Lipa (lipase A, lysosomal acid type) - Rat Genome Database

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Gene: Lipa (lipase A, lysosomal acid type) Rattus norvegicus
Analyze
Symbol: Lipa
Name: lipase A, lysosomal acid type
RGD ID: 3008
Description: Enables sterol ester esterase activity. Involved in fatty acid metabolic process and sterol metabolic process. Located in lysosome. Human ortholog(s) of this gene implicated in Wolman disease and cholesterol ester storage disease. Orthologous to human LIPA (lipase A, lysosomal acid type); PARTICIPATES IN alendronate pharmacodynamics pathway; bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acid cholesteryl ester hydrolase; Chole; Chole2; CHOLEST; cholesterol esterase (pancreatic); Cholesterol esterase (pancreatic) see D3Wox12 D3Wox13 D3Wox26 and D3Mgh25; cholesteryl esterase; diacylglycerol lipase; LAL; Lip1; lipase A; lipase A, lysosomal acid; lipase A, lysosomal acid, cholesterol esterase; lysosomal acid lipase 1; lysosomal acid lipase A; lysosomal acid lipase/cholesteryl ester hydrolase; pancreatic cholesterol esterase; RATCHOLEST; sterol esterase; triacylglycerol ester hydrolase; triacylglycerol lipase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Lipam1Hyo
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,437,524 - 241,470,936 (-)NCBIGRCr8
GRCr8 Ensembl1241,437,524 - 241,470,740 (-)EnsemblGRCr8 Ensembl
mRatBN7.21232,024,351 - 232,057,735 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,024,356 - 232,057,633 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1240,414,292 - 240,447,547 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,337,140 - 247,370,358 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01240,175,338 - 240,208,560 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01252,816,536 - 252,959,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,816,527 - 252,849,904 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01260,038,180 - 260,091,819 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,466,493 - 238,500,195 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1229,136,934 - 229,170,119 (-)NCBICelera
RGSC_v3.11238,630,381 - 238,664,124 (-)NCBI
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
antimony(0)  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbamate ester  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
ethanol  (EXP)
etoposide  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
glafenine  (EXP)
haloperidol  (ISO)
hydrogen cyanide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
linalool  (ISO)
LY294002  (ISO)
lycopene  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methidathion  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Morroniside  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
Nivalenol  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
progesterone  (EXP)
Propiverine  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiadiazoles  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (IEA,ISO)
adaptive thermogenesis  (IEA,ISO)
adipose tissue development  (IEA,ISO)
ATP biosynthetic process  (IEA,ISO)
blood vessel endothelial cell differentiation  (IEA,ISO)
bone marrow development  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell proliferation in bone marrow  (IEA,ISO)
cholesterol biosynthetic process  (IEA,ISO)
cholesterol efflux  (IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
cholesterol storage  (IEA,ISO)
cholesterol transport  (IEA,ISO)
common myeloid progenitor cell proliferation  (IEA,ISO)
defecation  (IEA,ISO)
determination of adult lifespan  (IEA,ISO)
endocytosis  (IEA,ISO)
endosome to lysosome transport  (IEA,ISO)
endothelial cell proliferation  (IEA,ISO)
energy homeostasis  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
fat cell proliferation  (IEA,ISO)
fatty acid metabolic process  (IDA,IEA,ISO)
gene expression  (IEA,ISO)
glucose metabolic process  (IEA,ISO)
glycolytic process  (IEA,ISO)
hematopoietic progenitor cell differentiation  (IEA,ISO)
hemopoiesis  (IEA,ISO)
homeostasis of number of cells  (IEA,ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
inflammatory response  (IEA,ISO)
lipid biosynthetic process  (IEA,ISO)
lipid catabolic process  (IEA)
lipid homeostasis  (IEA,ISO)
lipid import into cell  (IEA,ISO)
lipid metabolic process  (IEA,ISO)
lipid storage  (IEA,ISO)
lipoprotein catabolic process  (IEA,ISO)
liver development  (IEA,ISO)
liver morphogenesis  (IEA,ISO)
