Cdk5 (cyclin-dependent kinase 5) - Rat Genome Database

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Gene: Cdk5 (cyclin-dependent kinase 5) Mus musculus
Symbol: Cdk5
Name: cyclin-dependent kinase 5
RGD ID: 70826
Description: Enables several functions, including Hsp90 protein binding activity; acetylcholine receptor activator activity; and signaling receptor binding activity. Involved in regulation of dendritic spine morphogenesis; regulation of glutamatergic synaptic transmission; and regulation of protein localization to plasma membrane. Acts upstream of or within several processes, including chemical synaptic transmission; nervous system development; and regulation of intracellular protein transport. Located in several cellular components, including axon; filopodium; and lamellipodium. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5); PARTICIPATES IN dopamine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; Reelin signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3',4,4',5-Pentachlorobiphenyl; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW048668; cell division protein kinase 5; CR6 protein kinase; Crk; Crk6; cyclin-dependent-like kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit; TPKII catalytic subunit
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39524,612,595 - 24,628,737 (-)NCBIGRCm39mm39
GRCm39 Ensembl524,623,239 - 24,628,528 (-)Ensembl
GRCm38524,407,597 - 24,423,587 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,418,241 - 24,423,530 (-)EnsemblGRCm38mm10GRCm38
MGSCv37523,924,060 - 23,929,348 (-)NCBIGRCm37mm9NCBIm37
MGSCv36523,928,307 - 23,933,595 (-)NCBImm8
Celera521,368,049 - 21,373,342 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map511.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
alvocidib  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
Calpeptin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlorpromazine  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
clofibrate  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
doxorubicin  (EXP)
ethanol  (EXP)
fluoxetine  (EXP)
flutamide  (ISO)
folic acid  (EXP)
genistein  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
isotretinoin  (ISO)
lead diacetate  (EXP,ISO)
lovastatin  (ISO)
lycopene  (ISO)
methamphetamine  (EXP,ISO)
methoxyacetic acid  (ISO)
methylseleninic acid  (ISO)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel dichloride  (ISO)
oxidopamine  (ISO)
paracetamol  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
ritonavir  (ISO)
sarin  (ISO)
simvastatin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IDA)
associative learning  (IMP)
axonogenesis  (IBA,IMP)
behavioral response to cocaine  (IMP)
calcium ion import  (IMP)
cell division  (IEA)
cell migration  (IDA,IMP)
cell-matrix adhesion  (IDA)
cellular response to amyloid-beta  (ISO)
central nervous system neuron development  (IMP)
cerebellar cortex development  (IMP)
cerebellar cortex formation  (IMP)
cerebellum development  (IMP)
cerebral cortex development  (IMP)
corpus callosum development  (IMP)
cortical actin cytoskeleton organization  (ISO)
dendrite morphogenesis  (IMP)
excitatory postsynaptic potential  (IMP)
exocytosis  (ISO)
forebrain development  (IMP)
hippocampus development  (IMP)
histone phosphorylation  (ISO)
intracellular protein transport  (IMP)
layer formation in cerebral cortex  (IMP)
mitochondrion organization  (ISO)
motor neuron axon guidance  (IMP)
negative regulation of axon extension  (IGI)
negative regulation of cell cycle  (IMP)
negative regulation of neuron death  (ISO)
negative regulation of protein export from nucleus  (IMP)
negative regulation of protein ubiquitination  (IMP)
negative regulation of proteolysis  (ISO)
negative regulation of synaptic plasticity  (IMP)
negative regulation of transcription, DNA-templated  (ISO)
nervous system development  (IEA)
neuron apoptotic process  (IBA,IMP,ISO)
neuron differentiation  (IMP,ISA,ISO)
neuron migration  (IMP)
neuron projection development  (ISO)
neuron projection morphogenesis  (ISO)
nucleocytoplasmic transport  (ISO)
oligodendrocyte differentiation  (ISO)
peptidyl-serine phosphorylation  (IDA,IMP,ISO)
peptidyl-threonine phosphorylation  (IDA,IMP)
phosphorylation  (ISO)
positive regulation of calcium ion-dependent exocytosis  (IDA)
positive regulation of glial cell apoptotic process  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of presynaptic cytosolic calcium concentration  (ISO)
positive regulation of protein binding  (IMP)
positive regulation of protein kinase activity  (IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein targeting to membrane  (IMP)
positive regulation of voltage-gated calcium channel activity  (ISO)
protein autophosphorylation  (ISO)
protein localization to synapse  (IMP)
protein phosphorylation  (IBA,IDA,IGI,IMP,ISO)
receptor catabolic process  (IMP)
receptor clustering  (IMP)
regulated exocytosis  (ISO)
regulation of cell migration  (IMP)
regulation of dendritic spine morphogenesis  (IMP)
regulation of postsynaptic membrane potential  (IMP)
regulation of protein localization to plasma membrane  (IMP)
regulation of synaptic plasticity  (ISO)
regulation of synaptic transmission, glutamatergic  (IMP)
regulation of transcription involved in G1/S transition of mitotic cell cycle  (IBA)
response to cocaine  (IMP)
response to wounding  (ISO)
rhythmic process  (IEA)
Schwann cell development  (IMP)
sensory perception of pain  (IMP)
serine phosphorylation of STAT protein  (IDA)
skeletal muscle tissue development  (IDA,ISO)
synapse assembly  (IMP)
synapse pruning  (ISO)
synaptic transmission, dopaminergic  (IMP)
synaptic transmission, glutamatergic  (IMP)
synaptic vesicle endocytosis  (ISO)
synaptic vesicle transport  (IBA)
telencephalon development  (IMP)
