(+)-catechin multiple interactions ISO RGD:1343460 6480464 Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K2 protein] CTD PMID:21882252 1-(5-isoquinolinesulfonyl)-2-methylpiperazine multiple interactions ISO RGD:62181 6480464 [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K2 protein CTD PMID:14654170 1-(5-isoquinolinesulfonyl)-2-methylpiperazine decreases phosphorylation ISO RGD:62181 6480464 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased phosphorylation of MAP2K2 protein CTD PMID:14654170 17alpha-ethynylestradiol increases expression ISO RGD:62181 6480464 Ethinyl Estradiol results in increased expression of MAP2K2 mRNA CTD PMID:16174780 PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of MAP2K2 mRNA CTD PMID:16174780 PMID:17351261 17alpha-ethynylestradiol multiple interactions ISO RGD:62181 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAP2K2 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:1343460 6480464 IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAP2K2 mRNA] CTD PMID:23094148 17beta-estradiol increases phosphorylation ISO RGD:1343460 6480464 Estradiol results in increased phosphorylation of MAP2K2 protein CTD PMID:27026707 17beta-estradiol increases expression ISO RGD:1343460 6480464 Estradiol results in increased expression of MAP2K2 mRNA CTD PMID:23094148 17beta-estradiol 3-benzoate decreases phosphorylation EXP 6480464 estradiol 3-benzoate results in decreased phosphorylation of MAP2K2 protein CTD PMID:15778002 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO RGD:1343460 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; more ... CTD PMID:15466214 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:62181 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAP2K2 mRNA; more ... CTD PMID:17942748 PMID:20450880 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:62181 6480464 Tetrachlorodibenzodioxin affects the expression of MAP2K2 mRNA CTD PMID:21570461 2,4,6-trinitrotoluene affects expression EXP 6480464 Trinitrotoluene affects the expression of MAP2K2 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2,6-dinitrotoluene affects the expression of MAP2K2 mRNA CTD PMID:21346803 2-arachidonoylglycerol multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; more ... CTD PMID:12657697 3',5'-cyclic GMP decreases phosphorylation ISO RGD:1343460 6480464 Cyclic GMP results in decreased phosphorylation of MAP2K2 protein CTD PMID:18225537 3',5'-cyclic GMP multiple interactions ISO RGD:1343460 6480464 Cyclic GMP affects the reaction [NPPA protein alternative form results in decreased phosphorylation of and results in decreased activity of MAP2K2 protein] CTD PMID:18225537 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:62181 6480464 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MAP2K2 mRNA] CTD PMID:19467301 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:62181 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MAP2K2 mRNA CTD PMID:19285098 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO RGD:1343460 6480464 bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K2 protein] CTD PMID:11861786 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions ISO RGD:1343460 6480464 [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K2 protein; more ... CTD PMID:21882252 5-(2-methylpiperazine-1-sulfonyl)isoquinoline multiple interactions ISO RGD:62181 6480464 [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K2 protein CTD PMID:14654170 5-(2-methylpiperazine-1-sulfonyl)isoquinoline decreases phosphorylation ISO RGD:62181 6480464 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased phosphorylation of MAP2K2 protein CTD PMID:14654170 5-fluorouracil multiple interactions ISO RGD:1343460 6480464 [U 0126 results in decreased activity of MAP2K2 protein] results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]; more ... CTD PMID:21444628 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of MAP2K2 mRNA CTD PMID:19483382 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of MAP2K2 mRNA CTD PMID:19483382 acetylsalicylic acid decreases expression ISO RGD:1343460 6480464 Aspirin results