Oxct1 (3-oxoacid CoA transferase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Oxct1 (3-oxoacid CoA transferase 1) Rattus norvegicus
Analyze
Symbol: Oxct1
Name: 3-oxoacid CoA transferase 1
RGD ID: 1584008
Description: Enables identical protein binding activity and succinyl-CoA:3-oxo-acid CoA-transferase activity. Involved in several processes, including cellular ketone body metabolic process; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to ethanol. Predicted to be active in mitochondrion. Biomarker of obesity and type 2 diabetes mellitus. Orthologous to human OXCT1 (3-oxoacid CoA-transferase 1); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-oxoacid CoA-transferase 1; 3-oxoacid-CoA transferase 1; LOC100359544; LOC690163; MGC187935; SCOT; scot-S; similar to 3-oxoacid CoA transferase 1; somatic-type succinyl CoA:3-oxoacid CoA-transferase; somatic-type succinyl-CoA:3-oxoacid CoA-transferase; succinyl-CoA:3-ketoacid CoA transferase; succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial; succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial-like; succinyl-CoA:3-oxoacid CoA transferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8254,963,964 - 55,112,303 (+)NCBIGRCr8
mRatBN7.2253,236,370 - 53,384,715 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl253,236,368 - 53,384,714 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx260,341,203 - 60,475,958 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0258,399,945 - 58,534,694 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0253,425,153 - 53,555,506 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0253,859,738 - 54,007,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl253,859,737 - 54,007,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0272,891,713 - 73,037,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4253,189,358 - 53,217,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera248,914,408 - 49,050,216 (+)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
folic acid  (ISO)
folpet  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
hydrogen sulfide  (ISO)
indometacin  (EXP,ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentanal  (ISO)
PhIP  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Fatty acid and ketone body metabolism in the rat: response to diet and exercise. Askew EW, etal., J Nutr. 1975 Nov;105(11):1422-32.
2. Effects of age and calorie restriction on tryptophan nitration, protein content, and activity of succinyl-CoA:3-ketoacid CoA transferase in rat kidney mitochondria. Bregere C, etal., Free Radic Biol Med. 2010 Feb 15;48(4):609-18. Epub 2009 Dec 16.
3. Glycemia, ketonemia, and brain enzymes of ketone body utilization in suckling and adult rats undernourished from intrauterine life. Escriva F, etal., J Neurochem. 1985 May;44(5):1358-62.
4. Circulating glucose, insulin and ketone bodies and enzymes of ketone body utilization in brain mitochondria from suckling rats treated with high L-thyroxine doses. Escriva F, etal., Rev Esp Fisiol. 1983 Dec;39(4):363-71.
5. Prenatal diagnosis of succinyl-coenzyme A:3-ketoacid coenzyme A transferase deficiency. Fukao T, etal., Prenat Diagn. 1996 May;16(5):471-4.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Decreased rate of ketone-body oxidation and decreased activity of D-3-hydroxybutyrate dehydrogenase and succinyl-CoA:3-oxo-acid CoA-transferase in heart mitochondria of diabetic rats. Grinblat L, etal., Biochem J. 1986 Nov 15;240(1):49-56.
8. Regulation of succinyl-CoA:3-oxoacid CoA-transferase in developing rat brain: responsiveness associated with prenatal but not postnatal hyperketonemia. Haney PM and Patel MS, Arch Biochem Biophys. 1985 Jul;240(1):426-34.
9. Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells. Hasan NM, etal., Arch Biochem Biophys. 2010 Jul;499(1-2):62-8. Epub 2010 May 9.
10. The course of ketosis and the activity of key enzymes of ketogenesis and ketone-body utilization during development of the postnatal rat. Lockwood EA and Bailey E, Biochem J. 1971 Aug;124(1):249-54.
11. Utilization of ketone bodies by the rat liver, brain and heart in chronic alcohol intoxication. Lukivskaya OYa and Buko VU, Alcohol Alcohol. 1993 Jul;28(4):431-6.
12. Cerebral ketone body metabolism. Morris AA J Inherit Metab Dis. 2005;28(2):109-21.
13. Genetic obesity affects neural ketone body utilization in the rat brain. Narishima R, etal., Obesity (Silver Spring). 2009 Mar;17(3):611-5. Epub 2008 Dec 11.
14. Tamoxifen induces oxidative stress and mitochondrial apoptosis via stimulating mitochondrial nitric oxide synthase. Nazarewicz RR, etal., Cancer Res. 2007 Feb 1;67(3):1282-90.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. Nitration of tryptophan 372 in succinyl-CoA:3-ketoacid CoA transferase during aging in rat heart mitochondria. Rebrin I, etal., Biochemistry. 2007 Sep 4;46(35):10130-44. Epub 2007 Aug 8.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Purification and properties of succinyl-CoA:3-oxo-acid CoA-transferase from rat brain. Russell JJ and Patel MS, J Neurochem. 1982 May;38(5):1446-52.
