Lipa (lipase A, lysosomal acid type)

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Gene: Lipa (lipase A, lysosomal acid type) Rattus norvegicus

Analyze

Symbol:

Lipa

Name:

lipase A, lysosomal acid type

RGD ID:

3008

Description:

Exhibits sterol esterase activity. Involved in fatty acid metabolic process and sterol metabolic process. Localizes to lysosome. Human ortholog(s) of this gene implicated in Wolman disease; cholesterol ester storage disease; and lysosomal and lipase deficiency. Orthologous to human LIPA (lipase A, lysosomal acid type); PARTICIPATES IN alendronate pharmacodynamics pathway; bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3H-1,2-dithiole-3-thione.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

acid cholesteryl ester hydrolase; Chole; Chole2; CHOLEST; cholesterol esterase (pancreatic); Cholesterol esterase (pancreatic) see D3Wox12 D3Wox13 D3Wox26 and D3Mgh25; cholesteryl esterase; LAL; Lip1; lipase A; lipase A, lysosomal acid; lipase A, lysosomal acid, cholesterol esterase; lysosomal acid lipase 1; lysosomal acid lipase A; lysosomal acid lipase/cholesteryl ester hydrolase; pancreatic cholesterol esterase; RATCHOLEST; sterol esterase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LIPA (lipase A, lysosomal acid type)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Lipa (lysosomal acid lipase A)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Lipa (lipase A, lysosomal acid type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LIPA (lipase A, lysosomal acid type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LIPA (lipase A, lysosomal acid type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LIPA (lipase A, lysosomal acid type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	LIPA (lipase A, lysosomal acid type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lipa (lipase A, lysosomal acid type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	LIPA (lipase A, lysosomal acid type)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Lipa (lysosomal acid lipase A)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	lipf (lipase, gastric)	Alliance	DIOPT (PhylomeDB\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	TGL1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector)
Caenorhabditis elegans (roundworm):	lipl-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	lipl-3	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	lipl-5	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG18301	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG31871	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG7329	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG8093	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Lip3	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Lip4	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Is Marker For:

Strains: ALD/Hyo

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	232,024,351 - 232,167,329 (-)	NCBI
Rnor_6.0 Ensembl	1	252,816,527 - 252,849,904 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	252,816,536 - 252,959,348 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	260,038,180 - 260,091,819 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	238,466,493 - 238,500,195 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	238,630,381 - 238,664,124 (-)	NCBI
Celera	1	229,136,934 - 229,170,119 (-)	NCBI		Celera
Cytogenetic Map	1	q53	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune lymphoproliferative syndrome (ISO)

cholesterol ester storage disease (ISO)

coronary artery disease (ISO)

COVID-19 (ISO)

lysosomal and lipase deficiency (ISO)

Niemann-Pick disease type C1 (ISO)

Wolman disease (ISO,ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-butoxyethanol (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4-hydroxynon-2-enal (ISO)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

ammonium chloride (EXP)

antimony(0) (ISO)

benzo[a]pyrene (ISO)

bexarotene (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

captan (ISO)

carbamate ester (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

chrysene (ISO)

cisplatin (ISO)

clofibric acid (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO)

dorsomorphin (ISO)

ethanol (EXP)

etoposide (ISO)

fenamidone (ISO)

folic acid (ISO)

folpet (ISO)

glafenine (EXP)

lead diacetate (ISO)

linalool (ISO)

LY294002 (ISO)

lycopene (ISO)

mercury atom (ISO)

mercury(0) (ISO)

mitoxantrone (ISO)

mono(2-ethylhexyl) phthalate (EXP)

N-methyl-4-phenylpyridinium (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (EXP)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (ISO)

nefazodone (EXP)

nickel atom (ISO)

nickel dichloride (ISO)

ozone (ISO)

paracetamol (ISO)

paraoxon (ISO)

pentachlorophenol (ISO)

phenobarbital (EXP,ISO)

pirinixic acid (ISO)

progesterone (EXP)

Propiverine (EXP)

quercetin (ISO)

SB 431542 (ISO)

sodium dichromate (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

thiadiazoles (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

tunicamycin (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Yessotoxin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell morphogenesis (IEA,ISO)

cell population proliferation (IEA,ISO)

fatty acid metabolic process (IDA)

homeostasis of number of cells within a tissue (IEA,ISO)

inflammatory response (IEA,ISO)

lipid catabolic process (IEA)

lung development (IEA,ISO)

sterol metabolic process (IBA,IDA)

tissue remodeling (IEA,ISO)

Cellular Component

cytosol (IEA,ISO)

fibrillar center (IEA,ISO)

intracellular membrane-bounded organelle (IBA,ISO)

lysosome (IDA)

nucleoplasm (IEA,ISO)

Molecular Function

lipase activity (IDA,ISO)

sterol esterase activity (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

alendronate pharmacodynamics pathway (ISO)

bile acid biosynthetic pathway (ISO)

cerebrotendinous xanthomatosis pathway (ISO)

cholesterol biosynthetic pathway (ISO)

cholesterol ester storage disease pathway (ISO)

congenital bile acid synthesis defect pathway (ISO)

congenital hemidysplasia with ichthyosiform erythroderma and limb defects pathway (ISO)

desmosterolosis pathway (ISO)

familial hypercholanemia pathway (ISO)

hypercholesterolemia pathway (ISO)

ibandronate pharmacodynamics pathway (ISO)

mevalonic aciduria pathway (ISO)

nitrogenous bisphosphonate pharmacodynamics pathway (ISO)

pamidronate pharmacodynamics pathway (ISO)

risedronate pharmacodynamics pathway (ISO)

Smith-Lemli-Opitz Syndrome pathway (ISO)

statin pharmacodynamics pathway (ISO)

steroid biosynthetic pathway (IEA)

Wolman disease pathway (ISO)

X-linked dominant chondrodysplasia punctata 2 pathway (ISO)

Zellweger syndrome pathway (ISO)

zoledronate pharmacodynamics pathway (ISO)

References

References - curated


1.	Amanuma K, etal., Biochem Int. 1985 Sep;11(3):349-55.
2.	Anderson RA, etal., Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2718-22.
3.	Fontaine RN, etal., Biochemistry 1991 Jul 16;30(28):7008-14.
4.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	GOA data from the GO Consortium
6.	Hoeg JM, etal., Am J Hum Genet. 1984 Nov;36(6):1190-203.
7.	Inoue Y, etal., Biosci Biotechnol Biochem. 1999 May;63(5):937-9.
8.	KEGG
9.	Lakowska H, etal., Med Sci Monit. 2001 Nov-Dec;7(6):1193-7.
10.	MGD data from the GO Consortium
11.	Nakagawa H, etal., J Lipid Res 1995 Oct;36(10):2212-8.
12.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	OMIM Disease Annotation Pipeline
14.	Pipeline to import KEGG annotations from KEGG into RGD
15.	Pipeline to import SMPDB annotations from SMPDB into RGD
16.	RGD automated data pipeline
17.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18.	RGD automated import pipeline for gene-chemical interactions
19.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:1718995	PMID:7204383	PMID:8112342	PMID:9633819	PMID:12477932	PMID:14644759	PMID:15269241	PMID:23376485

