CDK5 (cyclin dependent kinase 5) - Rat Genome Database
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Gene: CDK5 (cyclin dependent kinase 5) Canis lupus familiaris
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Symbol: CDK5
Name: cyclin dependent kinase 5
RGD ID: 12107141
Description: ENCODES a protein that exhibits acetylcholine receptor activator activity (ortholog); cyclin-dependent protein serine/threonine kinase activity (ortholog); cytoskeletal protein binding (ortholog); INVOLVED IN apoptotic process (ortholog); associative learning (ortholog); axonogenesis (ortholog); PARTICIPATES IN dopamine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; Reelin signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); brain ischemia (ortholog); FOUND IN axon (ortholog); cell junction (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: cyclin-dependent-like kinase 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1615,101,230 - 15,109,269 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11615,105,177 - 15,113,085 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
associative learning  (ISO)
axonogenesis  (IBA,ISO)
behavioral response to cocaine  (ISO)
calcium ion import  (ISO)
cell migration  (ISO)
cell-matrix adhesion  (ISO)
cellular response to amyloid-beta  (ISO)
central nervous system neuron development  (ISO)
cerebellar cortex development  (ISO)
cerebellar cortex formation  (ISO)
cerebellum development  (ISO)
cerebral cortex development  (ISO)
corpus callosum development  (ISO)
cortical actin cytoskeleton organization  (ISO)
dendrite morphogenesis  (ISO)
excitatory postsynaptic potential  (ISO)
exocytosis  (ISO)
forebrain development  (ISO)
hippocampus development  (ISO)
histone phosphorylation  (ISO)
intracellular protein transport  (ISO)
layer formation in cerebral cortex  (ISO)
mitochondrion organization  (ISO)
motor neuron axon guidance  (ISO)
negative regulation of axon extension  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of protein export from nucleus  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of proteolysis  (ISO)
negative regulation of synaptic plasticity  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
neuron apoptotic process  (IBA,ISO)
neuron differentiation  (ISO)
neuron migration  (ISO)
neuron projection development  (ISO)
neuron projection morphogenesis  (ISO)
nucleocytoplasmic transport  (ISO)
oligodendrocyte differentiation  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
phosphorylation  (ISO)
positive regulation of calcium ion-dependent exocytosis  (ISO)
positive regulation of glial cell apoptotic process  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of presynaptic cytosolic calcium concentration  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of voltage-gated calcium channel activity  (ISO)
protein autophosphorylation  (ISO)
protein localization to synapse  (ISO)
protein phosphorylation  (IBA,IEA,ISO)
receptor catabolic process  (ISO)
receptor clustering  (ISO)
regulated exocytosis  (ISO)
regulation of cell cycle  (IEA)
regulation of cell migration  (ISO)
regulation of dendritic spine morphogenesis  (ISO)
regulation of postsynaptic membrane potential  (ISO)
regulation of protein localization to plasma membrane  (ISO)
regulation of synaptic plasticity  (ISO)
regulation of synaptic transmission, glutamatergic  (ISO)
regulation of transcription involved in G1/S transition of mitotic cell cycle  (IBA)
response to cocaine  (ISO)
response to wounding  (ISO)
Schwann cell development  (ISO)
sensory perception of pain  (ISO)
serine phosphorylation of STAT protein  (ISO)
skeletal muscle tissue development  (ISO)
synapse assembly  (ISO)
synapse pruning  (ISO)
synaptic transmission, dopaminergic  (ISO)
synaptic transmission, glutamatergic  (ISO)
synaptic vesicle endocytosis  (ISO)
synaptic vesicle transport  (IBA)
telencephalon development  (ISO)
visual learning  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
CDK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1615,101,230 - 15,109,269 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11615,105,177 - 15,113,085 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CDK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7151,053,815 - 151,057,897 (-)EnsemblGRCh38hg38GRCh38
GRCh387151,053,815 - 151,057,897 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377150,750,902 - 150,754,984 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,381,832 - 150,385,929 (-)NCBINCBI36hg18NCBI36