lung development  (IEA,ISO)
lysosome organization  (IEA,ISO)
macrophage homeostasis  (IEA,ISO)
mitochondrion organization  (IEA,ISO)
mitotic cell cycle  (IEA,ISO)
multicellular organismal-level chemical homeostasis  (IEA,ISO)
multicellular organismal-level homeostasis  (IEA,ISO)
myeloid cell apoptotic process  (IEA,ISO)
myeloid cell differentiation  (IEA,ISO)
neutral lipid metabolic process  (IEA,ISO)
positive regulation of T cell receptor signaling pathway  (IEA,ISO)
programmed cell death  (IEA,ISO)
reactive oxygen species biosynthetic process  (IEA,ISO)
regulation of membrane potential  (IEA,ISO)
regulation of mitochondrial membrane potential  (IEA,ISO)
respiratory burst involved in inflammatory response  (IEA,ISO)
response to cold  (IEA,ISO)
response to dietary excess  (IEA,ISO)
response to lipid  (IEA,ISO)
response to rapamycin  (IEA,ISO)
response to vitamin A  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
retinoid metabolic process  (IEA,ISO)
small GTPase-mediated signal transduction  (IEA,ISO)
spleen development  (IEA,ISO)
sterol metabolic process  (IBA,IDA,IEA,ISO)
T cell apoptotic process  (IEA,ISO)
T cell differentiation  (IEA,ISO)
T cell proliferation  (IEA,ISO)
tissue remodeling  (IEA,ISO)
TOR signaling  (IEA,ISO)
triglyceride metabolic process  (IEA,ISO)
triglyceride-rich lipoprotein particle clearance  (IEA,ISO)
vitamin A metabolic process  (IEA,ISO)

Cellular Component
cytosol  (IEA,ISO)
fibrillar center  (IEA,ISO)
lysosome  (IDA,IEA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Subcellular localization of acid lipase in rat liver. Amanuma K, etal., Biochem Int. 1985 Sep;11(3):349-55.
2. Mutations at the lysosomal acid cholesteryl ester hydrolase gene locus in Wolman disease. Anderson RA, etal., Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2718-22.
3. Structure of the rat pancreatic cholesterol esterase gene. Fontaine RN, etal., Biochemistry 1991 Jul 16;30(28):7008-14.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Cholesteryl ester storage disease and Wolman disease: phenotypic variants of lysosomal acid cholesteryl ester hydrolase deficiency. Hoeg JM, etal., Am J Hum Genet. 1984 Nov;36(6):1190-203.
7. Inhibition of the acid lipase activity by apolipoprotein A-I in the presence of lysosomal proteases. Inoue Y, etal., Biosci Biotechnol Biochem. 1999 May;63(5):937-9.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Changes in the activity of lysosomal enzymes in rat kidneys in the course of acute pancreatitis. Lakowska H, etal., Med Sci Monit. 2001 Nov-Dec;7(6):1193-7.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Cloning of rat lysosomal acid lipase cDNA and identification of the mutation in the rat model of Wolman's disease. Nakagawa H, etal., J Lipid Res 1995 Oct;36(10):2212-8.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1718995   PMID:7204383   PMID:8112342   PMID:9633819   PMID:12477932   PMID:14644759   PMID:15269241   PMID:23376485  


Genomics

Comparative Map Data
Lipa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,437,524 - 241,470,936 (-)NCBIGRCr8
GRCr8 Ensembl1241,437,524 - 241,470,740 (-)EnsemblGRCr8 Ensembl
mRatBN7.21232,024,351 - 232,057,735 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,024,356 - 232,057,633 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1240,414,292 - 240,447,547 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,337,140 - 247,370,358 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01240,175,338 - 240,208,560 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01252,816,536 - 252,959,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,816,527 - 252,849,904 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01260,038,180 - 260,091,819 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,466,493 - 238,500,195 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1229,136,934 - 229,170,119 (-)NCBICelera
RGSC_v3.11238,630,381 - 238,664,124 (-)NCBI
Cytogenetic Map1q53NCBI
LIPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381089,330,997 - 89,342,689 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh381089,213,572 - 89,251,775 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh381089,405,329 - 89,421,494 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1089,213,569 - 89,414,557 (-)EnsemblGRCh38hg38GRCh38
GRCh371090,973,329 - 91,011,532 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,963,309 - 91,001,640 (-)NCBINCBI36Build 36hg18NCBI36
Build 341090,963,308 - 91,001,640NCBI