in decreased expression of MAP2K2 mRNA CTD PMID:15928584 afimoxifene decreases response to substance ISO RGD:1343460 6480464 MAP2K2 results in decreased susceptibility to afimoxifene CTD PMID:21233418 aflatoxin B1 decreases methylation ISO RGD:1343460 6480464 Aflatoxin B1 results in decreased methylation of MAP2K2 intron CTD PMID:30157460 all-trans-retinoic acid increases phosphorylation ISO RGD:1343460 6480464 Tretinoin results in increased phosphorylation of MAP2K2 protein CTD PMID:19038232 all-trans-retinoic acid multiple interactions ISO RGD:1343460 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K2 protein]]; more ... CTD PMID:20615082 all-trans-retinol multiple interactions EXP 6480464 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]; more ... CTD PMID:16510265 all-trans-retinol increases phosphorylation EXP 6480464 Vitamin A results in increased phosphorylation of MAP2K2 protein CTD PMID:16510265 alpha-mangostin increases phosphorylation ISO RGD:1343460 6480464 mangostin analog results in increased phosphorylation of MAP2K2 protein CTD PMID:28722351 amiodarone affects expression EXP 6480464 Amiodarone affects the expression of MAP2K2 mRNA CTD PMID:19483382 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of MAP2K2 mRNA CTD PMID:16483693 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of MAP2K2 mRNA; more ... CTD PMID:12420312 PMID:16483693 anandamide multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; more ... CTD PMID:12657697 arsenic acid increases activity ISO RGD:1343460 6480464 arsenic acid results in increased activity of MAP2K2 protein CTD PMID:14674888 arsenite(3-) increases activity ISO RGD:1343460 6480464 arsenite results in increased activity of MAP2K2 protein CTD PMID:14674888 benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of MAP2K2 mRNA CTD PMID:19483382 benzo[a]pyrene multiple interactions ISO RGD:62181 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of MAP2K2 mRNA]; more ... CTD PMID:19654925 PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:1343460 6480464 Benzo(a)pyrene affects the methylation of MAP2K2 intron CTD PMID:30157460 benzo[a]pyrene multiple interactions ISO RGD:1343460 6480464 [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K2 protein; more ... CTD PMID:21882252 benzo[a]pyrene increases expression ISO RGD:62181 6480464 Benzo(a)pyrene results in increased expression of MAP2K2 mRNA CTD PMID:22228805 bicalutamide multiple interactions ISO RGD:1343460 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; more ... CTD PMID:15466214 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of MAP2K2 mRNA CTD PMID:25181051 bortezomib decreases expression ISO RGD:1343460 6480464 Bortezomib results in decreased expression of MAP2K2 mRNA CTD PMID:20977926 cadmium atom increases phosphorylation ISO RGD:1343460 6480464 Cadmium results in increased phosphorylation of MAP2K2 protein CTD PMID:14499349 cadmium dichloride multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K2 protein] CTD PMID:18703135 cadmium dichloride multiple interactions ISO RGD:1343460 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K2 protein] CTD PMID:18703135 cadmium dichloride increases phosphorylation EXP 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K2 protein CTD PMID:18703135 cadmium dichloride increases methylation EXP 6480464 Cadmium Chloride results in increased methylation of MAP2K2 promoter CTD PMID:22457795 cadmium dichloride increases phosphorylation ISO RGD:1343460 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K2 protein CTD PMID:18703135 calciol increases expression ISO RGD:62181 6480464 Cholecalciferol results in increased expression of MAP2K2 mRNA CTD PMID:17170073 calcium atom affects expression EXP 6480464 Calcium affects the expression of MAP2K2 mRNA CTD PMID:15913539 calcium(0) affects expression EXP 6480464 Calcium affects the expression of MAP2K2 mRNA CTD PMID:15913539 carbon nanotube increases expression ISO RGD:62181 6480464 Nanotubes, Carbon analog results in increased expression of MAP2K2 mRNA CTD PMID:25554681 catechin multiple interactions ISO RGD:1343460 6480464 Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K2 protein] CTD PMID:21882252 celecoxib decreases phosphorylation ISO RGD:1343460 6480464 Celecoxib results in decreased phosphorylation of MAP2K2 protein CTD PMID:16123214 cisplatin multiple interactions ISO RGD:1343460 6480464 [U 0126 results in decreased activity of MAP2K2 protein] results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]; more ... CTD PMID:21444628 cisplatin decreases response to substance ISO RGD:1343460 6480464 MAP2K2 results in decreased susceptibility to Cisplatin CTD PMID:21849418 cisplatin increases phosphorylation ISO RGD:1343460 6480464 Cisplatin results in increased phosphorylation of MAP2K2 protein CTD PMID:21444628 clofibrate affects expression EXP 6480464 Clofibrate affects the expression of MAP2K2 mRNA CTD PMID:19483382 clozapine increases expression ISO RGD:62181 6480464 Clozapine results in increased expression of MAP2K2 mRNA CTD PMID:14647396 clozapine decreases expression EXP 6480464 Clozapine results in decreased expression of MAP2K2 mRNA CTD PMID:15860345 cobalt dichloride increases expression ISO RGD:1343460 6480464 cobaltous chloride results in increased expression of MAP2K2 mRNA CTD PMID:19376846 cocaine multiple interactions ISO RGD:62181 6480464 CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K2 protein] CTD PMID:15665076 cocaine increases phosphorylation ISO RGD:62181 6480464 Cocaine results in increased phosphorylation of MAP2K2 protein CTD PMID:15665076 copper(II) sulfate multiple interactions ISO RGD:1343460 6480464 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Copper Sulfate results in increased phosphorylation of MAP2K2 protein]; more ... CTD PMID:10564177 crocidolite asbestos increases phosphorylation ISO RGD:1343460 6480464 Asbestos, Crocidolite results in increased phosphorylation of MAP2K2 protein CTD PMID:18314537 curcumin multiple interactions ISO RGD:1343460 6480464 MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; more ... CTD PMID:21810436 D-mannitol multiple interactions EXP 6480464 Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein] CTD PMID:16510265 Deguelin decreases expression ISO RGD:1343460 6480464 deguelin results in decreased expression of MAP2K2 protein CTD PMID:19336726 dibutyl phthalate decreases expression ISO RGD:62181 6480464 Dibutyl Phthalate results in decreased expression of MAP2K2 mRNA CTD PMID:17361019 dibutyl phthalate multiple interactions ISO RGD:1343460 6480464 [Dibutyl Phthalate co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MAP2K2 protein CTD PMID:30218697 dieldrin multiple interactions ISO RGD:1343460 6480464 Dieldrin results in increased phosphorylation of and results in increased activity of MAP2K2 protein CTD PMID:15888667 disodium selenite increases expression ISO RGD:1343460 6480464 Sodium Selenite results in increased expression of MAP2K2 mRNA CTD PMID:18175754 doxorubicin increases phosphorylation ISO RGD:1343460 6480464 Doxorubicin results in increased phosphorylation of MAP2K2 protein CTD PMID:17974986 doxorubicin increases phosphorylation ISO RGD:62181 6480464 Doxorubicin results in increased phosphorylation of MAP2K2 protein CTD PMID:17974986 elemental selenium increases expression ISO RGD:1343460 6480464 Selenium results in increased expression of MAP2K2 mRNA CTD PMID:19244175 emodin multiple interactions EXP 6480464 Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein] CTD PMID:15288473 endosulfan multiple interactions ISO RGD:1343460 6480464 Endosulfan results in increased phosphorylation of and results in increased activity of MAP2K2 protein CTD PMID:15888667 ethanol increases expression EXP 6480464 Ethanol results in increased expression of MAP2K2 mRNA CTD PMID:20655511 finasteride increases expression EXP 6480464 Finasteride results in increased expression of MAP2K2 mRNA CTD PMID:24136188 fipronil decreases activity ISO RGD:62181 6480464 fipronil results in decreased activity of MAP2K2 protein CTD PMID:21167920 flutamide increases expression EXP 6480464 Flutamide results in increased expression of MAP2K2 mRNA CTD PMID:24136188 gamma-hexachlorocyclohexane multiple interactions ISO RGD:1343460 