Birc3 (baculoviral IAP repeat-containing 3) - Rat Genome Database

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Gene: Birc3 (baculoviral IAP repeat-containing 3) Rattus norvegicus
Analyze
Symbol: Birc3
Name: baculoviral IAP repeat-containing 3
RGD ID: 621282
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Involved in spermatogenesis. Located in membrane raft. Part of protein-containing complex. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: baculoviral IAP repeat-containing protein 3; Birc2; IAP1; inhibitor of apoptosis protein 1; MGC93416
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Birc3m1Mcwi   Birc3m2Mcwi  
Genetic Models: BN-Birc3m1Mcwi SS-Birc3m2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.285,000,844 - 5,028,470 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl85,000,845 - 5,015,802 (-)Ensembl
Rnor_6.086,048,590 - 6,076,828 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,048,969 - 6,076,598 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,047,454 - 6,075,236 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,682,202 - 4,696,856 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.184,682,202 - 4,696,856 (-)NCBI
Celera86,558,921 - 6,573,882 (-)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(aminomethyl)phosphonic acid  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-aminopyridine  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alvocidib  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
aprepitant  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
beauvericin  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bryostatin 1  (ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chrysazin  (ISO)
cisplatin  (ISO)
cladribine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cryptolepine  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
dichloromethane  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
fenofibrate  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gastrin-17  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
gentamycin  (EXP)
gliotoxin  (ISO)
glutathione  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
homocysteine  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibrutinib  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
linalool  (ISO)
lipopolysaccharide  (ISO)
lonafarnib  (ISO)
LY294002  (ISO)
lysophosphatidylethanolamine  (ISO)
melittin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
Mitotane  (EXP)
morin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nitric oxide  (ISO)
o-xylene  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
PD 0325901  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
staurosporine  (ISO)
succimer  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tephrosin  (ISO)
testosterone  (EXP,ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

References

Additional References at PubMed
PMID:8889548   PMID:10797013   PMID:12477932   PMID:15665297   PMID:16115895   PMID:16123224   PMID:16395405   PMID:18621737   PMID:19008929   PMID:19720604   PMID:21052097   PMID:21737330  
PMID:21931591   PMID:23028454   PMID:23192759   PMID:24357921  


Genomics

Comparative Map Data
Birc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.285,000,844 - 5,028,470 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl85,000,845 - 5,015,802 (-)Ensembl
Rnor_6.086,048,590 - 6,076,828 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,048,969 - 6,076,598 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,047,454 - 6,075,236 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,682,202 - 4,696,856 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.184,682,202 - 4,696,856 (-)NCBI
Celera86,558,921 - 6,573,882 (-)NCBICelera
Cytogenetic Map8q11NCBI
BIRC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,317,484 - 102,339,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11102,317,450 - 102,339,403 (+)EnsemblGRCh38hg38GRCh38
GRCh3711102,188,215 - 102,210,134 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,693,404 - 101,713,675 (+)NCBINCBI36hg18NCBI36
Build 3411101,693,403 - 101,713,674NCBI
Celera1199,349,739 - 99,370,012 (+)NCBI
Cytogenetic Map11q22.2NCBI
HuRef1198,114,738 - 98,136,703 (+)NCBIHuRef
CHM1_111102,071,142 - 102,093,097 (+)NCBICHM1_1
T2T-CHM13v2.011102,319,603 - 102,341,520 (+)NCBI
Birc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,848,698 - 7,873,199 (-)NCBIGRCm39mm39
GRCm39 Ensembl97,848,700 - 7,873,187 (-)Ensembl
GRCm3897,847,468 - 7,873,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,848,699 - 7,873,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv3797,848,699 - 7,873,170 (-)NCBIGRCm37mm9NCBIm37
MGSCv3697,849,220 - 7,873,545 (-)NCBImm8
Celera95,240,413 - 5,264,652 (-)NCBICelera
Cytogenetic Map9A1NCBI
Birc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,628,973 - 5,643,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,624,865 - 5,643,520 (+)NCBIChiLan1.0ChiLan1.0
BIRC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111100,763,274 - 100,785,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,763,274 - 100,785,194 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01197,269,778 - 97,290,112 (+)NCBIMhudiblu_PPA_v0panPan3
BIRC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,324,893 - 29,343,322 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,325,331 - 29,337,240 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,274,261 - 29,286,176 (-)NCBI
ROS_Cfam_1.0529,377,538 - 29,396,454 (-)NCBI
ROS_Cfam_1.0 Ensembl529,377,570 - 29,395,969 (-)Ensembl
UMICH_Zoey_3.1529,434,557 - 29,446,661 (-)NCBI
UNSW_CanFamBas_1.0529,292,001 - 29,303,913 (-)NCBI
UU_Cfam_GSD_1.0529,466,940 - 29,478,850 (-)NCBI
Birc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494785,977,221 - 85,992,462 (+)NCBI
SpeTri2.0NW_0049365515,544,047 - 5,556,550 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BIRC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,003,276 - 33,063,420 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,003,570 - 33,020,252 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2936,951,995 - 36,969,108 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BIRC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,692,239 - 93,711,905 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604332,150,453 - 32,171,737 (-)NCBIVero_WHO_p1.0
Birc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624878523,300 - 536,062 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624878516,750 - 541,475 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH139096  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.285,001,178 - 5,001,384 (+)MAPPERmRatBN7.2
Rnor_6.086,048,925 - 6,049,130NCBIRnor6.0
Rnor_5.086,047,789 - 6,047,994UniSTSRnor5.0
RGSC_v3.484,682,230 - 4,682,435UniSTSRGSC3.4
Celera86,559,256 - 6,559,461UniSTS
Cytogenetic Map8q11UniSTS
UniSTS:236051  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.285,000,971 - 5,001,203 (+)MAPPERmRatBN7.2
Rnor_6.086,048,718 - 6,048,949NCBIRnor6.0
Rnor_5.086,047,582 - 6,047,813UniSTSRnor5.0
RGSC_v3.484,682,023 - 4,682,254UniSTSRGSC3.4
Celera86,559,049 - 6,559,280UniSTS
Cytogenetic Map8q11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat


Genetic Models
This gene Birc3 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:52
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000007702
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 8 19 1 10 10
Low 43 49 41 41 8 11 69 34 31 1 8
Below cutoff 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007702   ⟹   ENSRNOP00000007702
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl85,001,422 - 5,015,802 (-)Ensembl
Rnor_6.0 Ensembl86,049,168 - 6,061,837 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090774   ⟹   ENSRNOP00000068729
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl85,000,845 - 5,015,802 (-)Ensembl
Rnor_6.0 Ensembl86,048,969 - 6,076,598 (-)Ensembl
RefSeq Acc Id: NM_023987   ⟹   NP_076477
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.285,000,844 - 5,015,802 (-)NCBI
Rnor_6.086,048,590 - 6,063,975 (-)NCBI
Rnor_5.086,047,454 - 6,075,236 (-)NCBI
RGSC_v3.484,682,202 - 4,696,856 (-)RGD
Celera86,558,921 - 6,573,882 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242499   ⟹   XP_006242561
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.285,000,844 - 5,015,728 (-)NCBI
Rnor_6.086,048,590 - 6,063,901 (-)NCBI
Rnor_5.086,047,454 - 6,075,236 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242500   ⟹   XP_006242562
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.285,000,844 - 5,015,728 (-)NCBI
Rnor_6.086,048,590 - 6,063,901 (-)NCBI
Rnor_5.086,047,454 - 6,075,236 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242502   ⟹   XP_006242564
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.285,000,844 - 5,028,431 (-)NCBI
Rnor_6.086,048,590 - 6,076,828 (-)NCBI
Rnor_5.086,047,454 - 6,075,236 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242503   ⟹   XP_006242565
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.285,000,844 - 5,028,470 (-)NCBI
Rnor_6.086,048,590 - 6,076,828 (-)NCBI
Rnor_5.086,047,454 - 6,075,236 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082193   ⟹   XP_038938121
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.285,000,844 - 5,015,728 (-)NCBI
RefSeq Acc Id: XR_005487928
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.285,005,310 - 5,015,733 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_076477   ⟸   NM_023987
- UniProtKB: F7FLN8 (UniProtKB/TrEMBL),   Q5XIW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242565   ⟸   XM_006242503
- Peptide Label: isoform X2
- UniProtKB: Q5XIW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242564   ⟸   XM_006242502
- Peptide Label: isoform X2
- UniProtKB: Q5XIW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242562   ⟸   XM_006242500
- Peptide Label: isoform X1
- UniProtKB: F7FLN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242561   ⟸   XM_006242499
- Peptide Label: isoform X1
- UniProtKB: F7FLN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068729   ⟸   ENSRNOT00000090774
RefSeq Acc Id: ENSRNOP00000007702   ⟸   ENSRNOT00000007702
RefSeq Acc Id: XP_038938121   ⟸   XM_039082193
- Peptide Label: isoform X1
Protein Domains
CARD   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FLN8-F1-model_v2 AlphaFold F7FLN8 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695738
Promoter ID:EPDNEW_R6262
Type:single initiation site
Name:Birc3_1
Description:baculoviral IAP repeat-containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.086,076,489 - 6,076,549EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621282 AgrOrtholog
BioCyc Gene G2FUF-31766 BioCyc
Ensembl Genes ENSRNOG00000005731 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007702 UniProtKB/TrEMBL
  ENSRNOP00000068729 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007702 UniProtKB/TrEMBL
  ENSRNOT00000090774 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7112819 IMAGE-MGC_LOAD
InterPro BIRC2/BIRC3_UBA UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  Prot_inh_I32_IAP UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
KEGG Report rno:78971 UniProtKB/TrEMBL
MGC_CLONE MGC:93416 IMAGE-MGC_LOAD
NCBI Gene 78971 ENTREZGENE
Pfam BIR UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
PhenoGen Birc3 PhenoGen
PROSITE BIR_REPEAT_1 UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART BIR UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
UniProt F7FLN8 ENTREZGENE, UniProtKB/TrEMBL
  Q5XIW4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-08   baculoviral IAP repeat-containing 3  Birc3  inhibitor of apoptosis protein 1  Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Birc3  inhibitor of apoptosis protein 1  Birc2    Symbol and Name updated 1299863 APPROVED
2002-08-07 Birc2  inhibitor of apoptosis protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology has 73% and 89.2% homology to human and mouse IAP1, respectively 632436