Celera1084,720,143 - 84,758,472 (-)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1084,607,788 - 84,646,145 (-)NCBIHuRef
CHM1_11091,255,383 - 91,293,719 (-)NCBICHM1_1
T2T-CHM13v2.01090,212,385 - 90,228,814 (-)NCBIT2T-CHM13v2.0
T2T-CHM13v2.01090,097,469 - 90,135,709 (-)NCBIT2T-CHM13v2.0
Lipa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391934,469,716 - 34,504,874 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1934,469,718 - 34,504,874 (-)EnsemblGRCm39 Ensembl
GRCm381934,492,316 - 34,527,474 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,492,318 - 34,527,474 (-)EnsemblGRCm38mm10GRCm38
MGSCv371934,566,806 - 34,601,964 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361934,558,313 - 34,593,419 (-)NCBIMGSCv36mm8
Celera1935,267,889 - 35,303,040 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1929.7NCBI
Lipa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554253,718,206 - 3,756,142 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554253,718,291 - 3,755,942 (+)NCBIChiLan1.0ChiLan1.0
LIPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28101,231,830 - 101,270,354 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110101,237,141 - 101,275,629 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01085,938,240 - 85,976,610 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11089,478,502 - 89,516,580 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,477,082 - 89,516,874 (-)Ensemblpanpan1.1panPan2
LIPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12638,892,771 - 38,918,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2638,893,337 - 38,918,436 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2638,643,855 - 38,671,678 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02640,476,944 - 40,504,767 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2640,476,940 - 40,505,350 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12638,347,241 - 38,375,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02637,910,947 - 37,938,676 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02639,180,692 - 39,208,434 (-)NCBIUU_Cfam_GSD_1.0
LIPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14101,126,257 - 101,193,614 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114101,131,372 - 101,254,739 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214110,116,088 - 110,152,009 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1982,639,220 - 82,677,479 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl982,638,621 - 82,677,488 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604843,315,133 - 43,353,408 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lipa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473749,371 - 83,514 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473749,471 - 82,981 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lipa
213 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:146
Interacting mature miRNAs:159
Transcripts:ENSRNOT00000025845
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
D3Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8332,287,769 - 32,288,017 (+)Marker Load Pipeline
RH 3.4 Map321.9UniSTS
RH 3.4 Map321.9RGD
Cytogenetic Map1q52UniSTS
D3Wox26   No map positions available.
D3Mgh25  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map327.2UniSTS
RH 3.4 Map327.2RGD
Cytogenetic Map1q52UniSTS
RH142813  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21232,024,884 - 232,025,032 (+)MAPPERmRatBN7.2
Rnor_6.01252,817,070 - 252,817,217NCBIRnor6.0
Rnor_5.01260,038,714 - 260,038,861UniSTSRnor5.0
RGSC_v3.41238,467,025 - 238,467,172UniSTSRGSC3.4
Celera1229,137,466 - 229,137,613UniSTS
RH 3.4 Map4490.82UniSTS
Cytogenetic Map1q52UniSTS
RH135375  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21232,025,259 - 232,025,445 (+)MAPPERmRatBN7.2
Rnor_6.01252,817,445 - 252,817,630NCBIRnor6.0
Rnor_5.01260,039,089 - 260,039,274UniSTSRnor5.0
RGSC_v3.41238,467,400 - 238,467,585UniSTSRGSC3.4
Celera1229,137,841 - 229,138,026UniSTS
Cytogenetic Map1q52UniSTS
RH139563  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21232,024,414 - 232,024,629 (+)MAPPERmRatBN7.2
Rnor_6.01252,816,600 - 252,816,814NCBIRnor6.0
Rnor_5.01260,038,244 - 260,038,458UniSTSRnor5.0
RGSC_v3.41238,466,555 - 238,466,769UniSTSRGSC3.4
Celera1229,136,996 - 229,137,210UniSTS
Cytogenetic Map1q52UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025845   ⟹   ENSRNOP00000025845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,437,524 - 241,470,740 (-)Ensembl
