Birc3 (baculoviral IAP repeat-containing 3) - Rat Genome Database

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Gene: Birc3 (baculoviral IAP repeat-containing 3) Rattus norvegicus
Symbol: Birc3
Name: baculoviral IAP repeat-containing 3
RGD ID: 621282
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Involved in spermatogenesis. Part of protein-containing complex. Human ortholog(s) of this gene implicated in colorectal carcinoma; esophagus adenocarcinoma; extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: baculoviral IAP repeat-containing protein 3; Birc2; IAP1; inhibitor of apoptosis protein 1; MGC93416
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Birc3m1Mcwi   Birc3m2Mcwi  
Genetic Models: SS-Birc3m2Mcwi BN-Birc3m1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8813,285,702 - 13,313,329 (-)NCBIGRCr8
mRatBN7.285,000,844 - 5,028,470 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl85,000,845 - 5,015,802 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,960,993 - 8,975,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,258,675 - 7,273,532 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,260,542 - 5,275,505 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.086,048,590 - 6,076,828 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,048,969 - 6,076,598 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,047,454 - 6,075,236 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,682,202 - 4,696,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,682,202 - 4,696,856 (-)NCBI
Celera86,558,921 - 6,573,882 (-)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(aminomethyl)phosphonic acid  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-monopalmitoylglycerol  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene  (ISO)
2-butoxyethanol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-aminopyridine  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5Z-7-oxozeaenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
alvocidib  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
aprepitant  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Bardoxolone methyl  (ISO)
beauvericin  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bryostatin 1  (ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chrysazin  (ISO)
cisplatin  (ISO)
cladribine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cryptolepine  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
dichloromethane  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
fenofibrate  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gastrin-17  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
gentamycin  (EXP)
gliotoxin  (ISO)
glutathione  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
guggulsterone  (ISO)
homocysteine  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibrutinib  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
L-ascorbic acid  (ISO)
LCL161  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
linalool  (ISO)
lipopolysaccharide  (ISO)
lobaplatin  (ISO)
lonafarnib  (ISO)
LY294002  (ISO)
lysophosphatidylethanolamine  (ISO)
melittin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
Mitotane  (EXP)
morin  (ISO)
N,N'-(hexane-1,6-diyl)bis(1-\{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl\}-L-prolyl-beta-phenyl-L-phenylalaninamide)  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nitric oxide  (ISO)
o-xylene  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
PD 0325901  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
SM-164  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
staurosporine  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tephrosin  (ISO)
testosterone  (EXP,ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)


References - curated
# Reference Title Reference Citation
1. Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts. An MJ, etal., Cancer Lett. 2009 Jun 28;279(1):93-100. doi: 10.1016/j.canlet.2009.01.026. Epub 2009 Feb 18.
2. [Association of cellular inhibitor of apoptosis protein-2 expression with clinical outcomes of hepatocellular carcinoma]. Bi M, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2012 Jun;32(7):1020-5, 1030.
3. Identification of microRNA-124 in regulation of Hepatocellular carcinoma through BIRC3 and the NF-κB pathway. Cao J, etal., J Cancer. 2018 Jul 30;9(17):3006-3015. doi: 10.7150/jca.25956. eCollection 2018.
4. Cytoplasmic HuR expression: correlation with cellular inhibitors of apoptosis protein-2 expression and clinicopathologic factors in oral squamous cell carcinoma cells. Cha JD, etal., Head Neck. 2014 Aug;36(8):1168-75. doi: 10.1002/hed.23431. Epub 2014 Jan 16.
5. Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. Chen JY, etal., Life Sci. 2010 Sep 11;87(11-12):350-7. doi: 10.1016/j.lfs.2010.06.017. Epub 2010 Jul 17.
6. Expression of inhibitor of apoptosis family proteins in human oral squamous cell carcinogenesis. Chen YK, etal., Head Neck. 2011 Jul;33(7):985-98. doi: 10.1002/hed.21582. Epub 2010 Oct 21.
7. Lobaplatin induces pyroptosis through regulating cIAP1/2, Ripoptosome and ROS in nasopharyngeal carcinoma. Chen Z, etal., Biochem Pharmacol. 2020 Jul;177:114023. doi: 10.1016/j.bcp.2020.114023. Epub 2020 May 13.
8. Tumor necrosis factor. Chu WM, Cancer Lett. 2013 Jan 28;328(2):222-5. doi: 10.1016/j.canlet.2012.10.014. Epub 2012 Oct 22.
9. A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways. Dagenais M, etal., Mucosal Immunol. 2016 Jan;9(1):146-58. doi: 10.1038/mi.2015.46. Epub 2015 Jun 3.