6480464 Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAP2K2 protein CTD PMID:15888667 geldanamycin decreases phosphorylation ISO RGD:1343460 6480464 geldanamycin results in decreased phosphorylation of MAP2K2 protein CTD PMID:19167484 genistein decreases phosphorylation EXP 6480464 Genistein results in decreased phosphorylation of MAP2K2 protein CTD PMID:15781664 genistein increases phosphorylation ISO RGD:1343460 6480464 Genistein results in increased phosphorylation of MAP2K2 protein CTD PMID:19038232 haloperidol decreases expression EXP 6480464 Haloperidol results in decreased expression of MAP2K2 mRNA CTD PMID:15860345 haloperidol increases expression ISO RGD:62181 6480464 Haloperidol results in increased expression of MAP2K2 mRNA CTD PMID:14647396 heparin multiple interactions EXP 6480464 Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K2 protein]; more ... CTD PMID:14966081 heptachlor multiple interactions ISO RGD:1343460 6480464 Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K2 protein CTD PMID:15888667 hyaluronic acid increases phosphorylation ISO RGD:1343460 6480464 Hyaluronic Acid analog results in increased phosphorylation of MAP2K2 protein CTD PMID:12402308 hydrogen peroxide increases activity ISO RGD:1343460 6480464 Hydrogen Peroxide results in increased activity of MAP2K2 protein CTD PMID:19038233 ionomycin multiple interactions ISO RGD:1343460 6480464 [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAP2K2 mRNA; more ... CTD PMID:15477007 ketamine multiple interactions ISO RGD:62181 6480464 Ketamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP2K2 protein] CTD PMID:19540866 L-ethionine affects expression EXP 6480464 Ethionine affects the expression of MAP2K2 mRNA CTD PMID:19483382 lead diacetate multiple interactions ISO RGD:1343460 6480464 bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; more ... CTD PMID:11861786 lead(0) increases phosphorylation ISO RGD:1343460 6480464 Lead results in increased phosphorylation of MAP2K2 protein CTD PMID:19133285 lead(2+) increases phosphorylation ISO RGD:1343460 6480464 Lead results in increased phosphorylation of MAP2K2 protein CTD PMID:19133285 letrozole increases expression ISO RGD:62181 6480464 letrozole results in increased expression of MAP2K2 protein CTD PMID:15967659 lipopolysaccharide increases phosphorylation ISO RGD:1343460 6480464 Lipopolysaccharides results in increased phosphorylation of MAP2K2 protein CTD PMID:19010997 lipopolysaccharide multiple interactions EXP 6480464 rosiglitazone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K2 protein] CTD PMID:21247645 lipopolysaccharide increases phosphorylation EXP 6480464 Lipopolysaccharides results in increased phosphorylation of MAP2K2 protein CTD PMID:21247645 lipopolysaccharide multiple interactions ISO RGD:62181 6480464 [Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein; more ... CTD PMID:19540866 PMID:23362215 lipoteichoic acid increases phosphorylation ISO RGD:62181 6480464 lipoteichoic acid results in increased phosphorylation of MAP2K2 protein CTD PMID:19573522 lipoteichoic acid multiple interactions ISO RGD:62181 6480464 Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K2 protein] CTD PMID:19573522 lycopene decreases expression ISO RGD:1343460 6480464 lycopene results in decreased expression of MAP2K2 protein CTD PMID:17337101 mercury atom increases expression ISO RGD:1343460 6480464 Mercury results in increased expression of MAP2K2 mRNA CTD PMID:16823088 mercury(0) increases expression ISO RGD:1343460 6480464 Mercury results in increased expression of MAP2K2 mRNA CTD PMID:16823088 mercury(2+) increases expression ISO RGD:1343460 6480464 Mercury results in increased expression of MAP2K2 mRNA CTD PMID:16823088 methotrexate affects response to substance ISO RGD:1343460 6480464 MAP2K2 protein affects the susceptibility to Methotrexate CTD PMID:16217747 mitomycin C multiple interactions ISO RGD:1343460 6480464 MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; more ... CTD PMID:21810436 N-acetyl-L-cysteine multiple interactions ISO RGD:1343460 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K2 