Lipg (lipase G, endothelial type) - Rat Genome Database

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Gene: Lipg (lipase G, endothelial type) Rattus norvegicus
Analyze
Symbol: Lipg
Name: lipase G, endothelial type
RGD ID: 1310740
Description: Predicted to enable lipoprotein lipase activity and phospholipase A1 activity. Involved in response to nutrient. Located in extracellular space. Used to study hypertension. Human ortholog(s) of this gene implicated in cardiovascular system disease; cerebral infarction; coronary artery disease; and myocardial infarction. Orthologous to human LIPG (lipase G, endothelial type); PARTICIPATES IN glycerolipid metabolic pathway; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EDL; endothelial lipase; endothelial-derived lipase; lipase; lipase G; lipase G, endothelial; lipase, endothelial; LOC291437; phospholipase A1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81870,790,077 - 70,811,259 (-)NCBIGRCr8
mRatBN7.21868,514,923 - 68,536,105 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1868,514,923 - 68,536,260 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1870,627,517 - 70,648,729 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01871,296,048 - 71,317,297 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01869,153,529 - 69,174,741 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01870,903,528 - 70,924,434 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1870,901,710 - 70,924,708 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01870,043,855 - 70,064,759 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41871,795,150 - 71,816,056 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11871,868,350 - 71,889,257 (-)NCBI
Celera1866,690,471 - 66,711,384 (-)NCBICelera
Cytogenetic Map18q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1-octadecanoyl-2-[(9Z)-octadecenoyl]-sn-glycerol  (ISO)
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine  (ISO)
1-palmitoyl-2-oleoyl-sn-glycerol  (ISO)
1-stearoyl-2-linoleoyl-sn-glycerol  (ISO)
1-stearoyl-sn-glycero-3-phosphocholine  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
Acetyl tributyl citrate  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
chlorpyrifos  (ISO)
cholesteryl arachidonate  (ISO)
cholesteryl linoleate  (ISO)
cholesteryl linolenate  (ISO)
cholesteryl myristate  (ISO)
cholesteryl oleate  (ISO)
cholesteryl palmitate  (ISO)
cholesteryl stearate  (ISO)
choline  (ISO)
clotrimazole  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
glucose  (ISO)
hexadecanoic acid  (ISO)
hydroquinone  (ISO)
inulin  (ISO)
leflunomide  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methylisothiazolinone  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-hexadecanoylsphingosine  (ISO)
N-methylformamide  (ISO)
N-Nitrosopyrrolidine  (ISO)
nevirapine  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
O-methyleugenol  (ISO)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phosphatidylcholine  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
Triptolide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis. Badellino KO, etal., PLoS Med. 2006 Feb;3(2):e22. Epub 2005 Dec 20.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans. Hutter CM, etal., Atherosclerosis. 2006 Mar;185(1):78-86. Epub 2005 Jul 14.
5. Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. Ishida T, etal., J Biol Chem. 2004 Oct 22;279(43):45085-92. Epub 2004 Aug 9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Visceral adiposity and endothelial lipase. Paradis ME, etal., J Clin Endocrinol Metab. 2006 Sep;91(9):3538-43. Epub 2006 Jun 13.
8. Involvement of catecholamines in the effect of fasting on hepatic endothelial lipase activity in the rat. Peinado-Onsurbe J, etal., Endocrinology. 1991 Nov;129(5):2599-606.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels. Shimizu M, etal., Circ J. 2007 Jun;71(6):842-6.
15. Increased expression of endothelial lipase in rat models of hypertension. Shimokawa Y, etal., Cardiovasc Res. 2005 Jun 1;66(3):594-600.
16. Lipoprotein-stimulated mesangial cell proliferation and gene expression are regulated by lipoprotein lipase. Stevenson FT, etal., Kidney Int. 2001 Jun;59(6):2062-8.
17. The distribution of lipoprotein lipase in rat adipose tissue. Changes with nutritional state engage the extracellular enzyme. Wu G, etal., J Biol Chem. 2003 Apr 4;278(14):11925-30. Epub 2003 Jan 27.
18. Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis. Yamaguchi S, etal., Int J Mol Med. 2006 Nov;18(5):871-83.
Additional References at PubMed
PMID:10192396   PMID:10318835   PMID:11924532   PMID:12032167   PMID:17681148   PMID:19136670   PMID:19567873   PMID:19931348   PMID:23918928  


Genomics

Comparative Map Data
Lipg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81870,790,077 - 70,811,259 (-)NCBIGRCr8
mRatBN7.21868,514,923 - 68,536,105 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1868,514,923 - 68,536,260 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1870,627,517 - 70,648,729 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01871,296,048 - 71,317,297 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01869,153,529 - 69,174,741 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01870,903,528 - 70,924,434 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1870,901,710 - 70,924,708 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01870,043,855 - 70,064,759 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41871,795,150 - 71,816,056 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11871,868,350 - 71,889,257 (-)NCBI
Celera1866,690,471 - 66,711,384 (-)NCBICelera
Cytogenetic Map18q12.2NCBI
LIPG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381849,561,479 - 49,599,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1849,560,699 - 49,599,185 (+)EnsemblGRCh38hg38GRCh38
GRCh371847,088,427 - 47,125,555 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361845,342,425 - 45,373,276 (+)NCBINCBI36Build 36hg18NCBI36
Build 341845,342,424 - 45,373,062NCBI
Celera1843,943,480 - 43,974,820 (+)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1843,942,649 - 43,973,220 (+)NCBIHuRef
CHM1_11847,083,758 - 47,114,772 (+)NCBICHM1_1
T2T-CHM13v2.01849,759,293 - 49,797,014 (+)NCBIT2T-CHM13v2.0
Lipg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391875,072,393 - 75,095,380 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1875,072,393 - 75,094,334 (-)EnsemblGRCm39 Ensembl
GRCm381874,939,322 - 74,961,263 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1874,939,322 - 74,961,263 (-)EnsemblGRCm38mm10GRCm38
MGSCv371875,098,976 - 75,120,917 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361875,064,728 - 75,086,471 (-)NCBIMGSCv36mm8
Celera1876,168,769 - 76,190,731 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1850.94NCBI
Lipg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540234,667,036 - 34,687,568 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540234,666,757 - 34,689,726 (+)NCBIChiLan1.0ChiLan1.0
LIPG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21767,088,437 - 67,118,414 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11852,781,037 - 52,811,017 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01842,942,132 - 42,972,112 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11846,291,051 - 46,320,652 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1846,292,154 - 46,320,652 (+)Ensemblpanpan1.1panPan2
LIPG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1779,201,514 - 79,221,090 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl779,201,496 - 79,222,552 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha778,609,001 - 78,628,250 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0779,270,275 - 79,289,621 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl779,269,933 - 79,289,565 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1778,985,951 - 79,005,300 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0779,014,058 - 79,033,404 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0779,300,625 - 79,319,973 (-)NCBIUU_Cfam_GSD_1.0
Lipg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494438,167,652 - 38,190,835 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649713,406,357 - 13,429,890 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649713,406,402 - 13,429,833 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIPG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl199,081,938 - 99,110,874 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1199,081,940 - 99,110,671 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21108,638,415 - 108,667,182 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LIPG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11831,368,189 - 31,395,103 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1831,368,857 - 31,394,278 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660505,524,070 - 5,624,780 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lipg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477813,107,283 - 13,133,270 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477813,107,037 - 13,133,162 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lipg
169 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:50
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000025257
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185933040970263868Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat

Markers in Region
D18Got104  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21868,515,236 - 68,515,373 (+)MAPPERmRatBN7.2
Rnor_6.01870,903,842 - 70,903,978NCBIRnor6.0
Rnor_5.01870,044,169 - 70,044,305UniSTSRnor5.0
RGSC_v3.41871,795,464 - 71,795,600UniSTSRGSC3.4
Celera1866,690,785 - 66,690,915UniSTS
Cytogenetic Map18q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 47 113 77 76 45 25 45 6 202 95 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000025257   ⟹   ENSRNOP00000025257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1868,514,923 - 68,536,260 (-)Ensembl
Rnor_6.0 Ensembl1870,901,710 - 70,924,708 (-)Ensembl
RefSeq Acc Id: NM_001012741   ⟹   NP_001012759
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,790,077 - 70,811,259 (-)NCBI
mRatBN7.21868,514,923 - 68,536,105 (-)NCBI
Rnor_6.01870,903,528 - 70,924,434 (-)NCBI
Rnor_5.01870,043,855 - 70,064,759 (-)NCBI
RGSC_v3.41871,795,150 - 71,816,056 (-)RGD
Celera1866,690,471 - 66,711,384 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012759 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK14774 (Get FASTA)   NCBI Sequence Viewer  
  AAK14775 (Get FASTA)   NCBI Sequence Viewer  
  AAX11354 (Get FASTA)   NCBI Sequence Viewer  
  EDL82874 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025257.5
  ENSRNOP00055014420
  ENSRNOP00060011763
  ENSRNOP00065031500
GenBank Protein Q8VBX1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012759   ⟸   NM_001012741
- Peptide Label: precursor
- UniProtKB: Q5D216 (UniProtKB/Swiss-Prot),   Q8VBX1 (UniProtKB/Swiss-Prot),   A6KRH1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025257   ⟸   ENSRNOT00000025257
Protein Domains
PLAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VBX1-F1-model_v2 AlphaFold Q8VBX1 1-493 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700868
Promoter ID:EPDNEW_R11391
Type:single initiation site
Name:Lipg_1
Description:lipase G, endothelial type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01870,924,710 - 70,924,770EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310740 AgrOrtholog
BioCyc Gene G2FUF-6998 BioCyc
Ensembl Genes ENSRNOG00000018694 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055010572 UniProtKB/Swiss-Prot
  ENSRNOG00060009029 UniProtKB/Swiss-Prot
  ENSRNOG00065022748 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025257.7 UniProtKB/Swiss-Prot
  ENSRNOT00055017907 UniProtKB/Swiss-Prot
  ENSRNOT00060015138 UniProtKB/Swiss-Prot
  ENSRNOT00065038840 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipo_Lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAG_lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:291437 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 291437 ENTREZGENE
PANTHER ENDOTHELIAL LIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPASE UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam Lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lipg PhenoGen
PIRSF Lipoprotein_lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LIPOLIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAGLIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018694 RatGTEx
  ENSRNOG00055010572 RatGTEx
  ENSRNOG00060009029 RatGTEx
  ENSRNOG00065022748 RatGTEx
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP alpha/beta-Hydrolases UniProtKB/TrEMBL
  Lipase/lipooxygenase domain (PLAT/LH2 domain) UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF53474 UniProtKB/Swiss-Prot
UniProt A6KRH1 ENTREZGENE, UniProtKB/TrEMBL
  LIPE_RAT UniProtKB/Swiss-Prot
  Q5D216 ENTREZGENE
  Q8VBX1 ENTREZGENE
UniProt Secondary Q5D216 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Lipg  lipase G, endothelial type  Lipg  lipase G, endothelial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Lipg  lipase G, endothelial  Lipg  lipase, endothelial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Lipg  lipase, endothelial  Lipg_predicted  lipase, endothelial (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lipg_predicted  lipase, endothelial (predicted)      Symbol and Name status set to approved 70820 APPROVED