProtKB/TrEMBL),   A0A8L2UIH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011052   ⟸   ENSRNOT00000011052
RefSeq Acc Id: ENSRNOP00000078022   ⟸   ENSRNOT00000095452
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03114-F1-model_v2 AlphaFold Q03114 1-292 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692790
Promoter ID:EPDNEW_R3315
Type:initiation region
Description:cyclin-dependent kinase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.047,282,962 - 7,283,022EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70514 AgrOrtholog
BioCyc Gene G2FUF-46042 BioCyc
Ensembl Genes ENSRNOG00000008017 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011052.5 UniProtKB/TrEMBL
  ENSRNOT00000095452.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140908 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdk5 PhenoGen
RatGTEx ENSRNOG00000008017 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y6S3_RAT UniProtKB/TrEMBL
  A6K558_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Cdk5  cyclin-dependent kinase 5      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Cdk5  cyclin-dependent kinase 5      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in uterine tumors 70557
gene_expression expressed in uterus 70557
gene_expression prominently expressed in the central nervous system 632377
gene_function phosphorylates serine/threonine sites in (K/RT/SPXK)-type motifs, including synaptic proteins; associates with and phosphorylates NMDA receptor modulatory subunits (Grin2a) 70569
gene_physical_interaction interacts with Pctaire1 at the neuromuscular junction in cultured myotubes and skeletal muscle 632377
gene_process necessary for cAMP-induced apoptosis and inhibition of activity can prevent the cleavage of pro-caspase-3 in cAMP-treated cells 625522
gene_process plays an essential role in neuronal migration, neurite outgrowth, and laminar configuration of the cerebral cortex 69667
gene_process may play a key role in synaptic transmission and plasticity through its up-regulation of N-methyl-D-aspartate (NMDA) class of glutamate receptors (NMDARs) 70569