Genomics

Comparative Map Data

Lipa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	232,024,351 - 232,167,329 (-)	NCBI
Rnor_6.0 Ensembl	1	252,816,527 - 252,849,904 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	252,816,536 - 252,959,348 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	260,038,180 - 260,091,819 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	238,466,493 - 238,500,195 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	238,630,381 - 238,664,124 (-)	NCBI
Celera	1	229,136,934 - 229,170,119 (-)	NCBI		Celera
Cytogenetic Map	1	q53	NCBI

LIPA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	10	89,213,569 - 89,414,557 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	10	89,213,571 - 89,251,926 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	10	90,973,329 - 91,011,532 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	90,963,309 - 91,001,640 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	10	90,963,308 - 91,001,640	NCBI
Celera	10	84,720,143 - 84,758,472 (-)	NCBI
Cytogenetic Map	10	q23.31	NCBI
HuRef	10	84,607,788 - 84,646,145 (-)	NCBI		HuRef
CHM1_1	10	91,255,383 - 91,293,855 (-)	NCBI		CHM1_1

Lipa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	34,469,716 - 34,504,874 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	19	34,469,718 - 34,504,874 (-)	Ensembl
GRCm38	19	34,492,316 - 34,527,474 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	34,492,318 - 34,527,474 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	34,566,806 - 34,601,964 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	19	34,558,313 - 34,593,419 (-)	NCBI			mm8
Celera	19	35,267,889 - 35,303,040 (-)	NCBI		Celera
Cytogenetic Map	19	C1	NCBI

Lipa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955425	3,718,206 - 3,756,142 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955425	3,718,291 - 3,755,942 (+)	NCBI	ChiLan1.0	ChiLan1.0

LIPA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	10	89,478,502 - 89,516,580 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	89,477,082 - 89,516,874 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	10	85,938,240 - 85,976,610 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

LIPA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	38,892,771 - 38,918,441 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	38,893,337 - 38,918,436 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	38,643,855 - 38,671,678 (-)	NCBI
ROS_Cfam_1.0	26	40,476,944 - 40,504,767 (-)	NCBI
UMICH_Zoey_3.1	26	38,347,241 - 38,375,054 (-)	NCBI
UNSW_CanFamBas_1.0	26	37,910,947 - 37,938,676 (-)	NCBI
UU_Cfam_GSD_1.0	26	39,180,692 - 39,208,434 (-)	NCBI

LIPA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	101,123,381 - 101,254,725 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	101,131,372 - 101,254,739 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	110,116,088 - 110,152,009 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LIPA
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	82,639,220 - 82,677,479 (-)	NCBI
ChlSab1.1 Ensembl	9	82,638,621 - 82,677,488 (-)	Ensembl
Vero_WHO_p1.0	NW_023666048	43,315,133 - 43,353,408 (-)	NCBI

Lipa
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624737	49,471 - 82,981 (-)	NCBI

Position Markers

D3Wox13

Rat Assembly	Chr	Position (strand)	Source
RH 3.4 Map	3	21.9	UniSTS
RH 3.4 Map	3	21.9	RGD
Cytogenetic Map	1	q52	UniSTS

D3Wox26

No map positions available.

D3Mgh25

Rat Assembly	Chr	Position (strand)	Source
RH 3.4 Map	3	27.2	UniSTS
RH 3.4 Map	3	27.2	RGD
Cytogenetic Map	1	q52	UniSTS

RH142813

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	232,024,884 - 232,025,032 (+)	MAPPER
Rnor_6.0	1	252,817,070 - 252,817,217	NCBI	Rnor6.0
Rnor_5.0	1	260,038,714 - 260,038,861	UniSTS	Rnor5.0
RGSC_v3.4	1	238,467,025 - 238,467,172	UniSTS	RGSC3.4
Celera	1	229,137,466 - 229,137,613	UniSTS
RH 3.4 Map	4	490.82	UniSTS
Cytogenetic Map	1	q52	UniSTS

RH135375

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	232,025,259 - 232,025,445 (+)	MAPPER
Rnor_6.0	1	252,817,445 - 252,817,630	NCBI	Rnor6.0
Rnor_5.0	1	260,039,089 - 260,039,274	UniSTS	Rnor5.0
RGSC_v3.4	1	238,467,400 - 238,467,585	UniSTS	RGSC3.4
Celera	1	229,137,841 - 229,138,026	UniSTS
Cytogenetic Map	1	q52	UniSTS