10. Death receptor 5 (DR5) and a 5-gene apoptotic biomarker panel with significant differential diagnostic potential in colorectal cancer. Devetzi M, etal., Sci Rep. 2016 Nov 9;6:36532. doi: 10.1038/srep36532.
11. Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Ebert G, etal., Proc Natl Acad Sci U S A. 2015 May 5;112(18):5797-802. doi: 10.1073/pnas.1502390112. Epub 2015 Apr 20.
12. New insight into BIRC3: A novel prognostic indicator and a potential therapeutic target for liver cancer. Fu PY, etal., J Cell Biochem. 2019 Apr;120(4):6035-6045. doi: 10.1002/jcb.27890. Epub 2018 Oct 28.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Cloning and characterization of the rat homologues of the Inhibitor of Apoptosis protein 1, 2, and 3 genes. Holcik M, etal., BMC Genomics 2002;3(1):5.
15. Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells. Hu Y, etal., Biochem Pharmacol. 2013 Apr 1;85(7):1007-17. doi: 10.1016/j.bcp.2013.01.023. Epub 2013 Feb 8.
16. cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF-κB pathway. Jiang X, etal., Cancer Sci. 2017 Jun;108(6):1144-1156. doi: 10.1111/cas.13236. Epub 2017 May 31.
17. cIAP2 via NF-κB signalling affects cell proliferation and invasion in hepatocellular carcinoma. Jiang XJ, etal., Life Sci. 2021 Feb 1;266:118867. doi: 10.1016/j.lfs.2020.118867. Epub 2020 Dec 10.
18. Down-regulation of the expression of rat inhibitor-of-apoptosis protein-1 and -3 during transforming growth factor-beta1-mediated apoptosis in rat brain microglia. Jung B, etal., Neuroreport 2003 May 6;14(6):857-60.
19. Expression parameters of the inhibitors of apoptosis cIAP1 and cIAP2 in renal cell carcinomas and their prognostic relevance. Kempkensteffen C, etal., Int J Cancer. 2007 Mar 1;120(5):1081-6.
20. t(11;18)(q21;q21) translocation as predictive marker for non-responsiveness to salvage thalidomide therapy in patients with marginal zone B-cell lymphoma with gastric involvement. Kuo SH, etal., Cancer Chemother Pharmacol. 2011 Dec;68(6):1387-95. doi: 10.1007/s00280-011-1631-y. Epub 2011 Apr 5.
21. Haem oxygenase-1 plays a central role in NNK-mediated lung carcinogenesis. Li MY, etal., Eur Respir J. 2008 Oct;32(4):911-23. doi: 10.1183/09031936.00064508. Epub 2008 May 28.
22. Toll-like receptor 2 stimulation promotes colorectal cancer cell growth via PI3K/Akt and NF-κB signaling pathways. Liu YD, etal., Int Immunopharmacol. 2018 Jun;59:375-383. doi: 10.1016/j.intimp.2018.04.033. Epub 2018 Apr 24.
23. Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain. Lotocki G, etal., J Neurosci. 2004 Dec 8;24(49):11010-6.
24. Concomitant activation of caspase-9 and down-regulation of IAP proteins as a mechanism of apoptotic death in HepG2, T47D and HCT-116 cells upon exposure to a derivative from 4-aryl-4H-chromenes family. Mahdavi M, etal., Biomed Pharmacother. 2011 Jun;65(3):175-82. doi: 10.1016/j.biopha.2011.03.001. Epub 2011 Apr 8.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors. Mitsuishi T, etal., BMC Cancer. 2010 Mar 27;10:118. doi: 10.1186/1471-2407-10-118.
27. Overexpression of cIAP2 contributes to 5-FU resistance and a poor prognosis in oral squamous cell carcinoma. Nagata M, etal., Br J Cancer. 2011 Oct 25;105(9):1322-30. doi: 10.1038/bjc.2011.387. Epub 2011 Sep 27.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis. Nguyen L, etal., Exp Mol Pathol. 2018 Feb;104(1):45-49. doi: 10.1016/j.yexmp.2017.12.007. Epub 2018 Jan 4.
30. Gene signature distinguishes patients with chronic ulcerative colitis harboring remote neoplastic lesions. Pekow J, etal., Inflamm Bowel Dis. 2013 Mar;19(3):461-70. doi: 10.1097/MIB.0b013e3182802bac.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
33. TAK1-regulated expression of BIRC3 predicts resistance to preoperative chemoradiotherapy in oesophageal adenocarcinoma patients. Piro G, etal., Br J Cancer. 2015 Sep 15;113(6):878-85. doi: 10.1038/bjc.2015.283. Epub 2015 Aug 20.
34. An apoptosis-independent role of SMAC in tumor suppression. Qiu W, etal., Oncogene. 2013 May 9;32(19):2380-9. doi: 10.1038/onc.2012.265. Epub 2012 Jul 2.
35. GOA pipeline RGD automated data pipeline
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Shinoda S, etal., Eur J Neurosci. 2003 May;17(10):2065-76.
38. API2-MALT1 chimeric transcript is a predictive marker for the responsiveness of H. pylori eradication treatment in low-grade gastric MALT lymphoma. Sugiyama T, etal., Gastroenterology. 2001 Jun;120(7):1884-5. doi: 10.1053/gast.2001.25305.
39. Genetic variants of BIRC3 and NRG1 in the NLRP3 inflammasome pathway are associated with non-small cell lung cancer survival. Tang D, etal., Am J Cancer Res. 2020 Aug 1;10(8):2582-2595. eCollection 2020.
40. Synergistic effects of IAP inhibitor LCL161 and paclitaxel on hepatocellular carcinoma cells. Tian A, etal., Cancer Lett. 2014 Sep 1;351(2):232-41. doi: 10.1016/j.canlet.2014.06.006. Epub 2014 Jun 27.
41. Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6. Tomicic MT, etal., Arch Toxicol. 2019 Aug;93(8):2265-2277. doi: 10.1007/s00204-019-02513-7. Epub 2019 Jul 9.
42. Antianoikis effect of nuclear factor-kappaB through up-regulated expression of osteoprotegerin, BCL-2, and IAP-1. Toruner M, etal., J Biol Chem. 2006 Mar 31;281(13):8686-96. Epub 2006 Jan 5.
43. CircDOCK1 suppresses cell apoptosis via inhibition of miR‑196a‑5p by targeting BIRC3 in OSCC. Wang L, etal., Oncol Rep. 2018 Mar;39(3):951-966. doi: 10.3892/or.2017.6174. Epub 2017 Dec 28.
44. The regulated expression of c-IAP1 and c-IAP2 during the rat seminiferous epithelial cycle plays a role in the protection of germ cells from Fas-mediated apoptosis. Wang Y, etal., Mol Cell Endocrinol. 2005 Dec 21;245(1-2):111-20. Epub 2005 Dec 15.
45. Identification of cyclin B1 and Sec62 as biomarkers for recurrence in patients with HBV-related hepatocellular carcinoma after surgical resection. Weng L, etal., Mol Cancer. 2012 Jun 8;11:39. doi: 10.1186/1476-4598-11-39.
46. cIAP2 upregulated by E6 oncoprotein via epidermal growth factor receptor/phosphatidylinositol 3-kinase/AKT pathway confers resistance to cisplatin in human papillomavirus 16/18-infected lung cancer. Wu HH, etal., Clin Cancer Res. 2010 Nov 1;16(21):5200-10. doi: 10.1158/1078-0432.CCR-10-0020. Epub 2010 Oct 19.
47. The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells. Wu P, etal., Cell Death Dis. 2014 Feb 27;5:e1085. doi: 10.1038/cddis.2014.13.
48. LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC. Yang C, etal., J Exp Clin Cancer Res. 2016 Sep 30;35(1):158. doi: 10.1186/s13046-016-0435-7.
49. Helicobacter pylori Eradication Downregulates Cellular Inhibitor of Apoptosis Protein 2 in Gastric Carcinogenesis. Yoon H, etal., Gut Liver. 2017 Jan 15;11(1):79-86. doi: 10.5009/gnl15585.
50. Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer. Zhang S, etal., J Exp Clin Cancer Res. 2019 Jan 10;38(1):14. doi: 10.1186/s13046-018-0985-y.
51. Increased HMGB1 expression correlates with higher expression of c-IAP2 and pERK in colorectal cancer. Zhang W, etal., Medicine (Baltimore). 2019 Jan;98(3):e14069. doi: 10.1097/MD.0000000000014069.
52. Evironmental pollutant perfluorodecanoic acid upregulates cIAP2 to suppress gastric cell senescence. Zhang Z, etal., Oncol Rep. 2019 Feb;41(2):981-988. doi: 10.3892/or.2018.6856. Epub 2018 Nov 9.
Additional References at PubMed
PMID:8889548   PMID:10797013   PMID:12477932   PMID:15665297   PMID:16115895   PMID:16123224   PMID:16395405   PMID:18621737   PMID:19008929   PMID:19720604   PMID:21052097   PMID:21737330  
PMID:21931591   PMID:23028454   PMID:23192759   PMID:24357921  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8813,285,702 - 13,313,329 (-)NCBIGRCr8
mRatBN7.285,000,844 - 5,028,470 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl85,000,845 - 5,015,802 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,960,993 - 8,975,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,258,675 - 7,273,532 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,260,542 - 5,275,505 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.086,048,590 - 6,076,828 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,048,969 - 6,076,598 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,047,454 - 6,075,236 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,682,202 - 4,696,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,682,202 - 4,696,856 (-)NCBI
Celera86,558,921 - 6,573,882 (-)NCBICelera
Cytogenetic Map8q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811102,317,484 - 102,339,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,317,484 - 102,339,403 (+)EnsemblGRCh38hg38GRCh38
GRCh3711102,188,215 - 102,210,134 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,693,404 - 101,713,675 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411101,693,403 - 101,713,674NCBI
Celera1199,349,739 - 99,370,012 (+)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,114,738 - 98,136,703 (+)NCBIHuRef
CHM1_111102,071,142 - 102,093,097 (+)NCBICHM1_1
T2T-CHM13v2.011102,319,603 - 102,341,520 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3997,848,698 - 7,873,199 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,848,700 - 7,873,187 (-)EnsemblGRCm39 Ensembl
GRCm3897,847,468 - 7,873,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,848,699 - 7,873,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv3797,848,699 - 7,873,170 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,849,220 - 7,873,545 (-)NCBIMGSCv36mm8
Celera95,240,413 - 5,264,652 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554125,628,973 - 5,643,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,624,865 - 5,643,520 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v29103,122,394 - 103,144,359 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,210,806 - 104,232,727 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,269,778 - 97,290,112 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111100,763,274 - 100,785,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,763,274 - 100,785,194 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1529,324,893 - 29,343,322 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,325,331 - 29,337,240 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,274,261 - 29,286,176 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,377,538 - 29,396,454 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,377,570 - 29,395,969 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,434,557 - 29,446,661 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,292,001 - 29,303,913 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,466,940 - 29,478,850 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494785,977,221 - 85,992,462 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,544,065 - 5,556,555 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,544,047 - 5,556,550 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl933,003,276 - 33,020,242 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,003,570 - 33,020,252 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2936,951,995 - 36,969,108 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1193,692,239 - 93,711,905 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604332,150,453 - 32,171,737 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624878523,300 - 536,062 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624878516,750 - 541,475 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Birc3
100 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:52
Interacting mature miRNAs:57
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.285,001,178 - 5,001,384 (+)MAPPERmRatBN7.2
Rnor_6.086,048,925 - 6,049,130NCBIRnor6.0
Rnor_5.086,047,789 - 6,047,994UniSTSRnor5.0
RGSC_v3.484,682,230 - 4,682,435UniSTSRGSC3.4
Celera86,559,256 - 6,559,461UniSTS
Cytogenetic Map8q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.285,000,971 - 5,001,203 (+)MAPPERmRatBN7.2
Rnor_6.086,048,718 - 6,048,949NCBIRnor6.0
Rnor_5.086,047,582 - 6,047,813UniSTSRnor5.0
RGSC_v3.484,682,023 - 4,682,254UniSTSRGSC3.4
Celera86,559,049 - 6,559,280UniSTS
Cytogenetic Map8q11UniSTS

Genetic Models