visual learning  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
1. Bibb JA, etal., Nature 2001 Mar 15;410(6826):376-80.
2. Cao Y, etal., Acta Biochim Biophys Sin (Shanghai). 2016 May;48(5):437-46. doi: 10.1093/abbs/gmw024.
3. Cho YE, etal., PLoS One. 2017 Jan 20;12(1):e0169945. doi: 10.1371/journal.pone.0169945. eCollection 2017.
4. Lemon WJ, etal., J Med Genet 2002 Sep;39(9):644-55.
5. Li W, etal., Shanghai Kou Qiang Yi Xue. 2010 Oct;19(5):545-8.
6. Meyer DA, etal., J Neurosci. 2014 Jun 11;34(24):8259-67. doi: 10.1523/JNEUROSCI.4368-13.2014.
7. MGD and Homologene mouse data transfer
8. MGD data from the GO Consortium
10. Nguyen MD, etal., Neuron 2001 Apr;30(1):135-47.
11. Pareek TK, etal., Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):791-6. doi: 10.1073/pnas.0510405103. Epub 2006 Jan 9.
12. Pipeline to import KEGG annotations from KEGG into RGD
13. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Prema A, etal., J Alzheimers Dis. 2017;60(s1):S209-S220. doi: 10.3233/JAD-161103.
15. Rademakers R, etal., Neurobiol Aging. 2005 Aug-Sep;26(8):1145-51. doi: 10.1016/j.neurobiolaging.2004.10.003. Epub 2004 Dec 22.
16. RGD automated import pipeline
17. RGD automated import pipeline for gene-chemical interactions
18. Shukla V, etal., J Alzheimers Dis. 2017;56(1):335-349. doi: 10.3233/JAD-160916.
19. Tian F, etal., Neurosci Lett. 2015 Jan 1;584:50-5. doi: 10.1016/j.neulet.2014.09.049. Epub 2014 Oct 7.
20. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
21. Wang J, etal., Nat Neurosci 2003 Oct;6(10):1039-47. Epub 2003 Sep 21.
22. Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
23. Zhao W, etal., Biochem Biophys Res Commun. 2017 Apr 15;485(4):775-781. doi: 10.1016/j.bbrc.2017.02.130. Epub 2017 Feb 27.