RH139563

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	232,024,414 - 232,024,629 (+)	MAPPER
Rnor_6.0	1	252,816,600 - 252,816,814	NCBI	Rnor6.0
Rnor_5.0	1	260,038,244 - 260,038,458	UniSTS	Rnor5.0
RGSC_v3.4	1	238,466,555 - 238,466,769	UniSTS	RGSC3.4
Celera	1	229,136,996 - 229,137,210	UniSTS
Cytogenetic Map	1	q52	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2292216	Bw80	Body weight QTL 80	3.23	0.0019	body mass (VT:0001259)	body weight (CMO:0000012)	1	233490105	264802994	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	236795785	281795785	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	245529606	282763074	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	236265430	281265430	Rat
2302375	Bw83	Body weight QTL 83	4.87	0.0002	body mass (VT:0001259)	body weight (CMO:0000012)	1	215711860	260711860	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	156446196	274977688	Rat
61455	Niddm7	Non-insulin dependent diabetes mellitus QTL 7	5.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	236763415	258766873	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	161321152	273792054	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	238830534	278228767	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	233663100	273792054	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	243272341	282763074	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	244401175	282365384	Rat
734768	Niddm59	Non-insulin dependent diabetes mellitus QTL 59			body mass (VT:0001259)	body weight (CMO:0000012)	1	235850810	280850810	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	244992467	282365384	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	215828102	260828102	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	216324817	261324817	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	252955158	280632620	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	167394665	278228889	Rat
1581544	Rf52	Renal function QTL 52		0.05	total urine protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	1	252948438	281795785	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	241482188	281795785	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	191825895	279986079	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	215711860	258765521	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	238824734	279986079	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	221901238	266901238	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	221901238	266901238	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	221901238	266901238	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	221901238	266901238	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	244401175	264636028	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	244401175	264636028	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	244401175	282365384	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	217054291	281795785	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	193968438	261264776	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	215828102	260828102	Rat
1357399	Bw45	Body weight QTL 45	3.05		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	1	225689973	270689973	Rat
1357404	Bw42	Body weight QTL 42	4.49	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	225689973	270689973	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	195598053	265002735	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	215684498	260684498	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	213476630	278978026	Rat
1600392	Bw123	Body weight QTL 123		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	244087148	282763074	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	213476630	278978026	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	213476630	278978026	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	226706329	271706329	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	161321256	273791893	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	196395041	282763074	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	161321256	273791893	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	249206242	281795785	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	161784169	278228889	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	192639698	278228889	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	161784169	278228889	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	192639698	278228889	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	161784169	278228889	Rat
1549910	Bw54	Body weight QTL 54		0.05	body mass (VT:0001259)	body weight (CMO:0000012)	1	236795785	281795785	Rat
2316896	Gluco57	Glucose level QTL 57	7.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	249607907	266793958	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	163796316	282763074	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	210360774	264802828	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	174905700	264802994	Rat
1358890	Bp259	Blood pressure QTL 259	3.06		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	230420627	282645769	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	208517798	266948272	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	230420627	262031693	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	0.00000081	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	216324817	261324817	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	236265430	281265430	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	215828102	260828102	Rat
61400	Niddm1	Non-insulin dependent diabetes mellitus QTL 1	11		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	238830408	266793958	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	202571665	264802994	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	122614824	262664716	Rat
8693637	Alc29	Alcohol consumption QTL 29	2.7	0.258	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	227509470	255131140	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	125875758	262433692	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	210652654	255652654	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	221901238	266901238	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	244148899	282763074	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	202571665	264802994	Rat
10053715	Scort24	Serum corticosterone level QTL 24	2.13	0.0088	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	242302911	282763074	Rat
10059587	Bw173	Body weight QTL 173	3.23	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	1	222492538	267492538	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	210990171	255990171	Rat

Related Rat Strains

The following Strains have been annotated to Lipa

ALD/Hyo

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	188
Count of miRNA genes:	146
Interacting mature miRNAs:	159
Transcripts:	ENSRNOT00000025845
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	34	11	8
Low											7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006231275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760321	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588801	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC098155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC120570	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC126192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC072532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S81497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000025845 ⟹ ENSRNOP00000025845

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	252,816,538 - 252,849,756 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000078279 ⟹ ENSRNOP00000074398

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	252,816,527 - 252,849,904 (-)	Ensembl

RefSeq Acc Id:

NM_012732 ⟹ NP_036864

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	232,024,353 - 232,057,573 (-)	NCBI
Rnor_6.0	1	252,816,538 - 252,849,756 (-)	NCBI
Rnor_5.0	1	260,038,180 - 260,091,819 (-)	NCBI
RGSC_v3.4	1	238,466,493 - 238,500,195 (-)	RGD
Celera	1	229,136,934 - 229,170,119 (-)	RGD

Sequence:

show sequence

GCCTCGGGCCTGCTCTGTGCAGCGGTCTCGGGAGCTGGTGCCCTGCGGATCGCCAGGCCTGGGA
GAGGAGCCCCCACCACGATCTCTGGTCACCAGTTGCTCTGCTCCCGGAGCATGTTCTGTGTCCG
GTATCCAAAGAGACGGCTGCAGTCGTTCGGTTCCTGTCTGCCTTCCGTGTAGGATTTGATTTCT
CCTAAACTTGGTTTAAGACTTTTAAAGAAGGCCCTAATTTATCGAGGCCTGTTTGTGAAGTAAA
ATTCGGCTGGCTACTCTCAACGGAAGAAAGATGCAACTGCTAGGCCGGGTGATCTGTTTCGTCG
TTGGGATCCTGCTTTCTGGGGGCCCAACGGGGACCATATCAGCTGTGGACCCTGAAGCAAACAT
GAATGTGACTGAGATAATCATGCACTGGGGATATCCTGGCGAAGAGCACTCAGTACAGACAGGA
GATGGCTACATTCTGGGTGTTCACCGAATCCCGCATGGGCGGAAGAACCAGTTTGATAAAGGTC
CCAAACCAGTTGTGTATCTTCAGCATGGCTTCCTGGCAGATTCTAGTAACTGGGTCACAAACAT
TGACAACAACAGCCTGGGCTTCATCCTGGCAGATGCTGGCTTTGATGTGTGGATGGGAAACAGC
AGAGGAAACACCTGGTCTCGGAAGCACAAGACTCTGTCAGTTTCTCAGGATGAATACTGGGCCT
TCAGTTTTGATGAGATGGCAAAATATGACCTCCCTGCTTCAATTAACTACATTTTGAATAAAAC
TGGCCAAGAACAGCTGTATTATGTGGGCCACTCTCAAGGCTGCACCATAGGTTTTATAGCATTT
TCACAGATGCCTGAACTGGCAAAGAAGGTTAAAATGTTTTTTGCCCTGGCTCCTGTGTTGTCTC
TCAATTTTGCTTCGGGCCCGATGGTCAAATTGGGACGGTTGCCGGATCTGCTTCTTGAGGACTT
GTTTGGGCAGAAGCAATTTCTTCCTCAGAGTGCAATGGTGAAATGGCTAAGCACTCACATTTGC
ACGCACGTCATCATGAAGGAGCTTTGCGCCAACATCTTCTTTCTGATATGTGGCTTCAATGAGA
AGAATTTAAACATGTCTAGAGTGGATGTGTATACAACACACTGTCCTGCGGGAACCTCTGTGCA
AAACATGGTACACTGGACCCAGGTTGTTAAATACCATAAGCTTCAAGCTTTTGACTGGGGAAGC
AGTGACAAGAATTATTTTCATTACAATCAGAGTTATCCACCCTTGTACAGCATAAAAGACATGC
AACTACCCACTGCTTTATGGAGCGGGGGCAAGGACTGGCTGGCAGACACCAGTGACATCAATAT
CTTACTGACTGAAATCCCCACGTTAGTGTACCACAAGAACATTCCCGAGTGGGACCATCTGGAT
TTTATCTGGGGTTTGGATGCCCCCTGGAGGCTGTATAATGAAGTAGTCAGTCTAATGAAGAAAT
ACCAGTGAGTGCCAAGACTTGAGATGCTTCCCCTTCACTAGGGGAAAAAAGGACAGATGTTTGC
TTAATTCCTGCAAAATACTTGTGTTTTCCTGGTCTAGATCATTTGTATTTTTTATGTGCAAGAA
AACGATGATGTTGAAGACATACATGGGTCTGGTCAGTAAGAAGCACGCTGGCTGTCTTCTGCTT
CATTCTGACTGACAAGCCAGAGTCACAACCAGCGATGCCTTTGAAGTTTTTAGAAAGTATGGGT
GTTACGTGAAGAAGCCATTGCAATCCTCTTGTTTACTTTTTACGGTCGTTTTCGGTGTCTGCAT
GCTGTGCATATACATGCCTATGTGTGTGCCCTGTGCTGGCCAGAGCCTCCTTGTGTGGAGGTAA
GGGCTCACATCAGGGTATCTTCCTCAGACACTTTCCACTTTACTTTTTGAGACCTGGTCTCTCG
ACGAACCAGTCAGTAGCTTGCTATTCCAGTTAGACTGGCTGACCAGGGAGCCTCCAGAATCTGT
CCGTCTCTACCTTCCCCCTCACCAGGTCTACGGAGGGTGATGTCCCAGCCAGCATTTTTACACT
GGTTCTAGGGACAGGAACTCAGGTTCTCATGCTTGAATAGCAAGCCCTTTCTTCACCAAACCAT
TGCCTCAAACCCTCTGTGATCGAAAAGCTGCTCAATTACCTTTATGTTCCCACCCAATGCAAGT
GAACGAGCACAAGACATTTCAAGCTGTTGTTTGTGAGCAAAAATCAATCTGCCAGTGACTTGAA
CATGCTAGGAGAAACTCCTCGCTCTGAGCTTGACAAACCTGCAGTCCAGGTTCTCCAGAGATTG
AGACAGGGAGGCTGCTGTTACATTTAGGGTTCATTTGGAGAGTGAGACTTTGTCTCTACAAAAC
CAAAGACAAAGGAGAAGAAGAAAAAAAAAACCCTAAAGTACTCAGTTCTCATCTGTTAGCCTCA
GAGGGCTTAGAGAGTTCCTGTGTTTACCTATCCGAACAACATTTTCATGTCTTTATGCAGTAGC
TACCTAGTGAAATCCAGTGTTATCCCAGCTTCTCCAGGCGTAAACATTCTCTCTTCAATCTCAT
CAGACCTCAGTAGCAAGCATTTAGTGAATATTTAGATTTTTCAGGCCAAGCCAAGACAAAAATG
AATAGAATAAAAGAAAAAAGAGCCCAGACTCTTGAAAGCGGTTTGCACTGATTTAAAAATAAAA
AAAAAGAATCTTGAAGAATGACATGATAAACTGTGTTGGTTCCGCATGTGTAGTCGGATCCCTT
TTCTGTGGAGAACGTTCTGTGGAGGGACAAACCACTAATTTGCCCCAAGTGAATGTGGCTGTAG
TGACAGCGACAGTGCCTCTGATCTGAGAAGCAGGGCTGGCTGCCGGTGACAAGCATCCCAGTTC
CTTTCCCCAGAGATGAAGCGGATGTTTTCAGACAGAGCTCGGCTCAGGAATTTCGCTTGGAGAA
TCAGTGTTTATGTGCACAATGTTTTAGTGAGCCTGCTCTGCGCCTGCATATGGGGAAGCCCTCG
ACTGTTCACCGGGCTCGTGGGCGACGGCTGCCGTCAGCTGGACAGTGGATAAGTTTTCTGACGT
AGTCACCACAGATTCAGGGATATCGCTTTGTGTCGACTCCTAAGGAAGGCAGGACGATATGACT
TGGTAACATTGTAAAGGTTCACATTTAAACTTTTCAATAAATCTCAGCCTCACAGGCCTGAACA
TCAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006231275 ⟹ XP_006231337

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	232,024,351 - 232,057,735 (-)	NCBI
Rnor_6.0	1	252,816,536 - 252,849,873 (-)	NCBI
Rnor_5.0	1	260,038,180 - 260,091,819 (-)	NCBI

Sequence:

show sequence

TGGGGCGTCTCGGCCCTCCCACCAGGTCTGTAGGCTCCTGGTTGGCCATGCTCGCCTGGTTGTA
GTGGGCACTGCTCCTGGAGACTGAGGTTGAAGGACTACTCCGGAGACGGCTGCAGTCGTTCGGT
TCCTGTCTGCCTTCCGTGTAGGATTTGATTTCTCCTAAACTTGGTTTAAGACTTTTAAAGAAGG
CCCTAATTTATCGAGGCCTGTTTGTGAAGTAAAATTCGGCTGGCTACTCTCAACGGAAGAAAGA
TGCAACTGCTAGGCCGGGTGATCTGTTTCGTCGTTGGGATCCTGCTTTCTGGGGGCCCAACGGG
GACCATATCAGCTGTGGACCCTGAAGCAAACATGAATGTGACTGAGATAATCATGCACTGGGGA
TATCCTGGCGAAGAGCACTCAGTACAGACAGGAGATGGCTACATTCTGGGTGTTCACCGAATCC
CGCATGGGCGGAAGAACCAGTTTGATAAAGGTCCCAAACCAGTTGTGTATCTTCAGCATGGCTT
CCTGGCAGATTCTAGTAACTGGGTCACAAACATTGACAACAACAGCCTGGGCTTCATCCTGGCA
GATGCTGGCTTTGATGTGTGGATGGGAAACAGCAGAGGAAACACCTGGTCTCGGAAGCACAAGA
CTCTGTCAGTTTCTCAGGATGAATACTGGGCCTTCAGTTTTGATGAGATGGCAAAATATGACCT
CCCTGCTTCAATTAACTACATTTTGAATAAAACTGGCCAAGAACAGCTGTATTATGTGGGCCAC
TCTCAAGGCTGCACCATAGGTTTTATAGCATTTTCACAGATGCCTGAACTGGCAAAGAAGGTTA
AAATGTTTTTTGCCCTGGCTCCTGTGTTGTCTCTCAATTTTGCTTCGGGCCCGATGGTCAAATT
GGGACGGTTGCCGGATCTGCTTCTTGAGGACTTGTTTGGGCAGAAGCAATTTCTTCCTCAGAGT
GCAATGGTGAAATGGCTAAGCACTCACATTTGCACGCACGTCATCATGAAGGAGCTTTGCGCCA
ACATCTTCTTTCTGATATGTGGCTTCAATGAGAAGAATTTAAACATGTCTAGAGTGGATGTGTA
TACAACACACTGTCCTGCGGGAACCTCTGTGCAAAACATGGTACACTGGACCCAGGTTGTTAAA
TACCATAAGCTTCAAGCTTTTGACTGGGGAAGCAGTGACAAGAATTATTTTCATTACAATCAGA
GTTATCCACCCTTGTACAGCATAAAAGACATGCAACTACCCACTGCTTTATGGAGCGGGGGCAA
GGACTGGCTGGCAGACACCAGTGACATCAATATCTTACTGACTGAAATCCCCACGTTAGTGTAC
CACAAGAACATTCCCGAGTGGGACCATCTGGATTTTATCTGGGGTTTGGATGCCCCCTGGAGGC
TGTATAATGAAGTAGTCAGTCTAATGAAGAAATACCAGTGAGTGCCAAGACTTGAGATGCTTCC
CCTTCACTAGGGGAAAAAAGGACAGATGTTTGCTTAATTCCTGCAAAATACTTGTGTTTTCCTG
GTCTAGATCATTTGTATTTTTTATGTGCAAGAAAACGATGATGTTGAAGACATACATGGGTCTG
GTCAGTAAGAAGCACGCTGGCTGTCTTCTGCTTCATTCTGACTGACAAGCCAGAGTCACAACCA
GCGATGCCTTTGAAGTTTTTAGAAAGTATGGGTGTTACGTGAAGAAGCCATTGCAATCCTCTTG
TTTACTTTTTACGGTCGTTTTCGGTGTCTGCATGCTGTGCATATACATGCCTATGTGTGTGCCC
TGTGCTGGCCAGAGCCTCCTTGTGTGGAGGTAAGGGCTCACATCAGGGTATCTTCCTCAGACAC
TTTCCACTTTACTTTTTGAGACCTGGTCTCTCGACGAACCAGTCAGTAGCTTGCTATTCCAGTT
AGACTGGCTGACCAGGGAGCCTCCAGAATCTGTCCGTCTCTACCTTCCCCCTCACCAGGTCTAC
GGAGGGTGATGTCCCAGCCAGCATTTTTACACTGGTTCTAGGGACAGGAACTCAGGTTCTCATG
CTTGAATAGCAAGCCCTTTCTTCACCAAACCATTGCCTCAAACCCTCTGTGATCGAAAAGCTGC
TCAATTACCTTTATGTTCCCACCCAATGCAAGTGAACGAGCACAAGACATTTCAAGCTGTTGTT
TGTGAGCAAAAATCAATCTGCCAGTGACTTGAACATGCTAGGAGAAACTCCTCGCTCTGAGCTT
GACAAACCTGCAGTCCAGGTTCTCCAGAGATTGAGACAGGGAGGCTGCTGTTACATTTAGGGTT
CATTTGGAGAGTGAGACTTTGTCTCTACAAAACCAAAGACAAAGGAGAAGAAGAAAAAAAAAAC
CCTAAAGTACTCAGTTCTCATCTGTTAGCCTCAGAGGGCTTAGAGAGTTCCTGTGTTTACCTAT
CCGAACAACATTTTCATGTCTTTATGCAGTAGCTACCTAGTGAAATCCAGTGTTATCCCAGCTT
CTCCAGGCGTAAACATTCTCTCTTCAATCTCATCAGACCTCAGTAGCAAGCATTTAGTGAATAT
TTAGATTTTTCAGGCCAAGCCAAGACAAAAATGAATAGAATAAAAGAAAAAAGAGCCCAGACTC
TTGAAAGCGGTTTGCACTGATTTAAAAATAAAAAAAAAGAATCTTGAAGAATGACATGATAAAC
TGTGTTGGTTCCGCATGTGTAGTCGGATCCCTTTTCTGTGGAGAACGTTCTGTGGAGGGACAAA
CCACTAATTTGCCCCAAGTGAATGTGGCTGTAGTGACAGCGACAGTGCCTCTGATCTGAGAAGC
AGGGCTGGCTGCCGGTGACAAGCATCCCAGTTCCTTTCCCCAGAGATGAAGCGGATGTTTTCAG
ACAGAGCTCGGCTCAGGAATTTCGCTTGGAGAATCAGTGTTTATGTGCACAATGTTTTAGTGAG
CCTGCTCTGCGCCTGCATATGGGGAAGCCCTCGACTGTTCACCGGGCTCGTGGGCGACGGCTGC
CGTCAGCTGGACAGTGGATAAGTTTTCTGACGTAGTCACCACAGATTCAGGGATATCGCTTTGT
GTCGACTCCTAAGGAAGGCAGGACGATATGACTTGGTAACATTGTAAAGGTTCACATTTAAACT
TTTCAATAAATCTCAGCCTCACAGGCCTGAACATCTA

hide sequence

RefSeq Acc Id:

XM_008760321 ⟹ XP_008758543

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	232,024,351 - 232,167,320 (-)	NCBI
Rnor_6.0	1	252,816,536 - 252,959,337 (-)	NCBI

Sequence:

show sequence

ATGCAGGTAGGATTTCCAGAAGCAGTTCTTCAGAATGAGTCCTCACCGTCAGCAATTCTGCCTT
GAAATGGAGAACCATCTCTGCCAACTTGGATGCAAAAGTCTCCTCAGATGGTCCCAGGCTTAGA
GTCTGTGGGTTTGGTCTCTCTCTGCACCACCCAGCCTGTCTTCACATCCTTCAGTCCCTCCGAG
ACCATAGCACCCGTGGCCAACAAGACGGCTGCAGTCGTTCGGTTCCTGTCTGCCTTCCGTGTAG
GATTTGATTTCTCCTAAACTTGGTTTAAGACTTTTAAAGAAGGCCCTAATTTATCGAGGCCTGT
TTGTGAAGTAAAATTCGGCTGGCTACTCTCAACGGAAGAAAGATGCAACTGCTAGGCCGGGTGA
TCTGTTTCGTCGTTGGGATCCTGCTTTCTGGGGGCCCAACGGGGACCATATCAGCTGTGGACCC
TGAAGCAAACATGAATGTGACTGAGATAATCATGCACTGGGGATATCCTGGCGAAGAGCACTCA
GTACAGACAGGAGATGGCTACATTCTGGGTGTTCACCGAATCCCGCATGGGCGGAAGAACCAGT
TTGATAAAGGTCCCAAACCAGTTGTGTATCTTCAGCATGGCTTCCTGGCAGATTCTAGTAACTG
GGTCACAAACATTGACAACAACAGCCTGGGCTTCATCCTGGCAGATGCTGGCTTTGATGTGTGG
ATGGGAAACAGCAGAGGAAACACCTGGTCTCGGAAGCACAAGACTCTGTCAGTTTCTCAGGATG
AATACTGGGCCTTCAGTTTTGATGAGATGGCAAAATATGACCTCCCTGCTTCAATTAACTACAT
TTTGAATAAAACTGGCCAAGAACAGCTGTATTATGTGGGCCACTCTCAAGGCTGCACCATAGGT
TTTATAGCATTTTCACAGATGCCTGAACTGGCAAAGAAGGTTAAAATGTTTTTTGCCCTGGCTC
CTGTGTTGTCTCTCAATTTTGCTTCGGGCCCGATGGTCAAATTGGGACGGTTGCCGGATCTGCT
TCTTGAGGACTTGTTTGGGCAGAAGCAATTTCTTCCTCAGAGTGCAATGGTGAAATGGCTAAGC
ACTCACATTTGCACGCACGTCATCATGAAGGAGCTTTGCGCCAACATCTTCTTTCTGATATGTG
GCTTCAATGAGAAGAATTTAAACATGTCTAGAGTGGATGTGTATACAACACACTGTCCTGCGGG
AACCTCTGTGCAAAACATGGTACACTGGACCCAGGTTGTTAAATACCATAAGCTTCAAGCTTTT
GACTGGGGAAGCAGTGACAAGAATTATTTTCATTACAATCAGAGTTATCCACCCTTGTACAGCA
TAAAAGACATGCAACTACCCACTGCTTTATGGAGCGGGGGCAAGGACTGGCTGGCAGACACCAG
TGACATCAATATCTTACTGACTGAAATCCCCACGTTAGTGTACCACAAGAACATTCCCGAGTGG
GACCATCTGGATTTTATCTGGGGTTTGGATGCCCCCTGGAGGCTGTATAATGAAGTAGTCAGTC
TAATGAAGAAATACCAGTGAGTGCCAAGACTTGAGATGCTTCCCCTTCACTAGGGGAAAAAAGG
ACAGATGTTTGCTTAATTCCTGCAAAATACTTGTGTTTTCCTGGTCTAGATCATTTGTATTTTT
TATGTGCAAGAAAACGATGATGTTGAAGACATACATGGGTCTGGTCAGTAAGAAGCACGCTGGC
TGTCTTCTGCTTCATTCTGACTGACAAGCCAGAGTCACAACCAGCGATGCCTTTGAAGTTTTTA
GAAAGTATGGGTGTTACGTGAAGAAGCCATTGCAATCCTCTTGTTTACTTTTTACGGTCGTTTT
CGGTGTCTGCATGCTGTGCATATACATGCCTATGTGTGTGCCCTGTGCTGGCCAGAGCCTCCTT
GTGTGGAGGTAAGGGCTCACATCAGGGTATCTTCCTCAGACACTTTCCACTTTACTTTTTGAGA
CCTGGTCTCTCGACGAACCAGTCAGTAGCTTGCTATTCCAGTTAGACTGGCTGACCAGGGAGCC
TCCAGAATCTGTCCGTCTCTACCTTCCCCCTCACCAGGTCTACGGAGGGTGATGTCCCAGCCAG
CATTTTTACACTGGTTCTAGGGACAGGAACTCAGGTTCTCATGCTTGAATAGCAAGCCCTTTCT
TCACCAAACCATTGCCTCAAACCCTCTGTGATCGAAAAGCTGCTCAATTACCTTTATGTTCCCA
CCCAATGCAAGTGAACGAGCACAAGACATTTCAAGCTGTTGTTTGTGAGCAAAAATCAATCTGC
CAGTGACTTGAACATGCTAGGAGAAACTCCTCGCTCTGAGCTTGACAAACCTGCAGTCCAGGTT
CTCCAGAGATTGAGACAGGGAGGCTGCTGTTACATTTAGGGTTCATTTGGAGAGTGAGACTTTG
TCTCTACAAAACCAAAGACAAAGGAGAAGAAGAAAAAAAAAACCCTAAAGTACTCAGTTCTCAT
CTGTTAGCCTCAGAGGGCTTAGAGAGTTCCTGTGTTTACCTATCCGAACAACATTTTCATGTCT
TTATGCAGTAGCTACCTAGTGAAATCCAGTGTTATCCCAGCTTCTCCAGGCGTAAACATTCTCT
CTTCAATCTCATCAGACCTCAGTAGCAAGCATTTAGTGAATATTTAGATTTTTCAGGCCAAGCC
AAGACAAAAATGAATAGAATAAAAGAAAAAAGAGCCCAGACTCTTGAAAGCGGTTTGCACTGAT
TTAAAAATAAAAAAAAAGAATCTTGAAGAATGACATGATAAACTGTGTTGGTTCCGCATGTGTA
GTCGGATCCCTTTTCTGTGGAGAACGTTCTGTGGAGGGACAAACCACTAATTTGCCCCAAGTGA
ATGTGGCTGTAGTGACAGCGACAGTGCCTCTGATCTGAGAAGCAGGGCTGGCTGCCGGTGACAA
GCATCCCAGTTCCTTTCCCCAGAGATGAAGCGGATGTTTTCAGACAGAGCTCGGCTCAGGAATT
TCGCTTGGAGAATCAGTGTTTATGTGCACAATGTTTTAGTGAGCCTGCTCTGCGCCTGCATATG
GGGAAGCCCTCGACTGTTCACCGGGCTCGTGGGCGACGGCTGCCGTCAGCTGGACAGTGGATAA
GTTTTCTGACGTAGTCACCACAGATTCAGGGATATCGCTTTGTGTCGACTCCTAAGGAAGGCAG
GACGATATGACTTGGTAACATTGTAAAGGTTCACATTTAAACTTTTCAATAAATCTCAGCCTCA
CAGGCCTGAACATCTA

hide sequence

RefSeq Acc Id:

XM_017588801 ⟹ XP_017444290

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	232,024,351 - 232,167,329 (-)	NCBI
Rnor_6.0	1	252,816,536 - 252,959,348 (-)	NCBI

Sequence:

show sequence

GAAAACTAAGGATGCAGGTAGGATTTCCAGAAGCAGTTCTTCAGAATGAGTCCTCACCGTCAGC
AATTCTGCCTTGAAATGGAGCCACAGGTGAGCAGTTTCCGCCTGTCATGTCCTTCCACTGGGAA
CGTCTGCCTTGCCGCAAGCTTAAATTCCGTGGTACCAGGCAACAGTGGATTGGGATCTCTGCAA
CCAACCATCTCTGCCAACTTGGATGCAAAAGTCTCCTCAGATGGTCCCAGGCTTAGAGTCTGTG
GGTTTGGTCTCTCTCTGCACCACCCAGCCTGTCTTCACATCCTTCAGTCCCTCCGAGACCATAG
CACCCGTGGCCAACAAGACGGCTGCAGTCGTTCGGTTCCTGTCTGCCTTCCGTGTAGGATTTGA
TTTCTCCTAAACTTGGTTTAAGACTTTTAAAGAAGGCCCTAATTTATCGAGGCCTGTTTGTGAA
GTAAAATTCGGCTGGCTACTCTCAACGGAAGAAAGATGCAACTGCTAGGCCGGGTGATCTGTTT
CGTCGTTGGGATCCTGCTTTCTGGGGGCCCAACGGGGACCATATCAGCTGTGGACCCTGAAGCA
AACATGAATGTGACTGAGATAATCATGCACTGGGGATATCCTGGCGAAGAGCACTCAGTACAGA
CAGGAGATGGCTACATTCTGGGTGTTCACCGAATCCCGCATGGGCGGAAGAACCAGTTTGATAA
AGGTCCCAAACCAGTTGTGTATCTTCAGCATGGCTTCCTGGCAGATTCTAGTAACTGGGTCACA
AACATTGACAACAACAGCCTGGGCTTCATCCTGGCAGATGCTGGCTTTGATGTGTGGATGGGAA
ACAGCAGAGGAAACACCTGGTCTCGGAAGCACAAGACTCTGTCAGTTTCTCAGGATGAATACTG
GGCCTTCAGTTTTGATGAGATGGCAAAATATGACCTCCCTGCTTCAATTAACTACATTTTGAAT
AAAACTGGCCAAGAACAGCTGTATTATGTGGGCCACTCTCAAGGCTGCACCATAGGTTTTATAG
CATTTTCACAGATGCCTGAACTGGCAAAGAAGGTTAAAATGTTTTTTGCCCTGGCTCCTGTGTT
GTCTCTCAATTTTGCTTCGGGCCCGATGGTCAAATTGGGACGGTTGCCGGATCTGCTTCTTGAG
GACTTGTTTGGGCAGAAGCAATTTCTTCCTCAGAGTGCAATGGTGAAATGGCTAAGCACTCACA
TTTGCACGCACGTCATCATGAAGGAGCTTTGCGCCAACATCTTCTTTCTGATATGTGGCTTCAA
TGAGAAGAATTTAAACATGTCTAGAGTGGATGTGTATACAACACACTGTCCTGCGGGAACCTCT
GTGCAAAACATGGTACACTGGACCCAGGTTGTTAAATACCATAAGCTTCAAGCTTTTGACTGGG
GAAGCAGTGACAAGAATTATTTTCATTACAATCAGAGTTATCCACCCTTGTACAGCATAAAAGA
CATGCAACTACCCACTGCTTTATGGAGCGGGGGCAAGGACTGGCTGGCAGACACCAGTGACATC
AATATCTTACTGACTGAAATCCCCACGTTAGTGTACCACAAGAACATTCCCGAGTGGGACCATC
TGGATTTTATCTGGGGTTTGGATGCCCCCTGGAGGCTGTATAATGAAGTAGTCAGTCTAATGAA
GAAATACCAGTGAGTGCCAAGACTTGAGATGCTTCCCCTTCACTAGGGGAAAAAAGGACAGATG
TTTGCTTAATTCCTGCAAAATACTTGTGTTTTCCTGGTCTAGATCATTTGTATTTTTTATGTGC
AAGAAAACGATGATGTTGAAGACATACATGGGTCTGGTCAGTAAGAAGCACGCTGGCTGTCTTC
TGCTTCATTCTGACTGACAAGCCAGAGTCACAACCAGCGATGCCTTTGAAGTTTTTAGAAAGTA
TGGGTGTTACGTGAAGAAGCCATTGCAATCCTCTTGTTTACTTTTTACGGTCGTTTTCGGTGTC
TGCATGCTGTGCATATACATGCCTATGTGTGTGCCCTGTGCTGGCCAGAGCCTCCTTGTGTGGA
GGTAAGGGCTCACATCAGGGTATCTTCCTCAGACACTTTCCACTTTACTTTTTGAGACCTGGTC
TCTCGACGAACCAGTCAGTAGCTTGCTATTCCAGTTAGACTGGCTGACCAGGGAGCCTCCAGAA
TCTGTCCGTCTCTACCTTCCCCCTCACCAGGTCTACGGAGGGTGATGTCCCAGCCAGCATTTTT
ACACTGGTTCTAGGGACAGGAACTCAGGTTCTCATGCTTGAATAGCAAGCCCTTTCTTCACCAA
ACCATTGCCTCAAACCCTCTGTGATCGAAAAGCTGCTCAATTACCTTTATGTTCCCACCCAATG
CAAGTGAACGAGCACAAGACATTTCAAGCTGTTGTTTGTGAGCAAAAATCAATCTGCCAGTGAC
TTGAACATGCTAGGAGAAACTCCTCGCTCTGAGCTTGACAAACCTGCAGTCCAGGTTCTCCAGA
GATTGAGACAGGGAGGCTGCTGTTACATTTAGGGTTCATTTGGAGAGTGAGACTTTGTCTCTAC
AAAACCAAAGACAAAGGAGAAGAAGAAAAAAAAAACCCTAAAGTACTCAGTTCTCATCTGTTAG
CCTCAGAGGGCTTAGAGAGTTCCTGTGTTTACCTATCCGAACAACATTTTCATGTCTTTATGCA
GTAGCTACCTAGTGAAATCCAGTGTTATCCCAGCTTCTCCAGGCGTAAACATTCTCTCTTCAAT
CTCATCAGACCTCAGTAGCAAGCATTTAGTGAATATTTAGATTTTTCAGGCCAAGCCAAGACAA
AAATGAATAGAATAAAAGAAAAAAGAGCCCAGACTCTTGAAAGCGGTTTGCACTGATTTAAAAA
TAAAAAAAAAGAATCTTGAAGAATGACATGATAAACTGTGTTGGTTCCGCATGTGTAGTCGGAT
CCCTTTTCTGTGGAGAACGTTCTGTGGAGGGACAAACCACTAATTTGCCCCAAGTGAATGTGGC
TGTAGTGACAGCGACAGTGCCTCTGATCTGAGAAGCAGGGCTGGCTGCCGGTGACAAGCATCCC
AGTTCCTTTCCCCAGAGATGAAGCGGATGTTTTCAGACAGAGCTCGGCTCAGGAATTTCGCTTG
GAGAATCAGTGTTTATGTGCACAATGTTTTAGTGAGCCTGCTCTGCGCCTGCATATGGGGAAGC
CCTCGACTGTTCACCGGGCTCGTGGGCGACGGCTGCCGTCAGCTGGACAGTGGATAAGTTTTCT
GACGTAGTCACCACAGATTCAGGGATATCGCTTTGTGTCGACTCCTAAGGAAGGCAGGACGATA
TGACTTGGTAACATTGTAAAGGTTCACATTTAAACTTTTCAATAAATCTCAGCCTCACAGGCCT
GAACATCTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_036864	(Get FASTA)	NCBI Sequence Viewer
	XP_006231337	(Get FASTA)	NCBI Sequence Viewer
	XP_008758543	(Get FASTA)	NCBI Sequence Viewer
	XP_017444290	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB36043	(Get FASTA)	NCBI Sequence Viewer
	AAH72532	(Get FASTA)	NCBI Sequence Viewer
	EDM13161	(Get FASTA)	NCBI Sequence Viewer
	EDM13162	(Get FASTA)	NCBI Sequence Viewer
	EDM13163	(Get FASTA)	NCBI Sequence Viewer
	EDM13164	(Get FASTA)	NCBI Sequence Viewer
	Q64194	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_036864 ⟸ NM_012732
- Peptide Label:	precursor
- UniProtKB:	Q6IMY6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQLLGRVICFVVGILLSGGPTGTISAVDPEANMNVTEIIMHWGYPGEEHSVQTGDGYILGVHRI PHGRKNQFDKGPKPVVYLQHGFLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHK TLSVSQDEYWAFSFDEMAKYDLPASINYILNKTGQEQLYYVGHSQGCTIGFIAFSQMPELAKKV KMFFALAPVLSLNFASGPMVKLGRLPDLLLEDLFGQKQFLPQSAMVKWLSTHICTHVIMKELCA NIFFLICGFNEKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSDKNYFHYNQ SYPPLYSIKDMQLPTALWSGGKDWLADTSDINILLTEIPTLVYHKNIPEWDHLDFIWGLDAPWR LYNEVVSLMKKYQ hide sequence

RefSeq Acc Id:	XP_006231337 ⟸ XM_006231275
- Peptide Label:	isoform X1
- UniProtKB:	Q6IMY6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQLLGRVICFVVGILLSGGPTGTISAVDPEANMNVTEIIMHWGYPGEEHSVQTGDGYILGVHRI PHGRKNQFDKGPKPVVYLQHGFLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHK TLSVSQDEYWAFSFDEMAKYDLPASINYILNKTGQEQLYYVGHSQGCTIGFIAFSQMPELAKKV KMFFALAPVLSLNFASGPMVKLGRLPDLLLEDLFGQKQFLPQSAMVKWLSTHICTHVIMKELCA NIFFLICGFNEKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSDKNYFHYNQ SYPPLYSIKDMQLPTALWSGGKDWLADTSDINILLTEIPTLVYHKNIPEWDHLDFIWGLDAPWR LYNEVVSLMKKYQ hide sequence

RefSeq Acc Id:	XP_008758543 ⟸ XM_008760321
- Peptide Label:	isoform X1
- UniProtKB:	Q6IMY6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQLLGRVICFVVGILLSGGPTGTISAVDPEANMNVTEIIMHWGYPGEEHSVQTGDGYILGVHRI PHGRKNQFDKGPKPVVYLQHGFLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHK TLSVSQDEYWAFSFDEMAKYDLPASINYILNKTGQEQLYYVGHSQGCTIGFIAFSQMPELAKKV KMFFALAPVLSLNFASGPMVKLGRLPDLLLEDLFGQKQFLPQSAMVKWLSTHICTHVIMKELCA NIFFLICGFNEKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSDKNYFHYNQ SYPPLYSIKDMQLPTALWSGGKDWLADTSDINILLTEIPTLVYHKNIPEWDHLDFIWGLDAPWR LYNEVVSLMKKYQ hide sequence

RefSeq Acc Id:	XP_017444290 ⟸ XM_017588801
- Peptide Label:	isoform X1
- UniProtKB:	Q6IMY6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQLLGRVICFVVGILLSGGPTGTISAVDPEANMNVTEIIMHWGYPGEEHSVQTGDGYILGVHRI PHGRKNQFDKGPKPVVYLQHGFLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHK TLSVSQDEYWAFSFDEMAKYDLPASINYILNKTGQEQLYYVGHSQGCTIGFIAFSQMPELAKKV KMFFALAPVLSLNFASGPMVKLGRLPDLLLEDLFGQKQFLPQSAMVKWLSTHICTHVIMKELCA NIFFLICGFNEKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSDKNYFHYNQ SYPPLYSIKDMQLPTALWSGGKDWLADTSDINILLTEIPTLVYHKNIPEWDHLDFIWGLDAPWR LYNEVVSLMKKYQ hide sequence

RefSeq Acc Id:

ENSRNOP00000074398 ⟸ ENSRNOT00000078279

RefSeq Acc Id:

ENSRNOP00000025845 ⟸ ENSRNOT00000025845

Protein Domains

AB hydrolase-1

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690864

Promoter ID:

EPDNEW_R1389

Type:

initiation region

Name:

Lipa_1

Description:

lipase A, lysosomal acid type

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	252,849,812 - 252,849,872	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3008	AgrOrtholog
Ensembl Genes	ENSRNOG00000019077	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000025845	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000074398	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025845	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000078279	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7099460	IMAGE-MGC_LOAD
InterPro	AB_hydrolase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AB_hydrolase_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Lipase_euk	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25055	UniProtKB/TrEMBL
MGC_CLONE	MGC:91515	IMAGE-MGC_LOAD
NCBI Gene	25055	ENTREZGENE
Pfam	Abhydrolase_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Lipa	PhenoGen
PIRSF	Steryl_ester_lip	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF53474	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC207304
UniProt	LICH_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6IMY6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Lipa	lipase A, lysosomal acid type	Lipa	lipase A, lysosomal acid	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-03	Lipa	lipase A, lysosomal acid	Lipa	lipase A, lysosomal acid, cholesterol esterase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-23	Lipa	lipase A, lysosomal acid, cholesterol esterase	Lipa	lysosomal acid lipase A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-15	Lipa	lysosomal acid lipase A	Lip1	lysosomal acid lipase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Lip1	lysosomal acid lipase 1			Symbol and Name updated	1299863	APPROVED
2002-06-10	Lipa	lipase A, lysosomal acid			Symbol and Name status set to approved	70586	APPROVED
2001-04-10	Chole	Cholesterol esterase (pancreatic)			Symbol withdrawn, duplicate entry of Lipa (RGD:3008)	61478	WITHDRAWN
2001-04-06	Lipa	Cholesterol esterase (pancreatic)			Name inconsistent with current symbol	61478	WITHDRAWN
2001-04-06	Lipa	Lipase A, lysosomal acid			Name updated to reflect symbol	61478	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	mutation in gene causing substitution of 367Ile to Asn, 368Pro to stop codon, and deletion of the C-terminal 29 amino acids results in Wolman's disease	729052
gene_homology	79.9% homology with human lysosomal acid lipase (LAL)	729052

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InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)

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Imported Disease Annotations - OMIM

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Imported Annotations - KEGG (archival)