23. Effect of enteral nutrition of monoacetoacetin on bacterial translocation in burned rats. Takahata T, etal., JPEN J Parenter Enteral Nutr. 2004 Sep-Oct;28(5):301-7.
24. Activities of enzymes of acetoacetate metabolism in rat brown adipose tissue during development. Williamson DH and Ilic V, Biochem J. 1985 Nov 1;231(3):773-5.
Additional References at PubMed
PMID:868435   PMID:6594997   PMID:8751852   PMID:9671268   PMID:10964512   PMID:11756565   PMID:12463743   PMID:12477932   PMID:12534938   PMID:14651853   PMID:15388917   PMID:17718512  
PMID:18614015   PMID:20606260   PMID:20977214   PMID:21209089   PMID:26316108   PMID:29867124  


Genomics

Comparative Map Data
Oxct1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8254,963,964 - 55,112,303 (+)NCBIGRCr8
mRatBN7.2253,236,370 - 53,384,715 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl253,236,368 - 53,384,714 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx260,341,203 - 60,475,958 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0258,399,945 - 58,534,694 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0253,425,153 - 53,555,506 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0253,859,738 - 54,007,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl253,859,737 - 54,007,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0272,891,713 - 73,037,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4253,189,358 - 53,217,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera248,914,408 - 49,050,216 (+)NCBICelera
Cytogenetic Map2q16NCBI
OXCT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38541,730,065 - 41,870,425 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl541,730,065 - 41,870,425 (-)EnsemblGRCh38hg38GRCh38
GRCh37541,730,167 - 41,870,527 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36541,765,924 - 41,906,548 (-)NCBINCBI36Build 36hg18NCBI36
Build 34541,765,924 - 41,906,360NCBI
Celera541,618,583 - 41,759,082 (-)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef541,683,008 - 41,823,471 (-)NCBIHuRef
CHM1_1541,732,020 - 41,872,646 (-)NCBICHM1_1
T2T-CHM13v2.0541,986,435 - 42,126,806 (-)NCBIT2T-CHM13v2.0
Oxct1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39154,055,910 - 4,184,826 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl154,055,865 - 4,184,826 (+)EnsemblGRCm39 Ensembl
GRCm38154,026,428 - 4,155,344 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl154,026,383 - 4,155,344 (+)EnsemblGRCm38mm10GRCm38
MGSCv37153,976,428 - 4,105,344 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36153,976,749 - 4,104,101 (+)NCBIMGSCv36mm8
Celera153,888,106 - 4,016,714 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.86NCBI
Oxct1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542625,885,518 - 26,003,743 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542625,885,518 - 25,998,187 (-)NCBIChiLan1.0ChiLan1.0
OXCT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2468,480,013 - 68,619,508 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1566,633,110 - 66,773,139 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0568,528,765 - 68,668,305 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1573,571,227 - 73,710,316 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl573,563,758 - 73,710,316 (+)Ensemblpanpan1.1panPan2
OXCT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1467,709,846 - 67,841,737 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl467,527,531 - 67,841,518 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha467,392,579 - 67,524,955 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0468,221,131 - 68,355,789 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl468,221,108 - 68,382,024 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1467,962,898 - 68,117,238 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0468,093,650 - 68,227,696 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0468,633,289 - 68,767,738 (+)NCBIUU_Cfam_GSD_1.0
Oxct1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213230,314,635 - 230,446,563 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936518924,840 - 1,057,201 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OXCT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1626,512,401 - 26,659,808 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11626,514,497 - 26,659,739 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21627,702,633 - 27,729,489 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21627,840,670 - 27,923,998 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OXCT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1440,477,983 - 40,620,971 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607130,913,067 - 31,057,690 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oxct1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475913,093,408 - 13,247,244 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475913,093,409 - 13,247,244 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Oxct1
833 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:465
Count of miRNA genes:254
Interacting mature miRNAs:322
Transcripts:ENSRNOT00000065313
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat

Markers in Region
AA819087  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map2331.5UniSTS
Cytogenetic Map2q16UniSTS