Build 347150,188,546 - 150,192,644NCBI
Celera7145,308,208 - 145,312,361 (-)NCBI
Cytogenetic Map7q36.1NCBI
HuRef7144,563,235 - 144,567,388 (-)NCBIHuRef
CHM1_17150,759,247 - 150,763,400 (-)NCBICHM1_1
CRA_TCAGchr7v27150,080,438 - 150,084,591 (-)NCBI
Cdk5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,612,595 - 24,628,737 (-)NCBIGRCm39mm39
GRCm39 Ensembl524,623,239 - 24,628,528 (-)Ensembl
GRCm38524,407,597 - 24,423,587 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,418,241 - 24,423,530 (-)EnsemblGRCm38mm10GRCm38
MGSCv37523,924,060 - 23,929,348 (-)NCBIGRCm37mm9NCBIm37
MGSCv36523,928,307 - 23,933,595 (-)NCBImm8
Celera521,368,049 - 21,373,342 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map511.73NCBI
Cdk5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2410,754,682 - 10,760,110 (+)NCBI
Rnor_6.0 Ensembl47,282,948 - 7,288,383 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.047,282,945 - 7,287,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.047,294,309 - 7,298,791 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,119,704 - 6,124,186 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.146,119,703 - 6,124,185 (+)NCBI
Celera46,369,255 - 6,373,737 (+)NCBICelera
Cytogenetic Map4q11NCBI
Cdk5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,491,744 - 5,497,280 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,491,744 - 5,497,280 (-)NCBIChiLan1.0ChiLan1.0
CDK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17154,793,344 - 154,797,499 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,793,344 - 154,797,499 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07142,640,630 - 142,644,785 (-)NCBIMhudiblu_PPA_v0panPan3
Cdk5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365276,478,934 - 6,483,848 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1186,166,914 - 6,171,157 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,536,973 - 6,541,192 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap18q12-q13NCBI
CDK5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,235,687 - 119,240,163 (-)NCBI
Cdk5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248005,562,468 - 5,566,458 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 16 2 6 12 8 6
Low 2 5 6 6 4 6 6 8 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000007612   ⟹   ENSCAFP00000007048
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1615,105,319 - 15,109,269 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000047662   ⟹   ENSCAFP00000037506
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1615,105,319 - 15,109,269 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000070661   ⟹   ENSCAFP00000051905
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1615,105,319 - 15,109,265 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000079546   ⟹   ENSCAFP00000056740
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1615,101,230 - 15,109,269 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000080617   ⟹   ENSCAFP00000044636
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1615,104,523 - 15,109,269 (-)Ensembl
RefSeq Acc Id: XM_005629752   ⟹   XP_005629809
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11615,105,177 - 15,113,085 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005629809   ⟸   XM_005629752
- Sequence:
RefSeq Acc Id: ENSCAFP00000051905   ⟸   ENSCAFT00000070661
RefSeq Acc Id: ENSCAFP00000037506   ⟸   ENSCAFT00000047662
RefSeq Acc Id: ENSCAFP00000044636   ⟸   ENSCAFT00000080617
RefSeq Acc Id: ENSCAFP00000056740   ⟸   ENSCAFT00000079546
RefSeq Acc Id: ENSCAFP00000007048   ⟸   ENSCAFT00000007612
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004725 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000007048 UniProtKB/TrEMBL
  ENSCAFP00000037506 UniProtKB/TrEMBL
  ENSCAFP00000044636 UniProtKB/TrEMBL
  ENSCAFP00000051905 UniProtKB/TrEMBL
  ENSCAFP00000056740 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000007612 UniProtKB/TrEMBL
  ENSCAFT00000047662 UniProtKB/TrEMBL
  ENSCAFT00000070661 UniProtKB/TrEMBL
  ENSCAFT00000079546 UniProtKB/TrEMBL
  ENSCAFT00000080617 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene CDK5 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A5F4BS56_CANLF UniProtKB/TrEMBL
  A0A5F4CCB1_CANLF UniProtKB/TrEMBL
  A0A5F4CTH3_CANLF UniProtKB/TrEMBL
  E2RGN2_CANLF UniProtKB/TrEMBL
  J9NWG1_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:51795 ENTREZGENE