mRatBN7.2 Ensembl1232,024,509 - 232,057,619 (-)Ensembl
Rnor_6.0 Ensembl1252,816,538 - 252,849,756 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078279   ⟹   ENSRNOP00000074398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,437,524 - 241,470,740 (-)Ensembl
mRatBN7.2 Ensembl1232,024,356 - 232,057,633 (-)Ensembl
Rnor_6.0 Ensembl1252,816,527 - 252,849,904 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000149365   ⟹   ENSRNOP00000105407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,442,233 - 241,470,740 (-)Ensembl
RefSeq Acc Id: NM_012732   ⟹   NP_036864
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,437,524 - 241,470,740 (-)NCBI
mRatBN7.21232,024,353 - 232,057,573 (-)NCBI
Rnor_6.01252,816,538 - 252,849,756 (-)NCBI
Rnor_5.01260,038,180 - 260,091,819 (-)NCBI
RGSC_v3.41238,466,493 - 238,500,195 (-)RGD
Celera1229,136,934 - 229,170,119 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231275   ⟹   XP_006231337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,437,524 - 241,470,936 (-)NCBI
mRatBN7.21232,024,351 - 232,057,735 (-)NCBI
Rnor_6.01252,816,536 - 252,849,873 (-)NCBI
Rnor_5.01260,038,180 - 260,091,819 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036864   ⟸   NM_012732
- Peptide Label: precursor
- UniProtKB: Q64194 (UniProtKB/Swiss-Prot),   Q6IMY6 (UniProtKB/TrEMBL),   A0A0G2K7Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231337   ⟸   XM_006231275
- Peptide Label: isoform X1
- UniProtKB: Q64194 (UniProtKB/Swiss-Prot),   Q6IMY6 (UniProtKB/TrEMBL),   A0A0G2K7Y6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074398   ⟸   ENSRNOT00000078279
Ensembl Acc Id: ENSRNOP00000025845   ⟸   ENSRNOT00000025845
Ensembl Acc Id: ENSRNOP00000105407   ⟸   ENSRNOT00000149365
Protein Domains
AB hydrolase-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64194-F1-model_v2 AlphaFold Q64194 1-397 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690864
Promoter ID:EPDNEW_R1389
Type:initiation region
Name:Lipa_1
Description:lipase A, lysosomal acid type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01252,849,812 - 252,849,872EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3008 AgrOrtholog
BioCyc Gene G2FUF-55873 BioCyc
BioCyc Pathway PWY-7424 [sterol:steryl ester interconversion (yeast)] BioCyc
BioCyc Pathway Image PWY-7424 BioCyc
Ensembl Genes ENSRNOG00000019077 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000078279 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099460 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  AB_hydrolase_1 UniProtKB/Swiss-Prot
  Lipase_euk UniProtKB/Swiss-Prot
MGC_CLONE MGC:91515 IMAGE-MGC_LOAD
NCBI Gene 25055 ENTREZGENE
PANTHER LYSOSOMAL ACID LIPASE-RELATED UniProtKB/Swiss-Prot
Pfam Abhydrolase_1 UniProtKB/Swiss-Prot
PhenoGen Lipa PhenoGen
PIRSF Steryl_ester_lip UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019077 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
TIGR TC207304
UniProt A0A0G2K7Y6 ENTREZGENE, UniProtKB/TrEMBL
  F7F0N1_RAT UniProtKB/TrEMBL
  LICH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IMY6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Lipa  lipase A, lysosomal acid type  Lipa  lipase A, lysosomal acid  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Lipa  lipase A, lysosomal acid  Lipa  lipase A, lysosomal acid, cholesterol esterase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Lipa  lipase A, lysosomal acid, cholesterol esterase  Lipa  lysosomal acid lipase A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Lipa  lysosomal acid lipase A  Lip1  lysosomal acid lipase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Lip1  lysosomal acid lipase 1      Symbol and Name updated 1299863 APPROVED
2002-06-10 Lipa  lipase A, lysosomal acid      Symbol and Name status set to approved 70586 APPROVED
2001-04-10 Chole  Cholesterol esterase (pancreatic)      Symbol withdrawn, duplicate entry of Lipa (RGD:3008) 61478 WITHDRAWN
2001-04-06 Lipa  Lipase A, lysosomal acid      Name updated to reflect symbol 61478 APPROVED
2001-04-06 Lipa  Cholesterol esterase (pancreatic)      Name inconsistent with current symbol 61478 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_disease mutation in gene causing substitution of 367Ile to Asn, 368Pro to stop codon, and deletion of the C-terminal 29 amino acids results in Wolman's disease 729052
gene_homology 79.9% homology with human lysosomal acid lipase (LAL) 729052