RH136940  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2253,384,354 - 53,384,568 (+)MAPPERmRatBN7.2
Rnor_6.0254,007,373 - 54,007,586NCBIRnor6.0
Rnor_5.0273,037,257 - 73,037,470UniSTSRnor5.0
RGSC_v3.4253,217,488 - 53,217,701UniSTSRGSC3.4
Celera249,049,856 - 49,050,069UniSTS
RH 3.4 Map2330.8UniSTS
Cytogenetic Map2q16UniSTS
BF416594  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2253,237,699 - 53,237,796 (+)MAPPERmRatBN7.2
Rnor_6.0253,861,068 - 53,861,164NCBIRnor6.0
Rnor_5.0272,893,043 - 72,893,139UniSTSRnor5.0
RGSC_v3.4253,935,763 - 53,935,859UniSTSRGSC3.4
Celera248,915,738 - 48,915,834UniSTS
RH 3.4 Map2330.8UniSTS
Cytogenetic Map2q16UniSTS
AU049976  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2253,288,652 - 53,288,845 (+)MAPPERmRatBN7.2
Rnor_6.0253,912,268 - 53,912,458NCBIRnor6.0
Rnor_5.0272,944,216 - 72,944,406UniSTSRnor5.0
RGSC_v3.4253,987,390 - 53,987,582UniSTSRGSC3.4
Cytogenetic Map2q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 36 20 19 20 8 11 74 35 37 11 8
Low 21 21 21 4
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000065313   ⟹   ENSRNOP00000063646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl253,236,420 - 53,384,714 (+)Ensembl
Rnor_6.0 Ensembl253,859,737 - 54,007,756 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107045   ⟹   ENSRNOP00000090363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl253,244,927 - 53,384,710 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000120275   ⟹   ENSRNOP00000077241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl253,236,368 - 53,383,069 (+)Ensembl
RefSeq Acc Id: NM_001127580   ⟹   NP_001121052
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8254,963,964 - 55,112,303 (+)NCBI
mRatBN7.2253,236,370 - 53,384,715 (+)NCBI
Rnor_6.0253,859,738 - 54,007,733 (+)NCBI
Rnor_5.0272,891,713 - 73,037,617 (+)NCBI
RGSC_v3.4253,189,358 - 53,217,848 (+)RGD
Celera248,914,408 - 49,050,216 (+)RGD
Sequence:
RefSeq Acc Id: NP_001121052   ⟸   NM_001127580
- Peptide Label: precursor
- UniProtKB: B2GV06 (UniProtKB/Swiss-Prot),   A0A8L2UNL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063646   ⟸   ENSRNOT00000065313
RefSeq Acc Id: ENSRNOP00000077241   ⟸   ENSRNOT00000120275
RefSeq Acc Id: ENSRNOP00000090363   ⟸   ENSRNOT00000107045

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GV06-F1-model_v2 AlphaFold B2GV06 1-520 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691165
Promoter ID:EPDNEW_R1690
Type:initiation region
Name:Oxct1_1
Description:3-oxoacid CoA transferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0253,859,736 - 53,859,796EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584008 AgrOrtholog
BioCyc Gene G2FUF-54192 BioCyc
BioCyc Pathway PWY66-368 [ketolysis] BioCyc
BioCyc Pathway Image PWY66-368 BioCyc
Ensembl Genes ENSRNOG00000043094 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055006328 UniProtKB/Swiss-Prot
  ENSRNOG00060014219 UniProtKB/Swiss-Prot
  ENSRNOG00065021604 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000065313 ENTREZGENE
  ENSRNOT00000065313.4 UniProtKB/TrEMBL
  ENSRNOT00000107045.1 UniProtKB/TrEMBL
  ENSRNOT00000120275.1 UniProtKB/TrEMBL
  ENSRNOT00055010297 UniProtKB/Swiss-Prot
  ENSRNOT00060024375 UniProtKB/Swiss-Prot
  ENSRNOT00065036753 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaconate Coenzyme A-transferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9102243 IMAGE-MGC_LOAD
InterPro 3-oxoacid_CoA-transf_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3-oxoacid_CoA-transf_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3-oxoacid_CoA-transferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CoA_trans_fam_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CoA_transf_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CoA_transf_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NagB/RpiA_transferase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:690163 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187935 IMAGE-MGC_LOAD
NCBI Gene 690163 ENTREZGENE
PANTHER PTHR13707 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUCCINYL-COA:3-KETOACID COENZYME A TRANSFERASE 1, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CoA_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Oxct1 PhenoGen
PIRSF SCOT-t UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE COA_TRANSF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COA_TRANSF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043094 RatGTEx
  ENSRNOG00055006328 RatGTEx
  ENSRNOG00060014219 RatGTEx
  ENSRNOG00065021604 RatGTEx
SMART CoA_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100950 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y5J4_RAT UniProtKB/TrEMBL
  A0A8I6A9X8_RAT UniProtKB/TrEMBL
  A0A8L2UNL5 ENTREZGENE, UniProtKB/TrEMBL
  B2GV06 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Oxct1  3-oxoacid CoA transferase 1  LOC100359544  succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial-like  Data merged from RGD:2323650 737654 PROVISIONAL
2010-05-06 LOC100359544  succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Oxct1  3-oxoacid CoA transferase 1  LOC690163  similar to 3-oxoacid CoA transferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC690163  similar to 3-oxoacid CoA transferase 1      Symbol and Name status set to provisional 70820 PROVISIONAL