24. Zhu WL, etal., Int J Neuropsychopharmacol. 2012 Jul;15(6):795-809. doi: 10.1017/S1461145711000915. Epub 2011 Jun 20.
Additional References at PubMed
PMID:3627430   PMID:7490100   PMID:7834371   PMID:8090221   PMID:8275715   PMID:8306873   PMID:8444355   PMID:8543173   PMID:8855328   PMID:8889548   PMID:8891282   PMID:9126296  
PMID:9191048   PMID:9202329   PMID:9231734   PMID:9438340   PMID:9547506   PMID:9619503   PMID:9698328   PMID:10349636   PMID:10407039   PMID:10557205   PMID:10567344   PMID:10579588  
PMID:10753743   PMID:10896159   PMID:11042159   PMID:11076861   PMID:11160434   PMID:11162238   PMID:11163260   PMID:11217851   PMID:11226314   PMID:11239428   PMID:11276227   PMID:11517264  
PMID:11604394   PMID:11739578   PMID:11823425   PMID:11932941   PMID:11955625   PMID:11965495   PMID:11973352   PMID:11978846   PMID:12019323   PMID:12077184   PMID:12130536   PMID:12372285  
PMID:12466851   PMID:12477932   PMID:12496365   PMID:12526740   PMID:12536148   PMID:12730604   PMID:12824184   PMID:12941275   PMID:12950086   PMID:12972605   PMID:14595022   PMID:14623869  
PMID:14627648   PMID:14642273   PMID:14651959   PMID:14681479   PMID:14712065   PMID:14741103   PMID:14749431   PMID:14769920   PMID:15048935   PMID:15055521   PMID:15067135   PMID:15096606  
PMID:15123626   PMID:15280426   PMID:15471880   PMID:15489224   PMID:15489334   PMID:15492003   PMID:15572359   PMID:15665076   PMID:15676027   PMID:15782199   PMID:15935062   PMID:16021178  
PMID:16141072   PMID:16141073   PMID:16155576   PMID:16166266   PMID:16192386   PMID:16203963   PMID:16237170   PMID:16341208   PMID:16407541   PMID:16529723   PMID:16600913   PMID:16602821  
PMID:16766706   PMID:16803897   PMID:16921254   PMID:17021036   PMID:17035538   PMID:17060449   PMID:17108173   PMID:17121546   PMID:17143272   PMID:17194758   PMID:17202132   PMID:17209049  
PMID:17224448   PMID:17295212   PMID:17341134   PMID:17400554   PMID:17416967   PMID:17492640   PMID:17507397   PMID:17517623   PMID:17529984   PMID:17591690   PMID:17694053   PMID:17875933  
PMID:17908241   PMID:18003833   PMID:18032654   PMID:18032670   PMID:18042622   PMID:18054859   PMID:18076569   PMID:18190909   PMID:18239462   PMID:18322105   PMID:18325333   PMID:18341989  
PMID:18385322   PMID:18463240   PMID:18550843   PMID:18603407   PMID:18618229   PMID:18691386   PMID:18753376   PMID:18786638   PMID:18799693   PMID:18829967   PMID:18948252   PMID:18998770  
PMID:19017796   PMID:19017804   PMID:19037081   PMID:19118186   PMID:19156541   PMID:19255425   PMID:19326393   PMID:19457112   PMID:19501082   PMID:19513615   PMID:19514264   PMID:19514265  
PMID:19529798   PMID:19776350   PMID:19830249   PMID:19895631   PMID:19948833   PMID:20189989   PMID:20200223   PMID:20392944   PMID:20403084   PMID:20422042   PMID:20492361   PMID:20534669  
PMID:20573893   PMID:20651683   PMID:20724472   PMID:20810788   PMID:20863901   PMID:20937706   PMID:20962218   PMID:20977891   PMID:21151568   PMID:21210220   PMID:21267068   PMID:21335063  
PMID:21346193   PMID:21368891   PMID:21378178   PMID:21389115   PMID:21415596   PMID:21435449   PMID:21482799   PMID:21499257   PMID:21640796   PMID:21677750   PMID:21701498   PMID:21741478  
PMID:21766205   PMID:21791703   PMID:21813649   PMID:21832185   PMID:21849563   PMID:21873635   PMID:21944720   PMID:21984943   PMID:22114287   PMID:22223639   PMID:22262481   PMID:22398430  
PMID:22451679   PMID:22456337   PMID:22467861   PMID:22573681   PMID:22614921   PMID:22654103   PMID:22899714   PMID:22920258   PMID:22995860   PMID:23064382   PMID:23085039   PMID:23292680  
PMID:23342106   PMID:23362255   PMID:23416045   PMID:23543736   PMID:23583582   PMID:23589330   PMID:23602570   PMID:23645679   PMID:23668392   PMID:23737518   PMID:23816988   PMID:23982957  
PMID:23991155   PMID:24039692   PMID:24085300   PMID:24142862   PMID:24184637   PMID:24235147   PMID:24341874   PMID:24359609   PMID:24368089   PMID:24391960   PMID:24448753   PMID:24486837  
PMID:24495352   PMID:24607229   PMID:24637538   PMID:24658276   PMID:24662752   PMID:24703879   PMID:24768698   PMID:24790206   PMID:24872417   PMID:24872548   PMID:24917152   PMID:24952961  
PMID:25078650   PMID:25080600   PMID:25104559   PMID:25183872   PMID:25309427   PMID:25329792   PMID:25331900   PMID:25359615   PMID:25404232   PMID:25404468   PMID:25409143   PMID:25465240  
PMID:25500740   PMID:25533468   PMID:25673832   PMID:25673854   PMID:25694605   PMID:25711385   PMID:25760945   PMID:25784544   PMID:25785643   PMID:25864429   PMID:25878277   PMID:25952543  
PMID:25964330   PMID:26002103   PMID:26027726   PMID:26057048   PMID:26160434   PMID:26192746   PMID:26198700   PMID:26206088   PMID:26206584   PMID:26268594   PMID:26503494   PMID:26585834  