This gene Birc3 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 8 19 1 10 10
Low 43 49 41 41 8 11 69 34 31 1 8
Below cutoff 5


RefSeq Acc Id: ENSRNOT00000007702   ⟹   ENSRNOP00000007702
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl85,001,422 - 5,015,802 (-)Ensembl
Rnor_6.0 Ensembl86,049,168 - 6,061,837 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090774   ⟹   ENSRNOP00000068729
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl85,000,845 - 5,015,802 (-)Ensembl
Rnor_6.0 Ensembl86,048,969 - 6,076,598 (-)Ensembl
RefSeq Acc Id: NM_023987   ⟹   NP_076477
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8813,285,702 - 13,300,659 (-)NCBI
mRatBN7.285,000,844 - 5,015,802 (-)NCBI
Rnor_6.086,048,590 - 6,063,975 (-)NCBI
Rnor_5.086,047,454 - 6,075,236 (-)NCBI
RGSC_v3.484,682,202 - 4,696,856 (-)RGD
Celera86,558,921 - 6,573,882 (-)NCBI
RefSeq Acc Id: XM_006242499   ⟹   XP_006242561
Rat AssemblyChrPosition (strand)Source
GRCr8813,285,705 - 13,300,588 (-)NCBI
mRatBN7.285,000,844 - 5,015,728 (-)NCBI
Rnor_6.086,048,590 - 6,063,901 (-)NCBI
Rnor_5.086,047,454 - 6,075,236 (-)NCBI
RefSeq Acc Id: XM_006242500   ⟹   XP_006242562
Rat AssemblyChrPosition (strand)Source
GRCr8813,285,705 - 13,300,807 (-)NCBI
mRatBN7.285,000,844 - 5,015,728 (-)NCBI
Rnor_6.086,048,590 - 6,063,901 (-)NCBI
Rnor_5.086,047,454 - 6,075,236 (-)NCBI
RefSeq Acc Id: XM_006242502   ⟹   XP_006242564
Rat AssemblyChrPosition (strand)Source
GRCr8813,285,705 - 13,313,285 (-)NCBI
mRatBN7.285,000,844 - 5,028,431 (-)NCBI
Rnor_6.086,048,590 - 6,076,828 (-)NCBI
Rnor_5.086,047,454 - 6,075,236 (-)NCBI
RefSeq Acc Id: XM_006242503   ⟹   XP_006242565
Rat AssemblyChrPosition (strand)Source
GRCr8813,285,705 - 13,313,329 (-)NCBI
mRatBN7.285,000,844 - 5,028,470 (-)NCBI
Rnor_6.086,048,590 - 6,076,828 (-)NCBI
Rnor_5.086,047,454 - 6,075,236 (-)NCBI
RefSeq Acc Id: XM_039082193   ⟹   XP_038938121
Rat AssemblyChrPosition (strand)Source
GRCr8813,285,705 - 13,300,588 (-)NCBI
mRatBN7.285,000,844 - 5,015,728 (-)NCBI
RefSeq Acc Id: XM_063266200   ⟹   XP_063122270
Rat AssemblyChrPosition (strand)Source
GRCr8813,285,705 - 13,300,807 (-)NCBI
RefSeq Acc Id: XR_005487928
Rat AssemblyChrPosition (strand)Source
GRCr8813,290,112 - 13,300,593 (-)NCBI
mRatBN7.285,005,310 - 5,015,733 (-)NCBI
RefSeq Acc Id: NP_076477   ⟸   NM_023987
- UniProtKB: A0A0G2JTI9 (UniProtKB/TrEMBL),   Q9ESE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242565   ⟸   XM_006242503
- Peptide Label: isoform X2
- UniProtKB: Q5XIW4 (UniProtKB/TrEMBL),   Q9ESE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242564   ⟸   XM_006242502
- Peptide Label: isoform X2
- UniProtKB: Q5XIW4 (UniProtKB/TrEMBL),   Q9ESE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242562   ⟸   XM_006242500
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTI9 (UniProtKB/TrEMBL),   Q9ESE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242561   ⟸   XM_006242499
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTI9 (UniProtKB/TrEMBL),   Q9ESE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068729   ⟸   ENSRNOT00000090774
RefSeq Acc Id: ENSRNOP00000007702   ⟸   ENSRNOT00000007702
RefSeq Acc Id: XP_038938121   ⟸   XM_039082193
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTI9 (UniProtKB/TrEMBL),   Q9ESE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122270   ⟸   XM_063266200
- Peptide Label: isoform X1
- UniProtKB: Q9ESE9 (UniProtKB/TrEMBL),   A0A0G2JTI9 (UniProtKB/TrEMBL)
Protein Domains
CARD   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FLN8-F1-model_v2 AlphaFold F7FLN8 1-638 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695738
Promoter ID:EPDNEW_R6262
Type:single initiation site
Description:baculoviral IAP repeat-containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.086,076,489 - 6,076,549EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621282 AgrOrtholog
BioCyc Gene G2FUF-31766 BioCyc
Ensembl Genes ENSRNOG00000005731 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007702.8 UniProtKB/TrEMBL
  ENSRNOT00000090774.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro BIRC2-3-like_UBA UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  Prot_inh_I32_IAP UniProtKB/TrEMBL
KEGG Report rno:78971 UniProtKB/TrEMBL
  BIRC2-3-like_UBA UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
PhenoGen Birc3 PhenoGen
RatGTEx ENSRNOG00000005731 RatGTEx
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  Inhibitor of apoptosis (IAP) repeat UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-08   baculoviral IAP repeat-containing 3  Birc3  inhibitor of apoptosis protein 1  Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Birc3  inhibitor of apoptosis protein 1  Birc2    Symbol and Name updated 1299863 APPROVED
2002-08-07 Birc2  inhibitor of apoptosis protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology has 73% and 89.2% homology to human and mouse IAP1, respectively 632436