RGD Reference Report - Cdk5 is required for the neuroprotective effect of transforming growth factor-ß1 against cerebral ischemia-reperfusion. - Rat Genome Database

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Cdk5 is required for the neuroprotective effect of transforming growth factor-ß1 against cerebral ischemia-reperfusion.

Authors: Zhao, Wenhui  Yan, Jing  Gao, Liyun  Zhao, Jinfeng  Zhao, Conglin  Gao, Chao  Luo, Xiaoqiu  Zhu, Xinshu 
Citation: Zhao W, etal., Biochem Biophys Res Commun. 2017 Apr 15;485(4):775-781. doi: 10.1016/j.bbrc.2017.02.130. Epub 2017 Feb 27.
RGD ID: 13506925
Pubmed: PMID:28254431   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2017.02.130   (Journal Full-text)

Transforming Growth Factor ß1 (TGF-ß1), a well-known neuroprotective and neurotrophic factor in the central nervous system, is also involved in the repair process responses after ischemia-reperfusion injury. Herein, we found that TGF-ß1 enhanced Cdk5 expression while decreased Tunel-positive cells compared with the ischemia group, and roscovitine(Cdk5 inhibitor) treatment could blunt these effects. In vitro study, TGF-ß1 facilitated Cdk5/p35 complex, the proliferation, neurite growth and differentiation of PC12 cells, effects of which could be blunted by roscovitine and Cdk5 silencing. Moreover, ERK1/2 inhibitor SCH772984 abrogated the effects of TGF- ß1 on Cdk5 and Bax levels. Taken together, we conclude that Cdk5 contributes to the neuroprotective function of TGF- ß1 via ERK1/2 signaling.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CDK5Humantransient cerebral ischemia treatmentISOCdk5 (Rattus norvegicus) RGD 
Cdk5Rattransient cerebral ischemia treatmentIEP  RGD 
Cdk5Mousetransient cerebral ischemia treatmentISOCdk5 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdk5  (cyclin-dependent kinase 5)

Genes (Mus musculus)
Cdk5  (cyclin dependent kinase 5)

Genes (Homo sapiens)
CDK5  (cyclin dependent kinase 5)


Additional Information