PMID:26602020   PMID:26631721   PMID:26819770   PMID:26823173   PMID:26853432   PMID:26902776   PMID:26930193   PMID:26961956   PMID:26998748   PMID:27053712   PMID:27073218   PMID:27113764  
PMID:27283769   PMID:27346674   PMID:27402274   PMID:27443506   PMID:27463676   PMID:27479491   PMID:27480591   PMID:27506619   PMID:27507650   PMID:27796283   PMID:27807169   PMID:28024901  
PMID:28064242   PMID:28123016   PMID:28157684   PMID:28589675   PMID:28671696   PMID:28706196   PMID:28712289   PMID:28751497   PMID:28760951   PMID:29031852   PMID:29111393   PMID:29158185  
PMID:29288339   PMID:29314417   PMID:29345339   PMID:29352128   PMID:29729246   PMID:29890311   PMID:30068389   PMID:30618612   PMID:30661667   PMID:31060804   PMID:31069610   PMID:31076103  
PMID:31235685   PMID:31597102   PMID:31687929   PMID:31699822   PMID:31786229   PMID:31787240   PMID:31807777   PMID:31888027   PMID:31950315   PMID:31981925   PMID:32016637   PMID:32024968  
PMID:32193336   PMID:32325033   PMID:32353462   PMID:32550230   PMID:32883957   PMID:33127972  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39524,612,595 - 24,628,737 (-)NCBIGRCm39mm39
GRCm39 Ensembl524,623,239 - 24,628,528 (-)Ensembl
GRCm38524,407,597 - 24,423,587 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,418,241 - 24,423,530 (-)EnsemblGRCm38mm10GRCm38
MGSCv37523,924,060 - 23,929,348 (-)NCBIGRCm37mm9NCBIm37
MGSCv36523,928,307 - 23,933,595 (-)NCBImm8
Celera521,368,049 - 21,373,342 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map511.73NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl7151,053,815 - 151,057,897 (-)EnsemblGRCh38hg38GRCh38
GRCh387151,053,815 - 151,057,897 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377150,750,902 - 150,754,984 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,381,832 - 150,385,929 (-)NCBINCBI36hg18NCBI36
Build 347150,188,546 - 150,192,644NCBI
Celera7145,308,208 - 145,312,361 (-)NCBI
Cytogenetic Map7q36.1NCBI
HuRef7144,563,235 - 144,567,388 (-)NCBIHuRef
CHM1_17150,759,247 - 150,763,400 (-)NCBICHM1_1
CRA_TCAGchr7v27150,080,438 - 150,084,591 (-)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2410,754,682 - 10,760,110 (+)NCBI
Rnor_6.0 Ensembl47,282,948 - 7,288,383 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.047,282,945 - 7,287,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.047,294,309 - 7,298,791 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,119,704 - 6,124,186 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.146,119,703 - 6,124,185 (+)NCBI
Celera46,369,255 - 6,373,737 (+)NCBICelera
Cytogenetic Map4q11NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554915,491,744 - 5,497,280 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,491,744 - 5,497,280 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.17154,793,344 - 154,797,499 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,793,344 - 154,797,499 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07142,640,630 - 142,644,785 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11615,105,177 - 15,113,085 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,101,230 - 15,109,269 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,713,427 - 15,717,637 (-)NCBI
ROS_Cfam_1.01616,827,407 - 16,831,617 (-)NCBI
UMICH_Zoey_3.11615,199,846 - 15,204,056 (-)NCBI
UNSW_CanFamBas_1.01615,781,300 - 15,785,509 (-)NCBI
UU_Cfam_GSD_1.01615,832,007 - 15,836,217 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244051186,419,559 - 6,424,495 (+)NCBI
SpeTri2.0NW_0049365276,478,934 - 6,483,848 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1186,166,914 - 6,171,157 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,536,973 - 6,541,192 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap18q12-q13NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.121119,235,687 - 119,240,163 (-)NCBI
Vero_WHO_p1.0NW_02366607215,206,191 - 15,211,917 (-)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248005,562,468 - 5,566,458 (+)NCBI

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38524,419,249 - 24,419,323UniSTSGRCm38
MGSCv37523,925,067 - 23,925,141UniSTSGRCm37
Celera521,369,056 - 21,369,130UniSTS
Cytogenetic Map5A3-B1UniSTS
Whitehead_YAC5 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38524,418,296 - 24,418,531UniSTSGRCm38
MGSCv37523,924,114 - 23,924,349UniSTSGRCm37
Celera521,368,103 - 21,368,338UniSTS
Cytogenetic Map5A3-B1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38524,418,428 - 24,418,539UniSTSGRCm38
MGSCv37523,924,246 - 23,924,357UniSTSGRCm37
Celera521,368,235 - 21,368,346UniSTS
Cytogenetic Map5A3-B1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37523,925,071 - 23,925,231UniSTSGRCm37
Celera521,369,060 - 21,369,220UniSTS
Cytogenetic Map5A3-B1UniSTS