protein] CTD PMID:18703135 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K2 protein] CTD PMID:18703135 N-nitrosodiethylamine affects phosphorylation ISO RGD:62181 6480464 Diethylnitrosamine affects the phosphorylation of MAP2K2 protein CTD PMID:24535843 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of MAP2K2 mRNA CTD PMID:24136188 ochratoxin A increases phosphorylation ISO RGD:1343460 6480464 ochratoxin A results in increased phosphorylation of MAP2K2 protein CTD PMID:25002221 omeprazole affects expression EXP 6480464 Omeprazole affects the expression of MAP2K2 mRNA CTD PMID:19483382 paracetamol affects expression ISO RGD:62181 6480464 Acetaminophen affects the expression of MAP2K2 mRNA CTD PMID:17562736 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of MAP2K2 mRNA CTD PMID:20136073 PhIP increases phosphorylation ISO RGD:1343460 6480464 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAP2K2 protein CTD PMID:22307971 phlorizin increases expression ISO RGD:62181 6480464 Phlorhizin results in increased expression of MAP2K2 mRNA CTD PMID:22538082 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1343460 6480464 [Dibutyl Phthalate co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MAP2K2 protein; more ... CTD PMID:11861786 more ... phorbol 13-acetate 12-myristate increases phosphorylation ISO RGD:1343460 6480464 Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K2 protein CTD PMID:20479004 pirinixic acid multiple interactions ISO RGD:62181 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAP2K2 mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:62181 6480464 pirinixic acid results in increased expression of MAP2K2 mRNA CTD PMID:23811191 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of MAP2K2 mRNA CTD PMID:19483382 pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of MAP2K2 mRNA CTD PMID:19162173 propofol multiple interactions ISO RGD:62181 6480464 Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K2 protein] CTD PMID:19573522 prostaglandin F2alpha increases phosphorylation ISO RGD:62181 6480464 Dinoprost results in increased phosphorylation of MAP2K2 protein CTD PMID:24333336 prostaglandin F2alpha multiple interactions ISO RGD:62181 6480464 resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K2 protein]; more ... CTD PMID:24333336 pyocyanine increases phosphorylation ISO RGD:1343460 6480464 Pyocyanine results in increased phosphorylation of MAP2K2 protein CTD PMID:24015256 pyrrolidine dithiocarbamate multiple interactions ISO RGD:1343460 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAP2K2 mRNA] CTD PMID:15477007 resveratrol increases expression ISO RGD:62181 6480464 resveratrol results in increased expression of MAP2K2 protein CTD PMID:25505154 resveratrol multiple interactions ISO RGD:62181 6480464 resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K2 protein] CTD PMID:24333336 sarin decreases expression ISO RGD:1343460 6480464 Sarin results in decreased expression of MAP2K2 mRNA CTD PMID:19522546 selenium atom increases expression ISO RGD:1343460 6480464 Selenium results in increased expression of MAP2K2 mRNA CTD PMID:19244175 silver atom decreases expression ISO RGD:62181 6480464 Silver results in decreased expression of MAP2K2 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:62181 6480464 Silver results in decreased expression of MAP2K2 mRNA CTD PMID:27131904 silver(1+) decreases expression ISO RGD:62181 6480464 Silver results in decreased expression of MAP2K2 mRNA CTD PMID:27131904 sirolimus multiple interactions ISO RGD:1343460 6480464 [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of MAP2K2 protein CTD PMID:15767555 sodium arsenite multiple interactions ISO RGD:1343460 6480464 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [sodium arsenite results in increased phosphorylation of MAP2K2 protein]; more ... CTD PMID:10564177 PMID:11943669 sodium arsenite increases phosphorylation ISO RGD:1343460 6480464 sodium arsenite results in increased phosphorylation of MAP2K2 protein CTD PMID:11943669 sodium arsenite increases expression ISO RGD:1343460 6480464 sodium arsenite results in increased expression of MAP2K2 mRNA CTD PMID:24431212 sodium arsenite affects expression ISO RGD:1343460 6480464 sodium arsenite affects the expression of MAP2K2 protein modified form CTD PMID:17384772 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of MAP2K2 mRNA CTD PMID:12325037 sodium fluoride increases phosphorylation EXP 6480464 Sodium Fluoride results in increased phosphorylation of MAP2K2 protein CTD PMID:19900517 sorafenib multiple interactions ISO RGD:1343460 6480464 [sorafenib co-treated with PI103] inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K2 protein]; more ... CTD PMID:21187475 sorafenib decreases phosphorylation EXP 6480464 sorafenib results in decreased phosphorylation of MAP2K2 protein CTD PMID:17341847 sorafenib decreases phosphorylation ISO RGD:1343460 6480464 sorafenib results in decreased phosphorylation of MAP2K2 protein CTD PMID:17341847 PMID:18200035 tetrahydropalmatine decreases expression ISO RGD:1343460 6480464 tetrahydropalmatine results in decreased expression of MAP2K2 protein CTD PMID:20109541 thimerosal decreases expression ISO RGD:1343460 6480464 Thimerosal results in decreased expression of MAP2K2 mRNA CTD PMID:27188386 thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of MAP2K2 mRNA CTD PMID:19483382 titanium dioxide increases phosphorylation ISO RGD:62181 6480464 titanium dioxide analog results in increased phosphorylation of MAP2K2 protein CTD PMID:25111187 toluene affects expression EXP 6480464 Toluene affects the expression of MAP2K2 mRNA CTD PMID:21827849 trichloroethene increases expression ISO RGD:62181 6480464 Trichloroethylene results in increased expression of MAP2K2 mRNA CTD PMID:19448997 tyrphostin AG 1478 multiple interactions EXP 6480464 RTKI cpd inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAP2K2 protein] CTD PMID:16269455 urethane increases expression ISO RGD:1343460 6480464 Urethane results in increased expression of MAP2K2 mRNA CTD PMID:28818685 valdecoxib increases expression EXP 6480464 valdecoxib results in increased expression of MAP2K2 mRNA CTD PMID:24136188 valproic acid affects expression ISO RGD:62181 6480464 Valproic Acid affects the expression of MAP2K2 mRNA CTD PMID:17292431 vanadyl sulfate multiple interactions ISO RGD:1343460 6480464 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [vanadyl sulfate results in increased phosphorylation of MAP2K2 protein]; more ... CTD PMID:10564177 PMID:11943669 vanadyl sulfate increases phosphorylation ISO RGD:1343460 6480464 vanadyl sulfate results in increased phosphorylation of MAP2K2 protein CTD PMID:11943669 vanillin decreases expression ISO RGD:1343460 6480464 vanillin results in decreased expression of MAP2K2 mRNA CTD PMID:17178418 wogonin multiple interactions ISO RGD:62181 6480464 wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein] CTD PMID:23362215 zinc sulfate multiple interactions ISO RGD:1343460 6480464 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAP2K2 protein]; more ... CTD PMID:10564177 PMID:11943669 zinc sulfate increases phosphorylation ISO RGD:1343460 6480464 Zinc Sulfate results in increased phosphorylation of MAP2K2 protein CTD PMID:11943669
Biological Process activation of MAPK activity TAS 8553538 PMID:19565474 UniProt activation of MAPK activity IBA FB:FBgn0261524|MGI:MGI:1346866|MGI:MGI:1346868|MGI:MGI:1346870|PANTHER:PTN000684494|RGD:61890|RGD:70495|SGD:S000002318|SGD:S000003664|UniProtKB:P52564|UniProtKB:Q02750|WB:WBGene00003185|WB:WBGene00003368|WB:WBGene00004758|dictyBase:DDB_G0269152 13792537 PMID:21873635 GO_Central activation of protein kinase activity IBA MGI:MGI:1919399|PANTHER:PTN000684825|RGD:727905|UniProtKB:Q7RTN6|UniProtKB:Q9C0K7 13792537 PMID:21873635 GO_Central epithelial cell proliferation involved in lung morphogenesis ISO RGD:62181 1624291 MGI:MGI:1346866 RGD MGI:MGI:5588044 PMID:25100655 epithelial cell proliferation involved in lung morphogenesis IEA UniProtKB:Q63932|ensembl:ENSMUSP00000121111 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ERK1 and ERK2 cascade ISO RGD:62181 1624291 MGI:MGI:1346866 RGD MGI:MGI:5588044 PMID:25100655 ERK1 and ERK2 cascade IEA UniProtKB:Q63932|ensembl:ENSMUSP00000121111 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ERK1 and ERK2 cascade ISO RGD:1343460 1624291 RGD PMID:24375836 face development ISO RGD:62181 1624291 MGI:MGI:1346866 RGD MGI:MGI:3832113 PMID:18952847 face development IEA UniProtKB:Q63932|ensembl:ENSMUSP00000121111 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 heart development ISO RGD:62181 1624291 MGI:MGI:1346866 RGD MGI:MGI:3832113 PMID:18952847 heart development IEA UniProtKB:Q63932|ensembl:ENSMUSP00000121111 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 lung morphogenesis ISO RGD:62181 1624291 MGI:MGI:1346866 RGD MGI:MGI:5588044 PMID:25100655 negative regulation of gene expression ISO RGD:1343460 1624291 UniProtKB:Q02750 RGD PMID:23626836 negative regulation of gene expression IGI UniProtKB:Q01986 13524616 PMID:28947594 BHF-UCL peptidyl-serine autophosphorylation ISO RGD:1343460 1624291 RGD PMID:8388392 peptidyl-tyrosine phosphorylation IEA GO:0004713 1600115 GO_REF:0000108 GOC GO_REF:0000108 positive regulation of axonogenesis ISO RGD:62181 1624291 MGI:MGI:1346866|MGI:MGI:88190 RGD MGI:MGI:5582953 PMID:24733831 positive regulation of axonogenesis IEA UniProtKB:Q63932|ensembl:ENSMUSP00000121111 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell motility ISO RGD:62181 1624291 RGD MGI:MGI:5285164 PMID:20179103 positive regulation of cell motility IEA UniProtKB:Q63932|ensembl:ENSMUSP00000121111 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of production of miRNAs involved in gene silencing by miRNA ISO RGD:1343460 1624291 RGD PMID:24375836 positive regulation of protein serine/threonine kinase activity ISO RGD:1343460 1624291 RGD PMID:8388392 positive regulation of transcription, DNA-templated ISO RGD:1343460 1624291 RGD PMID:24375836 protein phosphorylation IDA 61657 RGD protein phosphorylation IDA 2298674 RGD regulation of axon regeneration ISO RGD:62181 1624291 MGI:MGI:1346866|MGI:MGI:88190 RGD MGI:MGI:5582953 PMID:24733831 regulation of axon regeneration IEA UniProtKB:Q63932|ensembl:ENSMUSP00000121111 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of early endosome to late endosome transport TAS 8553538 PMID:19565474 UniProt regulation of Golgi inheritance TAS 8553538 PMID:19565474 UniProt regulation of protein phosphorylation ISO RGD:62181 1624291 MGI:MGI:1346866 RGD MGI:MGI:3828894 PMID:19047410 regulation of stress-activated MAPK cascade TAS 8553538 PMID:19565474 UniProt signal transduction by protein phosphorylation IBA PANTHER:PTN000684825|TAIR:locus:2205523|UniProtKB:Q9UEW8 13792537 PMID:21873635 GO_Central stress-activated protein kinase signaling cascade IBA PANTHER:PTN000684825|UniProtKB:A0A1D8PKE2|UniProtKB:A0A1D8PM87 13792537 PMID:21873635 GO_Central thymus development ISO RGD:62181 1624291 MGI:MGI:1346866 RGD MGI:MGI:3832113 PMID:18952847 thymus development IEA UniProtKB:Q63932|ensembl:ENSMUSP00000121111 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 thyroid gland development ISO RGD:62181 1624291 MGI:MGI:1346866 RGD MGI:MGI:3832113 PMID:18952847 thyroid gland development IEA UniProtKB:Q63932|ensembl:ENSMUSP00000121111 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 trachea formation ISO RGD:62181 1624291 MGI:MGI:1346866 RGD MGI:MGI:5588044 PMID:25100655 trachea formation IEA UniProtKB:Q63932|ensembl:ENSMUSP00000121111 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cell cortex IDA 2298675 RGD cell-cell junction ISO RGD:1343460 1624291 RGD PMID:21615688 cytoplasm ISO RGD:62181 1624291 RGD MGI:MGI:5529580 PMID:23920377 cytoplasm IBA FB:FBgn0023083|FB:FBgn0025743|FB:FBgn0267698|MGI:MGI:1339975|MGI:MGI:1344404|MGI:MGI:1346867|MGI:MGI:1346875|MGI:MGI:1891638|MGI:MGI:1928487|MGI:MGI:1929004|PANTHER:PTN000684825|PomBase:SPAC1F3.02c|PomBase:SPBC17F3.02|PomBase:SPBC1D7.05|PomBase:SPBC409.07c|PomBase:SPBC543.07|RGD:3780|RGD:620966|RGD:621643|SGD:S000000999|SGD:S000002318|SGD:S000002931|SGD:S000003664|SGD:S000004354|SGD:S000005757|SGD:S000006061|TAIR:locus:2017662|TAIR:locus:2074835|TAIR:locus:2087130|TAIR:locus:2170578|UniProtKB:A0A0B4KGS4|UniProtKB:O00506|UniProtKB:O95819|UniProtKB:Q13043|UniProtKB:Q13153|UniProtKB:Q13177|UniProtKB:Q13188|UniProtKB:Q57Y61|UniProtKB:Q7RTN6|UniProtKB:Q8N4C8|UniProtKB:Q96PY6|UniProtKB:Q9C0K7|UniProtKB:Q9H2G2|UniProtKB:Q9P289|UniProtKB:Q9S7U9|UniProtKB:Q9UKE5|UniProtKB:Q9Y4K4|UniProtKB:Q9Y6E0|UniProtKB:Q9Y6R4|WB:WBGene00002177|WB:WBGene00002201|WB:WBGene00003368|WB:WBGene00013355|dictyBase:DDB_G0284181|dictyBase:DDB_G0286359 13792537 PMID:21873635 GO_Central cytoplasmic side of plasma membrane ISO RGD:1343460 1624291 RGD PMID:21615688 cytosol IDA 2298675 RGD cytosol TAS 8553538 PMID:19565474 UniProt early endosome TAS 8553538 PMID:19565474 UniProt endoplasmic reticulum ISO RGD:1343460 1624291 RGD PMID:21615688 focal adhesion TAS 8553538 PMID:19565474 UniProt Golgi apparatus ISO RGD:1343460 1624291 RGD PMID:21615688 Golgi apparatus TAS 8553538 PMID:19565474 UniProt late endosome TAS 8553538 PMID:19565474 UniProt membrane IEA UniProtKB-SubCell:SL-0162 1600115 GO_REF:0000039 UniProt GO_REF:0000039 microtubule ISO RGD:1343460 1624291 RGD PMID:21615688 mitochondrion TAS 8553538 PMID:19565474 UniProt nucleus TAS 8553538 PMID:19565474 UniProt perinuclear region of cytoplasm ISO RGD:1343460 1624291 RGD PMID:21615688 Molecular Function ATP binding IDA 2298674 RGD MAP kinase kinase activity IDA 2298674 RGD MAP kinase kinase activity IBA FB:FBgn0261524|MGI:MGI:1346866|MGI:MGI:1346868|PANTHER:PTN000684494|PomBase:SPAC1D4.13|PomBase:SPBC409.07c|RGD:1307040|RGD:1560043|RGD:61888|RGD:620666|RGD:70495|SGD:S000002318|SGD:S000003664|TAIR:locus:2017662|TAIR:locus:2120855|TAIR:locus:2164981|TAIR:locus:2170578|TAIR:locus:2206885|UniProtKB:A0A1D8PKE2|UniProtKB:O14733|UniProtKB:P36507|UniProtKB:P52564|UniProtKB:Q02750|UniProtKB:Q5BEU9|UniProtKB:Q9S7U9|WB:WBGene00003185|WB:WBGene00003186|WB:WBGene00004758|dictyBase:DDB_G0269152 13792537 PMID:21873635 GO_Central MAP kinase kinase activity ISO RGD:1343460 1624291 RGD PMID:8388392 MAP kinase kinase activity IDA 61657 RGD metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000037 UniProt GO_REF:0000037 molecular adaptor activity IEA UniProtKB:Q63932|ensembl:ENSMUSP00000121111 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 molecular adaptor activity ISO RGD:62181 1624291 RGD MGI:MGI:5285164 PMID:20179103 PDZ domain binding ISO RGD:1343460 1624291 RGD PMID:21615688 protein binding IPI RGD:1308105 2298675 RGD protein binding ISO RGD:14072870 1624291 UniProtKB:Q5U8X5 RGD PMID:27605672 protein binding ISO RGD:1343460 1624291 UniProtKB:O95273|UniProtKB:P04049|UniProtKB:P10398|UniProtKB:P15056|UniProtKB:Q12959|UniProtKB:Q8IVT5 RGD PMID:11909642 more ... protein binding ISO RGD:62181 1624291 UniProtKB:P85298-4|UniProtKB:Q13526|UniProtKB:Q8CGE9 RGD MGI:MGI:5285164 more ... protein serine/threonine kinase activator activity ISO RGD:1343460 1624291 RGD PMID:8388392 protein serine/threonine kinase activity IBA FB:FBgn0023083|FB:FBgn0025743|FB:FBgn0031030|FB:FBgn0035001|FB:FBgn0261456|FB:FBgn0267698|MGI:MGI:1344404|MGI:MGI:1346882|MGI:MGI:1349394|MGI:MGI:1355329|MGI:MGI:1858416|MGI:MGI:1917378|MGI:MGI:1920334|PANTHER:PTN000684825|PomBase:SPBC1604.14c|PomBase:SPBC21.06c|RGD:3250|RGD:3251|RGD:621643|RGD:708455|RGD:727905|SGD:S000005242|TAIR:locus:2035989|TAIR:locus:2045658|TAIR:locus:2080394|TAIR:locus:2116417|TAIR:locus:2133559|TAIR:locus:2174969|TAIR:locus:2205523|TAIR:locus:2206885|UniProtKB:A0A0B4KGS4|UniProtKB:C0H4N8|UniProtKB:O75914|UniProtKB:O94804|UniProtKB:O95747|UniProtKB:O95819|UniProtKB:O96013|UniProtKB:Q02750|UniProtKB:Q12851|UniProtKB:Q13043|UniProtKB:Q13153|UniProtKB:Q13177|UniProtKB:Q13188|UniProtKB:Q13233|UniProtKB:Q8IVH8|UniProtKB:Q8N4C8|UniProtKB:Q92918|UniProtKB:Q99558|UniProtKB:Q9H2G2|UniProtKB:Q9H2K8|UniProtKB:Q9UEW8|UniProtKB:Q9UKE5|UniProtKB:Q9UL54|UniProtKB:Q9Y4K4|UniProtKB:Q9Y6E0|WB:WBGene00013355|WB:WBGene00017472|dictyBase:DDB_G0276459|dictyBase:DDB_G0286359 13792537 PMID:21873635 GO_Central protein serine/threonine/tyrosine kinase activity TAS 8553538 PMID:19565474 UniProt protein tyrosine kinase activity IEA UniProtKB-KW:KW-0829 1600115 GO_REF:0000037 UniProt GO_REF:0000037 scaffold protein binding ISO RGD:1343460 1624291 UniProtKB:Q12959|UniProtKB:Q61097 RGD PMID:10409742 PMID:21615688
Gene-Chemical Interaction Annotations