cM Map512.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38524,422,531 - 24,422,839UniSTSGRCm38
MGSCv37523,928,349 - 23,928,657UniSTSGRCm37
Celera521,372,338 - 21,372,646UniSTS
Cytogenetic Map5A3-B1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A3-B1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38524,419,253 - 24,419,413UniSTSGRCm38
MGSCv37523,925,071 - 23,925,231UniSTSGRCm37
Celera521,369,060 - 21,369,220UniSTS
Cytogenetic Map5A3-B1UniSTS
cM Map512.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38524,419,293 - 24,419,378UniSTSGRCm38
MGSCv37523,925,111 - 23,925,196UniSTSGRCm37
Celera521,369,100 - 21,369,185UniSTS
Cytogenetic Map5A3-B1UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12904958Gmmq8_mgastrocnemius muscle mass QTL 8 (mouse)5129371157Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined561814634618282Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5329982537299825Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5517952239179654Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5791911941919241Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5879767233318293Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5884069387693978Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5886594940372526Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51340580847405808Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51547674049476846Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52052964954529790Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52150995255510060Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52189582554342976Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52189582564649236Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:571
Count of miRNA genes:358
Interacting mature miRNAs:433
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_007668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_156449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006535626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI550418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY126868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D26605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D29678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S80121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X64604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000030814   ⟹   ENSMUSP00000030814
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl524,418,241 - 24,423,530 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197619
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl524,420,999 - 24,422,695 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198990   ⟹   ENSMUSP00000142413
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl524,419,376 - 24,423,485 (-)Ensembl
RefSeq Acc Id: NM_007668   ⟹   NP_031694
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39524,623,226 - 24,628,562 (-)NCBI
GRCm38524,418,228 - 24,423,564 (-)NCBI
MGSCv37523,924,060 - 23,929,348 (-)RGD
Celera521,368,049 - 21,373,342 (-)RGD
RefSeq Acc Id: NR_156449
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39524,623,226 - 24,628,562 (-)NCBI
GRCm38524,418,228 - 24,423,564 (-)NCBI
RefSeq Acc Id: XM_006535626   ⟹   XP_006535689
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39524,612,595 - 24,628,737 (-)NCBI
GRCm38524,407,597 - 24,423,587 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_031694   ⟸   NM_007668
- UniProtKB: P49615 (UniProtKB/Swiss-Prot),   Q543F6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006535689   ⟸   XM_006535626
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000142413   ⟸   ENSMUST00000198990
RefSeq Acc Id: ENSMUSP00000030814   ⟸   ENSMUST00000030814
Protein Domains
Protein kinase

RGD ID:6837241
Promoter ID:MM_KWN:41604
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000030814,   NM_007668,   OTTMUST00000059118,   OTTMUST00000059119,   OTTMUST00000059120
Mouse AssemblyChrPosition (strand)Source
MGSCv36523,929,231 - 23,929,852 (-)MPROMDB
RGD ID:6886138
Promoter ID:EPDNEW_M6520
Type:initiation region
Description:Mus musculus cyclin-dependent kinase 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38524,423,562 - 24,423,622EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:101765 AgrOrtholog
Ensembl Genes ENSMUSG00000028969 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000030814 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000142413 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000030814 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000198990 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12568 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdk5 PhenoGen
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL